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Protein

Glucose-6-phosphate 1-dehydrogenase

Gene

zwf

Organism
Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the oxidation of glucose 6-phosphate to 6-phosphogluconolactone.UniRule annotation

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.UniRule annotation

Catalytic activityi

D-glucose 6-phosphate + NADP+ = 6-phospho-D-glucono-1,5-lactone + NADPH.UniRule annotation

Pathwayi: pentose phosphate pathway

This protein is involved in step 1 of the subpathway that synthesizes D-ribulose 5-phosphate from D-glucose 6-phosphate (oxidative stage).UniRule annotation
Proteins known to be involved in the 3 steps of the subpathway in this organism are:
  1. Glucose-6-phosphate 1-dehydrogenase (zwf), Glucose-6-phosphate 1-dehydrogenase (zwf)
  2. 6-phosphogluconolactonase (pgl)
  3. 6-phosphogluconate dehydrogenase, decarboxylating (SCO0975)
This subpathway is part of the pathway pentose phosphate pathway, which is itself part of Carbohydrate degradation.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes D-ribulose 5-phosphate from D-glucose 6-phosphate (oxidative stage), the pathway pentose phosphate pathway and in Carbohydrate degradation.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei147NADPUniRule annotation1
Binding sitei254NADPUniRule annotation1
Binding sitei284SubstrateUniRule annotation1
Binding sitei288SubstrateUniRule annotation1
Binding sitei322SubstrateUniRule annotation1
Binding sitei341SubstrateUniRule annotation1
Active sitei346Proton acceptorUniRule annotation1
Binding sitei444SubstrateUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi189 – 190NADPUniRule annotation2

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductaseUniRule annotation
Biological processCarbohydrate metabolism, Glucose metabolismUniRule annotation
LigandNADPUniRule annotation

Enzyme and pathway databases

UniPathwayiUPA00115; UER00408

Names & Taxonomyi

Protein namesi
Recommended name:
Glucose-6-phosphate 1-dehydrogenaseUniRule annotation (EC:1.1.1.49UniRule annotation)
Short name:
G6PDUniRule annotation
Gene namesi
Name:zwfUniRule annotation
Ordered Locus Names:SCO6661Imported
OrganismiStreptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)Imported
Taxonomic identifieri100226 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaStreptomycetalesStreptomycetaceaeStreptomycesStreptomyces albidoflavus group
Proteomesi
  • UP000001973 Componenti: Chromosome

PTM / Processingi

Proteomic databases

PRIDEiO88017

Interactioni

Protein-protein interaction databases

STRINGi100226.SCO6661

Structurei

3D structure databases

ProteinModelPortaliO88017
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini110 – 293G6PD_NInterPro annotationAdd BLAST184
Domaini295 – 590G6PD_CInterPro annotationAdd BLAST296

Sequence similaritiesi

Belongs to the glucose-6-phosphate dehydrogenase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105D8W Bacteria
COG0364 LUCA
HOGENOMiHOG000046191
InParanoidiO88017
KOiK00036
OMAiVEESWKI
OrthoDBiPOG091H04ZM
PhylomeDBiO88017

Family and domain databases

HAMAPiMF_00966 G6PD, 1 hit
InterProiView protein in InterPro
IPR001282 G6P_DH
IPR019796 G6P_DH_AS
IPR022675 G6P_DH_C
IPR022674 G6P_DH_NAD-bd
IPR036291 NAD(P)-bd_dom_sf
PANTHERiPTHR23429 PTHR23429, 1 hit
PfamiView protein in Pfam
PF02781 G6PD_C, 1 hit
PF00479 G6PD_N, 1 hit
PRINTSiPR00079 G6PDHDRGNASE
SUPFAMiSSF51735 SSF51735, 1 hit
TIGRFAMsiTIGR00871 zwf, 1 hit
PROSITEiView protein in PROSITE
PS00069 G6P_DEHYDROGENASE, 1 hit

Sequencei

Sequence statusi: Complete.

O88017-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSEELPAGAP QETKATKEAK ETRTAQEAAG PLHAEEAEEA RAAEAAKASG
60 70 80 90 100
RAKAPRGAKK SATNRAAKEA KGKGAAGEGV EPVAPLDWSN PLRDPQDRRL
110 120 130 140 150
PRIAGPSGLV IFGVTGDLSR KKLMPAVYDL ANRGLLPPGF SLVGFARRDW
160 170 180 190 200
EDQDFAEVVH DAVREHARTP FREEVWQQLS EGMRFIPGDF DDDNAFEQLR
210 220 230 240 250
KAVEELDASR GTSGNYAFYL SVPPKFFPKV VQQLKKHGLT DAPAGSWRRA
260 270 280 290 300
VIEKPFGHDL DSARDLNALV HEVFDPEQVF RIDHYLGKET VQNILALRFA
310 320 330 340 350
NQMYEPIWNR SYVDHVQITM AEDIGIGGRA GYYDGIGAAR DVIQNHLLQL
360 370 380 390 400
MALTAMEEPA AFDARSLLTE KLKVLRAVRL PDDLGEHTVR GQYAGGWQGG
410 420 430 440 450
AQVPGYLEEE GIDPASTTDT YAAIKLGIDN RRWAGVPFYL RTGKRLGRRV
460 470 480 490 500
TEIAVVFQRA PHSPFDSTAT EELGENAIVI RVQPDEGMTV RFGSKVPGTS
510 520 530 540 550
MEIRDVSMDF AYGESFTESS PEAYERLILD VLLGDANLFP RHQEVEESWR
560 570 580 590
ILDPIEEYWA SHDKPAQYAS GGWGPREADE MLARDGRSWR RP
Length:592
Mass (Da):65,672
Last modified:November 1, 1998 - v1
Checksum:i87DBB53316FCB495
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL939128 Genomic DNA Translation: CAA19940.1
PIRiT35160
RefSeqiNP_630736.1, NC_003888.3
WP_011031084.1, NC_003888.3

Genome annotation databases

EnsemblBacteriaiCAA19940; CAA19940; CAA19940
GeneIDi1102100
KEGGisco:SCO6661
PATRICifig|100226.15.peg.6767

Similar proteinsi

Entry informationi

Entry nameiO88017_STRCO
AccessioniPrimary (citable) accession number: O88017
Entry historyiIntegrated into UniProtKB/TrEMBL: November 1, 1998
Last sequence update: November 1, 1998
Last modified: May 23, 2018
This is version 114 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

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