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Protein

Sensor protein TdiS

Gene

tdiS

Organism
Thauera aromatica
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Member of the two-component regulatory system TdiR/TdiS, which probably regulates transcription of toluene catabolic genes (bss operon). May activate TdiR by phosphorylation.1 Publication

Catalytic activityi

ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Kinase, Transferase

Keywords - Biological processi

Two-component regulatory system

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Sensor protein TdiS (EC:2.7.13.3)
Gene namesi
Name:tdiS
OrganismiThauera aromatica
Taxonomic identifieri59405 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaRhodocyclalesRhodocyclaceaeThauera

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00004188701 – 548Sensor protein TdiSAdd BLAST548

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei337Phosphohistidine; by autocatalysisPROSITE-ProRule annotation1

Post-translational modificationi

Autophosphorylated.By similarity

Keywords - PTMi

Phosphoprotein

Structurei

3D structure databases

ProteinModelPortaliO87939.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini20 – 89PAS 1PROSITE-ProRule annotationAdd BLAST70
Domaini94 – 145PAC 1PROSITE-ProRule annotationAdd BLAST52
Domaini185 – 256PAS 2PROSITE-ProRule annotationAdd BLAST72
Domaini263 – 314PAC 2PROSITE-ProRule annotationAdd BLAST52
Domaini334 – 548Histidine kinasePROSITE-ProRule annotationAdd BLAST215

Sequence similaritiesi

Contains 1 histidine kinase domain.PROSITE-ProRule annotation
Contains 2 PAC (PAS-associated C-terminal) domains.PROSITE-ProRule annotation
Contains 2 PAS (PER-ARNT-SIM) domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat

Family and domain databases

Gene3Di3.30.565.10. 1 hit.
InterProiIPR003594. HATPase_C.
IPR005467. His_kinase_dom.
IPR001610. PAC.
IPR000014. PAS.
IPR000700. PAS-assoc_C.
IPR004358. Sig_transdc_His_kin-like_C.
[Graphical view]
PfamiPF02518. HATPase_c. 1 hit.
PF13188. PAS_8. 1 hit.
PF13426. PAS_9. 1 hit.
[Graphical view]
PRINTSiPR00344. BCTRLSENSOR.
SMARTiSM00387. HATPase_c. 1 hit.
SM00086. PAC. 2 hits.
SM00091. PAS. 2 hits.
[Graphical view]
SUPFAMiSSF55785. SSF55785. 2 hits.
SSF55874. SSF55874. 1 hit.
TIGRFAMsiTIGR00229. sensory_box. 2 hits.
PROSITEiPS50109. HIS_KIN. 1 hit.
PS50113. PAC. 1 hit.
PS50112. PAS. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O87939-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSGNAIASTE TEMEADHGND PATGYEVIFR NTPLAICHLR NRAFVRCNTR
60 70 80 90 100
FEELFGYARG ELDNKSVRLL YPTDESFRTI GENYGHFFER HDTFKDERPI
110 120 130 140 150
IRKDGSVIWC IVTGSLLDSS NPRLGSIWVV QDISEHKRTE DDLKASVEKL
160 170 180 190 200
EILVHQRTLE LHKHVNKLEQ EVATRKLAEE VANEHREKYE KLFHMLPIGI
210 220 230 240 250
SITDNEGRIL EANRQFTELV GTPEKPPITW QQLPQRFFLS DGTKVARKRL
260 270 280 290 300
PWRIHDVQKD SIKNIEIGMR EEESRKQRWL SVSSSLLELK GQKMVVAAFT
310 320 330 340 350
DITYRKRIEE LERLRHAELT RLGRINAMAG MAAALAHQMG QPLVSALNYL
360 370 380 390 400
QGCRLRLEHI RGAAEISQSL GLAITHLDQA GEILRRVKDF VCKHTPERTP
410 420 430 440 450
ENINEVIQDT LSFLSFDVHR HNVTVNLQLI PSPPAVPLCK IEIQQVLFNL
460 470 480 490 500
VKNGIEAMSE MEPESRILTI GNEISTDGRS MKIFVQDHGV GVEKRAEKRA
510 520 530 540
FEPYFTTKPD GLGIGLTICR SIIESHGGEL SFSKTGERGS KFQFTLPI
Length:548
Mass (Da):62,441
Last modified:November 1, 1998 - v1
Checksum:iACEB9ADF05EFCA4A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ001848 Genomic DNA. Translation: CAA05048.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ001848 Genomic DNA. Translation: CAA05048.1.

3D structure databases

ProteinModelPortaliO87939.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Family and domain databases

Gene3Di3.30.565.10. 1 hit.
InterProiIPR003594. HATPase_C.
IPR005467. His_kinase_dom.
IPR001610. PAC.
IPR000014. PAS.
IPR000700. PAS-assoc_C.
IPR004358. Sig_transdc_His_kin-like_C.
[Graphical view]
PfamiPF02518. HATPase_c. 1 hit.
PF13188. PAS_8. 1 hit.
PF13426. PAS_9. 1 hit.
[Graphical view]
PRINTSiPR00344. BCTRLSENSOR.
SMARTiSM00387. HATPase_c. 1 hit.
SM00086. PAC. 2 hits.
SM00091. PAS. 2 hits.
[Graphical view]
SUPFAMiSSF55785. SSF55785. 2 hits.
SSF55874. SSF55874. 1 hit.
TIGRFAMsiTIGR00229. sensory_box. 2 hits.
PROSITEiPS50109. HIS_KIN. 1 hit.
PS50113. PAC. 1 hit.
PS50112. PAS. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiTDIS_THAAR
AccessioniPrimary (citable) accession number: O87939
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 5, 2012
Last sequence update: November 1, 1998
Last modified: May 11, 2016
This is version 87 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.