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Protein

Beta-1,3-galactosyltransferase 4

Gene

B3galt4

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Involved in GM1/GD1B/GA1 ganglioside biosynthesis.1 Publication

Catalytic activityi

UDP-alpha-D-galactose + an N-acetyl-beta-D-galactosaminyl-(1->4)-(alpha-N-acetylneuraminyl-(2->3))-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide = UDP + a beta-D-galactosyl-(1->3)-N-acetyl-beta-D-galactosaminyl-(1->4)-(alpha-N-acetylneuraminyl-(2->3))-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide.

Pathwayi: protein glycosylation

This protein is involved in the pathway protein glycosylation, which is part of Protein modification.
View all proteins of this organism that are known to be involved in the pathway protein glycosylation and in Protein modification.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Glycosyltransferase, Transferase

Enzyme and pathway databases

UniPathwayiUPA00378.

Protein family/group databases

CAZyiGT31. Glycosyltransferase Family 31.

Names & Taxonomyi

Protein namesi
Recommended name:
Beta-1,3-galactosyltransferase 4 (EC:2.4.1.62)
Short name:
Beta-1,3-GalTase 4
Short name:
Beta3Gal-T4
Short name:
Beta3GalT4
Short name:
b3Gal-T4
Alternative name(s):
Gal-T2
Ganglioside galactosyltransferase
UDP-galactose:beta-N-acetyl-galactosamine-beta-1,3-galactosyltransferase
Gene namesi
Name:B3galt4
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi620328. B3galt4.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 44CytoplasmicSequence analysis
Transmembranei5 – 2521Helical; Signal-anchor for type II membrane proteinSequence analysisAdd
BLAST
Topological domaini26 – 371346LumenalSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Golgi apparatus, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 371371Beta-1,3-galactosyltransferase 4PRO_0000219162Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi143 – 1431N-linked (GlcNAc...)Sequence analysis

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiO88178.
PRIDEiO88178.

Expressioni

Tissue specificityi

Highly expressed in thymus, spleen, kidney and testis and, to a lesser extent, in brain and liver.1 Publication

Developmental stagei

In the embryonic brain, expression begins at day 12 and continues until birth. Expression is maintained at low levels in adult brain.1 Publication

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000000550.

Structurei

3D structure databases

ProteinModelPortaliO88178.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the glycosyltransferase 31 family.Curated

Keywords - Domaini

Signal-anchor, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG2287. Eukaryota.
ENOG410ZZ1B. LUCA.
HOGENOMiHOG000064523.
HOVERGENiHBG050651.
InParanoidiO88178.
PhylomeDBiO88178.

Family and domain databases

InterProiIPR002659. Glyco_trans_31.
[Graphical view]
PANTHERiPTHR11214. PTHR11214. 2 hits.
PfamiPF01762. Galactosyl_T. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O88178-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPLSLFRRLL LAVLLLVIIW TLFGPSGLGE ELLSLSLASL LPAPASPGPP
60 70 80 90 100
LALPRLLIPN PQACGGSGPP PFLLILVCTA PEHLNQRNAI RGSWGAIREA
110 120 130 140 150
RGFRVQTLFL LGEPMGQQFA DLASESAAQG DVLQASFQDS YRNLTLKTLT
160 170 180 190 200
GLNWVNKYCP MARYILKTDD DVYVNVPELV SELIQRGGPS EQWQKGKEPQ
210 220 230 240 250
EETTAVHKEH KGQAVPLLYL GRVHWRVRPT RTPESRHHVS EELWPENWGP
260 270 280 290 300
FPPYASGTGY VLSISAVQLI LKVASRAPYL PLEDVFVGVS ARRVGLAPTH
310 320 330 340 350
CVKLAGATHY PLDRCCYGKF LLTSHKVDPW KMQEAWKLVR GLNGRRTEPF
360 370
CSWLQGFLGT LRCRFIAWLN S
Length:371
Mass (Da):41,254
Last modified:November 1, 1998 - v1
Checksum:i327FB76EFDACF131
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB003478 mRNA. Translation: BAA32045.1.
UniGeneiRn.24575.

Genome annotation databases

UCSCiRGD:620328. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB003478 mRNA. Translation: BAA32045.1.
UniGeneiRn.24575.

3D structure databases

ProteinModelPortaliO88178.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000000550.

Protein family/group databases

CAZyiGT31. Glycosyltransferase Family 31.

Proteomic databases

PaxDbiO88178.
PRIDEiO88178.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

UCSCiRGD:620328. rat.

Organism-specific databases

RGDi620328. B3galt4.

Phylogenomic databases

eggNOGiKOG2287. Eukaryota.
ENOG410ZZ1B. LUCA.
HOGENOMiHOG000064523.
HOVERGENiHBG050651.
InParanoidiO88178.
PhylomeDBiO88178.

Enzyme and pathway databases

UniPathwayiUPA00378.

Miscellaneous databases

PROiO88178.

Family and domain databases

InterProiIPR002659. Glyco_trans_31.
[Graphical view]
PANTHERiPTHR11214. PTHR11214. 2 hits.
PfamiPF01762. Galactosyl_T. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiB3GT4_RAT
AccessioniPrimary (citable) accession number: O88178
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 10, 2002
Last sequence update: November 1, 1998
Last modified: December 9, 2015
This is version 99 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.