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Protein

HTH-type transcriptional regulator CelR

Gene

celR

Organism
Thermobifida fusca (Thermomonospora fusca)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein predictedi

Functioni

Binds to the 14-bp operator sequence 5'-TGGGAGCGCTCCCA-3' in the upstream regions of cellulase genes; these operator sequences are modulated by cellobiose.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi9 – 28H-T-H motifPROSITE-ProRule annotationAdd BLAST20

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDNA-binding
Biological processTranscription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
HTH-type transcriptional regulator CelR
Gene namesi
Name:celR
OrganismiThermobifida fusca (Thermomonospora fusca)
Taxonomic identifieri2021 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaStreptosporangialesNocardiopsaceaeThermobifida

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001079371 – 340HTH-type transcriptional regulator CelRAdd BLAST340

Structurei

3D structure databases

ProteinModelPortaliO87590.
SMRiO87590.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini1 – 61HTH lacI-typePROSITE-ProRule annotationAdd BLAST61

Phylogenomic databases

eggNOGiENOG4105ETE. Bacteria.
COG1609. LUCA.

Family and domain databases

CDDicd01392. HTH_LacI. 1 hit.
InterProiView protein in InterPro
IPR000843. HTH_LacI.
IPR010982. Lambda_DNA-bd_dom.
IPR028082. Peripla_BP_I.
PfamiView protein in Pfam
PF00356. LacI. 1 hit.
SMARTiView protein in SMART
SM00354. HTH_LACI. 1 hit.
SUPFAMiSSF47413. SSF47413. 1 hit.
SSF53822. SSF53822. 1 hit.
PROSITEiView protein in PROSITE
PS50932. HTH_LACI_2. 1 hit.

Sequencei

Sequence statusi: Complete.

O87590-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MERRRRPTLE MVAALAGVGR GTVSRVINGS DQVSPATREA VKRAIKELGY
60 70 80 90 100
VPNRAARTLV TRRTDTVALV VSENNQKLFA EPFYAGIVLG VGVALSERGF
110 120 130 140 150
QFVLATGRSG IEHERLGGYL AGQHVDGVLL LSLHRDDPLP QMLDEAGVPY
160 170 180 190 200
VYGGRPLGVP EEQVSYVDID NIGGGRQATQ RLIETGHRRI ATIAGPQDMV
210 220 230 240 250
AGVERLQGYR EALLAAGMEY DETLVSYGDF TYDSGVAAMR ELLDRAPDVD
260 270 280 290 300
AVFAASDLMG LAALRVLRAS GRRVPEDVAV VGYDDSTVAE HAEPPMTSVN
310 320 330 340
QPTELMGREM ARLLVDRITG ETTEPVRLVL ETHLMVRESG
Length:340
Mass (Da):36,864
Last modified:November 1, 1998 - v1
Checksum:iBBE82B8EC77E7A2E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF086819 Genomic DNA. Translation: AAC42987.1.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Entry informationi

Entry nameiCELR_THEFU
AccessioniPrimary (citable) accession number: O87590
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: November 1, 1998
Last modified: July 5, 2017
This is version 77 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program