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Protein

Transaldolase 1

Gene

tal1

Organism
Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway.By similarity

Catalytic activityi

Sedoheptulose 7-phosphate + D-glyceraldehyde 3-phosphate = D-erythrose 4-phosphate + D-fructose 6-phosphate.

Pathwayi: pentose phosphate pathway

This protein is involved in step 2 of the subpathway that synthesizes D-glyceraldehyde 3-phosphate and beta-D-fructose 6-phosphate from D-ribose 5-phosphate and D-xylulose 5-phosphate (non-oxidative stage).
Proteins known to be involved in the 3 steps of the subpathway in this organism are:
  1. no protein annotated in this organism
  2. Transaldolase 1 (tal1), Transaldolase 2 (tal2)
  3. no protein annotated in this organism
This subpathway is part of the pathway pentose phosphate pathway, which is itself part of Carbohydrate degradation.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes D-glyceraldehyde 3-phosphate and beta-D-fructose 6-phosphate from D-ribose 5-phosphate and D-xylulose 5-phosphate (non-oxidative stage), the pathway pentose phosphate pathway and in Carbohydrate degradation.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei149Schiff-base intermediate with substrateBy similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionTransferase
Biological processPentose shunt
LigandSchiff base

Enzyme and pathway databases

UniPathwayiUPA00115; UER00414.

Names & Taxonomyi

Protein namesi
Recommended name:
Transaldolase 1 (EC:2.2.1.2)
Gene namesi
Name:tal1
Synonyms:tal
Ordered Locus Names:SCO6662
ORF Names:SC5A7.12c
OrganismiStreptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)
Taxonomic identifieri100226 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaStreptomycetalesStreptomycetaceaeStreptomycesStreptomyces albidoflavus group
Proteomesi
  • UP000001973 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001736411 – 381Transaldolase 1Add BLAST381

Proteomic databases

PRIDEiO88018.

Interactioni

Protein-protein interaction databases

STRINGi100226.SCO6662.

Structurei

3D structure databases

ProteinModelPortaliO88018.
SMRiO88018.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the transaldolase family. Type 2 subfamily.Curated

Phylogenomic databases

eggNOGiENOG4107QQX. Bacteria.
COG0176. LUCA.
HOGENOMiHOG000226074.
InParanoidiO88018.
KOiK00616.
OMAiIRIWTAV.
OrthoDBiPOG091H05RO.
PhylomeDBiO88018.

Family and domain databases

CDDicd00955. Transaldolase_like. 1 hit.
Gene3Di3.20.20.70. 1 hit.
HAMAPiMF_00493. Transaldolase_2. 1 hit.
InterProiView protein in InterPro
IPR013785. Aldolase_TIM.
IPR001585. TAL/FSA.
IPR004732. Transaldolase_2.
IPR018225. Transaldolase_AS.
PANTHERiPTHR10683. PTHR10683. 1 hit.
PTHR10683:SF19. PTHR10683:SF19. 1 hit.
PfamiView protein in Pfam
PF00923. TAL_FSA. 1 hit.
PIRSFiPIRSF036915. Trnald_Bac_Plnt. 1 hit.
TIGRFAMsiTIGR00876. tal_mycobact. 1 hit.
PROSITEiView protein in PROSITE
PS01054. TRANSALDOLASE_1. 1 hit.
PS00958. TRANSALDOLASE_2. 1 hit.

Sequencei

Sequence statusi: Complete.

O88018-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MITVTEATAT AGALQRLADQ GVSVWLDDLS RRRIESGNLA ELIRTKNVVG
60 70 80 90 100
VTTNPSIFQA AIGSGEGYEE QLADLATRGV TVDEAVRMMT TADVRAAADV
110 120 130 140 150
LRGVYDASGG RDGRVSIEVD PRLAHDTAAT VAEARQLSWL VDRPNVMIKI
160 170 180 190 200
PATKAGLPAI TEVIGAGISV NVTLIFSLER YREVMDAYLA GLEKAQAAGI
210 220 230 240 250
DLAGIHSVAS FFVSRVDSEI DKRLSLLGTE EALGLRGRAA LANARLAYEA
260 270 280 290 300
YENVFAGDRF TALAGARANA QRPLWASTGV KDPAFRDTLY VEELVAPGTV
310 320 330 340 350
NTMPEATLDA AADHGDVRGD TVTGGYAQAR ADLAAVERLG VSYDEVVEQL
360 370 380
EQEGVAKFEA AWQELLAAVT KSLDSKGVDG E
Length:381
Mass (Da):40,407
Last modified:November 1, 1998 - v1
Checksum:i44068BD43598F5B5
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL939128 Genomic DNA. Translation: CAA19941.1.
PIRiT35161.
RefSeqiNP_630737.1. NC_003888.3.
WP_011031085.1. NC_003888.3.

Genome annotation databases

EnsemblBacteriaiCAA19941; CAA19941; CAA19941.
GeneIDi1102101.
KEGGisco:SCO6662.
PATRICifig|100226.15.peg.6768.

Similar proteinsi

Entry informationi

Entry nameiTAL1_STRCO
AccessioniPrimary (citable) accession number: O88018
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 5, 2001
Last sequence update: November 1, 1998
Last modified: March 28, 2018
This is version 106 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome