Reviewed, UniProtKB/Swiss-Prot O86564 (SDHL_STRCO)

Names and origin

Protein names

Recommended name:
    L-serine dehydratase
      Short name=SDH
    EC=4.3.1.17
Alternative name(s):
    L-serine deaminase
      Short name=L-SD

Gene names

Name:	sdaA
Ordered Locus Names:	SCO5469
ORF Names:	SC2A11.03c

Organism

Streptomyces coelicolor [Complete proteome] [HAMAP]

Taxonomic identifier

1902 [NCBI]

Taxonomic lineage

Bacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Streptomycineae › Streptomycetaceae › Streptomyces

Protein attributes

Sequence length	455 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	L-serine = pyruvate + NH3.
Cofactor	Binds 1 4Fe-4S cluster Probable.
Pathway	Carbohydrate biosynthesis; gluconeogenesis.
Sequence similarities	Belongs to the iron-sulfur dependent L-serine dehydratase family.

Ontologies

Keywords
Biological process	Gluconeogenesis
Ligand	4Fe-4S Iron Iron-sulfur Metal-binding
Molecular function	Lyase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	gluconeogenesis Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	4 iron, 4 sulfur cluster binding Inferred from electronic annotation. Source: UniProtKB-KW L-serine ammonia-lyase activity Inferred from electronic annotation. Source: EC iron ion binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 455	455	L-serine dehydratase		PRO_0000171911

Sequences

	Sequence		Length	Mass (Da)
	O86564-1 [UniParc]. Last modified November 1, 1998. Version 1. Checksum: 3FE9DD03EEC4A526	FASTA	455	48,601
	10 20 30 40 50 60 MAISVFDLFS IGIGPSSSHT VGPMRAARMF ARRLRNEELL DSVASVRVEL YGSLGATGHG 70 80 90 100 110 120 HGTPKAVLLG LEGDSPRTVD VESADDRVET IKSSGRISLL GDHEIAFAYD DDMVLHRRKA 130 140 150 160 170 180 LPYHANGMTL WAYDAEGAEV LTKTYYSVGG GFVVDEDAVG ADRIVLDDTV LKYPFRTGDE 190 200 210 220 230 240 LLRLARETGL SISALMLENE RAWRDEDEIR EGLLEIWRVM RACVDRGMTR EGILPGGLKV 250 260 270 280 290 300 RRRAANTARK LRSEGDPQAL AMEWITLYAM AVNEENAAGG RVVTAPTNGA AGIIPAVLHY 310 320 330 340 350 360 YMNFVPGADE DGVVRFLLAA GAIGMLFKEN ASISGAEVGC QGEVGSACSM AAGALAEVLG 370 380 390 400 410 420 GSPEQVENAA EIGMEHNLGL TCDPVGGLVQ IPCIERNGMA AVKAVTAARM AMRGDGSHKV 430 440 450 SLDKVIKTMK ETGADMSVKY KETARGGLAV NIIEC

References

[1]

"Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2)." Bentley S.D., Chater K.F., Cerdeno-Tarraga A.-M., Challis G.L., Thomson N.R., James K.D., Harris D.E., Quail M.A., Kieser H., Harper D., Bateman A., Brown S., Chandra G., Chen C.W., Collins M., Cronin A., Fraser A., Goble A. , Hidalgo J., Hornsby T., Howarth S., Huang C.-H., Kieser T., Larke L., Murphy L.D., Oliver K., O'Neil S., Rabbinowitsch E., Rajandream M.A., Rutherford K.M., Rutter S., Seeger K., Saunders D., Sharp S., Squares R., Squares S., Taylor K., Warren T., Wietzorrek A., Woodward J.R., Barrell B.G., Parkhill J., Hopwood D.A. Nature 417:141-147(2002) [PubMed: 12000953] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC BAA-471 / A3(2) / M145.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AL939123 Genomic DNA. Translation: CAA20172.1.
PIR	T34749.
RefSeq	NP_629605.1.
3D structure databases
ModBase	Search...
Genome annotation databases
GeneID	1100909.
GenomeReviews	Gene locus SCO5469 in contig AL645882_GR.
KEGG	sco:SCO5469.
NMPDR	fig|100226.1.peg.5421.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	O86564.
OMA	PFVEKEH.
Enzyme and pathway databases
BioCyc	SCOE100226:SCO5469-MON.
BRENDA	4.3.1.17. 1084.
Family and domain databases
InterPro	IPR004644. Fe-S_L-Ser_mono. IPR005130. Ser_deHydtase_asu. IPR005131. Ser_deHydtase_bsu. [Graphical view]
Pfam	PF03313. SDH_alpha. 1 hit. PF03315. SDH_beta. 1 hit. [Graphical view]
TIGRFAMs	TIGR00720. sda_mono. 1 hit.
ProtoNet	Search...

Entry information

Entry name

SDHL_STRCO

Accession

Primary (citable) accession number: O86564

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 15, 1999
Last sequence update:	November 1, 1998
Last modified:	November 3, 2009
This is version 54 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)