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O87331

- RELA_CORGL

UniProt

O87331 - RELA_CORGL

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Protein

GTP pyrophosphokinase

Gene

relA

Organism
Corynebacterium glutamicum (strain ATCC 13032 / DSM 20300 / JCM 1318 / LMG 3730 / NCIMB 10025)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance. This enzyme catalyzes the formation of pppGpp which is then hydrolyzed to form ppGpp. It also has (p)ppGpp-degrading activities.

Catalytic activityi

ATP + GTP = AMP + guanosine 3'-diphosphate 5'-triphosphate.

Pathwayi

GO - Molecular functioni

  1. amino acid binding Source: InterPro
  2. ATP binding Source: UniProtKB-KW
  3. GTP binding Source: UniProtKB-KW
  4. GTP diphosphokinase activity Source: UniProtKB-EC
  5. kinase activity Source: UniProtKB-KW

GO - Biological processi

  1. guanosine tetraphosphate biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Transferase

Keywords - Ligandi

ATP-binding, GTP-binding, Nucleotide-binding

Enzyme and pathway databases

UniPathwayiUPA00908; UER00884.

Names & Taxonomyi

Protein namesi
Recommended name:
GTP pyrophosphokinase (EC:2.7.6.5)
Alternative name(s):
(p)ppGpp synthase
ATP:GTP 3'-pyrophosphotransferase
ppGpp synthase I
Gene namesi
Name:relA
Synonyms:rel
Ordered Locus Names:Cgl1653, cg1861
OrganismiCorynebacterium glutamicum (strain ATCC 13032 / DSM 20300 / JCM 1318 / LMG 3730 / NCIMB 10025)
Taxonomic identifieri196627 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesCorynebacterineaeCorynebacteriaceaeCorynebacterium
ProteomesiUP000000582: Chromosome, UP000001009: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 760760GTP pyrophosphokinasePRO_0000166545Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi196627.cg1861.

Structurei

3D structure databases

ProteinModelPortaliO87331.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini77 – 17498HDAdd
BLAST
Domaini684 – 75875ACTPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the RelA/SpoT family.Curated
Contains 1 ACT domain.PROSITE-ProRule annotation
Contains 1 HD domain.Curated

Phylogenomic databases

eggNOGiCOG0317.
HOGENOMiHOG000018301.
KOiK00951.
OMAiRDFADIY.
OrthoDBiEOG6SV551.

Family and domain databases

Gene3Di3.10.20.30. 1 hit.
InterProiIPR002912. ACT_dom.
IPR012675. Beta-grasp_dom.
IPR003607. HD/PDEase_dom.
IPR006674. HD_domain.
IPR004811. RelA/Spo_fam.
IPR007685. RelA_SpoT.
IPR004095. TGS.
IPR012676. TGS-like.
[Graphical view]
PfamiPF01842. ACT. 1 hit.
PF01966. HD. 1 hit.
PF04607. RelA_SpoT. 1 hit.
PF02824. TGS. 1 hit.
[Graphical view]
SMARTiSM00471. HDc. 1 hit.
SM00954. RelA_SpoT. 1 hit.
[Graphical view]
SUPFAMiSSF81271. SSF81271. 1 hit.
TIGRFAMsiTIGR00691. spoT_relA. 1 hit.
PROSITEiPS51671. ACT. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O87331-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSLERNTQKS SMGVRSMSAR LARSLTGNRV RTNPVLDPLL SIHRQFHPRA
60 70 80 90 100
DVQVLERAYD TAERLHDGVI RKSGDPYITH PLAVATIAAE IGMDTTTLVA
110 120 130 140 150
ALLHDTVEDT DYSLDDLTRD FGEEVARLVD GVTKLDKVAL GAAAEAETIR
160 170 180 190 200
KMIVAMSQDP RVLVIKVADR LHNMRTMRFL PPEKQAKKAR QTLEVIAPLA
210 220 230 240 250
HRLGMASVKW ELEDLSFAIL YPKKYEEIVR LVADRAPSRD RYLKEIIDQV
260 270 280 290 300
TGGLRENNIA AEVLGRPKHY WSIYQKMIVR GRDFDDIFDL VGIRILVDNV
310 320 330 340 350
NNCYAAIGVV HSLFNALPGR FKDYISAPRF GVYQSLHTTV MGPGGKPLEV
360 370 380 390 400
QARTHDMHYN AEFGIAAHWR YKETKGSHSG EQAEVDQMAW MRQLLDWQKE
410 420 430 440 450
AADPNEFLDS LRYDLTSKQI FVFTPKGDVV NLPVNSTPVD FAYAVHTEVG
460 470 480 490 500
HRCIGAKING KLVALETKLK SGDRVEVFTS KDQNAGPSRG WQEFVVSPRA
510 520 530 540 550
KAKIRQWFAK ERREEYLEAG RDALAAVIQR GGLPMHRLFT ASSMKTVATE
560 570 580 590 600
LHYPDVDALY TAIGSGSVSA QHVVNRLMAI FGDEEDAEDA LVARTPFSEL
610 620 630 640 650
VNSRATTESS TGILVEGSPD VMAKLAKCCM PVPGDEIFGF VTRGGGVSVH
660 670 680 690 700
RTDCTNVEKL KEEPERIVSV SWASEGQGSV FSATLQLEAL DRAGLLFELT
710 720 730 740 750
RVINEQKVSV TAMNSHCSED RVATVRFTFA VSDTKQLGSL MTQLRNAEGV
760
FDVYRVTSGG
Length:760
Mass (Da):84,447
Last modified:July 11, 2002 - v2
Checksum:i1A72E595DE85E073
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti262 – 2621E → G(PubMed:9695918)Curated
Sequence conflicti262 – 2621E → G(PubMed:12948626)Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF038651 Genomic DNA. Translation: AAC35494.1.
BA000036 Genomic DNA. Translation: BAB99046.1.
BX927153 Genomic DNA. Translation: CAF20036.1.
RefSeqiNP_600866.1. NC_003450.3.
WP_011265777.1. NC_006958.1.
YP_225937.1. NC_006958.1.

Genome annotation databases

EnsemblBacteriaiBAB99046; BAB99046; BAB99046.
CAF20036; CAF20036; cg1861.
GeneIDi1019621.
3343569.
KEGGicgl:NCgl1590.
PATRICi21495342. VBICorGlu203724_1614.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF038651 Genomic DNA. Translation: AAC35494.1 .
BA000036 Genomic DNA. Translation: BAB99046.1 .
BX927153 Genomic DNA. Translation: CAF20036.1 .
RefSeqi NP_600866.1. NC_003450.3.
WP_011265777.1. NC_006958.1.
YP_225937.1. NC_006958.1.

3D structure databases

ProteinModelPortali O87331.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 196627.cg1861.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai BAB99046 ; BAB99046 ; BAB99046 .
CAF20036 ; CAF20036 ; cg1861 .
GeneIDi 1019621.
3343569.
KEGGi cgl:NCgl1590.
PATRICi 21495342. VBICorGlu203724_1614.

Phylogenomic databases

eggNOGi COG0317.
HOGENOMi HOG000018301.
KOi K00951.
OMAi RDFADIY.
OrthoDBi EOG6SV551.

Enzyme and pathway databases

UniPathwayi UPA00908 ; UER00884 .

Family and domain databases

Gene3Di 3.10.20.30. 1 hit.
InterProi IPR002912. ACT_dom.
IPR012675. Beta-grasp_dom.
IPR003607. HD/PDEase_dom.
IPR006674. HD_domain.
IPR004811. RelA/Spo_fam.
IPR007685. RelA_SpoT.
IPR004095. TGS.
IPR012676. TGS-like.
[Graphical view ]
Pfami PF01842. ACT. 1 hit.
PF01966. HD. 1 hit.
PF04607. RelA_SpoT. 1 hit.
PF02824. TGS. 1 hit.
[Graphical view ]
SMARTi SM00471. HDc. 1 hit.
SM00954. RelA_SpoT. 1 hit.
[Graphical view ]
SUPFAMi SSF81271. SSF81271. 1 hit.
TIGRFAMsi TIGR00691. spoT_relA. 1 hit.
PROSITEi PS51671. ACT. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The role of the Corynebacterium glutamicum rel gene in (p)ppGpp metabolism."
    Wehmeier L., Schaefer A., Burkovski A., Kraemer R., Mechold U., Malke H., Puehler A., Kalinowski J.
    Microbiology 144:1853-1862(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: ATCC 13032 / DSM 20300 / JCM 1318 / LMG 3730 / NCIMB 10025.
  2. "The Corynebacterium glutamicum genome: features and impacts on biotechnological processes."
    Ikeda M., Nakagawa S.
    Appl. Microbiol. Biotechnol. 62:99-109(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 13032 / DSM 20300 / JCM 1318 / LMG 3730 / NCIMB 10025.
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 13032 / DSM 20300 / JCM 1318 / LMG 3730 / NCIMB 10025.

Entry informationi

Entry nameiRELA_CORGL
AccessioniPrimary (citable) accession number: O87331
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: July 11, 2002
Last modified: November 26, 2014
This is version 108 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3