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Protein

Elongation factor G 2

Gene

fusB

Organism
Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome (By similarity).By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi16 – 238GTPBy similarity
Nucleotide bindingi80 – 845GTPBy similarity
Nucleotide bindingi134 – 1374GTPBy similarity

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Elongation factor

Keywords - Biological processi

Protein biosynthesis

Keywords - Ligandi

GTP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Elongation factor G 2
Short name:
EF-G 2
Gene namesi
Name:fusB
Ordered Locus Names:SCO6589
ORF Names:SC8A6.10
OrganismiStreptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)
Taxonomic identifieri100226 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaStreptomycetalesStreptomycetaceaeStreptomycesStreptomyces albidoflavus group
Proteomesi
  • UP000001973 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 686686Elongation factor G 2PRO_0000091228Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi100226.SCO6589.

Structurei

3D structure databases

ProteinModelPortaliO87844.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini7 – 280274tr-type GAdd
BLAST

Sequence similaritiesi

Phylogenomic databases

eggNOGiENOG4108NVJ. Bacteria.
COG0480. LUCA.
HOGENOMiHOG000231585.
InParanoidiO87844.
KOiK02355.
OMAiHKRGEVH.
OrthoDBiEOG6F293W.
PhylomeDBiO87844.

Family and domain databases

Gene3Di3.30.230.10. 1 hit.
3.30.70.240. 1 hit.
3.40.50.300. 1 hit.
HAMAPiMF_00054_B. EF_G_EF_2_B.
InterProiIPR009022. EFG_III-V.
IPR000640. EFG_V.
IPR004161. EFTu-like_2.
IPR031157. G_TR_CS.
IPR027417. P-loop_NTPase.
IPR020568. Ribosomal_S5_D2-typ_fold.
IPR014721. Ribosomal_S5_D2-typ_fold_subgr.
IPR005225. Small_GTP-bd_dom.
IPR000795. TF_GTP-bd_dom.
IPR009000. Transl_B-barrel.
IPR004540. Transl_elong_EFG/EF2.
IPR005517. Transl_elong_EFG/EF2_IV.
[Graphical view]
PfamiPF00679. EFG_C. 1 hit.
PF14492. EFG_II. 1 hit.
PF03764. EFG_IV. 1 hit.
PF03144. GTP_EFTU_D2. 1 hit.
[Graphical view]
PRINTSiPR00315. ELONGATNFCT.
SMARTiSM00838. EFG_C. 1 hit.
SM00889. EFG_IV. 1 hit.
[Graphical view]
SUPFAMiSSF50447. SSF50447. 1 hit.
SSF52540. SSF52540. 1 hit.
SSF54211. SSF54211. 1 hit.
SSF54980. SSF54980. 2 hits.
TIGRFAMsiTIGR00484. EF-G. 1 hit.
TIGR00231. small_GTP. 1 hit.
PROSITEiPS00301. G_TR_1. 1 hit.
PS51722. G_TR_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O87844-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRTNPLTTVR NLGILAHVDA GKTTVTERIL YLTGTTHKRG EVHDGTTVTD
60 70 80 90 100
FDPQERDRGI TIFAAAVSCA WAGHRINLID TPGHVDFADE VERSLRVLDG
110 120 130 140 150
AVAVFDAVAG VEPQSESVWR QADRHGVPRI AFVNKMDRAG ADLDAAVASI
160 170 180 190 200
RERLHPVPLV VQLPIGTEDG FTGVVDLPRM RALVWADGAD AAEEGPVPGT
210 220 230 240 250
LREEAARRRR VLEEAVAERH PGALEEFCDR ETLTAATLTG ALRDLTRTGD
260 270 280 290 300
GVVVLCGSAY RNRGVEPLLD AVVAYLPSPL DVPPVRGTHD GAERERPADP
310 320 330 340 350
AAPMAALAFK VNATPTGRLT YLRVYSGTIG KGDTVWDAGT RRTERIGRIL
360 370 380 390 400
RVRADRHDPL ERAVAGDIVA VVGLKTARAG STLCAPGAPL LLEPPGVAEP
410 420 430 440 450
VVHVAVEARR STETDRLAAA LARLTEEDPS LALRTDPETA QTVLSGMGEL
460 470 480 490 500
HLEVAVERVR REYGLEVTVG RPGVAYRETV GEGVTGFVHR HVKQDGGAGQ
510 520 530 540 550
FAHIVLDVEP WEQDADGDGA GGGFVFRSTV VGGRVPQEYV RAVEAGCRDA
560 570 580 590 600
LAEGPLGGHP VTGLRVTLTD GRTHVKDSSD TAFRTAGRFG LRDALRASGM
610 620 630 640 650
ILLEPVVEVT VTVPEDGVGG VLGDLAARRG RVTGSDPRGG AVVVTATVPL
660 670 680
AELFGYATRL RSRTQGRGTF TARPTGYAQA PAAVVR
Length:686
Mass (Da):72,921
Last modified:November 1, 1998 - v1
Checksum:iBCFC581BFC9FAFC2
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL939128 Genomic DNA. Translation: CAA19782.1.
PIRiT35777.
RefSeqiNP_630668.1. NC_003888.3.
WP_011031026.1. NC_003888.3.

Genome annotation databases

EnsemblBacteriaiCAA19782; CAA19782; CAA19782.
GeneIDi1102028.
KEGGisco:SCO6589.
PATRICi23743101. VBIStrCoe124346_6696.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL939128 Genomic DNA. Translation: CAA19782.1.
PIRiT35777.
RefSeqiNP_630668.1. NC_003888.3.
WP_011031026.1. NC_003888.3.

3D structure databases

ProteinModelPortaliO87844.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi100226.SCO6589.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiCAA19782; CAA19782; CAA19782.
GeneIDi1102028.
KEGGisco:SCO6589.
PATRICi23743101. VBIStrCoe124346_6696.

Phylogenomic databases

eggNOGiENOG4108NVJ. Bacteria.
COG0480. LUCA.
HOGENOMiHOG000231585.
InParanoidiO87844.
KOiK02355.
OMAiHKRGEVH.
OrthoDBiEOG6F293W.
PhylomeDBiO87844.

Family and domain databases

Gene3Di3.30.230.10. 1 hit.
3.30.70.240. 1 hit.
3.40.50.300. 1 hit.
HAMAPiMF_00054_B. EF_G_EF_2_B.
InterProiIPR009022. EFG_III-V.
IPR000640. EFG_V.
IPR004161. EFTu-like_2.
IPR031157. G_TR_CS.
IPR027417. P-loop_NTPase.
IPR020568. Ribosomal_S5_D2-typ_fold.
IPR014721. Ribosomal_S5_D2-typ_fold_subgr.
IPR005225. Small_GTP-bd_dom.
IPR000795. TF_GTP-bd_dom.
IPR009000. Transl_B-barrel.
IPR004540. Transl_elong_EFG/EF2.
IPR005517. Transl_elong_EFG/EF2_IV.
[Graphical view]
PfamiPF00679. EFG_C. 1 hit.
PF14492. EFG_II. 1 hit.
PF03764. EFG_IV. 1 hit.
PF03144. GTP_EFTU_D2. 1 hit.
[Graphical view]
PRINTSiPR00315. ELONGATNFCT.
SMARTiSM00838. EFG_C. 1 hit.
SM00889. EFG_IV. 1 hit.
[Graphical view]
SUPFAMiSSF50447. SSF50447. 1 hit.
SSF52540. SSF52540. 1 hit.
SSF54211. SSF54211. 1 hit.
SSF54980. SSF54980. 2 hits.
TIGRFAMsiTIGR00484. EF-G. 1 hit.
TIGR00231. small_GTP. 1 hit.
PROSITEiPS00301. G_TR_1. 1 hit.
PS51722. G_TR_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC BAA-471 / A3(2) / M145.

Entry informationi

Entry nameiEFG2_STRCO
AccessioniPrimary (citable) accession number: O87844
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 15, 1998
Last sequence update: November 1, 1998
Last modified: July 6, 2016
This is version 106 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.