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O87331

- RELA_CORGL

UniProt

O87331 - RELA_CORGL

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Protein
GTP pyrophosphokinase
Gene
relA, rel, Cgl1653, cg1861
Organism
Corynebacterium glutamicum (strain ATCC 13032 / DSM 20300 / JCM 1318 / LMG 3730 / NCIMB 10025)
Status
Reviewed - Annotation score: 4 out of 5 - Protein inferred from homologyi

Functioni

In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance. This enzyme catalyzes the formation of pppGpp which is then hydrolyzed to form ppGpp. It also has (p)ppGpp-degrading activities.

Catalytic activityi

ATP + GTP = AMP + guanosine 3'-diphosphate 5'-triphosphate.

Pathwayi

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. GTP binding Source: UniProtKB-KW
  3. GTP diphosphokinase activity Source: UniProtKB-EC
  4. amino acid binding Source: InterPro
  5. kinase activity Source: UniProtKB-KW
  6. metal ion binding Source: InterPro
  7. phosphoric diester hydrolase activity Source: InterPro

GO - Biological processi

  1. guanosine tetraphosphate biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Transferase

Keywords - Ligandi

ATP-binding, GTP-binding, Nucleotide-binding

Enzyme and pathway databases

UniPathwayiUPA00908; UER00884.

Names & Taxonomyi

Protein namesi
Recommended name:
GTP pyrophosphokinase (EC:2.7.6.5)
Alternative name(s):
(p)ppGpp synthase
ATP:GTP 3'-pyrophosphotransferase
ppGpp synthase I
Gene namesi
Name:relA
Synonyms:rel
Ordered Locus Names:Cgl1653, cg1861
OrganismiCorynebacterium glutamicum (strain ATCC 13032 / DSM 20300 / JCM 1318 / LMG 3730 / NCIMB 10025)
Taxonomic identifieri196627 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesCorynebacterineaeCorynebacteriaceaeCorynebacterium
ProteomesiUP000000582: Chromosome, UP000001009: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 760760GTP pyrophosphokinase
PRO_0000166545Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi196627.cg1861.

Structurei

3D structure databases

ProteinModelPortaliO87331.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini77 – 17498HD
Add
BLAST
Domaini684 – 75875ACT
Add
BLAST

Sequence similaritiesi

Belongs to the RelA/SpoT family.
Contains 1 ACT domain.
Contains 1 HD domain.

Phylogenomic databases

eggNOGiCOG0317.
HOGENOMiHOG000018301.
KOiK00951.
K01139.
OMAiRDFADIY.
OrthoDBiEOG6SV551.

Family and domain databases

Gene3Di3.10.20.30. 1 hit.
InterProiIPR002912. ACT_dom.
IPR012675. Beta-grasp_dom.
IPR003607. HD/PDEase_dom.
IPR006674. HD_domain.
IPR004811. RelA/Spo_fam.
IPR007685. RelA_SpoT.
IPR004095. TGS.
IPR012676. TGS-like.
[Graphical view]
PfamiPF01842. ACT. 1 hit.
PF01966. HD. 1 hit.
PF04607. RelA_SpoT. 1 hit.
PF02824. TGS. 1 hit.
[Graphical view]
SMARTiSM00471. HDc. 1 hit.
SM00954. RelA_SpoT. 1 hit.
[Graphical view]
SUPFAMiSSF81271. SSF81271. 1 hit.
TIGRFAMsiTIGR00691. spoT_relA. 1 hit.
PROSITEiPS51671. ACT. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O87331-1 [UniParc]FASTAAdd to Basket

« Hide

MSLERNTQKS SMGVRSMSAR LARSLTGNRV RTNPVLDPLL SIHRQFHPRA    50
DVQVLERAYD TAERLHDGVI RKSGDPYITH PLAVATIAAE IGMDTTTLVA 100
ALLHDTVEDT DYSLDDLTRD FGEEVARLVD GVTKLDKVAL GAAAEAETIR 150
KMIVAMSQDP RVLVIKVADR LHNMRTMRFL PPEKQAKKAR QTLEVIAPLA 200
HRLGMASVKW ELEDLSFAIL YPKKYEEIVR LVADRAPSRD RYLKEIIDQV 250
TGGLRENNIA AEVLGRPKHY WSIYQKMIVR GRDFDDIFDL VGIRILVDNV 300
NNCYAAIGVV HSLFNALPGR FKDYISAPRF GVYQSLHTTV MGPGGKPLEV 350
QARTHDMHYN AEFGIAAHWR YKETKGSHSG EQAEVDQMAW MRQLLDWQKE 400
AADPNEFLDS LRYDLTSKQI FVFTPKGDVV NLPVNSTPVD FAYAVHTEVG 450
HRCIGAKING KLVALETKLK SGDRVEVFTS KDQNAGPSRG WQEFVVSPRA 500
KAKIRQWFAK ERREEYLEAG RDALAAVIQR GGLPMHRLFT ASSMKTVATE 550
LHYPDVDALY TAIGSGSVSA QHVVNRLMAI FGDEEDAEDA LVARTPFSEL 600
VNSRATTESS TGILVEGSPD VMAKLAKCCM PVPGDEIFGF VTRGGGVSVH 650
RTDCTNVEKL KEEPERIVSV SWASEGQGSV FSATLQLEAL DRAGLLFELT 700
RVINEQKVSV TAMNSHCSED RVATVRFTFA VSDTKQLGSL MTQLRNAEGV 750
FDVYRVTSGG 760
Length:760
Mass (Da):84,447
Last modified:July 11, 2002 - v2
Checksum:i1A72E595DE85E073
GO

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti262 – 2621E → G1 Publication
Sequence conflicti262 – 2621E → G1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF038651 Genomic DNA. Translation: AAC35494.1.
BA000036 Genomic DNA. Translation: BAB99046.1.
BX927153 Genomic DNA. Translation: CAF20036.1.
RefSeqiNP_600866.1. NC_003450.3.
WP_011265777.1. NC_006958.1.
YP_225937.1. NC_006958.1.

Genome annotation databases

EnsemblBacteriaiBAB99046; BAB99046; BAB99046.
CAF20036; CAF20036; cg1861.
GeneIDi1019621.
KEGGicgb:cg1861.
cgl:NCgl1590.
PATRICi21495342. VBICorGlu203724_1614.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF038651 Genomic DNA. Translation: AAC35494.1 .
BA000036 Genomic DNA. Translation: BAB99046.1 .
BX927153 Genomic DNA. Translation: CAF20036.1 .
RefSeqi NP_600866.1. NC_003450.3.
WP_011265777.1. NC_006958.1.
YP_225937.1. NC_006958.1.

3D structure databases

ProteinModelPortali O87331.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 196627.cg1861.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai BAB99046 ; BAB99046 ; BAB99046 .
CAF20036 ; CAF20036 ; cg1861 .
GeneIDi 1019621.
KEGGi cgb:cg1861.
cgl:NCgl1590.
PATRICi 21495342. VBICorGlu203724_1614.

Phylogenomic databases

eggNOGi COG0317.
HOGENOMi HOG000018301.
KOi K00951.
K01139.
OMAi RDFADIY.
OrthoDBi EOG6SV551.

Enzyme and pathway databases

UniPathwayi UPA00908 ; UER00884 .

Family and domain databases

Gene3Di 3.10.20.30. 1 hit.
InterProi IPR002912. ACT_dom.
IPR012675. Beta-grasp_dom.
IPR003607. HD/PDEase_dom.
IPR006674. HD_domain.
IPR004811. RelA/Spo_fam.
IPR007685. RelA_SpoT.
IPR004095. TGS.
IPR012676. TGS-like.
[Graphical view ]
Pfami PF01842. ACT. 1 hit.
PF01966. HD. 1 hit.
PF04607. RelA_SpoT. 1 hit.
PF02824. TGS. 1 hit.
[Graphical view ]
SMARTi SM00471. HDc. 1 hit.
SM00954. RelA_SpoT. 1 hit.
[Graphical view ]
SUPFAMi SSF81271. SSF81271. 1 hit.
TIGRFAMsi TIGR00691. spoT_relA. 1 hit.
PROSITEi PS51671. ACT. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The role of the Corynebacterium glutamicum rel gene in (p)ppGpp metabolism."
    Wehmeier L., Schaefer A., Burkovski A., Kraemer R., Mechold U., Malke H., Puehler A., Kalinowski J.
    Microbiology 144:1853-1862(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: ATCC 13032 / DSM 20300 / JCM 1318 / LMG 3730 / NCIMB 10025.
  2. "The Corynebacterium glutamicum genome: features and impacts on biotechnological processes."
    Ikeda M., Nakagawa S.
    Appl. Microbiol. Biotechnol. 62:99-109(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 13032 / DSM 20300 / JCM 1318 / LMG 3730 / NCIMB 10025.
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 13032 / DSM 20300 / JCM 1318 / LMG 3730 / NCIMB 10025.

Entry informationi

Entry nameiRELA_CORGL
AccessioniPrimary (citable) accession number: O87331
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: July 11, 2002
Last modified: September 3, 2014
This is version 105 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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