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Protein

Chaperone protein DnaK

Gene

dnaK

Organism
Coxiella burnetii (strain RSA 493 / Nine Mile phase I)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Acts as a chaperone (By similarity). Might have a role in the infectious process.By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Chaperone

Keywords - Biological processi

Stress response

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciCBUR227377:GJ7S-1278-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Chaperone protein DnaK
Alternative name(s):
HSP70
Heat shock 70 kDa protein
Heat shock protein 70
Gene namesi
Name:dnaK
Synonyms:hsp71
Ordered Locus Names:CBU_1290
OrganismiCoxiella burnetii (strain RSA 493 / Nine Mile phase I)
Taxonomic identifieri227377 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaLegionellalesCoxiellaceaeCoxiella
Proteomesi
  • UP000002671 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Cytoplasm, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 656656Chaperone protein DnaKPRO_0000078455Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei204 – 2041Phosphothreonine; by autocatalysisBy similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

PRIDEiO87712.

Expressioni

Inductioni

By heat shock and acidic conditions.

Interactioni

Protein-protein interaction databases

STRINGi227377.CBU_1290.

Structurei

3D structure databases

ProteinModelPortaliO87712.
SMRiO87712. Positions 1-605.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the heat shock protein 70 family.Curated

Phylogenomic databases

eggNOGiENOG4105CFG. Bacteria.
COG0443. LUCA.
HOGENOMiHOG000228136.
KOiK04043.
OMAiEKMAPPQ.

Family and domain databases

Gene3Di1.20.1270.10. 1 hit.
2.60.34.10. 1 hit.
HAMAPiMF_00332. DnaK. 1 hit.
InterProiIPR012725. Chaperone_DnaK.
IPR018181. Heat_shock_70_CS.
IPR029048. HSP70_C.
IPR029047. HSP70_peptide-bd.
IPR013126. Hsp_70_fam.
[Graphical view]
PfamiPF00012. HSP70. 1 hit.
[Graphical view]
PRINTSiPR00301. HEATSHOCK70.
SUPFAMiSSF100920. SSF100920. 1 hit.
SSF100934. SSF100934. 1 hit.
TIGRFAMsiTIGR02350. prok_dnaK. 1 hit.
PROSITEiPS00297. HSP70_1. 1 hit.
PS00329. HSP70_2. 1 hit.
PS01036. HSP70_3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O87712-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAEIIGIDLG TTNSCVAVME GGKVRVIENA EGSRTTPSIV AYTKDGEVLV
60 70 80 90 100
GASAKRQAVT NADRTLYAIK RLIGRRFDDN VVQKDIKMVP YKIIKADNGD
110 120 130 140 150
AWVEVKDKEG KSQKLAPPQI SAQVLIKMKK TAEDYLGHEV KDAVITVPAY
160 170 180 190 200
FNDSQRQATK DAGKIAGLNV KRIINEPTAA ALAYGMDKKK GDRKIAVYDL
210 220 230 240 250
GGGTFDISII EIAEVDGEHQ FEVLATNGDT FLGGEDFDLR LIDYLAGEFK
260 270 280 290 300
KDEGVDLHND PLALQRLKEA AEKAKIELSS SQQTDVNLPY ITADASGPKH
310 320 330 340 350
LNIRLTRAKL ESLVEDLVER TIEPCKVAIK DAGLKVSEID DVILVGGQTR
360 370 380 390 400
MPKVQEAVKN FFGKEARKDV NPDEAVAIGA AIQGAVLSGE VKDVLLLDVT
410 420 430 440 450
PLSLGIETLG GVMTKLIEKN TTIPTKANQV FSTADDNQTA VTVHVLQGER
460 470 480 490 500
EMASANKSLG RFDLSDIPPA PRGVPQIEVT FDIDANGILH VSAKDKATGK
510 520 530 540 550
EQSIVIKASS GLSDEEVEKM VKDAEAHRDS DRKFHELVDA RNQADAMIHA
560 570 580 590 600
AEKSVKDLGS EVSADEKSAI EKAVNELKEA MKGNDKDAIE AKTKALTEHS
610 620 630 640 650
SKLAERVYAK KGGAAGAPPG GEAEGEPQAQ AGGKKEDVVD AEFEEVKDEK

KKDEDK
Length:656
Mass (Da):70,755
Last modified:November 1, 1998 - v1
Checksum:i4FF43FDED22973FB
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ005700 Genomic DNA. Translation: CAA06685.1.
AE016828 Genomic DNA. Translation: AAO90796.1.
RefSeqiNP_820282.1. NC_002971.3.
WP_005770882.1. NZ_CDBG01000001.1.

Genome annotation databases

EnsemblBacteriaiAAO90796; AAO90796; CBU_1290.
GeneIDi1209195.
KEGGicbu:CBU_1290.
PATRICi17931321. VBICoxBur82552_1285.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ005700 Genomic DNA. Translation: CAA06685.1.
AE016828 Genomic DNA. Translation: AAO90796.1.
RefSeqiNP_820282.1. NC_002971.3.
WP_005770882.1. NZ_CDBG01000001.1.

3D structure databases

ProteinModelPortaliO87712.
SMRiO87712. Positions 1-605.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi227377.CBU_1290.

Proteomic databases

PRIDEiO87712.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAO90796; AAO90796; CBU_1290.
GeneIDi1209195.
KEGGicbu:CBU_1290.
PATRICi17931321. VBICoxBur82552_1285.

Phylogenomic databases

eggNOGiENOG4105CFG. Bacteria.
COG0443. LUCA.
HOGENOMiHOG000228136.
KOiK04043.
OMAiEKMAPPQ.

Enzyme and pathway databases

BioCyciCBUR227377:GJ7S-1278-MONOMER.

Family and domain databases

Gene3Di1.20.1270.10. 1 hit.
2.60.34.10. 1 hit.
HAMAPiMF_00332. DnaK. 1 hit.
InterProiIPR012725. Chaperone_DnaK.
IPR018181. Heat_shock_70_CS.
IPR029048. HSP70_C.
IPR029047. HSP70_peptide-bd.
IPR013126. Hsp_70_fam.
[Graphical view]
PfamiPF00012. HSP70. 1 hit.
[Graphical view]
PRINTSiPR00301. HEATSHOCK70.
SUPFAMiSSF100920. SSF100920. 1 hit.
SSF100934. SSF100934. 1 hit.
TIGRFAMsiTIGR02350. prok_dnaK. 1 hit.
PROSITEiPS00297. HSP70_1. 1 hit.
PS00329. HSP70_2. 1 hit.
PS01036. HSP70_3. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiDNAK_COXBU
AccessioniPrimary (citable) accession number: O87712
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 27, 2001
Last sequence update: November 1, 1998
Last modified: September 7, 2016
This is version 104 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Coxiella burnetii
    Coxiella burnetii (strain RSA 493): entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.