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Protein

GTPase Der

Gene

der

Organism
Neisseria gonorrhoeae (strain ATCC 700825 / FA 1090)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

GTPase that plays an essential role in the late steps of ribosome biogenesis.By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi9 – 168GTP 1Sequence analysis
Nucleotide bindingi56 – 605GTP 1Sequence analysis
Nucleotide bindingi119 – 1224GTP 1Sequence analysis
Nucleotide bindingi182 – 1898GTP 2Sequence analysis
Nucleotide bindingi229 – 2335GTP 2Sequence analysis
Nucleotide bindingi294 – 2974GTP 2Sequence analysis

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Ribosome biogenesis

Keywords - Ligandi

GTP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciNGON242231:GI2G-402-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
GTPase Der
Alternative name(s):
GTP-binding protein EngA
Gene namesi
Name:der
Synonyms:engA
Ordered Locus Names:NGO0424
OrganismiNeisseria gonorrhoeae (strain ATCC 700825 / FA 1090)
Taxonomic identifieri242231 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaNeisserialesNeisseriaceaeNeisseria
Proteomesi
  • UP000000535 Componenti: Chromosome

Pathology & Biotechi

Disruption phenotypei

Essential.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 485485GTPase DerPRO_0000179019Add
BLAST

Interactioni

Subunit structurei

Associates with the 50S ribosomal subunit.By similarity

Structurei

3D structure databases

ProteinModelPortaliO87407.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini3 – 167165EngA-type G 1Add
BLAST
Domaini176 – 349174EngA-type G 2Add
BLAST
Domaini350 – 43485KH-likeAdd
BLAST

Sequence similaritiesi

Contains 1 KH-like domain.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

HOGENOMiHOG000242862.
KOiK03977.
OMAiDVMGTPI.
OrthoDBiEOG6DC6K1.

Family and domain databases

Gene3Di3.30.300.20. 1 hit.
3.40.50.300. 2 hits.
HAMAPiMF_00195. GTPase_Der.
InterProiIPR003593. AAA+_ATPase.
IPR031166. G_ENGA.
IPR016484. GTP-bd_EngA.
IPR006073. GTP_binding_domain.
IPR032859. KH_dom-like.
IPR015946. KH_dom-like_a/b.
IPR027417. P-loop_NTPase.
IPR005225. Small_GTP-bd_dom.
[Graphical view]
PANTHERiPTHR11649:SF5. PTHR11649:SF5. 1 hit.
PfamiPF14714. KH_dom-like. 1 hit.
PF01926. MMR_HSR1. 2 hits.
[Graphical view]
PIRSFiPIRSF006485. GTP-binding_EngA. 1 hit.
PRINTSiPR00326. GTP1OBG.
SMARTiSM00382. AAA. 2 hits.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 2 hits.
TIGRFAMsiTIGR03594. GTPase_EngA. 1 hit.
TIGR00231. small_GTP. 2 hits.
PROSITEiPS51712. G_ENGA. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O87407-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKPTIALIGR PNVGKSTLFN RLTRTKDALV HDLPGLTRDR HYGHGKVGSK
60 70 80 90 100
PYFVIDTGGF EPVVDSGILH EMAKQTLQAV DEADAVVFLV DGRTGLTPQD
110 120 130 140 150
KIIADRLRQS PRPVYLAVNK GEGGDRAVLA AEFYELALGE PHVISGAHGD
160 170 180 190 200
GVYYLIEEIL ENFPEPEAEE ADAKHPVFAV IGRPNVGKST LVNAILGEKR
210 220 230 240 250
VIAFDMAGTT RDSIHIDFER EGKPFTIIDT AGVRRRGKVD EAVEKFSVIK
260 270 280 290 300
AMQAVEAANV AVLVLDAQQD IADQDATIAG FALEAGRALV VAVNKWDGIS
310 320 330 340 350
EERREQVKRD ISRKLYFLDF AKFHFISALK ERGIDGLFES IQAAYNAAMI
360 370 380 390 400
KMPTPKITRV LQTAVERQQP PRAGLVRPKM RYAHQGGMNP PVIVVHGNSL
410 420 430 440 450
HAISDSYTRY LTQTFRKAFN LQGTPLRIQY NVSENPYENA EDKPKKKPLR
460 470 480
RVSLSNRIEK REGRKEEKNR FKKKTKVSVK KQFSK
Length:485
Mass (Da):54,028
Last modified:November 1, 1998 - v1
Checksum:i19161A08B63857FC
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF058711 Genomic DNA. Translation: AAC63508.1.
AE004969 Genomic DNA. Translation: AAW89167.1.
RefSeqiWP_010951041.1. NC_002946.2.
YP_207579.1. NC_002946.2.

Genome annotation databases

EnsemblBacteriaiAAW89167; AAW89167; NGO_0424.
GeneIDi3282582.
KEGGingo:NGO0424.
PATRICi20333861. VBINeiGon24812_0508.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF058711 Genomic DNA. Translation: AAC63508.1.
AE004969 Genomic DNA. Translation: AAW89167.1.
RefSeqiWP_010951041.1. NC_002946.2.
YP_207579.1. NC_002946.2.

3D structure databases

ProteinModelPortaliO87407.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAW89167; AAW89167; NGO_0424.
GeneIDi3282582.
KEGGingo:NGO0424.
PATRICi20333861. VBINeiGon24812_0508.

Phylogenomic databases

HOGENOMiHOG000242862.
KOiK03977.
OMAiDVMGTPI.
OrthoDBiEOG6DC6K1.

Enzyme and pathway databases

BioCyciNGON242231:GI2G-402-MONOMER.

Family and domain databases

Gene3Di3.30.300.20. 1 hit.
3.40.50.300. 2 hits.
HAMAPiMF_00195. GTPase_Der.
InterProiIPR003593. AAA+_ATPase.
IPR031166. G_ENGA.
IPR016484. GTP-bd_EngA.
IPR006073. GTP_binding_domain.
IPR032859. KH_dom-like.
IPR015946. KH_dom-like_a/b.
IPR027417. P-loop_NTPase.
IPR005225. Small_GTP-bd_dom.
[Graphical view]
PANTHERiPTHR11649:SF5. PTHR11649:SF5. 1 hit.
PfamiPF14714. KH_dom-like. 1 hit.
PF01926. MMR_HSR1. 2 hits.
[Graphical view]
PIRSFiPIRSF006485. GTP-binding_EngA. 1 hit.
PRINTSiPR00326. GTP1OBG.
SMARTiSM00382. AAA. 2 hits.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 2 hits.
TIGRFAMsiTIGR03594. GTPase_EngA. 1 hit.
TIGR00231. small_GTP. 2 hits.
PROSITEiPS51712. G_ENGA. 2 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "A homologue of the recombination-dependent growth gene, rdgC, is involved in gonococcal pilin antigenic variation."
    Mehr I.J., Long C.D., Serkin C.D., Seifert H.S.
    Genetics 154:523-532(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], DISRUPTION PHENOTYPE.
  2. "The complete genome sequence of Neisseria gonorrhoeae."
    Lewis L.A., Gillaspy A.F., McLaughlin R.E., Gipson M., Ducey T.F., Ownbey T., Hartman K., Nydick C., Carson M.B., Vaughn J., Thomson C., Song L., Lin S., Yuan X., Najar F., Zhan M., Ren Q., Zhu H.
    , Qi S., Kenton S.M., Lai H., White J.D., Clifton S., Roe B.A., Dyer D.W.
    Submitted (MAR-2003) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 700825 / FA 1090.

Entry informationi

Entry nameiDER_NEIG1
AccessioniPrimary (citable) accession number: O87407
Secondary accession number(s): Q5F9H0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: November 1, 1998
Last modified: January 20, 2016
This is version 103 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.