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Protein

Argininosuccinate lyase

Gene

argH

Organism
Corynebacterium glutamicum (strain ATCC 13032 / DSM 20300 / JCM 1318 / LMG 3730 / NCIMB 10025)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic activityi

2-(N(omega)-L-arginino)succinate = fumarate + L-arginine.UniRule annotation

Pathwayi: L-arginine biosynthesis

This protein is involved in step 3 of the subpathway that synthesizes L-arginine from L-ornithine and carbamoyl phosphate.UniRule annotation
Proteins known to be involved in the 3 steps of the subpathway in this organism are:
  1. Ornithine carbamoyltransferase (argF)
  2. Argininosuccinate synthase (argG)
  3. Argininosuccinate lyase (argH)
This subpathway is part of the pathway L-arginine biosynthesis, which is itself part of Amino-acid biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes L-arginine from L-ornithine and carbamoyl phosphate, the pathway L-arginine biosynthesis and in Amino-acid biosynthesis.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionLyase
Biological processAmino-acid biosynthesis, Arginine biosynthesis

Enzyme and pathway databases

BioCyciCORYNE:G18NG-10980-MONOMER
UniPathwayiUPA00068; UER00114

Names & Taxonomyi

Protein namesi
Recommended name:
Argininosuccinate lyaseUniRule annotation (EC:4.3.2.1UniRule annotation)
Short name:
ASALUniRule annotation
Alternative name(s):
ArginosuccinaseUniRule annotation
Gene namesi
Name:argHUniRule annotation
Ordered Locus Names:Cgl1401, cg1588
OrganismiCorynebacterium glutamicum (strain ATCC 13032 / DSM 20300 / JCM 1318 / LMG 3730 / NCIMB 10025)
Taxonomic identifieri196627 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaCorynebacterialesCorynebacteriaceaeCorynebacterium
Proteomesi
  • UP000000582 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001377641 – 477Argininosuccinate lyaseAdd BLAST477

Proteomic databases

PRIDEiO88101

Interactioni

Protein-protein interaction databases

STRINGi196627.cg1588

Structurei

3D structure databases

ProteinModelPortaliO88101
SMRiO88101
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the lyase 1 family. Argininosuccinate lyase subfamily.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105CH7 Bacteria
COG0165 LUCA
HOGENOMiHOG000242744
KOiK01755
OMAiSIMPHKK

Family and domain databases

CDDicd01359 Argininosuccinate_lyase, 1 hit
Gene3Di1.10.275.10, 2 hits
HAMAPiMF_00006 Arg_succ_lyase, 1 hit
InterProiView protein in InterPro
IPR029419 Arg_succ_lyase_C
IPR009049 Argininosuccinate_lyase
IPR024083 Fumarase/histidase_N
IPR020557 Fumarate_lyase_CS
IPR000362 Fumarate_lyase_fam
IPR022761 Fumarate_lyase_N
IPR008948 L-Aspartase-like
PANTHERiPTHR43814 PTHR43814, 1 hit
PfamiView protein in Pfam
PF14698 ASL_C2, 1 hit
PF00206 Lyase_1, 1 hit
PRINTSiPR00149 FUMRATELYASE
SUPFAMiSSF48557 SSF48557, 1 hit
TIGRFAMsiTIGR00838 argH, 1 hit
PROSITEiView protein in PROSITE
PS00163 FUMARATE_LYASES, 1 hit

Sequencei

Sequence statusi: Complete.

O88101-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEQHGTNEGA LWGGRFSGGP SEAMFALSVS THFDWVLAPY DVLASKAHAK
60 70 80 90 100
VLHQADLLSD EDLATMLAGL DQLGKDVADG TFGPLPSDED VHGAMERGLI
110 120 130 140 150
DRVGPEVGGR LRAGRSRNDQ VATLFRMWVR DAVRDIALGT TELVDALSAQ
160 170 180 190 200
AKAHAGAIMP GKTHFQAAQP VLLAHQLLAH AQPLLRDIDR IRDLDKRLAV
210 220 230 240 250
SPYGSGALAG SSLKLNPEAI AEELGFDSAA DNSIDATSSR DFASETAFVL
260 270 280 290 300
AQLAVDMSRL AEEIIAWCTP EFGYITLSDS WSTGSSIMPQ KKNPDVAELT
310 320 330 340 350
RGKSGRLIGN LTGLLATLKA QPLAYNRDLQ EDKEPIVDSV AQLNLLLPAM
360 370 380 390 400
TGLVSTLTFN TERMRELAPA GFTLATDLAE WMVRQGVPFR EAHEASGACV
410 420 430 440 450
RIAESRGVDL IDLTDEELSG VDARLTPEVR EVLTIDGAVA SRATRGGTAG
460 470
VRVAEQRARV DAASTAHAEW ARAGVRR
Length:477
Mass (Da):51,042
Last modified:August 13, 2002 - v2
Checksum:i06364CA7FEE80E9B
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti10 – 13ALWG → GCGP in AAC24811 (Ref. 1) Curated4
Sequence conflicti10 – 13ALWG → GCGP in AAC24819 (Ref. 1) Curated4
Sequence conflicti41 – 66DVLAS…DLATM → HLHAPRAHTMVLFRAGLLTE EQRDGL in AAC24819 (Ref. 1) CuratedAdd BLAST26
Sequence conflicti72 – 75QLGK → SLAQ in AAC24811 (Ref. 1) Curated4
Sequence conflicti72 – 75QLGK → SLAQ in AAC24819 (Ref. 1) Curated4
Sequence conflicti81T → S in AAC24811 (Ref. 1) Curated1
Sequence conflicti81T → S in AAC24819 (Ref. 1) Curated1
Sequence conflicti86 – 87PS → VT in AAC24811 (Ref. 1) Curated2
Sequence conflicti86 – 87PS → VT in AAC24819 (Ref. 1) Curated2
Sequence conflicti93 – 95GAM → AAL in AAC24811 (Ref. 1) Curated3
Sequence conflicti93 – 95GAM → AAL in AAC24819 (Ref. 1) Curated3
Sequence conflicti152K → E in AAC24811 (Ref. 1) Curated1
Sequence conflicti152K → E in AAC24819 (Ref. 1) Curated1
Sequence conflicti214K → E in AAC24811 (Ref. 1) Curated1
Sequence conflicti214K → E in AAC24819 (Ref. 1) Curated1
Sequence conflicti299L → Q in AAC24811 (Ref. 1) Curated1
Sequence conflicti299L → Q in AAC24819 (Ref. 1) Curated1
Sequence conflicti302G → R in AAC24811 (Ref. 1) Curated1
Sequence conflicti302G → R in AAC24819 (Ref. 1) Curated1
Sequence conflicti305G → R in AAC24811 (Ref. 1) Curated1
Sequence conflicti305G → R in AAC24819 (Ref. 1) Curated1
Sequence conflicti308I → L in AAC24811 (Ref. 1) Curated1
Sequence conflicti308I → L in AAC24819 (Ref. 1) Curated1
Sequence conflicti315L → V in AAC24811 (Ref. 1) Curated1
Sequence conflicti315L → V in AAC24819 (Ref. 1) Curated1
Sequence conflicti319 – 321KAQ → EAH in AAC24811 (Ref. 1) Curated3
Sequence conflicti319 – 321KAQ → EAH in AAC24819 (Ref. 1) Curated3
Sequence conflicti326 – 328NRD → SRV in AAC24811 (Ref. 1) Curated3
Sequence conflicti326 – 328NRD → SRV in AAC24819 (Ref. 1) Curated3
Sequence conflicti337V → L in AAC24811 (Ref. 1) Curated1
Sequence conflicti337V → L in AAC24819 (Ref. 1) Curated1
Sequence conflicti340V → L in AAC24811 (Ref. 1) Curated1
Sequence conflicti340V → L in AAC24819 (Ref. 1) Curated1
Sequence conflicti361 – 369TERMRELAP → DQPDADLDR in AAC24811 (Ref. 1) Curated9
Sequence conflicti361 – 369TERMRELAP → DQPDADLDR in AAC24819 (Ref. 1) Curated9
Sequence conflicti375A → P in AAC24811 (Ref. 1) Curated1
Sequence conflicti375A → P in AAC24819 (Ref. 1) Curated1
Sequence conflicti379 – 390AEWMV…GVPFR → RERDRQGGSNSG in AAC24811 (Ref. 1) CuratedAdd BLAST12
Sequence conflicti379 – 390AEWMV…GVPFR → RERDRQGGSNSG in AAC24819 (Ref. 1) CuratedAdd BLAST12
Sequence conflicti396 – 419SGACV…DEELS → PARSGGSCGPSPGSGPYRSH RRRTR in AAC24811 (Ref. 1) CuratedAdd BLAST24
Sequence conflicti396 – 419SGACV…DEELS → PARSGGSCGPSPGSGPYRSH RRRTR in AAC24819 (Ref. 1) CuratedAdd BLAST24
Sequence conflicti425 – 465LTPEV…DAAST → PDPRGTGSAHHSWCSGFPSN RRWNRARAGCGATRTCRCRK Y in AAC24811 (Ref. 1) CuratedAdd BLAST41
Sequence conflicti425 – 465LTPEV…DAAST → PDPRGTGSAHHSWCSGFPSN RRWNRARAGCGATRTCRCRK Y in AAC24819 (Ref. 1) CuratedAdd BLAST41

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF048764 Genomic DNA Translation: AAC24811.1
AF049897 Genomic DNA Translation: AAC24819.1
BA000036 Genomic DNA Translation: BAB98794.1
BX927152 Genomic DNA Translation: CAF21412.1
RefSeqiNP_600620.1, NC_003450.3
WP_011014337.1, NC_006958.1

Genome annotation databases

EnsemblBacteriaiBAB98794; BAB98794; BAB98794
CAF21412; CAF21412; cg1588
GeneIDi1019377
KEGGicgb:cg1588
cgl:NCgl1347
PATRICifig|196627.13.peg.1370

Similar proteinsi

Entry informationi

Entry nameiARLY_CORGL
AccessioniPrimary (citable) accession number: O88101
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: August 13, 2002
Last modified: May 23, 2018
This is version 126 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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