ID   SUCC2_STRCO             Reviewed;         383 AA.
AC   O87840;
DT   27-MAY-2002, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1998, sequence version 1.
DT   16-JUN-2009, entry version 61.
DE   RecName: Full=Succinyl-CoA ligase [ADP-forming] subunit beta-2;
DE            EC=6.2.1.5;
DE   AltName: Full=Succinyl-CoA synthetase subunit beta-2;
DE            Short=SCS-beta-2;
GN   Name=sucC2; Synonyms=sucC; OrderedLocusNames=SCO6585;
GN   ORFNames=SC8A6.06;
OS   Streptomyces coelicolor.
OC   Bacteria; Actinobacteria; Actinobacteridae; Actinomycetales;
OC   Streptomycineae; Streptomycetaceae; Streptomyces.
OX   NCBI_TaxID=1902;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC BAA-471 / A3(2) / M145;
RX   MEDLINE=21996410; PubMed=12000953; DOI=10.1038/417141a;
RA   Bentley S.D., Chater K.F., Cerdeno-Tarraga A.-M., Challis G.L.,
RA   Thomson N.R., James K.D., Harris D.E., Quail M.A., Kieser H.,
RA   Harper D., Bateman A., Brown S., Chandra G., Chen C.W., Collins M.,
RA   Cronin A., Fraser A., Goble A., Hidalgo J., Hornsby T., Howarth S.,
RA   Huang C.-H., Kieser T., Larke L., Murphy L.D., Oliver K., O'Neil S.,
RA   Rabbinowitsch E., Rajandream M.A., Rutherford K.M., Rutter S.,
RA   Seeger K., Saunders D., Sharp S., Squares R., Squares S., Taylor K.,
RA   Warren T., Wietzorrek A., Woodward J.R., Barrell B.G., Parkhill J.,
RA   Hopwood D.A.;
RT   "Complete genome sequence of the model actinomycete Streptomyces
RT   coelicolor A3(2).";
RL   Nature 417:141-147(2002).
CC   -!- CATALYTIC ACTIVITY: ATP + succinate + CoA = ADP + phosphate +
CC       succinyl-CoA.
CC   -!- COFACTOR: Binds 1 magnesium or manganese ion per subunit (By
CC       similarity).
CC   -!- PATHWAY: Carbohydrate metabolism; tricarboxylic acid cycle.
CC   -!- SUBUNIT: Heterotetramer of two alpha and two beta subunits (By
CC       similarity).
CC   -!- SIMILARITY: Belongs to the succinate/malate CoA ligase beta
CC       subunit family.
CC   -!- SIMILARITY: Contains 1 ATP-grasp domain.
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DR   EMBL; AL939128; CAA19778.1; -; Genomic_DNA.
DR   PIR; T35773; T35773.
DR   RefSeq; NP_630664.1; -.
DR   HSSP; P07460; 1JKJ.
DR   GeneID; 1102024; -.
DR   GenomeReviews; AL645882_GR; SCO6585.
DR   KEGG; sco:SCO6585; -.
DR   NMPDR; fig|100226.1.peg.6523; -.
DR   HOGENOM; O87840; -.
DR   OMA; O87840; CGARPAN.
DR   BioCyc; SCOE100226:SCO6585-MON; -.
DR   BRENDA; 6.2.1.5; 1084.
DR   GO; GO:0005524; F:ATP binding; IEA:HAMAP.
DR   GO; GO:0000287; F:magnesium ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0030145; F:manganese ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0004775; F:succinate-CoA ligase (ADP-forming) activity; IEA:HAMAP.
DR   GO; GO:0006099; P:tricarboxylic acid cycle; IEA:HAMAP.
DR   HAMAP; MF_00558; -; 1.
DR   InterPro; IPR011761; ATP-grasp.
DR   InterPro; IPR013650; ATP-grasp_succ-CoA_synth-type.
DR   InterPro; IPR013816; ATP_grasp_subdomain_2.
DR   InterPro; IPR005811; CoA_ligase.
DR   InterPro; IPR017866; Succ-CoA_synthase_bsu_CS.
DR   InterPro; IPR005809; Succ_CoA_synthase_bsu.
DR   InterPro; IPR016102; Succinyl-CoA_synth-like.
DR   Gene3D; G3DSA:3.30.470.20; ATP_grasp_subdomain_2; 1.
DR   Gene3D; G3DSA:3.40.50.261; Succinyl-CoA_synth-like; 1.
DR   PANTHER; PTHR11815; CoA_lig_beta; 1.
DR   Pfam; PF08442; ATP-grasp_2; 1.
DR   Pfam; PF00549; Ligase_CoA; 1.
DR   TIGRFAMs; TIGR01016; sucCoAbeta; 1.
DR   PROSITE; PS50975; ATP_GRASP; 1.
DR   PROSITE; PS01217; SUCCINYL_COA_LIG_3; 1.
PE   3: Inferred from homology;
KW   ATP-binding; Complete proteome; Ligase; Magnesium; Manganese;
KW   Metal-binding; Nucleotide-binding; Tricarboxylic acid cycle.
FT   CHAIN         1    383       Succinyl-CoA ligase [ADP-forming] subunit
FT                                beta-2.
FT                                /FTId=PRO_0000102870.
FT   DOMAIN        9    231       ATP-grasp.
FT   NP_BIND      35    100       ATP (By similarity).
FT   METAL       185    185       Magnesium or manganese (By similarity).
FT   METAL       187    187       Magnesium or manganese (By similarity).
SQ   SEQUENCE   383 AA;  40162 MW;  5A3D05C0FD11DD03 CRC64;
     MDLYEHQARE LFKEHGIVVP RAEVTDSPER AREIARALGG RAVVKAQVKT GGRGKAGGVR
     LAADPAEAEE AARHILGMDI RGHTVDTVML AEPCEIEREF YVSYVLDRAS GGFLAIASAE
     GGTEIEEVAA RRPEAVARIP VDPATGVHTA TAVRIADAAG LPPQTVDTLV RLWKVLVRED
     ALLVEVNPLV RTAEGRIVAL DGKVTLDDNA RFRQSRWGET RQEDADSLEA RAGAKGLNYV
     KLDGEVGVIG NGAGLVMSTL DVVAGCGARP ANFLDIGGGA SARVMADGLS VVLSDPDVRS
     VLVNVFGGIT ACDAVADGIV RALDEVRLTK PLVVRLDGNN AARGRALLDA RAHPLVEQAT
     TMDGAARRAA RLATAASTAG QAG
//