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Protein
Submitted name:

Alkaline serine protease

Gene
N/A
Organism
Thermobifida fusca (Thermomonospora fusca)
Status
Unreviewed-Annotation score: Annotation score: 1 out of 5-Protein predictedi

Functioni

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei217 – 2171Charge relay systemUniRule annotation
Active sitei241 – 2411Charge relay systemUniRule annotation
Active sitei322 – 3221Charge relay systemUniRule annotation

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, ProteaseImported

Protein family/group databases

MEROPSiS01.470.

Names & Taxonomyi

Protein namesi
Submitted name:
Alkaline serine proteaseImported
OrganismiThermobifida fusca (Thermomonospora fusca)Imported
Taxonomic identifieri2021 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaStreptosporangialesNocardiopsaceaeThermobifida

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 3131Sequence analysisAdd
BLAST
Chaini32 – 368337Sequence analysisPRO_5004160760Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi198 ↔ 218UniRule annotation
Disulfide bondi280 ↔ 290UniRule annotation
Disulfide bondi316 ↔ 343UniRule annotation

Keywords - PTMi

Disulfide bondUniRule annotation

Interactioni

Protein-protein interaction databases

STRINGi269800.Tfu_0484.

Structurei

3D structure databases

ProteinModelPortaliO86984.
SMRiO86984. Positions 183-368.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiO86984.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini112 – 16655Pro_Al_proteaseInterPro annotationAdd
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili43 – 7028Sequence analysisAdd
BLAST

Keywords - Domaini

Coiled coilSequence analysis, SignalSequence analysis

Phylogenomic databases

eggNOGiENOG4106T9R. Bacteria.
ENOG410XQ6H. LUCA.

Family and domain databases

InterProiIPR004236. Pept_S1_alpha_lytic.
IPR001316. Pept_S1A_streptogrisin.
IPR009003. Peptidase_S1_PA.
IPR033116. TRYPSIN_SER.
[Graphical view]
PfamiPF02983. Pro_Al_protease. 1 hit.
[Graphical view]
PIRSFiPIRSF001134. Streptogrisin. 1 hit.
PRINTSiPR00861. ALYTICPTASE.
SUPFAMiSSF50494. SSF50494. 1 hit.
PROSITEiPS00135. TRYPSIN_SER. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O86984-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNHSSRRTTS LLFTAALAAT ALVAATTPAS AQELALKRDL GLSDAEVAEL
60 70 80 90 100
RAAEAEAVEL EEELRDSLGS DFGGVYLDAD TTEITVAVTD PAAVSRVDAD
110 120 130 140 150
DVTVDVVDFG ETALNDFVAS LNAIADTADP KVTGWYTDLE SDAVVITTLR
160 170 180 190 200
GGTPAAEELA ERAGLDERAV RIVEEDEEPQ SLAAIIGGNP YYFGNYRCSI
210 220 230 240 250
GFSVRQGSQT GFATAGHCGS TGTRVSSPSG TVAGSYFPGR DMGWVRITSA
260 270 280 290 300
DTVTPLVNRY NGGTVTVTGS QEAATGSSVC RSGATTGWRC GTIQSKNQTV
310 320 330 340 350
RYAEGTVTGL TRTTACAEGG DSGGPWLTGS QAQGVTSGGT GDCRSGGITF
360
FQPINPLLSY FGLQLVTG
Length:368
Mass (Da):38,032
Last modified:November 1, 1998 - v1
Checksum:i69CBACB8F15B2DEA
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U65895 Genomic DNA. Translation: AAC23545.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U65895 Genomic DNA. Translation: AAC23545.1.

3D structure databases

ProteinModelPortaliO86984.
SMRiO86984. Positions 183-368.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi269800.Tfu_0484.

Protein family/group databases

MEROPSiS01.470.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Phylogenomic databases

eggNOGiENOG4106T9R. Bacteria.
ENOG410XQ6H. LUCA.

Miscellaneous databases

EvolutionaryTraceiO86984.

Family and domain databases

InterProiIPR004236. Pept_S1_alpha_lytic.
IPR001316. Pept_S1A_streptogrisin.
IPR009003. Peptidase_S1_PA.
IPR033116. TRYPSIN_SER.
[Graphical view]
PfamiPF02983. Pro_Al_protease. 1 hit.
[Graphical view]
PIRSFiPIRSF001134. Streptogrisin. 1 hit.
PRINTSiPR00861. ALYTICPTASE.
SUPFAMiSSF50494. SSF50494. 1 hit.
PROSITEiPS00135. TRYPSIN_SER. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Cloning, sequencing, and expression of a Thermomonospora fusca protease gene in Streptomyces lividans."
    Lao G., Wilson D.B.
    Appl. Environ. Microbiol. 62:4256-4259(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: YXImported.
  2. Lao G., Wilson D.B.
    Submitted (JUN-1998) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: YXImported.

Entry informationi

Entry nameiO86984_THEFU
AccessioniPrimary (citable) accession number: O86984
Entry historyi
Integrated into UniProtKB/TrEMBL: November 1, 1998
Last sequence update: November 1, 1998
Last modified: May 11, 2016
This is version 78 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.