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Protein
Submitted name:

Inactive cytotoxin

Gene

vacA

Organism
Helicobacter pylori (Campylobacter pylori)
Status
Unreviewed-Annotation score: Annotation score: 1 out of 5-Protein predictedi

Functioni

GO - Biological processi

Complete GO annotation...

Names & Taxonomyi

Protein namesi
Submitted name:
Inactive cytotoxinImported
Gene namesi
Name:vacAImported
OrganismiHelicobacter pylori (Campylobacter pylori)Imported
Taxonomic identifieri210 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaEpsilonproteobacteriaCampylobacteralesHelicobacteraceaeHelicobacter

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 33Sequence analysisAdd BLAST33
ChainiPRO_500416108334 – 1323Sequence analysisAdd BLAST1290

Structurei

3D structure databases

ProteinModelPortaliO87018.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini1050 – 1323Autotransporter (TC 1.B.12)InterPro annotationAdd BLAST274

Keywords - Domaini

SignalSequence analysis

Family and domain databases

Gene3Di2.40.128.130. 1 hit.
InterProiIPR005546. Autotransporte_beta.
IPR006315. OM_autotransptr_brl.
IPR003842. Vacuolating_cytotoxin.
[Graphical view]
PfamiPF03797. Autotransporter. 1 hit.
PF02691. VacA. 1 hit.
[Graphical view]
PRINTSiPR01656. VACCYTOTOXIN.
SMARTiSM00869. Autotransporter. 1 hit.
[Graphical view]
SUPFAMiSSF103515. SSF103515. 1 hit.
TIGRFAMsiTIGR01414. autotrans_barl. 1 hit.
PROSITEiPS51208. AUTOTRANSPORTER. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O87018-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEIQQTHRKI NRPLVSLALV GALVSITPQQ SHAAFFTTVI IPAIVGGIAT
60 70 80 90 100
GAAVGTVSGL LSWGLKQAEE ANKTPDKPDK VWRIQAGRGF NNFPNKEYDL
110 120 130 140 150
YRSLLSSKID GGWDWGNAAR HYWVKGGQWN KLEVDMKDAV GTYTLSGLRN
160 170 180 190 200
FTGGDLDVNM QKATLRLGQF NGNSFTSYKD SADRTTRVDF NAKNILIDNF
210 220 230 240 250
LEINNRVGSG AGRKASSTVL TLQASEKITS RENAEISLYD GATLNLASNS
260 270 280 290 300
VKLMGNVWMG RLQYVGAYLA PSYSTINTSK VTGEVDFNHL TVGDHNAAQA
310 320 330 340 350
GIIASNKTHI GTLDLWQSAG LNIIAPPEGG YKDKPKDKPS NTTQNNANNN
360 370 380 390 400
QQNSAQNNSN TQVINPPNSA QKTEIQPTQV IDGPFAGGKD TVVNINRINT
410 420 430 440 450
NADGTIRAGG YKASLTTNAA HLYIGKGGVN LSNQASGRSL LVENLTGNIA
460 470 480 490 500
VEGTLRVNNQ VGGSAVAGSS ANFEFKAGTD TNNGTATFNN DIHLGKAVNL
510 520 530 540 550
RVDAHTAYFN GNIYLGKSTN LKVNGHSAHF KNIDATKSDN GLNTSALDFS
560 570 580 590 600
GVTDKVNINK LTTSATNVNI KNFDIKELVV TTRVQSFGQY TIFGENIGDK
610 620 630 640 650
SRIGVVSLQA GYSPAYSGGV TFKSGKKLVI DEIYHAPWNY FDARNVTDVE
660 670 680 690 700
INKRILFGSP GNIAGKTGLM FNNLTLNSNA SMDYGKDLDL TIQGHFTNNQ
710 720 730 740 750
GTMNLFVQDG RVATLNAGHQ ASMIFNNLVD SATGFYKPLI KINNAQNLTK
760 770 780 790 800
NKEHVLVRAR NIDYNLVGVQ GASYDNISAS NTNLQEQFKE RLALYNNNNR
810 820 830 840 850
MDICVVRKNN LNDIKACGMA IGNQSMVNNP ESYKYLEGKA WKNTGINKTA
860 870 880 890 900
NNTTIAVNLG NNSTPTENGG NTTDLPTNTT NNARFASYAL IKNAPFAHYN
910 920 930 940 950
ATPNLVAINQ HDFGTIESVF ELANRSSDID TLYANSGVQG RDLLQTLLID
960 970 980 990 1000
SHDAGYARTM IDATSANEIT KQLNAATTTL NNIASLDHKT SGLQTLSLSN
1010 1020 1030 1040 1050
AMILNSRLVN LSRRHTNNID SFAKHLQALK GQRFASLESA AEVLYQFAPK
1060 1070 1080 1090 1100
YEKPTNVWAN AIGGASLNNG GNASLYGTSA GVDAYLNGEV EAIVGGFGSY
1110 1120 1130 1140 1150
GYSSFNNQAN SLNSGANNTN FGVYSRIFAN QHEFDFEAQG ALGSDQSSLN
1160 1170 1180 1190 1200
FKSALLQDLN QSYNYLAYSA ATRASYGYDF AFFKNALVLK PSVGVSYNHL
1210 1220 1230 1240 1250
GSTNFKSNST NKVALSNGSS SQHLFNASAN VEARYYYGDT SYFYMNAGVL
1260 1270 1280 1290 1300
QEFANFGSSN AVSLNTFKVN AARNPLNTHA RVMMGGELKL AKEVFLNLGF
1310 1320
VYLHNLISNI GHFASNLGMR YSF
Length:1,323
Mass (Da):142,973
Last modified:November 1, 1998 - v1
Checksum:iE3A8B724C02FA2E3
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U95971 Genomic DNA. Translation: AAC25911.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U95971 Genomic DNA. Translation: AAC25911.1.

3D structure databases

ProteinModelPortaliO87018.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Family and domain databases

Gene3Di2.40.128.130. 1 hit.
InterProiIPR005546. Autotransporte_beta.
IPR006315. OM_autotransptr_brl.
IPR003842. Vacuolating_cytotoxin.
[Graphical view]
PfamiPF03797. Autotransporter. 1 hit.
PF02691. VacA. 1 hit.
[Graphical view]
PRINTSiPR01656. VACCYTOTOXIN.
SMARTiSM00869. Autotransporter. 1 hit.
[Graphical view]
SUPFAMiSSF103515. SSF103515. 1 hit.
TIGRFAMsiTIGR01414. autotrans_barl. 1 hit.
PROSITEiPS51208. AUTOTRANSPORTER. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiO87018_HELPX
AccessioniPrimary (citable) accession number: O87018
Entry historyi
Integrated into UniProtKB/TrEMBL: November 1, 1998
Last sequence update: November 1, 1998
Last modified: October 5, 2016
This is version 45 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.