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Protein

Chaperone protein DnaK

Gene

dnaK

Organism
Lactobacillus sakei
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

Acts as a chaperone.By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Chaperone

Keywords - Biological processi

Stress response

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Chaperone protein DnaK
Alternative name(s):
HSP70
Heat shock 70 kDa protein
Heat shock protein 70
Gene namesi
Name:dnaK
OrganismiLactobacillus sakei
Taxonomic identifieri1599 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesLactobacillaceaeLactobacillus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 613613Chaperone protein DnaKPRO_0000078476Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei174 – 1741Phosphothreonine; by autocatalysisBy similarity

Keywords - PTMi

Phosphoprotein

Expressioni

Inductioni

By heat shock as well as salt or ethanol stress.

Interactioni

Protein-protein interaction databases

STRINGi314315.LSA1236.

Structurei

3D structure databases

ProteinModelPortaliO87777.
SMRiO87777. Positions 1-506.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the heat shock protein 70 family.Curated

Phylogenomic databases

eggNOGiENOG4105CFG. Bacteria.
COG0443. LUCA.

Family and domain databases

Gene3Di1.20.1270.10. 1 hit.
2.60.34.10. 1 hit.
HAMAPiMF_00332. DnaK.
InterProiIPR012725. Chaperone_DnaK.
IPR018181. Heat_shock_70_CS.
IPR029048. HSP70_C.
IPR029047. HSP70_peptide-bd.
IPR013126. Hsp_70_fam.
[Graphical view]
PfamiPF00012. HSP70. 1 hit.
[Graphical view]
PRINTSiPR00301. HEATSHOCK70.
SUPFAMiSSF100920. SSF100920. 1 hit.
SSF100934. SSF100934. 1 hit.
TIGRFAMsiTIGR02350. prok_dnaK. 1 hit.
PROSITEiPS00297. HSP70_1. 1 hit.
PS00329. HSP70_2. 1 hit.
PS01036. HSP70_3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O87777-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSKVIGIDLG TTNSAVAVLE GGQPKIITNP EGARTTPSVV SFKNGEIQVG
60 70 80 90 100
EVAKRQAITN PDTIASIKRH IGEAGYKVTV GDKSYTPQEV SAMILQYIKK
110 120 130 140 150
FAEDYLGEEV TEAVITVPAY FNDSQRQATK DAGKIAGLDV KRIINEPTAS
160 170 180 190 200
ALAYGLDKTE TDEKVLVYDL GGGTFDVSVL ELGDGVFQVL STNGDTRLGG
210 220 230 240 250
DDFDEAIMNW LVENFKSDNG IDLSKDKMAM QRLKDAAEKA KKDLSGVSST
260 270 280 290 300
QISLPFISAG ENGPLHLEMT LSRTEFDRLT SDLVDRTKAP VMNALKDAGL
310 320 330 340 350
DANEIDKVIL NGGSTRIPAV QEAVKNWTGK EPDHSINPDE AVALGAAVQG
360 370 380 390 400
GVISGDVKDV VLLDVTPLSL GIETMGGVFT KLIDRNTTIP TSKAQTFSTA
410 420 430 440 450
ADNQPAVDIH VLQGERPMAA DNKTLGRFQL TDIPAAPRGV PQIEVKFDID
460 470 480 490 500
KNGIVNVSAK DLGTNKEQKI TIKSNSGLSD EEIDRMMKEA QENEEADTKR
510 520 530 540 550
KEEVDLKNDV DQLIFQTDKT LKELEGKVSD EELQKAKDAK EELVKAQQEN
560 570 580 590 600
NLEDMKTKRD ALSEIVQELT VKLYQQAQEA QQAAGGAEGN ATDAKTDDGT
610
VDGDFEEVKD DKE
Length:613
Mass (Da):66,276
Last modified:November 1, 1998 - v1
Checksum:i1D9348482479A64F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ006274 Genomic DNA. Translation: CAA06941.1.
RefSeqiWP_016265325.1. NZ_LSFF01000002.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ006274 Genomic DNA. Translation: CAA06941.1.
RefSeqiWP_016265325.1. NZ_LSFF01000002.1.

3D structure databases

ProteinModelPortaliO87777.
SMRiO87777. Positions 1-506.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi314315.LSA1236.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Phylogenomic databases

eggNOGiENOG4105CFG. Bacteria.
COG0443. LUCA.

Family and domain databases

Gene3Di1.20.1270.10. 1 hit.
2.60.34.10. 1 hit.
HAMAPiMF_00332. DnaK.
InterProiIPR012725. Chaperone_DnaK.
IPR018181. Heat_shock_70_CS.
IPR029048. HSP70_C.
IPR029047. HSP70_peptide-bd.
IPR013126. Hsp_70_fam.
[Graphical view]
PfamiPF00012. HSP70. 1 hit.
[Graphical view]
PRINTSiPR00301. HEATSHOCK70.
SUPFAMiSSF100920. SSF100920. 1 hit.
SSF100934. SSF100934. 1 hit.
TIGRFAMsiTIGR02350. prok_dnaK. 1 hit.
PROSITEiPS00297. HSP70_1. 1 hit.
PS00329. HSP70_2. 1 hit.
PS01036. HSP70_3. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Molecular characterisation of the dnaK operon of Lactobacillus sakei LTH681."
    Schmidt G., Hertel C., Hammes W.P.
    Syst. Appl. Microbiol. 22:321-328(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: LTH681.

Entry informationi

Entry nameiDNAK_LACSK
AccessioniPrimary (citable) accession number: O87777
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 27, 2001
Last sequence update: November 1, 1998
Last modified: July 6, 2016
This is version 69 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.