O86737 (ADDL1_STRCO) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Putative adenosine/adenine deaminase 1
EC=3.5.4.-

Alternative name(s):
Adenosine aminohydrolase 1

Gene names

Ordered Locus Names:	SCO5662
ORF Names:	SC6A9.05

Organism

Streptomyces coelicolor

Taxonomic identifier

1902 [NCBI]

Taxonomic lineage

Bacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Streptomycineae › Streptomycetaceae › Streptomyces

Protein attributes

Sequence length	387 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Putative nucleoside deaminase. May catalyze the hydrolytic deamination of adenosine or some similar substrate and play a role in purine metabolism By similarity.
Cofactor	Binds 1 zinc ion per subunit By similarity.
Sequence similarities	Belongs to the adenosine and AMP deaminases family.

Ontologies

Keywords
Biological process	Nucleotide metabolism
Ligand	Metal-binding Zinc
Molecular function	Hydrolase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	adenine catabolic process Inferred from Biological aspect of Ancestor. Source: RefGenome hypoxanthine salvage Inferred from Biological aspect of Ancestor. Source: RefGenome purine ribonucleoside monophosphate biosynthetic process Inferred from electronic annotation. Source: InterPro
Cellular component	cytosol Inferred from Biological aspect of Ancestor. Source: RefGenome
Molecular function	adenine deaminase activity Inferred from Biological aspect of Ancestor. Source: RefGenome metal ion binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 387	387	Putative adenosine/adenine deaminase 1		PRO_0000194387
Sites
	Active site	247	1	Proton donor By similarity
	Metal binding	61	1	Zinc; catalytic By similarity
	Metal binding	63	1	Zinc; catalytic By similarity
	Metal binding	244	1	Zinc; catalytic By similarity
	Metal binding	325	1	Zinc; catalytic By similarity
	Binding site	63	1	Substrate By similarity
	Binding site	217	1	Substrate; via amide nitrogen and carbonyl oxygen By similarity
	Binding site	326	1	Substrate By similarity
	Site	268	1	Important for catalytic activity By similarity

Sequences

	Sequence		Length	Mass (Da)
	O86737 [UniParc]. Last modified November 1, 1998. Version 1. Checksum: 660F2621C115EA5A	FASTA	387	42,430
	10 20 30 40 50 60 MRPAYDDPRT TDQPITRARP PPRAARGRRL GEEPLTEHLV DPDVPRDLHA FIAGLPKAEL 70 80 90 100 110 120 HVHHVGSASP RIVSELAARH ADSKVPTDPE ALVDYFTFTD FAHFIDVYLS VVDLIRTPED 130 140 150 160 170 180 VRLLTYEVAR DMARQQVRYA ELTITPFSST RRGIDEGAFM DAIEDARKAA EAEFGTVLRW 190 200 210 220 230 240 CFDIPGEAGL ESAEETARLA TDDRLRPEGL VSFGLGGPEI GVARPQFKPY FDRAIAAGLH 250 260 270 280 290 300 SVPHAGETTG PQTVWEALID LRAERIGHGT SSAQDPKLLA HLAERRIPLE VCPTSNIATR 310 320 330 340 350 360 AVRTLDEHPI KEFVRAGVPV TINSDDPPMF GTDLNNEYAV AARLLGLDER GLADLAKNGV 370 380 EASFLDAPGK ARIADEIDTY TAAWLAS

References

[1]

"Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2)." Bentley S.D., Chater K.F., Cerdeno-Tarraga A.-M., Challis G.L., Thomson N.R., James K.D., Harris D.E., Quail M.A., Kieser H., Harper D., Bateman A., Brown S., Chandra G., Chen C.W., Collins M., Cronin A., Fraser A., Goble A. , Hidalgo J., Hornsby T., Howarth S., Huang C.-H., Kieser T., Larke L., Murphy L.D., Oliver K., O'Neil S., Rabbinowitsch E., Rajandream M.A., Rutherford K.M., Rutter S., Seeger K., Saunders D., Sharp S., Squares R., Squares S., Taylor K., Warren T., Wietzorrek A., Woodward J.R., Barrell B.G., Parkhill J., Hopwood D.A. Nature 417:141-147(2002) [PubMed: 12000953] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC BAA-471 / A3(2) / M145.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AL939124 Genomic DNA. Translation: CAA19890.1.
PIR	T35436.
RefSeq	NP_629792.1. NC_003888.3.
3D structure databases
ProteinModelPortal	O86737.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	1101101.
GenomeReviews	Gene locus SCO5662 in contig AL645882_GR.
KEGG	sco:SCO5662.
NMPDR	fig|100226.1.peg.5611.
PATRIC	23741192. VBIStrCoe124346_5747.
Phylogenomic databases
HOGENOM	HBG630382.
OMA	AELHVHH.
PhylomeDB	O86737.
ProtClustDB	PRK09358.
Family and domain databases
InterPro	IPR001365. A/AMP_deaminase_dom. IPR006330. A_deaminase. [Graphical view]
KO	K01488.
Pfam	PF00962. A_deaminase. 1 hit. [Graphical view]
TIGRFAMs	TIGR01430. Aden_deam. 1 hit.
PROSITE	PS00485. A_DEAMINASE. False negative. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

ADDL1_STRCO

Accession

Primary (citable) accession number: O86737

Entry history

Integrated into UniProtKB/Swiss-Prot:	March 5, 2002
Last sequence update:	November 1, 1998
Last modified:	January 25, 2012
This is version 65 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program