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O87405

- GLSA_RHIEC

UniProt

O87405 - GLSA_RHIEC

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Protein

Thermolabile glutaminase

Gene
glsA, RHE_CH02311
Organism
Rhizobium etli (strain CFN 42 / ATCC 51251)
Status
Reviewed - Annotation score: 2 out of 5 - Experimental evidence at protein leveli

Functioni

Catalytic activityi

L-glutamine + H2O = L-glutamate + NH3.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei64 – 641Substrate By similarity
Binding sitei114 – 1141Substrate By similarity
Binding sitei160 – 1601Substrate By similarity
Binding sitei167 – 1671Substrate By similarity
Binding sitei191 – 1911Substrate By similarity
Binding sitei243 – 2431Substrate By similarity
Binding sitei261 – 2611Substrate; via amide nitrogen By similarity

GO - Molecular functioni

  1. glutaminase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. glutamine metabolic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Enzyme and pathway databases

BioCyciRETL347834:GJJ0-2322-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Thermolabile glutaminase (EC:3.5.1.2)
Alternative name(s):
Glutaminase A
Gene namesi
Name:glsA
Ordered Locus Names:RHE_CH02311
OrganismiRhizobium etli (strain CFN 42 / ATCC 51251)
Taxonomic identifieri347834 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesRhizobiaceaeRhizobium/Agrobacterium groupRhizobium
ProteomesiUP000001936: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 309309Thermolabile glutaminaseUniRule annotationPRO_0000110619Add
BLAST

Interactioni

Subunit structurei

Homotetramer By similarity.UniRule annotation

Protein-protein interaction databases

STRINGi347834.RHE_CH02311.

Structurei

3D structure databases

ProteinModelPortaliO87405.

Family & Domainsi

Sequence similaritiesi

Belongs to the glutaminase family.

Phylogenomic databases

eggNOGiCOG2066.
HOGENOMiHOG000216890.
KOiK01425.
OMAiQRARRIN.
OrthoDBiEOG6N94BK.

Family and domain databases

Gene3Di3.40.710.10. 1 hit.
HAMAPiMF_00313. Glutaminase.
InterProiIPR012338. Beta-lactam/transpept-like.
IPR015868. Glutaminase.
[Graphical view]
PANTHERiPTHR12544. PTHR12544. 1 hit.
PfamiPF04960. Glutaminase. 1 hit.
[Graphical view]
SUPFAMiSSF56601. SSF56601. 1 hit.
TIGRFAMsiTIGR03814. Gln_ase. 1 hit.

Sequencei

Sequence statusi: Complete.

O87405-1 [UniParc]FASTAAdd to Basket

« Hide

MADLQATLDS IYTDILPRIG EGKVADYIPE LAKIDPRQFG MAIVTVDGQV    50
FRVGDADIAF SIQSISKVFM LTLALGKVGE GLWKRVGREP SGSAFNSIVQ 100
LEHESGIPRN PFINAGAIAV TDVVMAGHAP REAIGELLRF VRYLADDESI 150
TIDDKVARSE TQTGYRNVAL ANFMRAYRNL DHPVDHVLGV YFHQCALAMS 200
CEQLARAGLF LAARGSNPMT GHSVVSPKRA RRINALMLTC GHYDGSGDFA 250
YHVGLPGKSG VGGGIFAVAP GIASIAVWSP GLNKVGNSQL GAVALEMLAA 300
RTGWSVFGD 309
Length:309
Mass (Da):32,987
Last modified:May 16, 2006 - v2
Checksum:iCC678FB5E6A048FD
GO

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti94 – 941A → T in AAC63991. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF057158 Genomic DNA. Translation: AAC63991.1.
CP000133 Genomic DNA. Translation: ABC91091.1.
RefSeqiYP_469818.1. NC_007761.1.

Genome annotation databases

EnsemblBacteriaiABC91091; ABC91091; RHE_CH02311.
GeneIDi3894584.
KEGGiret:RHE_CH02311.
PATRICi23086148. VBIRhiEtl108884_2727.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF057158 Genomic DNA. Translation: AAC63991.1 .
CP000133 Genomic DNA. Translation: ABC91091.1 .
RefSeqi YP_469818.1. NC_007761.1.

3D structure databases

ProteinModelPortali O87405.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 347834.RHE_CH02311.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABC91091 ; ABC91091 ; RHE_CH02311 .
GeneIDi 3894584.
KEGGi ret:RHE_CH02311.
PATRICi 23086148. VBIRhiEtl108884_2727.

Phylogenomic databases

eggNOGi COG2066.
HOGENOMi HOG000216890.
KOi K01425.
OMAi QRARRIN.
OrthoDBi EOG6N94BK.

Enzyme and pathway databases

BioCyci RETL347834:GJJ0-2322-MONOMER.

Family and domain databases

Gene3Di 3.40.710.10. 1 hit.
HAMAPi MF_00313. Glutaminase.
InterProi IPR012338. Beta-lactam/transpept-like.
IPR015868. Glutaminase.
[Graphical view ]
PANTHERi PTHR12544. PTHR12544. 1 hit.
Pfami PF04960. Glutaminase. 1 hit.
[Graphical view ]
SUPFAMi SSF56601. SSF56601. 1 hit.
TIGRFAMsi TIGR03814. Gln_ase. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Sequence and molecular analysis of the Rhizobium etli glsA gene, encoding a thermolabile glutaminase."
    Calderon J., Huerta-Saquero A., Du Pont G., Duran S.
    Biochim. Biophys. Acta 1444:451-456(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: CFN 42 / ATCC 51251.
  3. Cited for: CHARACTERIZATION.

Entry informationi

Entry nameiGLSA_RHIEC
AccessioniPrimary (citable) accession number: O87405
Secondary accession number(s): Q2K7U5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 24, 2001
Last sequence update: May 16, 2006
Last modified: May 14, 2014
This is version 74 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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