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Protein

Elongation factor G 2

Gene

fusB

Organism
Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome (By similarity).By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi16 – 23GTPBy similarity8
Nucleotide bindingi80 – 84GTPBy similarity5
Nucleotide bindingi134 – 137GTPBy similarity4

GO - Molecular functioni

Keywordsi

Molecular functionElongation factor
Biological processProtein biosynthesis
LigandGTP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Elongation factor G 2
Short name:
EF-G 2
Gene namesi
Name:fusB
Ordered Locus Names:SCO6589
ORF Names:SC8A6.10
OrganismiStreptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)
Taxonomic identifieri100226 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaStreptomycetalesStreptomycetaceaeStreptomycesStreptomyces albidoflavus group
Proteomesi
  • UP000001973 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000912281 – 686Elongation factor G 2Add BLAST686

Proteomic databases

PRIDEiO87844

Interactioni

Protein-protein interaction databases

STRINGi100226.SCO6589

Structurei

3D structure databases

ProteinModelPortaliO87844
SMRiO87844
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini7 – 280tr-type GAdd BLAST274

Sequence similaritiesi

Phylogenomic databases

eggNOGiENOG4108NVJ Bacteria
COG0480 LUCA
HOGENOMiHOG000231585
InParanoidiO87844
KOiK02355
OMAiHKRGEVH
OrthoDBiPOG091H02CO
PhylomeDBiO87844

Family and domain databases

CDDicd16262 EFG_III, 1 hit
cd03713 EFG_mtEFG_C, 1 hit
Gene3Di3.30.230.10, 2 hits
HAMAPiMF_00054_B EF_G_EF_2_B, 1 hit
InterProiView protein in InterPro
IPR009022 EFG_III
IPR035647 EFG_III/V
IPR035649 EFG_V
IPR000640 EFG_V-like
IPR004161 EFTu-like_2
IPR031157 G_TR_CS
IPR027417 P-loop_NTPase
IPR020568 Ribosomal_S5_D2-typ_fold
IPR014721 Ribosomal_S5_D2-typ_fold_subgr
IPR005225 Small_GTP-bd_dom
IPR000795 TF_GTP-bd_dom
IPR009000 Transl_B-barrel_sf
IPR004540 Transl_elong_EFG/EF2
IPR005517 Transl_elong_EFG/EF2_IV
PfamiView protein in Pfam
PF00679 EFG_C, 1 hit
PF03764 EFG_IV, 1 hit
PF00009 GTP_EFTU, 1 hit
PF03144 GTP_EFTU_D2, 1 hit
PRINTSiPR00315 ELONGATNFCT
SMARTiView protein in SMART
SM00838 EFG_C, 1 hit
SM00889 EFG_IV, 1 hit
SUPFAMiSSF50447 SSF50447, 1 hit
SSF52540 SSF52540, 1 hit
SSF54211 SSF54211, 1 hit
SSF54980 SSF54980, 2 hits
TIGRFAMsiTIGR00484 EF-G, 1 hit
TIGR00231 small_GTP, 1 hit
PROSITEiView protein in PROSITE
PS00301 G_TR_1, 1 hit
PS51722 G_TR_2, 1 hit

Sequencei

Sequence statusi: Complete.

O87844-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRTNPLTTVR NLGILAHVDA GKTTVTERIL YLTGTTHKRG EVHDGTTVTD
60 70 80 90 100
FDPQERDRGI TIFAAAVSCA WAGHRINLID TPGHVDFADE VERSLRVLDG
110 120 130 140 150
AVAVFDAVAG VEPQSESVWR QADRHGVPRI AFVNKMDRAG ADLDAAVASI
160 170 180 190 200
RERLHPVPLV VQLPIGTEDG FTGVVDLPRM RALVWADGAD AAEEGPVPGT
210 220 230 240 250
LREEAARRRR VLEEAVAERH PGALEEFCDR ETLTAATLTG ALRDLTRTGD
260 270 280 290 300
GVVVLCGSAY RNRGVEPLLD AVVAYLPSPL DVPPVRGTHD GAERERPADP
310 320 330 340 350
AAPMAALAFK VNATPTGRLT YLRVYSGTIG KGDTVWDAGT RRTERIGRIL
360 370 380 390 400
RVRADRHDPL ERAVAGDIVA VVGLKTARAG STLCAPGAPL LLEPPGVAEP
410 420 430 440 450
VVHVAVEARR STETDRLAAA LARLTEEDPS LALRTDPETA QTVLSGMGEL
460 470 480 490 500
HLEVAVERVR REYGLEVTVG RPGVAYRETV GEGVTGFVHR HVKQDGGAGQ
510 520 530 540 550
FAHIVLDVEP WEQDADGDGA GGGFVFRSTV VGGRVPQEYV RAVEAGCRDA
560 570 580 590 600
LAEGPLGGHP VTGLRVTLTD GRTHVKDSSD TAFRTAGRFG LRDALRASGM
610 620 630 640 650
ILLEPVVEVT VTVPEDGVGG VLGDLAARRG RVTGSDPRGG AVVVTATVPL
660 670 680
AELFGYATRL RSRTQGRGTF TARPTGYAQA PAAVVR
Length:686
Mass (Da):72,921
Last modified:November 1, 1998 - v1
Checksum:iBCFC581BFC9FAFC2
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL939128 Genomic DNA Translation: CAA19782.1
PIRiT35777
RefSeqiNP_630668.1, NC_003888.3
WP_011031026.1, NC_003888.3

Genome annotation databases

EnsemblBacteriaiCAA19782; CAA19782; CAA19782
GeneIDi1102028
KEGGisco:SCO6589
PATRICifig|100226.15.peg.6696

Similar proteinsi

Entry informationi

Entry nameiEFG2_STRCO
AccessioniPrimary (citable) accession number: O87844
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 15, 1998
Last sequence update: November 1, 1998
Last modified: May 23, 2018
This is version 117 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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