O86779 (COAA_STRCO) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Pantothenate kinase
EC=2.7.1.33

Alternative name(s):
Pantothenic acid kinase

Gene names

Name:	coaA
Ordered Locus Names:	SCO4738
ORF Names:	SC6G4.16c

Organism

Streptomyces coelicolor

Taxonomic identifier

1902 [NCBI]

Taxonomic lineage

Bacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Streptomycineae › Streptomycetaceae › Streptomyces

Protein attributes

Sequence length	329 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	ATP + (R)-pantothenate = ADP + (R)-4'-phosphopantothenate. HAMAP MF_00215
Pathway	Cofactor biosynthesis; coenzyme A biosynthesis; CoA from (R)-pantothenate: step 1/5. HAMAP MF_00215
Subcellular location	Cytoplasm Probable HAMAP MF_00215.
Sequence similarities	Belongs to the prokaryotic pantothenate kinase family.

Ontologies

Keywords
Biological process	Coenzyme A biosynthesis
Cellular component	Cytoplasm
Ligand	ATP-binding Nucleotide-binding
Molecular function	Kinase Transferase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	coenzyme A biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW pantothenate kinase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 329	329	Pantothenate kinase HAMAP MF_00215		PRO_0000194452
Regions
	Nucleotide binding	107 – 114	8	ATP Potential

Sequences

	Sequence		Length	Mass (Da)
	O86779 [UniParc]. Last modified November 1, 1998. Version 1. Checksum: 51346F19D82538D1	FASTA	329	37,116
	10 20 30 40 50 60 MISPVPSIPR SAHRQRPEAT PYVDLTRPEW SALRDKTPLP LTAEEVEKLR GLGDVIDLDE 70 80 90 100 110 120 VRDIYLPLSR LLNLYVGATD GLRGALNTFL GEQGSQSGTP FVIGVAGSVA VGKSTVARLL 130 140 150 160 170 180 QALLSRWPEH PRVELVTTDG FLLPTRELEA RGLMSRKGFP ESYDRRALTR FVADIKAGKA 190 200 210 220 230 240 EVTAPVYSHL IYDIVPDQRL VVRRPDILIV EGLNVLQPAL PGKDGRTRVG LADYFDFSVY 250 260 270 280 290 300 VDARTEDIER WYLNRFRKLR ATAFQNPSSY FRKYTQVSEE EALDYARTTW RTINKPNLVE 310 320 NVAPTRGRAT LVLRKGPDHK VQRLSLRKL

References

[1]

"Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2)." Bentley S.D., Chater K.F., Cerdeno-Tarraga A.-M., Challis G.L., Thomson N.R., James K.D., Harris D.E., Quail M.A., Kieser H., Harper D., Bateman A., Brown S., Chandra G., Chen C.W., Collins M., Cronin A., Fraser A., Goble A. , Hidalgo J., Hornsby T., Howarth S., Huang C.-H., Kieser T., Larke L., Murphy L.D., Oliver K., O'Neil S., Rabbinowitsch E., Rajandream M.A., Rutherford K.M., Rutter S., Seeger K., Saunders D., Sharp S., Squares R., Squares S., Taylor K., Warren T., Wietzorrek A., Woodward J.R., Barrell B.G., Parkhill J., Hopwood D.A. Nature 417:141-147(2002) [PubMed: 12000953] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC BAA-471 / A3(2) / M145.

+

Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AL939121 Genomic DNA. Translation: CAA20394.1.
PIR	T35567.
RefSeq	NP_628896.1. NC_003888.3.
3D structure databases
ProteinModelPortal	O86779.
SMR	O86779. Positions 18-329.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	1100179.
GenomeReviews	Gene locus SCO4738 in contig AL645882_GR.
KEGG	sco:SCO4738.
NMPDR	fig|100226.1.peg.4693.
PATRIC	23739298. VBIStrCoe124346_4809.
Phylogenomic databases
HOGENOM	HBG732538.
OMA	EVYLPLS.
PhylomeDB	O86779.
ProtClustDB	PRK05439.
Family and domain databases
HAMAP	MF_00215. Pantothen_kinase_1. [Tree]
InterPro	IPR004566. PanK_bact. IPR006083. PRK/URK. [Graphical view]
KO	K00867.
PANTHER	PTHR10285:SF7. PanK_bact. 1 hit.
Pfam	PF00485. PRK. 1 hit. [Graphical view]
PIRSF	PIRSF000545. Pantothenate_kin. 1 hit.
TIGRFAMs	TIGR00554. PanK_bact. 1 hit.
ProtoNet	Search...

Entry information

Entry name

COAA_STRCO

Accession

Primary (citable) accession number: O86779

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 30, 2000
Last sequence update:	November 1, 1998
Last modified:	January 25, 2012
This is version 76 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program