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Protein

Chemotaxis protein methyltransferase 1

Gene

cheR1

Organism
Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP.By similarity

Catalytic activityi

S-adenosyl-L-methionine + protein L-glutamate = S-adenosyl-L-homocysteine + protein L-glutamate methyl ester.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei72S-adenosyl-L-methionineBy similarity1
Binding sitei74S-adenosyl-L-methionineBy similarity1
Binding sitei78S-adenosyl-L-methionineBy similarity1
Binding sitei115S-adenosyl-L-methionineBy similarity1
Binding sitei144S-adenosyl-L-methionineBy similarity1

GO - Molecular functioni

Keywordsi

Molecular functionMethyltransferase, Transferase
LigandS-adenosyl-L-methionine

Names & Taxonomyi

Protein namesi
Recommended name:
Chemotaxis protein methyltransferase 1 (EC:2.1.1.80)
Gene namesi
Name:cheR1
Ordered Locus Names:PA3348
OrganismiPseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1)
Taxonomic identifieri208964 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPseudomonadalesPseudomonadaceaePseudomonas
Proteomesi
  • UP000002438 Componenti: Chromosome

Organism-specific databases

PseudoCAPiPA3348.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001760371 – 274Chemotaxis protein methyltransferase 1Add BLAST274

Proteomic databases

PaxDbiO87131.
PRIDEiO87131.

Interactioni

Protein-protein interaction databases

STRINGi208964.PA3348.

Structurei

3D structure databases

ProteinModelPortaliO87131.
SMRiO87131.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini1 – 274CheR-type methyltransferasePROSITE-ProRule annotationAdd BLAST274

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni200 – 201S-adenosyl-L-methionine bindingBy similarity2
Regioni217 – 218S-adenosyl-L-methionine bindingBy similarity2

Phylogenomic databases

eggNOGiENOG4105BZU. Bacteria.
ENOG410XNMH. LUCA.
HOGENOMiHOG000254354.
InParanoidiO87131.
KOiK00575.
OMAiSTEQIIM.
PhylomeDBiO87131.

Family and domain databases

Gene3Di1.10.155.10. 1 hit.
3.40.50.150. 1 hit.
InterProiView protein in InterPro
IPR026024. Chemotaxis_MeTrfase_CheR.
IPR022642. CheR_C.
IPR000780. CheR_MeTrfase.
IPR022641. CheR_N.
IPR029063. SAM-dependent_MTases.
PfamiView protein in Pfam
PF01739. CheR. 1 hit.
PF03705. CheR_N. 1 hit.
PIRSFiPIRSF000410. CheR. 1 hit.
PRINTSiPR00996. CHERMTFRASE.
SMARTiView protein in SMART
SM00138. MeTrc. 1 hit.
SUPFAMiSSF47757. SSF47757. 1 hit.
SSF53335. SSF53335. 1 hit.
PROSITEiView protein in PROSITE
PS50123. CHER. 1 hit.

Sequencei

Sequence statusi: Complete.

O87131-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSAANADFEL FRVFLEKTCG IVLGSNKQYL VSSRLNKLME QQGIKSLGEL
60 70 80 90 100
VQRIQTQRGG LREMVVDAMT TNETLWFRDT YPFEVLKQRV LPELIKANGG
110 120 130 140 150
QRLRIWSAAC SSGQEPYSLS MAIDEFEKTN LGQLKAGVQI VATDLSGSML
160 170 180 190 200
TAAKAGEYDT LAMGRGLSPE RLQRYFDAKG PGRWAVKPAI RSRVEFRALN
210 220 230 240 250
LLDSYASLGK FDMVFCRNVL IYFSAEVKRD ILLRIHGTLK PGGYLFLGAS
260 270
EALNNLPDHY QMVQCSPGII YRAK
Length:274
Mass (Da):30,647
Last modified:November 1, 1998 - v1
Checksum:i9B5DD76DFD2012BF
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB012768 Genomic DNA. Translation: BAA33556.1.
AE004091 Genomic DNA. Translation: AAG06736.1.
PIRiA83227.
RefSeqiNP_252038.1. NC_002516.2.
WP_003091728.1. NZ_ASJY01000539.1.

Genome annotation databases

EnsemblBacteriaiAAG06736; AAG06736; PA3348.
GeneIDi882515.
KEGGipae:PA3348.
PATRICi19841297. VBIPseAer58763_3507.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB012768 Genomic DNA. Translation: BAA33556.1.
AE004091 Genomic DNA. Translation: AAG06736.1.
PIRiA83227.
RefSeqiNP_252038.1. NC_002516.2.
WP_003091728.1. NZ_ASJY01000539.1.

3D structure databases

ProteinModelPortaliO87131.
SMRiO87131.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi208964.PA3348.

Proteomic databases

PaxDbiO87131.
PRIDEiO87131.

Protocols and materials databases

DNASUi882515.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAG06736; AAG06736; PA3348.
GeneIDi882515.
KEGGipae:PA3348.
PATRICi19841297. VBIPseAer58763_3507.

Organism-specific databases

PseudoCAPiPA3348.

Phylogenomic databases

eggNOGiENOG4105BZU. Bacteria.
ENOG410XNMH. LUCA.
HOGENOMiHOG000254354.
InParanoidiO87131.
KOiK00575.
OMAiSTEQIIM.
PhylomeDBiO87131.

Family and domain databases

Gene3Di1.10.155.10. 1 hit.
3.40.50.150. 1 hit.
InterProiView protein in InterPro
IPR026024. Chemotaxis_MeTrfase_CheR.
IPR022642. CheR_C.
IPR000780. CheR_MeTrfase.
IPR022641. CheR_N.
IPR029063. SAM-dependent_MTases.
PfamiView protein in Pfam
PF01739. CheR. 1 hit.
PF03705. CheR_N. 1 hit.
PIRSFiPIRSF000410. CheR. 1 hit.
PRINTSiPR00996. CHERMTFRASE.
SMARTiView protein in SMART
SM00138. MeTrc. 1 hit.
SUPFAMiSSF47757. SSF47757. 1 hit.
SSF53335. SSF53335. 1 hit.
PROSITEiView protein in PROSITE
PS50123. CHER. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiCHER1_PSEAE
AccessioniPrimary (citable) accession number: O87131
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 23, 2002
Last sequence update: November 1, 1998
Last modified: February 15, 2017
This is version 92 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.