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O87717 (CHEB1_CAUCR) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 91. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Chemotaxis response regulator protein-glutamate methylesterase of group 1 operon
EC=3.1.1.61
Gene names
Name:cheB1
Ordered Locus Names:CC_0436
OrganismCaulobacter crescentus (Caulobacter vibrioides)
Taxonomic identifier155892 [NCBI]
Taxonomic lineageBacteria › Proteobacteria › Alphaproteobacteria › Caulobacterales › Caulobacteraceae › Caulobacter

Protein attributes

Sequence length344 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Involved in the modulation of the chemotaxis system; catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins) by CheR By similarity. HAMAP MF_00099

Catalytic activity

Protein L-glutamate O(5)-methyl ester + H2O = protein L-glutamate + methanol. HAMAP MF_00099

Subcellular location

Cytoplasm HAMAP MF_00099.

Domain

The N-terminal regulatory domain inhibits the activity of the C-terminal effector domain. HAMAP MF_00099

Post-translational modification

Phosphorylated by CheA. Phosphorylation suppresses the inhibitory activity of the N-terminal domain By similarity. HAMAP MF_00099

Sequence similarities

Contains 1 cheB-type methylesterase domain.

Contains 1 response regulatory domain.

Ontologies

Keywords
   Biological processChemotaxis
   Cellular componentCytoplasm
   Molecular functionHydrolase
   PTMPhosphoprotein
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological processchemotaxis

Inferred from electronic annotation. Source: UniProtKB-KW

regulation of transcription, DNA-dependent

Inferred from electronic annotation. Source: InterPro

   Cellular componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular functionprotein-glutamate methylesterase activity

Inferred from electronic annotation. Source: EC

two-component response regulator activity

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 344344Chemotaxis response regulator protein-glutamate methylesterase of group 1 operon HAMAP MF_00099
PRO_0000157984

Regions

Domain5 – 122118Response regulatory
Domain151 – 343193CheB-type methylesterase

Sites

Active site1631 By similarity
Active site1891 By similarity
Active site2851 By similarity

Amino acid modifications

Modified residue5614-aspartylphosphate By similarity

Sequences

Sequence LengthMass (Da)Tools
O87717 [UniParc].

Last modified November 1, 1998. Version 1.
Checksum: AB46083B61D6A3BF

FASTA34435,729
        10         20         30         40         50         60 
MAKIRVLVVD DSATMRSLIS AALNRDPDIE VVGGAGDPFE ARGMIKALNP DVVTLDIEMP 

        70         80         90        100        110        120 
NMNGIDFLEK IMRLRPMPVV MVSTLTQAGA EMTLRALELG AVDCVGKPAD ATGTQEALAE 

       130        140        150        160        170        180 
IVAKVKIAAR ASVRTNAGAA PTSAPTRRKD FMPSGDIVAI GSSTGGVEAL LSILQLFPET 

       190        200        210        220        230        240 
CPPTVITQHM PATFTASFAA RLDRSSGAKV QEASDGALLE PGKVYVAPGG ATHLEVVRSA 

       250        260        270        280        290        300 
GLRCRLVAGD PVSGHRPSVD VLFNSVAHAV GDKAVGVILT GMGRDGAQGL LTMRKAGAKT 

       310        320        330        340 
LGQDEASCVV YGMPRSAFEI GAVERQVSLS SMGQSILDLA SARR

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		AJ006687 Genomic DNA. Translation: CAA07180.1.
AE005673 Genomic DNA. Translation: AAK22423.1.
PIRC87303.
RefSeqNP_419255.1. NC_002696.2.

3D structure databases

ProteinModelPortalO87717.
SMRO87717. Positions 1-342.
ModBaseSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID942022.
GenomeReviewsGene locus CC_0436 in contig AE005673_GR.
KEGGccr:CC_0436.
NMPDRfig|190650.1.peg.435.
PATRIC21297806. VBICauCre124313_0441.
TIGRCC_0436.

Phylogenomic databases

HOGENOMHBG705324.
OMAPPSVADF.
ProtClustDBPRK00742.

Family and domain databases

HAMAPMF_00099. CheB_methylest.
[Tree]
InterProIPR011006. CheY-like_superfamily.
IPR008248. Sig_transdc_resp-reg_CheB.
IPR000673. Sig_transdc_resp-reg_Me-estase.
IPR001789. Sig_transdc_resp-reg_receiver.
[Graphical view]
Gene3DG3DSA:3.40.50.180. Chemotax_RR_pGlu_Me-esterase. 1 hit.
KOK03412.
PfamPF01339. CheB_methylest. 1 hit.
PF00072. Response_reg. 1 hit.
[Graphical view]
PIRSFPIRSF000876. RR_chemtxs_CheB. 1 hit.
SMARTSM00448. REC. 1 hit.
[Graphical view]
SUPFAMSSF52738. Chemotax_RR_pGlu_Me-esterase. 1 hit.
SSF52172. CheY_like. 1 hit.
PROSITEPS50122. CHEB. 1 hit.
PS50110. RESPONSE_REGULATORY. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameCHEB1_CAUCR
AccessionPrimary (citable) accession number: O87717
Entry history
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: November 1, 1998
Last modified: January 25, 2012
This is version 91 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

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