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Protein
Submitted name:

Beta-lactamase inhibitory protein II

Gene

bliB

Organism
Streptomyces exfoliatus (Streptomyces hydrogenans)
Status
Unreviewed-Annotation score: Annotation score: 1 out of 5-Experimental evidence at protein leveli

Functioni

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi104 – 1041Calcium 1; via carbonyl oxygenCombined sources
Metal bindingi106 – 1061Calcium 1Combined sources
Metal bindingi120 – 1201Calcium 1Combined sources
Metal bindingi187 – 1871Calcium 2Combined sources
Metal bindingi188 – 1881Calcium 2; via carbonyl oxygenCombined sources
Metal bindingi221 – 2211Calcium 3; via carbonyl oxygenCombined sources
Metal bindingi223 – 2231Calcium 3Combined sources
Metal bindingi237 – 2371Calcium 3Combined sources

GO - Molecular functioni

Complete GO annotation...

Keywords - Ligandi

CalciumCombined sources, Metal-bindingCombined sources

Names & Taxonomyi

Protein namesi
Submitted name:
Beta-lactamase inhibitory protein IIImported
Gene namesi
Name:bliBImported
OrganismiStreptomyces exfoliatus (Streptomyces hydrogenans)Imported
Taxonomic identifieri1905 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaStreptomycetalesStreptomycetaceaeStreptomyces

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 3232Sequence analysisAdd
BLAST
Chaini33 – 311279Sequence analysisPRO_5004160518Add
BLAST

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1JTDX-ray2.30B39-311[»]
3QHYX-ray2.06B41-311[»]
3QI0X-ray2.80A/B/C/D/E/F41-311[»]
ProteinModelPortaliO87916.
SMRiO87916. Positions 39-311.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiO87916.

Family & Domainsi

Keywords - Domaini

SignalSequence analysis

Family and domain databases

Gene3Di2.130.10.30. 1 hit.
InterProiIPR009091. RCC1/BLIP-II.
IPR000408. Reg_chr_condens.
[Graphical view]
SUPFAMiSSF50985. SSF50985. 1 hit.
PROSITEiPS50012. RCC1_3. 4 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

O87916-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPNGIVRLHR FGAALVMSGL LSALSAAPGV AAEPSSVSVA ATSVVAWGGN
60 70 80 90 100
NDWGEATVPA EAQSGVDAIA GGYFHGLALK GGKVLGWGAN LNGQLTMPAA
110 120 130 140 150
TQSGVDAIAA GNYHSLALKD GEVIAWGGNE DGQTTVPAEA RSGVDAIAAG
160 170 180 190 200
AWASYALKDG KVIAWGDDSD GQTTVPAEAQ SGVTALDGGV YTALAVKNGG
210 220 230 240 250
VIAWGDNYFG QTTVPAEAQS GVDDVAGGIF HSLALKDGKV IAWGDNRYKQ
260 270 280 290 300
TTVPTEALSG VSAIASGEWY SLALKNGKVI AWGSSRTAPS SVQSGVSSIE
310
AGPNAAYALK G
Length:311
Mass (Da):31,056
Last modified:November 1, 1998 - v1
Checksum:i9C130EC2AC11F154
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U97057 Genomic DNA. Translation: AAC35427.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U97057 Genomic DNA. Translation: AAC35427.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1JTDX-ray2.30B39-311[»]
3QHYX-ray2.06B41-311[»]
3QI0X-ray2.80A/B/C/D/E/F41-311[»]
ProteinModelPortaliO87916.
SMRiO87916. Positions 39-311.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Miscellaneous databases

EvolutionaryTraceiO87916.

Family and domain databases

Gene3Di2.130.10.30. 1 hit.
InterProiIPR009091. RCC1/BLIP-II.
IPR000408. Reg_chr_condens.
[Graphical view]
SUPFAMiSSF50985. SSF50985. 1 hit.
PROSITEiPS50012. RCC1_3. 4 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Cloning and heterologous expression of the gene for BLIP-II, a beta-lactamase-inhibitory protein from Streptomyces exfoliatus SMF19."
    Park H.U., Lee K.J.
    Microbiology 144:2161-2167(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: SMF19Imported.
  2. "Crystal structure and kinetic analysis of beta-lactamase inhibitor protein-II in complex with TEM-1 beta-lactamase."
    Lim D., Park H.U., De Castro L., Kang S.G., Lee H.S., Jensen S., Lee K.J., Strynadka N.C.
    Nat. Struct. Biol. 8:848-852(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (2.30 ANGSTROMS) OF 39-311 IN COMPLEX WITH CALCIUM.
  3. "Analysis of the binding forces driving the tight interactions between beta-lactamase inhibitory protein-II (BLIP-II) and class A beta-lactamases."
    Brown N.G., Chow D.C., Sankaran B., Zwart P., Prasad B.V., Palzkill T.
    J. Biol. Chem. 286:32723-32735(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (2.06 ANGSTROMS) OF 41-311.

Entry informationi

Entry nameiO87916_STREX
AccessioniPrimary (citable) accession number: O87916
Entry historyi
Integrated into UniProtKB/TrEMBL: November 1, 1998
Last sequence update: November 1, 1998
Last modified: March 16, 2016
This is version 63 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

3D-structureCombined sources

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.