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Protein

Peroxisome assembly protein 12

Gene

Pex12

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Required for protein import into peroxisomes.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri304 – 343RING-type; degenerateAdd BLAST40

GO - Molecular functioni

GO - Biological processi

  • peroxisome organization Source: RGD
  • protein import into peroxisome matrix Source: GO_Central
  • protein monoubiquitination Source: GO_Central
Complete GO annotation...

Keywords - Biological processi

Protein transport, Transport

Keywords - Ligandi

Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Peroxisome assembly protein 12
Alternative name(s):
Peroxin-12
Peroxisome assembly factor 3
Short name:
PAF-3
Gene namesi
Name:Pex12
Synonyms:Paf3
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 10

Organism-specific databases

RGDi620757. Pex12.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 158CytoplasmicSequence analysisAdd BLAST158
Transmembranei159 – 179HelicalSequence analysisAdd BLAST21
Topological domaini180 – 239Peroxisomal matrixSequence analysisAdd BLAST60
Transmembranei240 – 260HelicalSequence analysisAdd BLAST21
Topological domaini261 – 359CytoplasmicSequence analysisAdd BLAST99

GO - Cellular componenti

  • integral component of peroxisomal membrane Source: GO_Central
  • peroxisomal importomer complex Source: GO_Central
  • peroxisomal membrane Source: HGNC
  • peroxisome Source: RGD
Complete GO annotation...

Keywords - Cellular componenti

Membrane, Peroxisome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002186121 – 359Peroxisome assembly protein 12Add BLAST359

Proteomic databases

PaxDbiO88177.
PRIDEiO88177.

Expressioni

Gene expression databases

BgeeiENSRNOG00000009718.
GenevisibleiO88177. RN.

Interactioni

Subunit structurei

Interacts with PEX5 and PEX10. Interacts with PEX19 via its cytoplasmic domain (By similarity).By similarity

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000064928.

Structurei

3D structure databases

ProteinModelPortaliO88177.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi280 – 285Poly-Pro6

Sequence similaritiesi

Belongs to the pex2/pex10/pex12 family.Curated
Contains 1 RING-type zinc finger.Curated

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri304 – 343RING-type; degenerateAdd BLAST40

Keywords - Domaini

Transmembrane, Transmembrane helix, Zinc-finger

Phylogenomic databases

eggNOGiKOG0826. Eukaryota.
ENOG410Y4Q2. LUCA.
GeneTreeiENSGT00390000016209.
HOGENOMiHOG000038427.
HOVERGENiHBG053569.
InParanoidiO88177.
KOiK13345.
OMAiFHYVRSH.
PhylomeDBiO88177.
TreeFamiTF314511.

Family and domain databases

Gene3Di3.30.40.10. 1 hit.
InterProiIPR017375. PEX12.
IPR006845. Pex_N.
IPR013083. Znf_RING/FYVE/PHD.
[Graphical view]
PANTHERiPTHR12888. PTHR12888. 1 hit.
PfamiPF04757. Pex2_Pex12. 1 hit.
[Graphical view]
PIRSFiPIRSF038074. Peroxisome_assembly_p12. 1 hit.

Sequencei

Sequence statusi: Complete.

O88177-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAEHGAHITT ASVADDQPSI FEVVAQDSLM TAVRPALQHV VKVLAESNPA
60 70 80 90 100
HYGFFWRWFD EIFTLLDFLL QQHYLSRTSA SFSEHFYGLK RIVAGSSPQL
110 120 130 140 150
QRPASAGLPK EHLWKSAMFL VLLPYLKVKL EKLASTLREE DEYSIHPPSS
160 170 180 190 200
HWKRFYRVFL AAYPFVTMTW EGWFLTQQLR YILGKAEHHS PLLKLAGVRL
210 220 230 240 250
GRLTAQDIQA MEHRLVEASA MQEPVRSIGK KIKSALKKAV GGVALSLSTG
260 270 280 290 300
LSVGVFFLQF LDWWYSSENQ ETIKSLTALP TPPPPVHLDY NSDSPLLPKM
310 320 330 340 350
KTVCPLCRKA RVNDTVLATS GYVFCYRCVF NYVRSHQACP ITGYPTEVQH

LIKLYSPEN
Length:359
Mass (Da):40,681
Last modified:November 1, 1998 - v1
Checksum:iE63C39801406733D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB002111 mRNA. Translation: BAA31558.1.
BC072481 mRNA. Translation: AAH72481.1.
RefSeqiNP_446373.1. NM_053921.1.
XP_003750938.1. XM_003750890.4.
XP_008766156.1. XM_008767934.2.
XP_008772090.1. XM_008773868.2.
XP_017452452.1. XM_017596963.1.
XP_017458013.1. XM_017602524.1.
UniGeneiRn.234355.

Genome annotation databases

EnsembliENSRNOT00000013233; ENSRNOP00000013233; ENSRNOG00000009718.
ENSRNOT00000082684; ENSRNOP00000071499; ENSRNOG00000009718.
ENSRNOT00000083350; ENSRNOP00000071737; ENSRNOG00000052864.
GeneIDi108348326.
116718.
KEGGirno:100909787.
rno:116718.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB002111 mRNA. Translation: BAA31558.1.
BC072481 mRNA. Translation: AAH72481.1.
RefSeqiNP_446373.1. NM_053921.1.
XP_003750938.1. XM_003750890.4.
XP_008766156.1. XM_008767934.2.
XP_008772090.1. XM_008773868.2.
XP_017452452.1. XM_017596963.1.
XP_017458013.1. XM_017602524.1.
UniGeneiRn.234355.

3D structure databases

ProteinModelPortaliO88177.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000064928.

Proteomic databases

PaxDbiO88177.
PRIDEiO88177.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000013233; ENSRNOP00000013233; ENSRNOG00000009718.
ENSRNOT00000082684; ENSRNOP00000071499; ENSRNOG00000009718.
ENSRNOT00000083350; ENSRNOP00000071737; ENSRNOG00000052864.
GeneIDi108348326.
116718.
KEGGirno:100909787.
rno:116718.

Organism-specific databases

CTDi5193.
RGDi620757. Pex12.

Phylogenomic databases

eggNOGiKOG0826. Eukaryota.
ENOG410Y4Q2. LUCA.
GeneTreeiENSGT00390000016209.
HOGENOMiHOG000038427.
HOVERGENiHBG053569.
InParanoidiO88177.
KOiK13345.
OMAiFHYVRSH.
PhylomeDBiO88177.
TreeFamiTF314511.

Miscellaneous databases

PROiO88177.

Gene expression databases

BgeeiENSRNOG00000009718.
GenevisibleiO88177. RN.

Family and domain databases

Gene3Di3.30.40.10. 1 hit.
InterProiIPR017375. PEX12.
IPR006845. Pex_N.
IPR013083. Znf_RING/FYVE/PHD.
[Graphical view]
PANTHERiPTHR12888. PTHR12888. 1 hit.
PfamiPF04757. Pex2_Pex12. 1 hit.
[Graphical view]
PIRSFiPIRSF038074. Peroxisome_assembly_p12. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiPEX12_RAT
AccessioniPrimary (citable) accession number: O88177
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 24, 2001
Last sequence update: November 1, 1998
Last modified: November 30, 2016
This is version 113 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.