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Protein

Beta-1,3-galactosyltransferase 4

Gene

B3galt4

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Involved in GM1/GD1B/GA1 ganglioside biosynthesis.1 Publication

Catalytic activityi

UDP-alpha-D-galactose + an N-acetyl-beta-D-galactosaminyl-(1->4)-(alpha-N-acetylneuraminyl-(2->3))-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide = UDP + a beta-D-galactosyl-(1->3)-N-acetyl-beta-D-galactosaminyl-(1->4)-(alpha-N-acetylneuraminyl-(2->3))-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide.1 Publication

Pathwayi: protein glycosylation

This protein is involved in the pathway protein glycosylation, which is part of Protein modification.
View all proteins of this organism that are known to be involved in the pathway protein glycosylation and in Protein modification.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionGlycosyltransferase, Transferase

Enzyme and pathway databases

UniPathwayiUPA00378

Protein family/group databases

CAZyiGT31 Glycosyltransferase Family 31

Names & Taxonomyi

Protein namesi
Recommended name:
Beta-1,3-galactosyltransferase 4 (EC:2.4.1.621 Publication)
Short name:
Beta-1,3-GalTase 4
Short name:
Beta3Gal-T4
Short name:
Beta3GalT4
Short name:
b3Gal-T4
Alternative name(s):
Gal-T2
Ganglioside galactosyltransferase
UDP-galactose:beta-N-acetyl-galactosamine-beta-1,3-galactosyltransferase
Gene namesi
Name:B3galt4
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi620328 B3galt4

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 4CytoplasmicSequence analysis4
Transmembranei5 – 25Helical; Signal-anchor for type II membrane proteinSequence analysisAdd BLAST21
Topological domaini26 – 371LumenalSequence analysisAdd BLAST346

Keywords - Cellular componenti

Golgi apparatus, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002191621 – 371Beta-1,3-galactosyltransferase 4Add BLAST371

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi143N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiO88178
PRIDEiO88178

Expressioni

Tissue specificityi

Highly expressed in thymus, spleen, kidney and testis and, to a lesser extent, in brain and liver.1 Publication

Developmental stagei

In the embryonic brain, expression begins at day 12 and continues until birth. Expression is maintained at low levels in adult brain.1 Publication

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000000550

Structurei

3D structure databases

ProteinModelPortaliO88178
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the glycosyltransferase 31 family.Curated

Keywords - Domaini

Signal-anchor, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG2287 Eukaryota
ENOG410ZZ1B LUCA
HOGENOMiHOG000064523
HOVERGENiHBG050651
InParanoidiO88178
PhylomeDBiO88178

Family and domain databases

InterProiView protein in InterPro
IPR002659 Glyco_trans_31
PANTHERiPTHR11214 PTHR11214, 1 hit
PfamiView protein in Pfam
PF01762 Galactosyl_T, 1 hit

Sequencei

Sequence statusi: Complete.

O88178-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPLSLFRRLL LAVLLLVIIW TLFGPSGLGE ELLSLSLASL LPAPASPGPP
60 70 80 90 100
LALPRLLIPN PQACGGSGPP PFLLILVCTA PEHLNQRNAI RGSWGAIREA
110 120 130 140 150
RGFRVQTLFL LGEPMGQQFA DLASESAAQG DVLQASFQDS YRNLTLKTLT
160 170 180 190 200
GLNWVNKYCP MARYILKTDD DVYVNVPELV SELIQRGGPS EQWQKGKEPQ
210 220 230 240 250
EETTAVHKEH KGQAVPLLYL GRVHWRVRPT RTPESRHHVS EELWPENWGP
260 270 280 290 300
FPPYASGTGY VLSISAVQLI LKVASRAPYL PLEDVFVGVS ARRVGLAPTH
310 320 330 340 350
CVKLAGATHY PLDRCCYGKF LLTSHKVDPW KMQEAWKLVR GLNGRRTEPF
360 370
CSWLQGFLGT LRCRFIAWLN S
Length:371
Mass (Da):41,254
Last modified:November 1, 1998 - v1
Checksum:i327FB76EFDACF131
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB003478 mRNA Translation: BAA32045.1
UniGeneiRn.24575

Genome annotation databases

UCSCiRGD:620328 rat

Similar proteinsi

Entry informationi

Entry nameiB3GT4_RAT
AccessioniPrimary (citable) accession number: O88178
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 10, 2002
Last sequence update: November 1, 1998
Last modified: May 23, 2018
This is version 104 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

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