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Protein

Glucose-6-phosphate 1-dehydrogenase

Gene

zwf

Organism
Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)
Status
Unreviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the oxidation of glucose 6-phosphate to 6-phosphogluconolactone.UniRule annotation

Catalytic activityi

D-glucose 6-phosphate + NADP+ = 6-phospho-D-glucono-1,5-lactone + NADPH.UniRule annotation

Pathwayi: pentose phosphate pathway

This protein is involved in step 1 of the subpathway that synthesizes D-ribulose 5-phosphate from D-glucose 6-phosphate (oxidative stage).UniRule annotation
Proteins known to be involved in the 3 steps of the subpathway in this organism are:
  1. Glucose-6-phosphate 1-dehydrogenase (zwf), Glucose-6-phosphate 1-dehydrogenase (zwf)
  2. 6-phosphogluconolactonase (pgl)
  3. 6-phosphogluconate dehydrogenase, decarboxylating (SCO0975)
This subpathway is part of the pathway pentose phosphate pathway, which is itself part of Carbohydrate degradation.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes D-ribulose 5-phosphate from D-glucose 6-phosphate (oxidative stage), the pathway pentose phosphate pathway and in Carbohydrate degradation.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei147 – 1471NADPUniRule annotation
Binding sitei254 – 2541NADPUniRule annotation
Binding sitei284 – 2841SubstrateUniRule annotation
Binding sitei288 – 2881SubstrateUniRule annotation
Binding sitei322 – 3221SubstrateUniRule annotation
Binding sitei341 – 3411SubstrateUniRule annotation
Active sitei346 – 3461Proton acceptorUniRule annotation
Binding sitei444 – 4441SubstrateUniRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi189 – 1902NADPUniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

OxidoreductaseUniRule annotation

Keywords - Biological processi

Carbohydrate metabolism, Glucose metabolismUniRule annotation

Keywords - Ligandi

NADPUniRule annotation

Enzyme and pathway databases

UniPathwayiUPA00115; UER00408.

Names & Taxonomyi

Protein namesi
Recommended name:
Glucose-6-phosphate 1-dehydrogenaseUniRule annotation (EC:1.1.1.49UniRule annotation)
Short name:
G6PDUniRule annotation
Gene namesi
Name:zwfUniRule annotation
Ordered Locus Names:SCO6661Imported
OrganismiStreptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)Imported
Taxonomic identifieri100226 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaStreptomycetalesStreptomycetaceaeStreptomycesStreptomyces albidoflavus group
Proteomesi
  • UP000001973 Componenti: Chromosome

PTM / Processingi

Proteomic databases

PRIDEiO88017.

Interactioni

Protein-protein interaction databases

STRINGi100226.SCO6661.

Structurei

3D structure databases

ProteinModelPortaliO88017.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini110 – 293184G6PD_NInterPro annotationAdd
BLAST
Domaini295 – 590296G6PD_CInterPro annotationAdd
BLAST

Sequence similaritiesi

Belongs to the glucose-6-phosphate dehydrogenase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105D8W. Bacteria.
COG0364. LUCA.
HOGENOMiHOG000046191.
InParanoidiO88017.
KOiK00036.
OMAiDNIYENT.
OrthoDBiEOG61308Z.
PhylomeDBiO88017.

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
HAMAPiMF_00966. G6PD.
InterProiIPR001282. G6P_DH.
IPR019796. G6P_DH_AS.
IPR022675. G6P_DH_C.
IPR022674. G6P_DH_NAD-bd.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
PANTHERiPTHR23429. PTHR23429. 1 hit.
PfamiPF02781. G6PD_C. 1 hit.
PF00479. G6PD_N. 1 hit.
[Graphical view]
PRINTSiPR00079. G6PDHDRGNASE.
SUPFAMiSSF51735. SSF51735. 1 hit.
TIGRFAMsiTIGR00871. zwf. 1 hit.
PROSITEiPS00069. G6P_DEHYDROGENASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O88017-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSEELPAGAP QETKATKEAK ETRTAQEAAG PLHAEEAEEA RAAEAAKASG
60 70 80 90 100
RAKAPRGAKK SATNRAAKEA KGKGAAGEGV EPVAPLDWSN PLRDPQDRRL
110 120 130 140 150
PRIAGPSGLV IFGVTGDLSR KKLMPAVYDL ANRGLLPPGF SLVGFARRDW
160 170 180 190 200
EDQDFAEVVH DAVREHARTP FREEVWQQLS EGMRFIPGDF DDDNAFEQLR
210 220 230 240 250
KAVEELDASR GTSGNYAFYL SVPPKFFPKV VQQLKKHGLT DAPAGSWRRA
260 270 280 290 300
VIEKPFGHDL DSARDLNALV HEVFDPEQVF RIDHYLGKET VQNILALRFA
310 320 330 340 350
NQMYEPIWNR SYVDHVQITM AEDIGIGGRA GYYDGIGAAR DVIQNHLLQL
360 370 380 390 400
MALTAMEEPA AFDARSLLTE KLKVLRAVRL PDDLGEHTVR GQYAGGWQGG
410 420 430 440 450
AQVPGYLEEE GIDPASTTDT YAAIKLGIDN RRWAGVPFYL RTGKRLGRRV
460 470 480 490 500
TEIAVVFQRA PHSPFDSTAT EELGENAIVI RVQPDEGMTV RFGSKVPGTS
510 520 530 540 550
MEIRDVSMDF AYGESFTESS PEAYERLILD VLLGDANLFP RHQEVEESWR
560 570 580 590
ILDPIEEYWA SHDKPAQYAS GGWGPREADE MLARDGRSWR RP
Length:592
Mass (Da):65,672
Last modified:November 1, 1998 - v1
Checksum:i87DBB53316FCB495
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL939128 Genomic DNA. Translation: CAA19940.1.
PIRiT35160.
RefSeqiNP_630736.1. NC_003888.3.
WP_011031084.1. NC_003888.3.

Genome annotation databases

EnsemblBacteriaiCAA19940; CAA19940; CAA19940.
GeneIDi1102100.
KEGGisco:SCO6661.
PATRICi23743243. VBIStrCoe124346_6767.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL939128 Genomic DNA. Translation: CAA19940.1.
PIRiT35160.
RefSeqiNP_630736.1. NC_003888.3.
WP_011031084.1. NC_003888.3.

3D structure databases

ProteinModelPortaliO88017.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi100226.SCO6661.

Proteomic databases

PRIDEiO88017.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiCAA19940; CAA19940; CAA19940.
GeneIDi1102100.
KEGGisco:SCO6661.
PATRICi23743243. VBIStrCoe124346_6767.

Phylogenomic databases

eggNOGiENOG4105D8W. Bacteria.
COG0364. LUCA.
HOGENOMiHOG000046191.
InParanoidiO88017.
KOiK00036.
OMAiDNIYENT.
OrthoDBiEOG61308Z.
PhylomeDBiO88017.

Enzyme and pathway databases

UniPathwayiUPA00115; UER00408.

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
HAMAPiMF_00966. G6PD.
InterProiIPR001282. G6P_DH.
IPR019796. G6P_DH_AS.
IPR022675. G6P_DH_C.
IPR022674. G6P_DH_NAD-bd.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
PANTHERiPTHR23429. PTHR23429. 1 hit.
PfamiPF02781. G6PD_C. 1 hit.
PF00479. G6PD_N. 1 hit.
[Graphical view]
PRINTSiPR00079. G6PDHDRGNASE.
SUPFAMiSSF51735. SSF51735. 1 hit.
TIGRFAMsiTIGR00871. zwf. 1 hit.
PROSITEiPS00069. G6P_DEHYDROGENASE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC BAA-471 / A3(2) / M145Imported.

Entry informationi

Entry nameiO88017_STRCO
AccessioniPrimary (citable) accession number: O88017
Entry historyi
Integrated into UniProtKB/TrEMBL: November 1, 1998
Last sequence update: November 1, 1998
Last modified: July 6, 2016
This is version 107 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.