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Protein

Chromosomal replication initiator protein DnaA

Gene

dnaA

Organism
Treponema denticola (strain ATCC 35405 / CIP 103919 / DSM 14222)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Plays an important role in the initiation and regulation of chromosomal replication. Binds to the origin of replication; it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box): 5'-TTATC[CA]A[CA]A-3'. DnaA binds to ATP and to acidic phospholipids (By similarity).By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi170 – 1778ATPSequence analysis

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

DNA replication

Keywords - Ligandi

ATP-binding, DNA-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciTDEN243275:GJ7G-1-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Chromosomal replication initiator protein DnaA
Gene namesi
Name:dnaA
Ordered Locus Names:TDE_0001
OrganismiTreponema denticola (strain ATCC 35405 / CIP 103919 / DSM 14222)
Taxonomic identifieri243275 [NCBI]
Taxonomic lineageiBacteriaSpirochaetesSpirochaetalesSpirochaetaceaeTreponema
Proteomesi
  • UP000008212 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 469469Chromosomal replication initiator protein DnaAPRO_0000114290Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi243275.TDE0001.

Structurei

3D structure databases

ProteinModelPortaliO87546.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the DnaA family.Curated

Phylogenomic databases

eggNOGiENOG4105CI4. Bacteria.
COG0593. LUCA.
KOiK02313.
OMAiQSKTRKR.
OrthoDBiPOG091H02FF.

Family and domain databases

CDDicd06571. Bac_DnaA_C. 1 hit.
Gene3Di1.10.1750.10. 1 hit.
3.40.50.300. 1 hit.
HAMAPiMF_00377. DnaA_bact. 1 hit.
InterProiIPR003593. AAA+_ATPase.
IPR001957. Chromosome_initiator_DnaA.
IPR020591. Chromosome_initiator_DnaA-like.
IPR018312. Chromosome_initiator_DnaA_CS.
IPR013317. DnaA.
IPR013159. DnaA_C.
IPR024633. DnaA_N_dom.
IPR027417. P-loop_NTPase.
IPR010921. Trp_repressor/repl_initiator.
[Graphical view]
PfamiPF00308. Bac_DnaA. 1 hit.
PF08299. Bac_DnaA_C. 1 hit.
PF11638. DnaA_N. 1 hit.
[Graphical view]
PRINTSiPR00051. DNAA.
SMARTiSM00382. AAA. 1 hit.
SM00760. Bac_DnaA_C. 1 hit.
[Graphical view]
SUPFAMiSSF48295. SSF48295. 1 hit.
SSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR00362. DnaA. 1 hit.
PROSITEiPS01008. DNAA. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O87546-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSEWDYKIFW DEAVNQFKEE LAFSIFSMWF LPSKYEKSTE NTVYLSVPSK
60 70 80 90 100
FFRDQMIHNY KNGIEKKLFE LSGKKISIDF IIKPNTSEDL SKAENEGGND
110 120 130 140 150
KKEDAAKPSS AESKKKSVKT EGGRGQHPDL RPEYNFEDFV VGPNNNFGVN
160 170 180 190 200
AAIAVSTNPG SAYNPFLIYG GVGLGKTHLM QAIGNKIWDT TKLKVIYVTA
210 220 230 240 250
ENFTNEFVEC VQKKMMPAFK SKYRKADVLL IDDIHFFQGK VETQEELFHT
260 270 280 290 300
FNELYEKNKQ IVFTCDRPPA ELKNLSQRLK SRFERGLNVD LQTPAYEIRY
310 320 330 340 350
AILLKKMEKH STKIPNEFID MVAKNVSSNV RDLEAALTKL IAYTELTKKT
360 370 380 390 400
MDEATAKNLL RDIFGSTRQR NVTIDLIQRT VADYFSISIS DIKSKKRTKS
410 420 430 440 450
FSFPRQIAMF LCREMTECST TELGNDFGGR DHTTILHGCN KIEEQIAADP
460
SLEKIIHELR NTIKENTNK
Length:469
Mass (Da):53,782
Last modified:November 1, 1998 - v1
Checksum:i80F56A05C393DFD2
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF083949 Genomic DNA. Translation: AAC62071.1.
AE017226 Genomic DNA. Translation: AAS10499.1.
RefSeqiNP_970618.1. NC_002967.9.
WP_002680852.1. NC_002967.9.

Genome annotation databases

EnsemblBacteriaiAAS10499; AAS10499; TDE_0001.
GeneIDi2741619.
KEGGitde:TDE0001.
PATRICi20522262. VBITreDen445_0001.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF083949 Genomic DNA. Translation: AAC62071.1.
AE017226 Genomic DNA. Translation: AAS10499.1.
RefSeqiNP_970618.1. NC_002967.9.
WP_002680852.1. NC_002967.9.

3D structure databases

ProteinModelPortaliO87546.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi243275.TDE0001.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAS10499; AAS10499; TDE_0001.
GeneIDi2741619.
KEGGitde:TDE0001.
PATRICi20522262. VBITreDen445_0001.

Phylogenomic databases

eggNOGiENOG4105CI4. Bacteria.
COG0593. LUCA.
KOiK02313.
OMAiQSKTRKR.
OrthoDBiPOG091H02FF.

Enzyme and pathway databases

BioCyciTDEN243275:GJ7G-1-MONOMER.

Family and domain databases

CDDicd06571. Bac_DnaA_C. 1 hit.
Gene3Di1.10.1750.10. 1 hit.
3.40.50.300. 1 hit.
HAMAPiMF_00377. DnaA_bact. 1 hit.
InterProiIPR003593. AAA+_ATPase.
IPR001957. Chromosome_initiator_DnaA.
IPR020591. Chromosome_initiator_DnaA-like.
IPR018312. Chromosome_initiator_DnaA_CS.
IPR013317. DnaA.
IPR013159. DnaA_C.
IPR024633. DnaA_N_dom.
IPR027417. P-loop_NTPase.
IPR010921. Trp_repressor/repl_initiator.
[Graphical view]
PfamiPF00308. Bac_DnaA. 1 hit.
PF08299. Bac_DnaA_C. 1 hit.
PF11638. DnaA_N. 1 hit.
[Graphical view]
PRINTSiPR00051. DNAA.
SMARTiSM00382. AAA. 1 hit.
SM00760. Bac_DnaA_C. 1 hit.
[Graphical view]
SUPFAMiSSF48295. SSF48295. 1 hit.
SSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR00362. DnaA. 1 hit.
PROSITEiPS01008. DNAA. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiDNAA_TREDE
AccessioniPrimary (citable) accession number: O87546
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 1, 2001
Last sequence update: November 1, 1998
Last modified: September 7, 2016
This is version 96 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.