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Protein

Peroxisome assembly protein 12

Gene

Pex12

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Required for protein import into peroxisomes.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri304 – 34340RING-type; degenerateAdd
BLAST

GO - Molecular functioni

GO - Biological processi

  • peroxisome organization Source: RGD
  • protein targeting to peroxisome Source: InterPro
Complete GO annotation...

Keywords - Biological processi

Protein transport, Transport

Keywords - Ligandi

Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Peroxisome assembly protein 12
Alternative name(s):
Peroxin-12
Peroxisome assembly factor 3
Short name:
PAF-3
Gene namesi
Name:Pex12
Synonyms:Paf3
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 10

Organism-specific databases

RGDi620757. Pex12.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 158158CytoplasmicSequence analysisAdd
BLAST
Transmembranei159 – 17921HelicalSequence analysisAdd
BLAST
Topological domaini180 – 23960Peroxisomal matrixSequence analysisAdd
BLAST
Transmembranei240 – 26021HelicalSequence analysisAdd
BLAST
Topological domaini261 – 35999CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

  • integral component of peroxisomal membrane Source: InterPro
  • peroxisomal membrane Source: HGNC
  • peroxisome Source: RGD
Complete GO annotation...

Keywords - Cellular componenti

Membrane, Peroxisome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 359359Peroxisome assembly protein 12PRO_0000218612Add
BLAST

Proteomic databases

PaxDbiO88177.
PRIDEiO88177.

Expressioni

Gene expression databases

GenevisibleiO88177. RN.

Interactioni

Subunit structurei

Interacts with PEX5 and PEX10. Interacts with PEX19 via its cytoplasmic domain (By similarity).By similarity

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000064928.

Structurei

3D structure databases

ProteinModelPortaliO88177.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi280 – 2856Poly-Pro

Sequence similaritiesi

Belongs to the pex2/pex10/pex12 family.Curated
Contains 1 RING-type zinc finger.Curated

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri304 – 34340RING-type; degenerateAdd
BLAST

Keywords - Domaini

Transmembrane, Transmembrane helix, Zinc-finger

Phylogenomic databases

eggNOGiKOG0826. Eukaryota.
ENOG410Y4Q2. LUCA.
GeneTreeiENSGT00390000016209.
HOGENOMiHOG000038427.
HOVERGENiHBG053569.
InParanoidiO88177.
KOiK13345.
OMAiFHYVRSH.
OrthoDBiEOG73NG3W.
PhylomeDBiO88177.
TreeFamiTF314511.

Family and domain databases

Gene3Di3.30.40.10. 1 hit.
InterProiIPR017375. PEX12.
IPR006845. Pex_N.
IPR013083. Znf_RING/FYVE/PHD.
[Graphical view]
PANTHERiPTHR12888. PTHR12888. 1 hit.
PfamiPF04757. Pex2_Pex12. 1 hit.
[Graphical view]
PIRSFiPIRSF038074. Peroxisome_assembly_p12. 1 hit.

Sequencei

Sequence statusi: Complete.

O88177-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAEHGAHITT ASVADDQPSI FEVVAQDSLM TAVRPALQHV VKVLAESNPA
60 70 80 90 100
HYGFFWRWFD EIFTLLDFLL QQHYLSRTSA SFSEHFYGLK RIVAGSSPQL
110 120 130 140 150
QRPASAGLPK EHLWKSAMFL VLLPYLKVKL EKLASTLREE DEYSIHPPSS
160 170 180 190 200
HWKRFYRVFL AAYPFVTMTW EGWFLTQQLR YILGKAEHHS PLLKLAGVRL
210 220 230 240 250
GRLTAQDIQA MEHRLVEASA MQEPVRSIGK KIKSALKKAV GGVALSLSTG
260 270 280 290 300
LSVGVFFLQF LDWWYSSENQ ETIKSLTALP TPPPPVHLDY NSDSPLLPKM
310 320 330 340 350
KTVCPLCRKA RVNDTVLATS GYVFCYRCVF NYVRSHQACP ITGYPTEVQH

LIKLYSPEN
Length:359
Mass (Da):40,681
Last modified:November 1, 1998 - v1
Checksum:iE63C39801406733D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB002111 mRNA. Translation: BAA31558.1.
BC072481 mRNA. Translation: AAH72481.1.
RefSeqiNP_446373.1. NM_053921.1.
XP_003750938.1. XM_003750890.3.
XP_006247029.1. XM_006246967.2.
XP_006247088.1. XM_006247026.2.
XP_008766156.1. XM_008767934.1.
XP_008772090.1. XM_008773868.1.
UniGeneiRn.234355.

Genome annotation databases

EnsembliENSRNOT00000013233; ENSRNOP00000013233; ENSRNOG00000009718.
ENSRNOT00000082684; ENSRNOP00000071499; ENSRNOG00000009718.
ENSRNOT00000083350; ENSRNOP00000071737; ENSRNOG00000052864.
GeneIDi116718.
KEGGirno:100909787.
rno:116718.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB002111 mRNA. Translation: BAA31558.1.
BC072481 mRNA. Translation: AAH72481.1.
RefSeqiNP_446373.1. NM_053921.1.
XP_003750938.1. XM_003750890.3.
XP_006247029.1. XM_006246967.2.
XP_006247088.1. XM_006247026.2.
XP_008766156.1. XM_008767934.1.
XP_008772090.1. XM_008773868.1.
UniGeneiRn.234355.

3D structure databases

ProteinModelPortaliO88177.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000064928.

Proteomic databases

PaxDbiO88177.
PRIDEiO88177.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000013233; ENSRNOP00000013233; ENSRNOG00000009718.
ENSRNOT00000082684; ENSRNOP00000071499; ENSRNOG00000009718.
ENSRNOT00000083350; ENSRNOP00000071737; ENSRNOG00000052864.
GeneIDi116718.
KEGGirno:100909787.
rno:116718.

Organism-specific databases

CTDi5193.
RGDi620757. Pex12.

Phylogenomic databases

eggNOGiKOG0826. Eukaryota.
ENOG410Y4Q2. LUCA.
GeneTreeiENSGT00390000016209.
HOGENOMiHOG000038427.
HOVERGENiHBG053569.
InParanoidiO88177.
KOiK13345.
OMAiFHYVRSH.
OrthoDBiEOG73NG3W.
PhylomeDBiO88177.
TreeFamiTF314511.

Miscellaneous databases

NextBioi619620.
PROiO88177.

Gene expression databases

GenevisibleiO88177. RN.

Family and domain databases

Gene3Di3.30.40.10. 1 hit.
InterProiIPR017375. PEX12.
IPR006845. Pex_N.
IPR013083. Znf_RING/FYVE/PHD.
[Graphical view]
PANTHERiPTHR12888. PTHR12888. 1 hit.
PfamiPF04757. Pex2_Pex12. 1 hit.
[Graphical view]
PIRSFiPIRSF038074. Peroxisome_assembly_p12. 1 hit.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "PEX12, the pathogenic gene of group III Zellweger syndrome: cDNA cloning by functional complementation on a CHO cell mutant, patient analysis, and characterization of PEX12p."
    Okumoto K., Shimozawa N., Kawai A., Tamura S., Tsukamoto T., Osumi T., Moser H., Wanders R.J.A., Suzuki Y., Kondo N., Fujiki Y.
    Mol. Cell. Biol. 18:4324-4336(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Heart.

Entry informationi

Entry nameiPEX12_RAT
AccessioniPrimary (citable) accession number: O88177
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 24, 2001
Last sequence update: November 1, 1998
Last modified: May 11, 2016
This is version 108 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.