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Protein

Isoprenyl transferase

Gene

uppS

Organism
Thermus thermophilus (strain HB27 / ATCC BAA-163 / DSM 7039)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids.UniRule annotation

Cofactori

Mg2+UniRule annotationNote: Binds 2 magnesium ions per subunit.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei38 – 381UniRule annotation
Metal bindingi38 – 381MagnesiumUniRule annotation
Binding sitei55 – 551SubstrateUniRule annotation
Active sitei86 – 861Proton acceptorUniRule annotation
Binding sitei87 – 871SubstrateUniRule annotation
Binding sitei89 – 891SubstrateUniRule annotation
Binding sitei212 – 2121SubstrateUniRule annotation
Metal bindingi231 – 2311MagnesiumUniRule annotation

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Transferase

Keywords - Ligandi

Magnesium, Metal-binding

Enzyme and pathway databases

BioCyciTTHE262724:GCAT-1573-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Isoprenyl transferaseUniRule annotation (EC:2.5.1.-UniRule annotation)
Gene namesi
Name:uppSUniRule annotation
Ordered Locus Names:TT_C1551
OrganismiThermus thermophilus (strain HB27 / ATCC BAA-163 / DSM 7039)
Taxonomic identifieri262724 [NCBI]
Taxonomic lineageiBacteriaDeinococcus-ThermusDeinococciThermalesThermaceaeThermus
Proteomesi
  • UP000000592 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 263263Isoprenyl transferasePRO_0000123702Add
BLAST

Interactioni

Subunit structurei

Homodimer.UniRule annotation

Protein-protein interaction databases

STRINGi262724.TTC1551.

Structurei

3D structure databases

ProteinModelPortaliO87197.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni39 – 424Substrate bindingUniRule annotation
Regioni83 – 853Substrate bindingUniRule annotation
Regioni218 – 2203Substrate bindingUniRule annotation

Sequence similaritiesi

Belongs to the UPP synthase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105CR3. Bacteria.
COG0020. LUCA.
KOiK12503.
OMAiWAKLKNK.

Family and domain databases

CDDicd00475. Cis_IPPS. 1 hit.
Gene3Di3.40.1180.10. 1 hit.
HAMAPiMF_01139. ISPT. 1 hit.
InterProiIPR001441. UPP_synth-like.
IPR018520. UPP_synth-like_CS.
[Graphical view]
PANTHERiPTHR10291. PTHR10291. 1 hit.
PfamiPF01255. Prenyltransf. 1 hit.
[Graphical view]
SUPFAMiSSF64005. SSF64005. 1 hit.
TIGRFAMsiTIGR00055. uppS. 1 hit.
PROSITEiPS01066. UPP_SYNTHASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O87197-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVRRLLALSR PLYWLYEQRL LREVKRGPMP RHLGLILDGN RRYARALGLS
60 70 80 90 100
PTKGHEFGVQ KAYEVLEWCL EMGIKTVTVW VFSTDNFKRP PEEVETLMNL
110 120 130 140 150
FLREAERMAE DHRILEHQVR VRFIGRREGF SPEVVRAIER LERRTEGHRG
160 170 180 190 200
MFLNIALGYG GREEIVDAVK RLLLEAEARG LSPKEVAEGL TPEDIARHLY
210 220 230 240 250
TAGLPDPDFI IRTSGEIRLS GFLLWQSAYS EFYFADVLWP EFRKIDFLRA
260
LRSYQARERR FGR
Length:263
Mass (Da):30,875
Last modified:November 1, 1998 - v1
Checksum:i5F7DCE00F7E66592
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB018379 Genomic DNA. Translation: BAA33784.1.
AE017221 Genomic DNA. Translation: AAS81893.1.
PIRiT51169.
RefSeqiWP_011173925.1. NC_005835.1.

Genome annotation databases

EnsemblBacteriaiAAS81893; AAS81893; TT_C1551.
KEGGitth:TTC1551.
PATRICi23953529. VBITheThe54392_1546.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB018379 Genomic DNA. Translation: BAA33784.1.
AE017221 Genomic DNA. Translation: AAS81893.1.
PIRiT51169.
RefSeqiWP_011173925.1. NC_005835.1.

3D structure databases

ProteinModelPortaliO87197.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi262724.TTC1551.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAS81893; AAS81893; TT_C1551.
KEGGitth:TTC1551.
PATRICi23953529. VBITheThe54392_1546.

Phylogenomic databases

eggNOGiENOG4105CR3. Bacteria.
COG0020. LUCA.
KOiK12503.
OMAiWAKLKNK.

Enzyme and pathway databases

BioCyciTTHE262724:GCAT-1573-MONOMER.

Family and domain databases

CDDicd00475. Cis_IPPS. 1 hit.
Gene3Di3.40.1180.10. 1 hit.
HAMAPiMF_01139. ISPT. 1 hit.
InterProiIPR001441. UPP_synth-like.
IPR018520. UPP_synth-like_CS.
[Graphical view]
PANTHERiPTHR10291. PTHR10291. 1 hit.
PfamiPF01255. Prenyltransf. 1 hit.
[Graphical view]
SUPFAMiSSF64005. SSF64005. 1 hit.
TIGRFAMsiTIGR00055. uppS. 1 hit.
PROSITEiPS01066. UPP_SYNTHASE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiISPT_THET2
AccessioniPrimary (citable) accession number: O87197
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 16, 2004
Last sequence update: November 1, 1998
Last modified: September 7, 2016
This is version 93 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.