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Protein

Chromosomal replication initiator protein DnaA

Gene

dnaA

Organism
Treponema denticola (strain ATCC 35405 / CIP 103919 / DSM 14222)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Plays an important role in the initiation and regulation of chromosomal replication. Binds to the origin of replication; it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box): 5'-TTATC[CA]A[CA]A-3'. DnaA binds to ATP and to acidic phospholipids (By similarity).By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi170 – 177ATPSequence analysis8

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDNA-binding
Biological processDNA replication
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciTDEN243275:G1G0Q-1-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Chromosomal replication initiator protein DnaA
Gene namesi
Name:dnaA
Ordered Locus Names:TDE_0001
OrganismiTreponema denticola (strain ATCC 35405 / CIP 103919 / DSM 14222)
Taxonomic identifieri243275 [NCBI]
Taxonomic lineageiBacteriaSpirochaetesSpirochaetalesSpirochaetaceaeTreponema
Proteomesi
  • UP000008212 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001142901 – 469Chromosomal replication initiator protein DnaAAdd BLAST469

Interactioni

Protein-protein interaction databases

STRINGi243275.TDE0001

Structurei

3D structure databases

ProteinModelPortaliO87546
SMRiO87546
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the DnaA family.Curated

Phylogenomic databases

eggNOGiENOG4105CI4 Bacteria
COG0593 LUCA
KOiK02313
OMAiREFNPLF
OrthoDBiPOG091H02FF

Family and domain databases

CDDicd06571 Bac_DnaA_C, 1 hit
Gene3Di1.10.1750.10, 1 hit
3.30.300.180, 1 hit
HAMAPiMF_00377 DnaA_bact, 1 hit
InterProiView protein in InterPro
IPR003593 AAA+_ATPase
IPR001957 Chromosome_initiator_DnaA
IPR020591 Chromosome_initiator_DnaA-like
IPR018312 Chromosome_initiator_DnaA_CS
IPR013317 DnaA
IPR013159 DnaA_C
IPR024633 DnaA_N_dom
IPR038454 DnaA_N_sf
IPR027417 P-loop_NTPase
IPR010921 Trp_repressor/repl_initiator
PANTHERiPTHR30050:SF2 PTHR30050:SF2, 1 hit
PfamiView protein in Pfam
PF00308 Bac_DnaA, 1 hit
PF08299 Bac_DnaA_C, 1 hit
PF11638 DnaA_N, 1 hit
PRINTSiPR00051 DNAA
SMARTiView protein in SMART
SM00382 AAA, 1 hit
SM00760 Bac_DnaA_C, 1 hit
SUPFAMiSSF48295 SSF48295, 1 hit
SSF52540 SSF52540, 1 hit
TIGRFAMsiTIGR00362 DnaA, 1 hit
PROSITEiView protein in PROSITE
PS01008 DNAA, 1 hit

Sequencei

Sequence statusi: Complete.

O87546-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSEWDYKIFW DEAVNQFKEE LAFSIFSMWF LPSKYEKSTE NTVYLSVPSK
60 70 80 90 100
FFRDQMIHNY KNGIEKKLFE LSGKKISIDF IIKPNTSEDL SKAENEGGND
110 120 130 140 150
KKEDAAKPSS AESKKKSVKT EGGRGQHPDL RPEYNFEDFV VGPNNNFGVN
160 170 180 190 200
AAIAVSTNPG SAYNPFLIYG GVGLGKTHLM QAIGNKIWDT TKLKVIYVTA
210 220 230 240 250
ENFTNEFVEC VQKKMMPAFK SKYRKADVLL IDDIHFFQGK VETQEELFHT
260 270 280 290 300
FNELYEKNKQ IVFTCDRPPA ELKNLSQRLK SRFERGLNVD LQTPAYEIRY
310 320 330 340 350
AILLKKMEKH STKIPNEFID MVAKNVSSNV RDLEAALTKL IAYTELTKKT
360 370 380 390 400
MDEATAKNLL RDIFGSTRQR NVTIDLIQRT VADYFSISIS DIKSKKRTKS
410 420 430 440 450
FSFPRQIAMF LCREMTECST TELGNDFGGR DHTTILHGCN KIEEQIAADP
460
SLEKIIHELR NTIKENTNK
Length:469
Mass (Da):53,782
Last modified:November 1, 1998 - v1
Checksum:i80F56A05C393DFD2
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF083949 Genomic DNA Translation: AAC62071.1
AE017226 Genomic DNA Translation: AAS10499.1
RefSeqiNP_970618.1, NC_002967.9
WP_002680852.1, NC_002967.9

Genome annotation databases

EnsemblBacteriaiAAS10499; AAS10499; TDE_0001
GeneIDi2741619
KEGGitde:TDE0001
PATRICifig|243275.7.peg.1

Similar proteinsi

Entry informationi

Entry nameiDNAA_TREDE
AccessioniPrimary (citable) accession number: O87546
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 1, 2001
Last sequence update: November 1, 1998
Last modified: March 28, 2018
This is version 104 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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