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Protein

Probable M18 family aminopeptidase 1

Gene

apeA

Organism
Thermotoga neapolitana
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Cofactori

Zn2+By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi93ZincSequence analysis1
Metal bindingi168ZincSequence analysis1
Metal bindingi427ZincSequence analysis1

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Aminopeptidase, Hydrolase, Metalloprotease, Protease

Keywords - Ligandi

Metal-binding, Zinc

Protein family/group databases

MEROPSiM18.004.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable M18 family aminopeptidase 1 (EC:3.4.11.-)
Gene namesi
Name:apeA
OrganismiThermotoga neapolitana
Taxonomic identifieri2337 [NCBI]
Taxonomic lineageiBacteriaThermotogaeThermotogalesThermotogaceaeThermotoga

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001734591 – 452Probable M18 family aminopeptidase 1Add BLAST452

Structurei

3D structure databases

ProteinModelPortaliO86957.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the peptidase M18 family.Curated

Family and domain databases

Gene3Di2.30.250.10. 1 hit.
HAMAPiMF_00466. Aminopeptidase_M18_1. 1 hit.
InterProiIPR022983. M18_aminopeptidase_1.
IPR001948. Peptidase_M18.
IPR023358. Peptidase_M18_dom2.
[Graphical view]
PfamiPF02127. Peptidase_M18. 1 hit.
[Graphical view]
PRINTSiPR00932. AMINO1PTASE.

Sequencei

Sequence statusi: Complete.

O86957-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKMERKNVWQ HRNREEIESF SKEYMDFMGR AKTERLAVRE IRKFLEKEGF
60 70 80 90 100
VPIEDFAGDP MDMAVYAVNR GKAIAAFRVV DDLKKGLNLV VAHIDSPRLD
110 120 130 140 150
FKPNPLVEDE QIALFKTHYY GGIKKYHWFN IPLEIHGVLF RGDGEEIEIH
160 170 180 190 200
VGDKPEDPVF TIPDLLPHLD KEDAKISEKF KGENLMLIAG TIPLSGEEKE
210 220 230 240 250
AVKMNVLKIL NEMYGISEED FVSGEIEVVP AFPPREVGID RSLIGAYGQD
260 270 280 290 300
DRICAYTALR AFLEANPKKS IGVVFLDKEE IGSDGNTGAK ARFYLRVLRQ
310 320 330 340 350
ILKIQGGPEI QNSHSMRYWK KSAVISGDVC AAVNPPYKDV HDLHNAPRSG
360 370 380 390 400
YGVALVKYTG ARGKYSTNDA HAEFVARVRQ VLNERNVIWQ VATLGKVDQG
410 420 430 440 450
GGGTYAKFFA ERGADVYDMG PALLGMHSPF EISSKADLFE TYRAYRALLE

DL
Length:452
Mass (Da):50,907
Last modified:November 1, 1998 - v1
Checksum:i970EB7DC0F79F051
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ009831 Genomic DNA. Translation: CAA08865.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ009831 Genomic DNA. Translation: CAA08865.1.

3D structure databases

ProteinModelPortaliO86957.
ModBaseiSearch...
MobiDBiSearch...

Protein family/group databases

MEROPSiM18.004.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Family and domain databases

Gene3Di2.30.250.10. 1 hit.
HAMAPiMF_00466. Aminopeptidase_M18_1. 1 hit.
InterProiIPR022983. M18_aminopeptidase_1.
IPR001948. Peptidase_M18.
IPR023358. Peptidase_M18_dom2.
[Graphical view]
PfamiPF02127. Peptidase_M18. 1 hit.
[Graphical view]
PRINTSiPR00932. AMINO1PTASE.
ProtoNetiSearch...

Entry informationi

Entry nameiAPEA_THENE
AccessioniPrimary (citable) accession number: O86957
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 24, 2001
Last sequence update: November 1, 1998
Last modified: October 5, 2016
This is version 65 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Documents

  1. Peptidase families
    Classification of peptidase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.