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O87765

- PCP_LACLM

UniProt

O87765 - PCP_LACLM

Protein

Pyrrolidone-carboxylate peptidase

Gene

pcp

Organism
Lactococcus lactis subsp. cremoris (strain MG1363)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 88 (01 Oct 2014)
      Sequence version 1 (01 Nov 1998)
      Previous versions | rss
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    • Comment

    Functioni

    Removes 5-oxoproline from various penultimate amino acid residues except L-proline.By similarity

    Catalytic activityi

    Release of an N-terminal pyroglutamyl group from a polypeptide, the second amino acid generally not being Pro.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei78 – 781By similarity
    Active sitei141 – 1411By similarity
    Active sitei165 – 1651By similarity

    GO - Molecular functioni

    1. cysteine-type peptidase activity Source: UniProtKB-KW

    Keywords - Molecular functioni

    Hydrolase, Protease, Thiol protease

    Enzyme and pathway databases

    BioCyciLLAC416870:GCDT-693-MONOMER.

    Protein family/group databases

    MEROPSiC15.001.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Pyrrolidone-carboxylate peptidase (EC:3.4.19.3)
    Alternative name(s):
    5-oxoprolyl-peptidase
    Pyroglutamyl-peptidase I
    Short name:
    PGP-I
    Short name:
    Pyrase
    Gene namesi
    Name:pcp
    Ordered Locus Names:llmg_0663
    OrganismiLactococcus lactis subsp. cremoris (strain MG1363)
    Taxonomic identifieri416870 [NCBI]
    Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesStreptococcaceaeLactococcus
    ProteomesiUP000000364: Chromosome

    Subcellular locationi

    Cytoplasm By similarity

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 215215Pyrrolidone-carboxylate peptidasePRO_0000184722Add
    BLAST

    Interactioni

    Subunit structurei

    Homotetramer.By similarity

    Protein-protein interaction databases

    STRINGi416870.llmg_0663.

    Structurei

    3D structure databases

    ProteinModelPortaliO87765.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the peptidase C15 family.Curated

    Phylogenomic databases

    eggNOGiCOG2039.
    HOGENOMiHOG000242641.
    KOiK01304.
    OMAiKPNTPSM.
    OrthoDBiEOG6X1124.

    Family and domain databases

    Gene3Di3.40.630.20. 1 hit.
    HAMAPiMF_00417. Pyrrolid_peptidase.
    InterProiIPR000816. Peptidase_C15.
    IPR016125. Peptidase_C15-like.
    [Graphical view]
    PANTHERiPTHR23402. PTHR23402. 1 hit.
    PfamiPF01470. Peptidase_C15. 1 hit.
    [Graphical view]
    PIRSFiPIRSF015592. Prld-crbxl_pptds. 1 hit.
    PRINTSiPR00706. PYROGLUPTASE.
    PROSITEiPS01334. PYRASE_CYS. 1 hit.
    PS01333. PYRASE_GLU. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    O87765-1 [UniParc]FASTAAdd to Basket

    « Hide

    MKILVTGFDP FGDDKINPAI EAVKRLPDEI AGAQIVKLEI PTKFNVSADV    50
    VKDAIAKEKP DYVLSIGQAG GRFELTPERV AINLDDGRIQ DNAGYQPLNH 100
    TIHGDDENAY FTQLPIKAMA KAIREAGVPS AVSNTAGTYV CNHIFYQVQY 150
    MRDKMFPDIK AGFMHIPFLP EQVVTRPETP ALSLDDDVLG ITAAIKAIVS 200
    RDGKGDIETI EGKDH 215
    Length:215
    Mass (Da):23,519
    Last modified:November 1, 1998 - v1
    Checksum:i70AE7E36E0882289
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AJ223960 Genomic DNA. Translation: CAA11691.1.
    AJ223962 Genomic DNA. Translation: CAA11699.1.
    AF323462 Genomic DNA. Translation: AAK20299.1.
    AM406671 Genomic DNA. Translation: CAL97264.1.
    AF168363 Genomic DNA. Translation: AAF36226.1.
    RefSeqiWP_011834666.1. NC_009004.1.
    YP_001032004.1. NC_009004.1.

    Genome annotation databases

    EnsemblBacteriaiCAL97264; CAL97264; llmg_0663.
    GeneIDi4797823.
    KEGGillm:llmg_0663.
    PATRICi22282430. VBILacLac4574_0679.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AJ223960 Genomic DNA. Translation: CAA11691.1 .
    AJ223962 Genomic DNA. Translation: CAA11699.1 .
    AF323462 Genomic DNA. Translation: AAK20299.1 .
    AM406671 Genomic DNA. Translation: CAL97264.1 .
    AF168363 Genomic DNA. Translation: AAF36226.1 .
    RefSeqi WP_011834666.1. NC_009004.1.
    YP_001032004.1. NC_009004.1.

    3D structure databases

    ProteinModelPortali O87765.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 416870.llmg_0663.

    Protein family/group databases

    MEROPSi C15.001.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai CAL97264 ; CAL97264 ; llmg_0663 .
    GeneIDi 4797823.
    KEGGi llm:llmg_0663.
    PATRICi 22282430. VBILacLac4574_0679.

    Phylogenomic databases

    eggNOGi COG2039.
    HOGENOMi HOG000242641.
    KOi K01304.
    OMAi KPNTPSM.
    OrthoDBi EOG6X1124.

    Enzyme and pathway databases

    BioCyci LLAC416870:GCDT-693-MONOMER.

    Family and domain databases

    Gene3Di 3.40.630.20. 1 hit.
    HAMAPi MF_00417. Pyrrolid_peptidase.
    InterProi IPR000816. Peptidase_C15.
    IPR016125. Peptidase_C15-like.
    [Graphical view ]
    PANTHERi PTHR23402. PTHR23402. 1 hit.
    Pfami PF01470. Peptidase_C15. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF015592. Prld-crbxl_pptds. 1 hit.
    PRINTSi PR00706. PYROGLUPTASE.
    PROSITEi PS01334. PYRASE_CYS. 1 hit.
    PS01333. PYRASE_GLU. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "A natural large chromosomal inversion in Lactococcus lactis is mediated by homologous recombination between two insertion sequences."
      Daveran-Mingot M.L., Campo N., Ritzenthaler P., le Bourgeois P.
      J. Bacteriol. 180:4834-4842(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    2. "Pyrrolidone carboxyl peptidase of Lactococcus lactis MG1363."
      Buist G., Haandrikman A.J., Benus G., Feenstra B., Venema G., Kok J.
      Submitted (NOV-2000) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    3. "The complete genome sequence of the lactic acid bacterial paradigm Lactococcus lactis subsp. cremoris MG1363."
      Wegmann U., O'Connell-Motherway M., Zomer A., Buist G., Shearman C., Canchaya C., Ventura M., Goesmann A., Gasson M.J., Kuipers O.P., van Sinderen D., Kok J.
      J. Bacteriol. 189:3256-3270(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: MG1363.
    4. "Identification and characterisation of a gene encoding aminoacylase activity from Lactococcus lactis MG1363."
      Curley P., van Sinderen D.
      FEMS Microbiol. Lett. 183:177-182(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 103-215.

    Entry informationi

    Entry nameiPCP_LACLM
    AccessioniPrimary (citable) accession number: O87765
    Secondary accession number(s): A2RJ15, Q9L9P5, Q9R805
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 15, 1999
    Last sequence update: November 1, 1998
    Last modified: October 1, 2014
    This is version 88 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. Peptidase families
      Classification of peptidase families and list of entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3