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O87765

- PCP_LACLM

UniProt

O87765 - PCP_LACLM

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Protein
Pyrrolidone-carboxylate peptidase
Gene
pcp, llmg_0663
Organism
Lactococcus lactis subsp. cremoris (strain MG1363)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Removes 5-oxoproline from various penultimate amino acid residues except L-proline By similarity.UniRule annotation

Catalytic activityi

Release of an N-terminal pyroglutamyl group from a polypeptide, the second amino acid generally not being Pro.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei78 – 781 By similarity
Active sitei141 – 1411 By similarity
Active sitei165 – 1651 By similarity

GO - Molecular functioni

  1. cysteine-type peptidase activity Source: UniProtKB-KW
  2. pyroglutamyl-peptidase activity Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protease, Thiol protease

Enzyme and pathway databases

BioCyciLLAC416870:GCDT-693-MONOMER.

Protein family/group databases

MEROPSiC15.001.

Names & Taxonomyi

Protein namesi
Recommended name:
Pyrrolidone-carboxylate peptidase (EC:3.4.19.3)
Alternative name(s):
5-oxoprolyl-peptidase
Pyroglutamyl-peptidase I
Short name:
PGP-I
Short name:
Pyrase
Gene namesi
Name:pcp
Ordered Locus Names:llmg_0663
OrganismiLactococcus lactis subsp. cremoris (strain MG1363)
Taxonomic identifieri416870 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesStreptococcaceaeLactococcus
ProteomesiUP000000364: Chromosome

Subcellular locationi

Cytoplasm By similarity UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 215215Pyrrolidone-carboxylate peptidaseUniRule annotation
PRO_0000184722Add
BLAST

Interactioni

Subunit structurei

Homotetramer By similarity.UniRule annotation

Protein-protein interaction databases

STRINGi416870.llmg_0663.

Structurei

3D structure databases

ProteinModelPortaliO87765.

Family & Domainsi

Sequence similaritiesi

Belongs to the peptidase C15 family.

Phylogenomic databases

eggNOGiCOG2039.
HOGENOMiHOG000242641.
KOiK01304.
OMAiKPNTPSM.
OrthoDBiEOG6X1124.

Family and domain databases

Gene3Di3.40.630.20. 1 hit.
HAMAPiMF_00417. Pyrrolid_peptidase.
InterProiIPR000816. Peptidase_C15.
IPR016125. Peptidase_C15-like.
[Graphical view]
PANTHERiPTHR23402. PTHR23402. 1 hit.
PfamiPF01470. Peptidase_C15. 1 hit.
[Graphical view]
PIRSFiPIRSF015592. Prld-crbxl_pptds. 1 hit.
PRINTSiPR00706. PYROGLUPTASE.
PROSITEiPS01334. PYRASE_CYS. 1 hit.
PS01333. PYRASE_GLU. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O87765-1 [UniParc]FASTAAdd to Basket

« Hide

MKILVTGFDP FGDDKINPAI EAVKRLPDEI AGAQIVKLEI PTKFNVSADV    50
VKDAIAKEKP DYVLSIGQAG GRFELTPERV AINLDDGRIQ DNAGYQPLNH 100
TIHGDDENAY FTQLPIKAMA KAIREAGVPS AVSNTAGTYV CNHIFYQVQY 150
MRDKMFPDIK AGFMHIPFLP EQVVTRPETP ALSLDDDVLG ITAAIKAIVS 200
RDGKGDIETI EGKDH 215
Length:215
Mass (Da):23,519
Last modified:November 1, 1998 - v1
Checksum:i70AE7E36E0882289
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AJ223960 Genomic DNA. Translation: CAA11691.1.
AJ223962 Genomic DNA. Translation: CAA11699.1.
AF323462 Genomic DNA. Translation: AAK20299.1.
AM406671 Genomic DNA. Translation: CAL97264.1.
AF168363 Genomic DNA. Translation: AAF36226.1.
RefSeqiWP_011834666.1. NC_009004.1.
YP_001032004.1. NC_009004.1.

Genome annotation databases

EnsemblBacteriaiCAL97264; CAL97264; llmg_0663.
GeneIDi4797823.
KEGGillm:llmg_0663.
PATRICi22282430. VBILacLac4574_0679.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AJ223960 Genomic DNA. Translation: CAA11691.1 .
AJ223962 Genomic DNA. Translation: CAA11699.1 .
AF323462 Genomic DNA. Translation: AAK20299.1 .
AM406671 Genomic DNA. Translation: CAL97264.1 .
AF168363 Genomic DNA. Translation: AAF36226.1 .
RefSeqi WP_011834666.1. NC_009004.1.
YP_001032004.1. NC_009004.1.

3D structure databases

ProteinModelPortali O87765.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 416870.llmg_0663.

Protein family/group databases

MEROPSi C15.001.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai CAL97264 ; CAL97264 ; llmg_0663 .
GeneIDi 4797823.
KEGGi llm:llmg_0663.
PATRICi 22282430. VBILacLac4574_0679.

Phylogenomic databases

eggNOGi COG2039.
HOGENOMi HOG000242641.
KOi K01304.
OMAi KPNTPSM.
OrthoDBi EOG6X1124.

Enzyme and pathway databases

BioCyci LLAC416870:GCDT-693-MONOMER.

Family and domain databases

Gene3Di 3.40.630.20. 1 hit.
HAMAPi MF_00417. Pyrrolid_peptidase.
InterProi IPR000816. Peptidase_C15.
IPR016125. Peptidase_C15-like.
[Graphical view ]
PANTHERi PTHR23402. PTHR23402. 1 hit.
Pfami PF01470. Peptidase_C15. 1 hit.
[Graphical view ]
PIRSFi PIRSF015592. Prld-crbxl_pptds. 1 hit.
PRINTSi PR00706. PYROGLUPTASE.
PROSITEi PS01334. PYRASE_CYS. 1 hit.
PS01333. PYRASE_GLU. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "A natural large chromosomal inversion in Lactococcus lactis is mediated by homologous recombination between two insertion sequences."
    Daveran-Mingot M.L., Campo N., Ritzenthaler P., le Bourgeois P.
    J. Bacteriol. 180:4834-4842(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. "Pyrrolidone carboxyl peptidase of Lactococcus lactis MG1363."
    Buist G., Haandrikman A.J., Benus G., Feenstra B., Venema G., Kok J.
    Submitted (NOV-2000) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  3. "The complete genome sequence of the lactic acid bacterial paradigm Lactococcus lactis subsp. cremoris MG1363."
    Wegmann U., O'Connell-Motherway M., Zomer A., Buist G., Shearman C., Canchaya C., Ventura M., Goesmann A., Gasson M.J., Kuipers O.P., van Sinderen D., Kok J.
    J. Bacteriol. 189:3256-3270(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: MG1363.
  4. "Identification and characterisation of a gene encoding aminoacylase activity from Lactococcus lactis MG1363."
    Curley P., van Sinderen D.
    FEMS Microbiol. Lett. 183:177-182(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 103-215.

Entry informationi

Entry nameiPCP_LACLM
AccessioniPrimary (citable) accession number: O87765
Secondary accession number(s): A2RJ15, Q9L9P5, Q9R805
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1999
Last sequence update: November 1, 1998
Last modified: September 3, 2014
This is version 87 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. Peptidase families
    Classification of peptidase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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