O87838 (FCTA_STRCO) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Formyl-coenzyme A transferase
Short name=Formyl-CoA transferase
EC=2.8.3.16

Gene names

Name:	frc
Ordered Locus Names:	SCO6583
ORF Names:	SC8A6.04c

Organism

Streptomyces coelicolor

Taxonomic identifier

1902 [NCBI]

Taxonomic lineage

Bacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Streptomycineae › Streptomycetaceae › Streptomyces

Protein attributes

Sequence length	410 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Catalyzes the transfer of the CoA moiety from formyl-CoA to oxalate By similarity. HAMAP MF_00742
Catalytic activity	Formyl-CoA + oxalate = formate + oxalyl-CoA. HAMAP MF_00742
Pathway	Metabolic intermediate degradation; oxalate degradation; CO(2) and formate from oxalate: step 1/2. HAMAP MF_00742
Sequence similarities	Belongs to the CaiB/BaiF CoA-transferase family.

Ontologies

Keywords
Molecular function	Transferase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Molecular function	formyl-CoA transferase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 410	410	Formyl-coenzyme A transferase HAMAP MF_00742		PRO_0000194724
Sites
	Active site	168	1	Nucleophile By similarity
	Binding site	96	1	Coenzyme A By similarity

Sequences

	Sequence		Length	Mass (Da)
	O87838 [UniParc]. Last modified November 1, 1998. Version 1. Checksum: 3760A61D3D3DCAA4	FASTA	410	44,664
	10 20 30 40 50 60 MTAKALEGIR VLDMTHVQSG PSATQLLAWL GADVVKLEAP HGDITRGQLR DLPDVDSLYF 70 80 90 100 110 120 TMLNCNKRSI TLNTKSERGK EILTELIRRS DVMVENFGPG AVDRMGFTWD RVKEINPRIV 130 140 150 160 170 180 YASIKGFGEG PYTAFKAYEV VAQAMGGSMS TTGFEDGPPL ATGAQIGDSG TGVHVVAGIL 190 200 210 220 230 240 AALYQREHTG RGQRVNVAMQ HAVLNLCRVK LRDQQRLSHG PLAEYPNEDF GDEVPRSGNA 250 260 270 280 290 300 SGGGQPGWAV KCAPGGPNDY VYVIVQPVGW QPLSELIGRP ELAEDPEWAT PRARLPKLNK 310 320 330 340 350 360 MFQLIEEWSS TLPKWEVLER LNAHNIPCGP ILSTKEIIED DSLVANEMVV TVPHPERGEF 370 380 390 400 410 VTVGSPLKLS DSPVEVTSSP LLGEHNEEVY VGELGLGDEE LRLLKSSGVI

References

[1]

"Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2)." Bentley S.D., Chater K.F., Cerdeno-Tarraga A.-M., Challis G.L., Thomson N.R., James K.D., Harris D.E., Quail M.A., Kieser H., Harper D., Bateman A., Brown S., Chandra G., Chen C.W., Collins M., Cronin A., Fraser A., Goble A. , Hidalgo J., Hornsby T., Howarth S., Huang C.-H., Kieser T., Larke L., Murphy L.D., Oliver K., O'Neil S., Rabbinowitsch E., Rajandream M.A., Rutherford K.M., Rutter S., Seeger K., Saunders D., Sharp S., Squares R., Squares S., Taylor K., Warren T., Wietzorrek A., Woodward J.R., Barrell B.G., Parkhill J., Hopwood D.A. Nature 417:141-147(2002) [PubMed: 12000953] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC BAA-471 / A3(2) / M145.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AL939128 Genomic DNA. Translation: CAA19776.1.
PIR	T35771.
RefSeq	NP_630662.1. NC_003888.3.
3D structure databases
ProteinModelPortal	O87838.
SMR	O87838. Positions 4-410.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	1102022.
GenomeReviews	Gene locus SCO6583 in contig AL645882_GR.
KEGG	sco:SCO6583.
NMPDR	fig|100226.1.peg.6521.
PATRIC	23743083. VBIStrCoe124346_6688.
Phylogenomic databases
HOGENOM	HBG659028.
OMA	NDYVYVI.
PhylomeDB	O87838.
ProtClustDB	PRK05398.
Family and domain databases
HAMAP	MF_00742. Formyl-CoA_transfer. [Tree]
InterPro	IPR003673. CoA-Trfase_fam_III. IPR023606. CoA-Trfase_III_dom. IPR017659. Formyl-CoA_transferase. [Graphical view]
Gene3D	G3DSA:3.40.50.10540. CoA-Trfase_fam_III. 1 hit.
KO	K07749.
PANTHER	PTHR11837. CAIB_BAIF. 1 hit.
Pfam	PF02515. CoA_transf_3. 1 hit. [Graphical view]
SUPFAM	SSF89796. CoA-Trfase_fam_III. 1 hit.
TIGRFAMs	TIGR03253. Oxalate_frc. 1 hit.
ProtoNet	Search...

Entry information

Entry name

FCTA_STRCO

Accession

Primary (citable) accession number: O87838

Entry history

Integrated into UniProtKB/Swiss-Prot:	December 15, 2003
Last sequence update:	November 1, 1998
Last modified:	January 25, 2012
This is version 67 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program