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O87331

- RELA_CORGL

UniProt

O87331 - RELA_CORGL

Protein

GTP pyrophosphokinase

Gene

relA

Organism
Corynebacterium glutamicum (strain ATCC 13032 / DSM 20300 / JCM 1318 / LMG 3730 / NCIMB 10025)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 106 (01 Oct 2014)
      Sequence version 2 (11 Jul 2002)
      Previous versions | rss
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    Functioni

    In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance. This enzyme catalyzes the formation of pppGpp which is then hydrolyzed to form ppGpp. It also has (p)ppGpp-degrading activities.

    Catalytic activityi

    ATP + GTP = AMP + guanosine 3'-diphosphate 5'-triphosphate.

    Pathwayi

    GO - Molecular functioni

    1. amino acid binding Source: InterPro
    2. ATP binding Source: UniProtKB-KW
    3. GTP binding Source: UniProtKB-KW
    4. GTP diphosphokinase activity Source: UniProtKB-EC
    5. kinase activity Source: UniProtKB-KW
    6. metal ion binding Source: InterPro
    7. phosphoric diester hydrolase activity Source: InterPro

    GO - Biological processi

    1. guanosine tetraphosphate biosynthetic process Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Kinase, Transferase

    Keywords - Ligandi

    ATP-binding, GTP-binding, Nucleotide-binding

    Enzyme and pathway databases

    UniPathwayiUPA00908; UER00884.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    GTP pyrophosphokinase (EC:2.7.6.5)
    Alternative name(s):
    (p)ppGpp synthase
    ATP:GTP 3'-pyrophosphotransferase
    ppGpp synthase I
    Gene namesi
    Name:relA
    Synonyms:rel
    Ordered Locus Names:Cgl1653, cg1861
    OrganismiCorynebacterium glutamicum (strain ATCC 13032 / DSM 20300 / JCM 1318 / LMG 3730 / NCIMB 10025)
    Taxonomic identifieri196627 [NCBI]
    Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesCorynebacterineaeCorynebacteriaceaeCorynebacterium
    ProteomesiUP000000582: Chromosome, UP000001009: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 760760GTP pyrophosphokinasePRO_0000166545Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi196627.cg1861.

    Structurei

    3D structure databases

    ProteinModelPortaliO87331.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini77 – 17498HDAdd
    BLAST
    Domaini684 – 75875ACTPROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Belongs to the RelA/SpoT family.Curated
    Contains 1 ACT domain.PROSITE-ProRule annotation
    Contains 1 HD domain.Curated

    Phylogenomic databases

    eggNOGiCOG0317.
    HOGENOMiHOG000018301.
    KOiK00951.
    K01139.
    OMAiRDFADIY.
    OrthoDBiEOG6SV551.

    Family and domain databases

    Gene3Di3.10.20.30. 1 hit.
    InterProiIPR002912. ACT_dom.
    IPR012675. Beta-grasp_dom.
    IPR003607. HD/PDEase_dom.
    IPR006674. HD_domain.
    IPR004811. RelA/Spo_fam.
    IPR007685. RelA_SpoT.
    IPR004095. TGS.
    IPR012676. TGS-like.
    [Graphical view]
    PfamiPF01842. ACT. 1 hit.
    PF01966. HD. 1 hit.
    PF04607. RelA_SpoT. 1 hit.
    PF02824. TGS. 1 hit.
    [Graphical view]
    SMARTiSM00471. HDc. 1 hit.
    SM00954. RelA_SpoT. 1 hit.
    [Graphical view]
    SUPFAMiSSF81271. SSF81271. 1 hit.
    TIGRFAMsiTIGR00691. spoT_relA. 1 hit.
    PROSITEiPS51671. ACT. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    O87331-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSLERNTQKS SMGVRSMSAR LARSLTGNRV RTNPVLDPLL SIHRQFHPRA    50
    DVQVLERAYD TAERLHDGVI RKSGDPYITH PLAVATIAAE IGMDTTTLVA 100
    ALLHDTVEDT DYSLDDLTRD FGEEVARLVD GVTKLDKVAL GAAAEAETIR 150
    KMIVAMSQDP RVLVIKVADR LHNMRTMRFL PPEKQAKKAR QTLEVIAPLA 200
    HRLGMASVKW ELEDLSFAIL YPKKYEEIVR LVADRAPSRD RYLKEIIDQV 250
    TGGLRENNIA AEVLGRPKHY WSIYQKMIVR GRDFDDIFDL VGIRILVDNV 300
    NNCYAAIGVV HSLFNALPGR FKDYISAPRF GVYQSLHTTV MGPGGKPLEV 350
    QARTHDMHYN AEFGIAAHWR YKETKGSHSG EQAEVDQMAW MRQLLDWQKE 400
    AADPNEFLDS LRYDLTSKQI FVFTPKGDVV NLPVNSTPVD FAYAVHTEVG 450
    HRCIGAKING KLVALETKLK SGDRVEVFTS KDQNAGPSRG WQEFVVSPRA 500
    KAKIRQWFAK ERREEYLEAG RDALAAVIQR GGLPMHRLFT ASSMKTVATE 550
    LHYPDVDALY TAIGSGSVSA QHVVNRLMAI FGDEEDAEDA LVARTPFSEL 600
    VNSRATTESS TGILVEGSPD VMAKLAKCCM PVPGDEIFGF VTRGGGVSVH 650
    RTDCTNVEKL KEEPERIVSV SWASEGQGSV FSATLQLEAL DRAGLLFELT 700
    RVINEQKVSV TAMNSHCSED RVATVRFTFA VSDTKQLGSL MTQLRNAEGV 750
    FDVYRVTSGG 760
    Length:760
    Mass (Da):84,447
    Last modified:July 11, 2002 - v2
    Checksum:i1A72E595DE85E073
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti262 – 2621E → G(PubMed:9695918)Curated
    Sequence conflicti262 – 2621E → G(PubMed:12948626)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF038651 Genomic DNA. Translation: AAC35494.1.
    BA000036 Genomic DNA. Translation: BAB99046.1.
    BX927153 Genomic DNA. Translation: CAF20036.1.
    RefSeqiNP_600866.1. NC_003450.3.
    WP_011265777.1. NC_006958.1.
    YP_225937.1. NC_006958.1.

    Genome annotation databases

    EnsemblBacteriaiBAB99046; BAB99046; BAB99046.
    CAF20036; CAF20036; cg1861.
    GeneIDi1019621.
    KEGGicgb:cg1861.
    cgl:NCgl1590.
    PATRICi21495342. VBICorGlu203724_1614.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF038651 Genomic DNA. Translation: AAC35494.1 .
    BA000036 Genomic DNA. Translation: BAB99046.1 .
    BX927153 Genomic DNA. Translation: CAF20036.1 .
    RefSeqi NP_600866.1. NC_003450.3.
    WP_011265777.1. NC_006958.1.
    YP_225937.1. NC_006958.1.

    3D structure databases

    ProteinModelPortali O87331.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 196627.cg1861.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai BAB99046 ; BAB99046 ; BAB99046 .
    CAF20036 ; CAF20036 ; cg1861 .
    GeneIDi 1019621.
    KEGGi cgb:cg1861.
    cgl:NCgl1590.
    PATRICi 21495342. VBICorGlu203724_1614.

    Phylogenomic databases

    eggNOGi COG0317.
    HOGENOMi HOG000018301.
    KOi K00951.
    K01139.
    OMAi RDFADIY.
    OrthoDBi EOG6SV551.

    Enzyme and pathway databases

    UniPathwayi UPA00908 ; UER00884 .

    Family and domain databases

    Gene3Di 3.10.20.30. 1 hit.
    InterProi IPR002912. ACT_dom.
    IPR012675. Beta-grasp_dom.
    IPR003607. HD/PDEase_dom.
    IPR006674. HD_domain.
    IPR004811. RelA/Spo_fam.
    IPR007685. RelA_SpoT.
    IPR004095. TGS.
    IPR012676. TGS-like.
    [Graphical view ]
    Pfami PF01842. ACT. 1 hit.
    PF01966. HD. 1 hit.
    PF04607. RelA_SpoT. 1 hit.
    PF02824. TGS. 1 hit.
    [Graphical view ]
    SMARTi SM00471. HDc. 1 hit.
    SM00954. RelA_SpoT. 1 hit.
    [Graphical view ]
    SUPFAMi SSF81271. SSF81271. 1 hit.
    TIGRFAMsi TIGR00691. spoT_relA. 1 hit.
    PROSITEi PS51671. ACT. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The role of the Corynebacterium glutamicum rel gene in (p)ppGpp metabolism."
      Wehmeier L., Schaefer A., Burkovski A., Kraemer R., Mechold U., Malke H., Puehler A., Kalinowski J.
      Microbiology 144:1853-1862(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: ATCC 13032 / DSM 20300 / JCM 1318 / LMG 3730 / NCIMB 10025.
    2. "The Corynebacterium glutamicum genome: features and impacts on biotechnological processes."
      Ikeda M., Nakagawa S.
      Appl. Microbiol. Biotechnol. 62:99-109(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 13032 / DSM 20300 / JCM 1318 / LMG 3730 / NCIMB 10025.
    3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 13032 / DSM 20300 / JCM 1318 / LMG 3730 / NCIMB 10025.

    Entry informationi

    Entry nameiRELA_CORGL
    AccessioniPrimary (citable) accession number: O87331
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 30, 2000
    Last sequence update: July 11, 2002
    Last modified: October 1, 2014
    This is version 106 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3