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Protein

Peroxisome assembly protein 12

Gene

Pex12

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Required for protein import into peroxisomes.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri304 – 343RING-type; degenerateAdd BLAST40

GO - Molecular functioni

GO - Biological processi

  • peroxisome organization Source: RGD
  • protein import into peroxisome matrix Source: GO_Central
  • protein monoubiquitination Source: GO_Central

Keywordsi

Biological processProtein transport, Transport
LigandMetal-binding, Zinc

Enzyme and pathway databases

ReactomeiR-RNO-8866654 E3 ubiquitin ligases ubiquitinate target proteins
R-RNO-9033241 Peroxisomal protein import

Names & Taxonomyi

Protein namesi
Recommended name:
Peroxisome assembly protein 12
Alternative name(s):
Peroxin-12
Peroxisome assembly factor 3
Short name:
PAF-3
Gene namesi
Name:Pex12
Synonyms:Paf3
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 10

Organism-specific databases

RGDi620757 Pex12

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 158CytoplasmicSequence analysisAdd BLAST158
Transmembranei159 – 179HelicalSequence analysisAdd BLAST21
Topological domaini180 – 239Peroxisomal matrixSequence analysisAdd BLAST60
Transmembranei240 – 260HelicalSequence analysisAdd BLAST21
Topological domaini261 – 359CytoplasmicSequence analysisAdd BLAST99

Keywords - Cellular componenti

Membrane, Peroxisome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002186121 – 359Peroxisome assembly protein 12Add BLAST359

Proteomic databases

PaxDbiO88177
PRIDEiO88177

Expressioni

Gene expression databases

BgeeiENSRNOG00000009718
GenevisibleiO88177 RN

Interactioni

Subunit structurei

Interacts with PEX5 and PEX10. Interacts with PEX19 via its cytoplasmic domain (By similarity).By similarity

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000064928

Structurei

3D structure databases

ProteinModelPortaliO88177
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi280 – 285Poly-Pro6

Sequence similaritiesi

Belongs to the pex2/pex10/pex12 family.Curated

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri304 – 343RING-type; degenerateAdd BLAST40

Keywords - Domaini

Transmembrane, Transmembrane helix, Zinc-finger

Phylogenomic databases

eggNOGiKOG0826 Eukaryota
ENOG410Y4Q2 LUCA
GeneTreeiENSGT00390000016209
HOGENOMiHOG000038427
HOVERGENiHBG053569
InParanoidiO88177
KOiK13345
OMAiYPTEVQH
PhylomeDBiO88177
TreeFamiTF314511

Family and domain databases

Gene3Di3.30.40.10, 1 hit
InterProiView protein in InterPro
IPR017375 PEX12
IPR006845 Pex_N
IPR013083 Znf_RING/FYVE/PHD
PANTHERiPTHR12888 PTHR12888, 1 hit
PfamiView protein in Pfam
PF04757 Pex2_Pex12, 1 hit
PIRSFiPIRSF038074 Peroxisome_assembly_p12, 1 hit

Sequencei

Sequence statusi: Complete.

O88177-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAEHGAHITT ASVADDQPSI FEVVAQDSLM TAVRPALQHV VKVLAESNPA
60 70 80 90 100
HYGFFWRWFD EIFTLLDFLL QQHYLSRTSA SFSEHFYGLK RIVAGSSPQL
110 120 130 140 150
QRPASAGLPK EHLWKSAMFL VLLPYLKVKL EKLASTLREE DEYSIHPPSS
160 170 180 190 200
HWKRFYRVFL AAYPFVTMTW EGWFLTQQLR YILGKAEHHS PLLKLAGVRL
210 220 230 240 250
GRLTAQDIQA MEHRLVEASA MQEPVRSIGK KIKSALKKAV GGVALSLSTG
260 270 280 290 300
LSVGVFFLQF LDWWYSSENQ ETIKSLTALP TPPPPVHLDY NSDSPLLPKM
310 320 330 340 350
KTVCPLCRKA RVNDTVLATS GYVFCYRCVF NYVRSHQACP ITGYPTEVQH

LIKLYSPEN
Length:359
Mass (Da):40,681
Last modified:November 1, 1998 - v1
Checksum:iE63C39801406733D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB002111 mRNA Translation: BAA31558.1
BC072481 mRNA Translation: AAH72481.1
RefSeqiNP_446373.1, NM_053921.1
XP_003750938.1, XM_003750890.4
XP_008766156.1, XM_008767934.2
XP_008772090.1, XM_008773868.2
XP_017452452.1, XM_017596963.1
XP_017458013.1, XM_017602524.1
UniGeneiRn.234355

Genome annotation databases

EnsembliENSRNOT00000013233; ENSRNOP00000013233; ENSRNOG00000009718
ENSRNOT00000082684; ENSRNOP00000071499; ENSRNOG00000009718
ENSRNOT00000083350; ENSRNOP00000071737; ENSRNOG00000052864
GeneIDi108348326
116718
KEGGirno:108348326
rno:116718

Similar proteinsi

Entry informationi

Entry nameiPEX12_RAT
AccessioniPrimary (citable) accession number: O88177
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 24, 2001
Last sequence update: November 1, 1998
Last modified: May 23, 2018
This is version 120 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

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