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Protein

Isoprenyl transferase

Gene

uppS

Organism
Thermus thermophilus (strain HB27 / ATCC BAA-163 / DSM 7039)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids.UniRule annotation

Cofactori

Mg2+UniRule annotationNote: Binds 2 magnesium ions per subunit.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei38UniRule annotation1
Metal bindingi38MagnesiumUniRule annotation1
Binding sitei55SubstrateUniRule annotation1
Active sitei86Proton acceptorUniRule annotation1
Binding sitei87SubstrateUniRule annotation1
Binding sitei89SubstrateUniRule annotation1
Binding sitei212SubstrateUniRule annotation1
Metal bindingi231MagnesiumUniRule annotation1

GO - Molecular functioni

Keywordsi

Molecular functionTransferase
LigandMagnesium, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Isoprenyl transferaseUniRule annotation (EC:2.5.1.-UniRule annotation)
Gene namesi
Name:uppSUniRule annotation
Ordered Locus Names:TT_C1551
OrganismiThermus thermophilus (strain HB27 / ATCC BAA-163 / DSM 7039)
Taxonomic identifieri262724 [NCBI]
Taxonomic lineageiBacteriaDeinococcus-ThermusDeinococciThermalesThermaceaeThermus
Proteomesi
  • UP000000592 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001237021 – 263Isoprenyl transferaseAdd BLAST263

Proteomic databases

PRIDEiO87197

Interactioni

Subunit structurei

Homodimer.UniRule annotation

Protein-protein interaction databases

STRINGi262724.TTC1551

Structurei

3D structure databases

ProteinModelPortaliO87197
SMRiO87197
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni39 – 42Substrate bindingUniRule annotation4
Regioni83 – 85Substrate bindingUniRule annotation3
Regioni218 – 220Substrate bindingUniRule annotation3

Sequence similaritiesi

Belongs to the UPP synthase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105CR3 Bacteria
COG0020 LUCA
KOiK12503
OMAiFDRRDLW

Family and domain databases

CDDicd00475 Cis_IPPS, 1 hit
Gene3Di3.40.1180.10, 1 hit
HAMAPiMF_01139 ISPT, 1 hit
InterProiView protein in InterPro
IPR001441 UPP_synth-like
IPR018520 UPP_synth-like_CS
IPR036424 UPP_synth-like_sf
PANTHERiPTHR10291 PTHR10291, 1 hit
PfamiView protein in Pfam
PF01255 Prenyltransf, 1 hit
SUPFAMiSSF64005 SSF64005, 1 hit
TIGRFAMsiTIGR00055 uppS, 1 hit
PROSITEiView protein in PROSITE
PS01066 UPP_SYNTHASE, 1 hit

Sequencei

Sequence statusi: Complete.

O87197-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVRRLLALSR PLYWLYEQRL LREVKRGPMP RHLGLILDGN RRYARALGLS
60 70 80 90 100
PTKGHEFGVQ KAYEVLEWCL EMGIKTVTVW VFSTDNFKRP PEEVETLMNL
110 120 130 140 150
FLREAERMAE DHRILEHQVR VRFIGRREGF SPEVVRAIER LERRTEGHRG
160 170 180 190 200
MFLNIALGYG GREEIVDAVK RLLLEAEARG LSPKEVAEGL TPEDIARHLY
210 220 230 240 250
TAGLPDPDFI IRTSGEIRLS GFLLWQSAYS EFYFADVLWP EFRKIDFLRA
260
LRSYQARERR FGR
Length:263
Mass (Da):30,875
Last modified:November 1, 1998 - v1
Checksum:i5F7DCE00F7E66592
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB018379 Genomic DNA Translation: BAA33784.1
AE017221 Genomic DNA Translation: AAS81893.1
PIRiT51169
RefSeqiWP_011173925.1, NC_005835.1

Genome annotation databases

EnsemblBacteriaiAAS81893; AAS81893; TT_C1551
KEGGitth:TT_C1551

Similar proteinsi

Entry informationi

Entry nameiISPT_THET2
AccessioniPrimary (citable) accession number: O87197
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 16, 2004
Last sequence update: November 1, 1998
Last modified: May 23, 2018
This is version 98 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

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