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Protein

Alanine racemase

Gene

alr

Organism
Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Catalyzes the interconversion of L-alanine and D-alanine. May also act on other amino acids.UniRule annotation

Catalytic activityi

L-alanine = D-alanine.UniRule annotation

Cofactori

pyridoxal 5'-phosphateUniRule annotation

Pathwayi: D-alanine biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes D-alanine from L-alanine.UniRule annotation
Proteins known to be involved in this subpathway in this organism are:
  1. Alanine racemase (alr)
This subpathway is part of the pathway D-alanine biosynthesis, which is itself part of Amino-acid biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes D-alanine from L-alanine, the pathway D-alanine biosynthesis and in Amino-acid biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei46Proton acceptor; specific for D-alanineUniRule annotation1
Binding sitei148SubstrateUniRule annotation1
Active sitei283Proton acceptor; specific for L-alanineUniRule annotation1
Binding sitei331Substrate; via amide nitrogenUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionIsomerase
LigandPyridoxal phosphate

Enzyme and pathway databases

UniPathwayiUPA00042; UER00497.

Names & Taxonomyi

Protein namesi
Recommended name:
Alanine racemaseUniRule annotation (EC:5.1.1.1UniRule annotation)
Gene namesi
Name:alr
Ordered Locus Names:SCO4745
ORF Names:SC6G4.23
OrganismiStreptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)
Taxonomic identifieri100226 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaStreptomycetalesStreptomycetaceaeStreptomycesStreptomyces albidoflavus group
Proteomesi
  • UP000001973 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001145801 – 391Alanine racemaseAdd BLAST391

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei46N6-(pyridoxal phosphate)lysineUniRule annotation1

Interactioni

Protein-protein interaction databases

STRINGi100226.SCO4745.

Structurei

Secondary structure

1391
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi3 – 12Combined sources10
Turni13 – 15Combined sources3
Beta strandi16 – 21Combined sources6
Helixi22 – 35Combined sources14
Beta strandi39 – 44Combined sources6
Helixi46 – 50Combined sources5
Helixi54 – 63Combined sources10
Beta strandi68 – 73Combined sources6
Helixi74 – 81Combined sources8
Beta strandi92 – 95Combined sources4
Helixi104 – 109Combined sources6
Beta strandi113 – 116Combined sources4
Helixi119 – 132Combined sources14
Beta strandi136 – 142Combined sources7
Beta strandi144 – 146Combined sources3
Beta strandi148 – 151Combined sources4
Helixi155 – 169Combined sources15
Beta strandi172 – 179Combined sources8
Helixi191 – 209Combined sources19
Beta strandi215 – 218Combined sources4
Helixi222 – 227Combined sources6
Helixi229 – 231Combined sources3
Helixi239 – 242Combined sources4
Turni249 – 251Combined sources3
Helixi255 – 257Combined sources3
Beta strandi263 – 268Combined sources6
Beta strandi270 – 275Combined sources6
Beta strandi280 – 282Combined sources3
Helixi283 – 285Combined sources3
Beta strandi290 – 299Combined sources10
Helixi302 – 304Combined sources3
Helixi308 – 310Combined sources3
Turni311 – 313Combined sources3
Beta strandi315 – 318Combined sources4
Beta strandi321 – 325Combined sources5
Beta strandi334 – 337Combined sources4
Beta strandi348 – 355Combined sources8
Helixi362 – 368Combined sources7
Helixi373 – 378Combined sources6
Beta strandi386 – 389Combined sources4

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
5FACX-ray2.80A/B/C/D1-391[»]
5FAGX-ray1.51A/B/C/D1-391[»]
5FAJX-ray1.64A/B/C/D1-391[»]
ProteinModelPortaliO86786.
SMRiO86786.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the alanine racemase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105CJ4. Bacteria.
COG0787. LUCA.
HOGENOMiHOG000031444.
InParanoidiO86786.
KOiK01775.
OMAiWEILCGF.
OrthoDBiPOG091H022F.
PhylomeDBiO86786.

Family and domain databases

Gene3Di2.40.37.10. 1 hit.
3.20.20.10. 1 hit.
HAMAPiMF_01201. Ala_racemase. 1 hit.
InterProiView protein in InterPro
IPR000821. Ala_racemase.
IPR009006. Ala_racemase/Decarboxylase_C.
IPR011079. Ala_racemase_C.
IPR001608. Ala_racemase_N.
IPR020622. Ala_racemase_pyridoxalP-BS.
IPR029066. PLP-binding_barrel.
PfamiView protein in Pfam
PF00842. Ala_racemase_C. 1 hit.
PF01168. Ala_racemase_N. 1 hit.
PRINTSiPR00992. ALARACEMASE.
SMARTiView protein in SMART
SM01005. Ala_racemase_C. 1 hit.
SUPFAMiSSF50621. SSF50621. 1 hit.
SSF51419. SSF51419. 1 hit.
TIGRFAMsiTIGR00492. alr. 1 hit.
PROSITEiView protein in PROSITE
PS00395. ALANINE_RACEMASE. 1 hit.

Sequencei

Sequence statusi: Complete.

O86786-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSETTARRDA DAVLRARAEI DLAALRANVR ALRERAPGAA LMAVVKADAY
60 70 80 90 100
GHGAIPCARA AVAAGATWLG TATPQEALAL RAAEPGLPDD VRIMCWLWTP
110 120 130 140 150
GGPWREAVEA RLDVSVSAMW AMEEVTGAAR AAGVPARVQL KADTGLGRGG
160 170 180 190 200
CQPGADWERL VGAALRAEEE GLLRVTGLWS HFACADEPGH PSIAAQLTRF
210 220 230 240 250
REMTAYAEQR GLRPEVRHIA NSPATLTLPD AHFDLVRPGI AMYGVSPSPE
260 270 280 290 300
IGTPADFGLR PVMTLAASLA LVKQVPGGHG VSYGHHYTTP GETTLGLVPL
310 320 330 340 350
GYADGIPRHA SSSGPVLVDG KWRTVAGRIA MDQFVVDLGG DRPEPGAEAV
360 370 380 390
LFGPGDRGEP TAEDWAQAAG TIAYEIVTRI GSRVPRVYVN E
Length:391
Mass (Da):41,200
Last modified:November 1, 1998 - v1
Checksum:i24754AC1385DCA1B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL939121 Genomic DNA. Translation: CAA20401.1.
PIRiT35574.
RefSeqiNP_628903.1. NC_003888.3.
WP_011029835.1. NC_003888.3.

Genome annotation databases

EnsemblBacteriaiCAA20401; CAA20401; CAA20401.
GeneIDi1100186.
KEGGisco:SCO4745.
PATRICifig|100226.15.peg.4817.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Entry informationi

Entry nameiALR_STRCO
AccessioniPrimary (citable) accession number: O86786
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: November 1, 1998
Last modified: June 7, 2017
This is version 118 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families