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Protein

Beta-galactosidase

Gene

lacZ

Organism
Lactococcus lactis
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

Hydrolysis of terminal non-reducing beta-D-galactose residues in beta-D-galactosides.UniRule annotationSAAS annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

GlycosidaseUniRule annotationSAAS annotation, Hydrolase

Protein family/group databases

CAZyiGH2. Glycoside Hydrolase Family 2.

Names & Taxonomyi

Protein namesi
Recommended name:
Beta-galactosidaseUniRule annotation (EC:3.2.1.23UniRule annotation)
Alternative name(s):
LactaseUniRule annotation
Gene namesi
Name:lacZImported
OrganismiLactococcus lactisImported
Taxonomic identifieri1358 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesStreptococcaceaeLactococcus

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

PTM / Processingi

Proteomic databases

PaxDbiO87523.

Interactioni

Protein-protein interaction databases

STRINGi272623.L0025.

Structurei

3D structure databases

ProteinModelPortaliO87523.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini717 – 994278Bgal_small_NInterPro annotationAdd
BLAST

Sequence similaritiesi

Belongs to the glycosyl hydrolase 2 family.UniRule annotationSAAS annotation

Phylogenomic databases

eggNOGiENOG4105CNT. Bacteria.
COG3250. LUCA.

Family and domain databases

Gene3Di2.60.120.260. 1 hit.
2.60.40.320. 2 hits.
2.70.98.10. 1 hit.
3.20.20.80. 1 hit.
InterProiIPR004199. B-gal_small/dom_5.
IPR011013. Gal_mutarotase_SF_dom.
IPR008979. Galactose-bd-like.
IPR014718. GH-type_carb-bd.
IPR006101. Glyco_hydro_2.
IPR013812. Glyco_hydro_2/20_Ig-like.
IPR023232. Glyco_hydro_2_AS.
IPR006103. Glyco_hydro_2_cat.
IPR023230. Glyco_hydro_2_CS.
IPR006102. Glyco_hydro_2_Ig-like.
IPR006104. Glyco_hydro_2_N.
IPR013781. Glyco_hydro_catalytic_dom.
IPR017853. Glycoside_hydrolase_SF.
IPR032312. LacZ_4.
[Graphical view]
PfamiPF02929. Bgal_small_N. 1 hit.
PF16353. DUF4981. 1 hit.
PF00703. Glyco_hydro_2. 1 hit.
PF02836. Glyco_hydro_2_C. 1 hit.
PF02837. Glyco_hydro_2_N. 1 hit.
[Graphical view]
PRINTSiPR00132. GLHYDRLASE2.
SMARTiSM01038. Bgal_small_N. 1 hit.
[Graphical view]
SUPFAMiSSF49303. SSF49303. 2 hits.
SSF49785. SSF49785. 1 hit.
SSF51445. SSF51445. 1 hit.
SSF74650. SSF74650. 1 hit.
PROSITEiPS00719. GLYCOSYL_HYDROL_F2_1. 1 hit.
PS00608. GLYCOSYL_HYDROL_F2_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O87523-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MMTMIDVLER KDWENPVVSN WNRLPMHTPM DFLEKQSLNG LWNFDHFSRI
60 70 80 90 100
SDVPKNWLEL TESKTEIIVP SNWQIEFKDK SDVPIYTNVT YPIPIQPPYV
110 120 130 140 150
PEANPVGAYS RYFDITKEWL ESGHVHLTFE GVGSAFHFWL NGEYGGYSED
160 170 180 190 200
SRLPAEFDIS NLAKEGQNCL KVLVFRWSKG TYFEDQDMWR MSGIFRSVNL
210 220 230 240 250
QWLPDNYLLD FSIKTDLDED LDFANVKLQA YAKNMDDACL EFKLYDDEQL
260 270 280 290 300
IGECHGFDAE IGVVNPKLWS DEIPYLYRLE LTLMDRSGAV FHKETKKIGI
310 320 330 340 350
RKIAIEKGQL KINGKALLVR GVNKHEFTPE HGYVVSEEVM IKDIKLMKEH
360 370 380 390 400
NFNAVRCSHY PNDSRWYELC DEYGLYVMDE ANIETHGMTP MNRLTNDPTY
410 420 430 440 450
LPLMSERVTR MVMRDRNHPS IIIWSLGNES GYGSNHQALY DWCKSFDSSR
460 470 480 490 500
PVHYEGGDDA SRGATDATDI ICPMYARVDS PSINAPYSLK TWMGVAGENR
510 520 530 540 550
PLILCEYAHD MGNSLGGFGK YWQAFREIDR LQGGFIWDWV DQGLLKDGNY
560 570 580 590 600
AYGGDFGDKP NDRQFSLNGL VFPNRQAKPA LREAKYWQQY YQFELEKTPL
610 620 630 640 650
GQVFAFTVTN EYLFRSTDNE KLCYQLTNGL EVLSQNELIL NMPAGGSMRI
660 670 680 690 700
DLSELPIDGT DNLFLNIQVK TIEKYNLLES DFEVAHQQFV LQEKINFTDK
710 720 730 740 750
IDSNEEITLL EDEELLTVRS AKQKFIFNKS NGNLSRWLDE KGNEKLLHEL
760 770 780 790 800
SEQFTRAPLD NDIGVSEVEH IDPNAWLERW KAVGFYELKT LLKNMIIQAT
810 820 830 840 850
ENEVIISVQT DYEAKGKIAF STIREYHIFR NGELLLKVDF KRNIEFPEPA
860 870 880 890 900
RIGLSLQLAE KAENVTYFGL GPDENYPDRR GASLFGQWNL RITDMTTPYI
910 920 930 940 950
FPSENGLRME TRELNYGRLK VRAMGQSFAF NLSPYSQNQL AKKGHWHLLE
960 970 980 990
EEAGTWLNID GFHMGVGGDD SWSPSVAQEY LLTKGNYHYE VSFKLT
Length:996
Mass (Da):115,089
Last modified:November 1, 1998 - v1
Checksum:i98A534BC3EA35EA3
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF082008 Genomic DNA. Translation: AAC63020.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF082008 Genomic DNA. Translation: AAC63020.1.

3D structure databases

ProteinModelPortaliO87523.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi272623.L0025.

Protein family/group databases

CAZyiGH2. Glycoside Hydrolase Family 2.

Proteomic databases

PaxDbiO87523.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Phylogenomic databases

eggNOGiENOG4105CNT. Bacteria.
COG3250. LUCA.

Family and domain databases

Gene3Di2.60.120.260. 1 hit.
2.60.40.320. 2 hits.
2.70.98.10. 1 hit.
3.20.20.80. 1 hit.
InterProiIPR004199. B-gal_small/dom_5.
IPR011013. Gal_mutarotase_SF_dom.
IPR008979. Galactose-bd-like.
IPR014718. GH-type_carb-bd.
IPR006101. Glyco_hydro_2.
IPR013812. Glyco_hydro_2/20_Ig-like.
IPR023232. Glyco_hydro_2_AS.
IPR006103. Glyco_hydro_2_cat.
IPR023230. Glyco_hydro_2_CS.
IPR006102. Glyco_hydro_2_Ig-like.
IPR006104. Glyco_hydro_2_N.
IPR013781. Glyco_hydro_catalytic_dom.
IPR017853. Glycoside_hydrolase_SF.
IPR032312. LacZ_4.
[Graphical view]
PfamiPF02929. Bgal_small_N. 1 hit.
PF16353. DUF4981. 1 hit.
PF00703. Glyco_hydro_2. 1 hit.
PF02836. Glyco_hydro_2_C. 1 hit.
PF02837. Glyco_hydro_2_N. 1 hit.
[Graphical view]
PRINTSiPR00132. GLHYDRLASE2.
SMARTiSM01038. Bgal_small_N. 1 hit.
[Graphical view]
SUPFAMiSSF49303. SSF49303. 2 hits.
SSF49785. SSF49785. 1 hit.
SSF51445. SSF51445. 1 hit.
SSF74650. SSF74650. 1 hit.
PROSITEiPS00719. GLYCOSYL_HYDROL_F2_1. 1 hit.
PS00608. GLYCOSYL_HYDROL_F2_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiO87523_9LACT
AccessioniPrimary (citable) accession number: O87523
Entry historyi
Integrated into UniProtKB/TrEMBL: November 1, 1998
Last sequence update: November 1, 1998
Last modified: July 6, 2016
This is version 77 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.