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Protein

60 kDa chaperonin

Gene

groL

Organism
Lawsonia intracellularis
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionChaperoneUniRule annotation
LigandATP-bindingUniRule annotation, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
60 kDa chaperoninUniRule annotation
Alternative name(s):
GroEL proteinUniRule annotation
Protein Cpn60UniRule annotation
Gene namesi
Name:groLUniRule annotation
Synonyms:groELUniRule annotation
Encoded oniPlasmid pISI-2Imported
OrganismiLawsonia intracellularisImported
Taxonomic identifieri29546 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaDeltaproteobacteriaDesulfovibrionalesDesulfovibrionaceaeLawsonia

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

CytoplasmUniRule annotation

Interactioni

Subunit structurei

Oligomer of 14 subunits composed of two stacked rings of 7 subunits.UniRule annotation

GO - Molecular functioni

Structurei

3D structure databases

ProteinModelPortaliO87888.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili339 – 366Sequence analysisAdd BLAST28

Sequence similaritiesi

Belongs to the chaperonin (HSP60) family.UniRule annotation

Keywords - Domaini

Coiled coilSequence analysis

Phylogenomic databases

eggNOGiENOG4105CJ9. Bacteria.
COG0459. LUCA.

Family and domain databases

CDDicd03344. GroEL. 1 hit.
Gene3Di1.10.560.10. 2 hits.
3.50.7.10. 1 hit.
HAMAPiMF_00600. CH60. 1 hit.
InterProiView protein in InterPro
IPR018370. Chaperonin_Cpn60_CS.
IPR001844. Chaprnin_Cpn60.
IPR002423. Cpn60/TCP-1.
IPR037290. Cpn60/TCP-1_sf.
IPR027409. GroEL-like_apical_dom_sf.
IPR027413. GROEL-like_equatorial_sf.
PANTHERiPTHR11353. PTHR11353. 1 hit.
PfamiView protein in Pfam
PF00118. Cpn60_TCP1. 1 hit.
PRINTSiPR00298. CHAPERONIN60.
SUPFAMiSSF48592. SSF48592. 2 hits.
SSF52029. SSF52029. 1 hit.
SSF54849. SSF54849. 1 hit.
TIGRFAMsiTIGR02348. GroEL. 1 hit.
PROSITEiView protein in PROSITE
PS00296. CHAPERONINS_CPN60. 1 hit.

Sequencei

Sequence statusi: Complete.

O87888-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MASKEILFDA KAREKLSRGV DKLANAVKVT LGPKGRNVVI EKSFGSPVIT
60 70 80 90 100
KDGVSVAKEI ELEDKFENMG AQMVKEVAPK TSDIAGDGTT TATVLAQAIY
110 120 130 140 150
REGVKLVAAG RNPMAIKRGI DKAVVAVTKE LSDITKPTRD QKEIAQVGTI
160 170 180 190 200
SANSDTTIGN IIAEAMAKVG KGGVITVEEA KGLETTLDVV EGMKFDRGYL
210 220 230 240 250
SPYFVTNPEK MVCELDNPYI LCNEKKITSM KDMLPILEQV AKVNRPLLII
260 270 280 290 300
AEDVEGEALA TLVVNKLRGA LQVVAVKAPG FGERRKAMLE DIAILTGGEA
310 320 330 340 350
IFEDRGIKLE NVSLSSLGTA KRVVIDKENT TIVDGAGKSE DIKARVKQIR
360 370 380 390 400
AQIEETSSDY DREKLQERLA KLVGGVAVIH VGAATETEMK EKKDRVEDAL
410 420 430 440 450
NATRAAVEEG IVPGGGTAFV RSIKVLDDIK PADDDELAGL NIIRRSLEEP
460 470 480 490 500
LRQIAANAGY EGSIVVEKVR EPKDGFGFNA ASGEYEDLIK AGVIDPKKVT
510 520 530 540
RIALQNAASV ASLLLTTECA IAEKPEPKKD MPMPGGGMGG MGGMDGMY
Length:548
Mass (Da):58,606
Last modified:November 1, 1998 - v1
Checksum:i6388C431E663E498
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U45241 Genomic DNA. Translation: AAC36500.1.

Similar proteinsi

Entry informationi

Entry nameiO87888_LAWIN
AccessioniPrimary (citable) accession number: O87888
Entry historyiIntegrated into UniProtKB/TrEMBL: November 1, 1998
Last sequence update: November 1, 1998
Last modified: November 22, 2017
This is version 88 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

PlasmidImported