UniProtKB - O87792 (PNP_PSEPU)
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Protein
Polyribonucleotide nucleotidyltransferase
Gene
pnp
Organism
Pseudomonas putida (Arthrobacter siderocapsulatus)
Status
Functioni
Involved in mRNA degradation. Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'- to 5'-direction.UniRule annotation
Catalytic activityi
RNA(n+1) + phosphate = RNA(n) + a nucleoside diphosphate.UniRule annotation
Cofactori
Mg2+UniRule annotation
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Metal bindingi | 487 | MagnesiumUniRule annotation | 1 | |
Metal bindingi | 493 | MagnesiumUniRule annotation | 1 |
GO - Molecular functioni
- metal ion binding Source: UniProtKB-KW
- polyribonucleotide nucleotidyltransferase activity Source: UniProtKB-EC
- RNA binding Source: UniProtKB-KW
GO - Biological processi
- mRNA catabolic process Source: InterPro
- RNA processing Source: InterPro
Keywordsi
Molecular function | Nucleotidyltransferase, RNA-binding, Transferase |
Ligand | Magnesium, Metal-binding |
Enzyme and pathway databases
BRENDAi | 2.7.7.8. 5092. |
Names & Taxonomyi
Protein namesi | Recommended name: Polyribonucleotide nucleotidyltransferaseUniRule annotation (EC:2.7.7.8UniRule annotation)Alternative name(s): Polynucleotide phosphorylaseUniRule annotation Short name: PNPaseUniRule annotation |
Gene namesi | Name:pnpUniRule annotation |
Organismi | Pseudomonas putida (Arthrobacter siderocapsulatus) |
Taxonomic identifieri | 303 [NCBI] |
Taxonomic lineagei | Bacteria › Proteobacteria › Gammaproteobacteria › Pseudomonadales › Pseudomonadaceae › Pseudomonas › |
Subcellular locationi
- Cytoplasm UniRule annotation
GO - Cellular componenti
- cytoplasm Source: UniProtKB-SubCell
Keywords - Cellular componenti
CytoplasmPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000197916 | 1 – 701 | Polyribonucleotide nucleotidyltransferaseAdd BLAST | 701 |
Interactioni
Subunit structurei
Component of the RNA degradosome, which is a multiprotein complex involved in RNA processing and mRNA degradation.UniRule annotation
Structurei
3D structure databases
ProteinModelPortali | O87792. |
SMRi | O87792. |
ModBasei | Search... |
MobiDBi | Search... |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 554 – 613 | KHUniRule annotationAdd BLAST | 60 | |
Domaini | 623 – 691 | S1 motifUniRule annotationAdd BLAST | 69 |
Sequence similaritiesi
Belongs to the polyribonucleotide nucleotidyltransferase family.UniRule annotation
Phylogenomic databases
eggNOGi | ENOG4105C62. Bacteria. COG1185. LUCA. |
Family and domain databases
Gene3Di | 3.30.1370.10. 1 hit. 3.30.230.70. 2 hits. |
HAMAPi | MF_01595. PNPase. 1 hit. |
InterProi | View protein in InterPro IPR001247. ExoRNase_PH_dom1. IPR015847. ExoRNase_PH_dom2. IPR036345. ExoRNase_PH_dom2_sf. IPR004087. KH_dom. IPR004088. KH_dom_type_1. IPR036612. KH_dom_type_1_sf. IPR012340. NA-bd_OB-fold. IPR012162. PNPase. IPR027408. PNPase/RNase_PH_dom_sf. IPR015848. PNPase_PH_RNA-bd_bac/org-type. IPR020568. Ribosomal_S5_D2-typ_fold. IPR022967. S1_dom. IPR003029. S1_domain. |
PANTHERi | PTHR11252. PTHR11252. 1 hit. |
Pfami | View protein in Pfam PF00013. KH_1. 1 hit. PF03726. PNPase. 1 hit. PF01138. RNase_PH. 2 hits. PF03725. RNase_PH_C. 2 hits. PF00575. S1. 1 hit. |
PIRSFi | PIRSF005499. PNPase. 1 hit. |
SMARTi | View protein in SMART SM00322. KH. 1 hit. SM00316. S1. 1 hit. |
SUPFAMi | SSF50249. SSF50249. 1 hit. SSF54211. SSF54211. 2 hits. SSF54791. SSF54791. 1 hit. SSF55666. SSF55666. 2 hits. |
TIGRFAMsi | TIGR03591. polynuc_phos. 1 hit. |
PROSITEi | View protein in PROSITE PS50084. KH_TYPE_1. 1 hit. PS50126. S1. 1 hit. |
i Sequence
Sequence statusi: Complete.
O87792-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MNPVIKTFQF GQSTVTLETG RIARQATGAV LVTVDNDVTV LVTVVGAKQA
60 70 80 90 100
DPGKGFFPLS VHYQEKTYAA GKIPGGFFKR EGRPSEKETL TSRLIDRPIR
110 120 130 140 150
PLFPEGFMNE VQVVCTVVST SKKTDPDIAA MIGTSAALAI SGIPFEGPIG
160 170 180 190 200
AARVAFHEST GYLLNPTYEQ LAASSLDMVV AGTSDAVLMV ESEAQELTED
210 220 230 240 250
QMLGAVLFAH DEFQAVIQAV KELAAEAGKP TWDWKPAVAN TELFNAIRAE
260 270 280 290 300
FGEAVSQGYT ITVKADRYAR LGELRDQAVA KFSGEEGQPS ASEVKEIFGE
310 320 330 340 350
IEYRTVRENI VNGKPRIDGR DNKTVRPLNI EVGVLPKTHG SALFTRGETQ
360 370 380 390 400
ALVVATLGTA RDAQLLDTLE GEKKDPFMLH YNFPPFSVGE CGRMGGAGRR
410 420 430 440 450
EIGHGRLARR SVQAMLPAAD VFPYTIRVVS EITESNGSSS MASVCGASLA
460 470 480 490 500
LMDAGVPMKA PVAGIAMGLV KEGDKFAVLT DILGDEDHLG DMDFKVAGTA
510 520 530 540 550
KGVTALQMDI KINGITEEIM EIALGQALEA RLNILGQMNQ VIGQSRTELS
560 570 580 590 600
ANAPTMIAMK IDTDKIRDVI GKGGATIRAI CEETKASIDI EDDGSIKIFG
610 620 630 640 650
ETKEAADAAK QRILGITAEA EIGKIYVGKV ERIVDFGAFV NILPGKDGLV
660 670 680 690 700
HISMLSDARV EKVTDILKEG QEVEVLVLDV DNRGRIKLSI KDVAAAKASG
V
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | Y18132 Genomic DNA. Translation: CAA77048.1. |
Similar proteinsi
Entry informationi
Entry namei | PNP_PSEPU | |
Accessioni | O87792Primary (citable) accession number: O87792 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | December 1, 2000 |
Last sequence update: | November 1, 1998 | |
Last modified: | February 28, 2018 | |
This is version 99 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Prokaryotic Protein Annotation Program |