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Protein

Holo-[acyl-carrier-protein] synthase

Gene

acpS

Organism
Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein.UniRule annotation

Catalytic activityi

CoA-(4'-phosphopantetheine) + apo-[acyl-carrier-protein] = adenosine 3',5'-bisphosphate + holo-[acyl-carrier-protein].UniRule annotation

Cofactori

Mg2+UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi9MagnesiumUniRule annotation1
Metal bindingi57MagnesiumUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionTransferase
Biological processFatty acid biosynthesis, Fatty acid metabolism, Lipid biosynthesis, Lipid metabolism
LigandMagnesium, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Holo-[acyl-carrier-protein] synthaseUniRule annotation (EC:2.7.8.7UniRule annotation)
Short name:
Holo-ACP synthaseUniRule annotation
Alternative name(s):
4'-phosphopantetheinyl transferase AcpSUniRule annotation
Gene namesi
Name:acpSUniRule annotation
Ordered Locus Names:SCO4744
ORF Names:SC6G4.22c
OrganismiStreptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)
Taxonomic identifieri100226 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaStreptomycetalesStreptomycetaceaeStreptomycesStreptomyces albidoflavus group
Proteomesi
  • UP000001973 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001757111 – 123Holo-[acyl-carrier-protein] synthaseAdd BLAST123

Proteomic databases

PRIDEiO86785

Interactioni

Protein-protein interaction databases

STRINGi100226.SCO4744

Structurei

Secondary structure

1123
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi2 – 12Combined sources11
Helixi13 – 22Combined sources10
Helixi26 – 30Combined sources5
Helixi33 – 36Combined sources4
Beta strandi41 – 43Combined sources3
Helixi46 – 62Combined sources17
Helixi71 – 73Combined sources3
Beta strandi74 – 78Combined sources5
Beta strandi84 – 88Combined sources5
Helixi90 – 99Combined sources10
Beta strandi103 – 111Combined sources9
Beta strandi114 – 123Combined sources10

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2JBZX-ray1.62A1-123[»]
2JCAX-ray1.98A/B/C1-123[»]
2WDOX-ray1.56A1-123[»]
2WDSX-ray1.35A1-123[»]
2WDYX-ray1.40A1-123[»]
ProteinModelPortaliO86785
SMRiO86785
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiO86785

Family & Domainsi

Sequence similaritiesi

Belongs to the P-Pant transferase superfamily. AcpS family.UniRule annotation

Phylogenomic databases

eggNOGiENOG41082KK Bacteria
ENOG4111TMY LUCA
HOGENOMiHOG000014315
InParanoidiO86785
KOiK00997
OMAiHLSMSHD
OrthoDBiPOG091H0071

Family and domain databases

Gene3Di3.90.470.20, 1 hit
HAMAPiMF_00101 AcpS, 1 hit
InterProiView protein in InterPro
IPR008278 4-PPantetheinyl_Trfase_dom
IPR037143 4-PPantetheinyl_Trfase_dom_sf
IPR002582 ACPS
IPR004568 Ppantetheine-prot_Trfase_dom
PANTHERiPTHR45198 PTHR45198, 1 hit
PfamiView protein in Pfam
PF01648 ACPS, 1 hit
ProDomiView protein in ProDom or Entries sharing at least one domain
PD004282 PPantethiene-prot_Trfase, 1 hit
SUPFAMiSSF56214 SSF56214, 1 hit
TIGRFAMsiTIGR00516 acpS, 1 hit
TIGR00556 pantethn_trn, 1 hit

Sequencei

Sequence statusi: Complete.

O86785-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSIIGVGIDV AEVERFGAAL ERTPALAGRL FLESELLLPG GERRGVASLA
60 70 80 90 100
ARFAAKEALA KALGAPAGLL WTDAEVWVEA GGRPRLRVTG TVAARAAELG
110 120
VASWHVSLSH DAGIASAVVI AEG
Length:123
Mass (Da):12,566
Last modified:November 1, 1998 - v1
Checksum:iC8301B17E510E56D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL939121 Genomic DNA Translation: CAA20400.1
PIRiT35573
RefSeqiNP_628902.1, NC_003888.3
WP_003974229.1, NC_003888.3

Genome annotation databases

EnsemblBacteriaiCAA20400; CAA20400; CAA20400
GeneIDi1100185
KEGGisco:SCO4744
PATRICifig|100226.15.peg.4816

Similar proteinsi

Entry informationi

Entry nameiACPS_STRCO
AccessioniPrimary (citable) accession number: O86785
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: November 1, 1998
Last modified: May 23, 2018
This is version 116 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

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