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Protein

Urease subunit alpha 2

Gene

ureC2

Organism
Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

Urea + H2O = CO2 + 2 NH3.UniRule annotation

Cofactori

Ni cationUniRule annotationNote: Binds 2 nickel ions per subunit.UniRule annotation

Pathwayi: urea degradation

This protein is involved in step 1 of the subpathway that synthesizes CO(2) and NH(3) from urea (urease route).UniRule annotation
Proteins known to be involved in this subpathway in this organism are:
  1. Urease subunit gamma/beta (ureAB), Urease subunit alpha 1 (ureC1), Urease subunit alpha 2 (ureC2), Urease subunit gamma (ureA), Urease subunit beta (ureB)
This subpathway is part of the pathway urea degradation, which is itself part of Nitrogen metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes CO(2) and NH(3) from urea (urease route), the pathway urea degradation and in Nitrogen metabolism.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi134 – 1341Nickel 1; via tele nitrogenUniRule annotation
Metal bindingi136 – 1361Nickel 1; via tele nitrogenUniRule annotation
Metal bindingi214 – 2141Nickel 1; via carbamate groupUniRule annotation
Metal bindingi214 – 2141Nickel 2; via carbamate groupUniRule annotation
Binding sitei216 – 2161SubstrateUniRule annotation
Metal bindingi243 – 2431Nickel 2; via pros nitrogenUniRule annotation
Metal bindingi269 – 2691Nickel 2; via tele nitrogenUniRule annotation
Active sitei317 – 3171Proton donorUniRule annotation
Metal bindingi357 – 3571Nickel 1UniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Ligandi

Metal-binding, Nickel

Enzyme and pathway databases

UniPathwayiUPA00258; UER00370.

Names & Taxonomyi

Protein namesi
Recommended name:
Urease subunit alpha 2UniRule annotation (EC:3.5.1.5UniRule annotation)
Alternative name(s):
Urea amidohydrolase subunit alpha 2UniRule annotation
Gene namesi
Name:ureC2UniRule annotation
Ordered Locus Names:SCO5526
ORF Names:SC1C2.07
OrganismiStreptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)
Taxonomic identifieri100226 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaStreptomycetalesStreptomycetaceaeStreptomycesStreptomyces albidoflavus group
Proteomesi
  • UP000001973 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 558558Urease subunit alpha 2PRO_0000234188Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei214 – 2141N6-carboxylysineUniRule annotation

Post-translational modificationi

Carbamylation allows a single lysine to coordinate two nickel ions.UniRule annotation

Interactioni

Subunit structurei

May form a heterohexamer of 3 UreC (alpha) and 3 UreAB (gamma/beta) subunits. May also form a heterotrimer of UreA (gamma), UreB (beta) and UreC (alpha) subunits. Three heterotrimers associate to form the active enzyme.UniRule annotation

Protein-protein interaction databases

STRINGi100226.SCO5526.

Structurei

3D structure databases

ProteinModelPortaliO86508.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini129 – 558430UreaseUniRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the urease family.UniRule annotation
Contains 1 urease domain.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105CQM. Bacteria.
COG0804. LUCA.
HOGENOMiHOG000075064.
InParanoidiO86508.
KOiK01428.
OMAiDGLNECL.
OrthoDBiEOG6R87B9.
PhylomeDBiO86508.

Family and domain databases

Gene3Di2.30.40.10. 1 hit.
HAMAPiMF_01953. Urease_alpha.
InterProiIPR006680. Amidohydro-rel.
IPR011059. Metal-dep_hydrolase_composite.
IPR032466. Metal_Hydrolase.
IPR011612. Urease_alpha_N_dom.
IPR005848. Urease_asu.
IPR017951. Urease_asu_c.
IPR029754. Urease_Ni-bd.
[Graphical view]
PfamiPF01979. Amidohydro_1. 1 hit.
PF00449. Urease_alpha. 1 hit.
[Graphical view]
PRINTSiPR01752. UREASE.
SUPFAMiSSF51338. SSF51338. 2 hits.
SSF51556. SSF51556. 2 hits.
PROSITEiPS01120. UREASE_1. 1 hit.
PS51368. UREASE_3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O86508-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTIDPYAYAA AHGPRAGDRL RLGDSGLVIR VESDAQHYGD EFLAGFGKTA
60 70 80 90 100
RDGLHLKAAA VRDTCDVVIS NVVVIDAVQG IRKVSIGIRE GRVHAIGRAG
110 120 130 140 150
NPDTLDGVDV VVGTGTSIVS GEGLIATAGA VDTHVHLLSP RIMEASLASG
160 170 180 190 200
VTTIIGQEFG PVWGVGVNSP WALKHAFGAF DAWPVNIGFL GRGSSSHEAP
210 220 230 240 250
LIEALAEGGA SGFKVHEDMG AHTRALDTAL RVAEEHDVQV ALHSDGLNEC
260 270 280 290 300
LSVEDTLRVL DGRTIHAFHI EGCGGGHVPN VLKMAGVPHV IGSSTNPTLP
310 320 330 340 350
FGRDAVAEHY GMIVSVHDLK TDLPGDAAMA RDRIRAGTMG AEDVLHDLGA
360 370 380 390 400
IGITSSDAQG MGRAGETVRR TFAMAGKMKA QFGAEGDDDN ARVLRYIAKL
410 420 430 440 450
TINPALAHGL AHEVGSIEVG KLADLVLWRP DHFGAKPQLV LKSGFPAYGV
460 470 480 490 500
VGDPNAATDT CEPLVLGPQF GAHGATPAEI SVAFVAQAAL DQGGDTMPTR
510 520 530 540 550
RRRVAVRGTR GIGPADLRLN SRTGAVDVDQ RTGLVTLDGD PLRSEPAESV

SLNRLYFL
Length:558
Mass (Da):58,351
Last modified:November 1, 1998 - v1
Checksum:i77C046B360256324
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL939124 Genomic DNA. Translation: CAA19974.1.
PIRiT29056.
RefSeqiNP_629660.1. NC_003888.3.
WP_011030294.1. NC_003888.3.

Genome annotation databases

EnsemblBacteriaiCAA19974; CAA19974; CAA19974.
GeneIDi1100966.
KEGGisco:SCO5526.
PATRICi23740914. VBIStrCoe124346_5613.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL939124 Genomic DNA. Translation: CAA19974.1.
PIRiT29056.
RefSeqiNP_629660.1. NC_003888.3.
WP_011030294.1. NC_003888.3.

3D structure databases

ProteinModelPortaliO86508.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi100226.SCO5526.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiCAA19974; CAA19974; CAA19974.
GeneIDi1100966.
KEGGisco:SCO5526.
PATRICi23740914. VBIStrCoe124346_5613.

Phylogenomic databases

eggNOGiENOG4105CQM. Bacteria.
COG0804. LUCA.
HOGENOMiHOG000075064.
InParanoidiO86508.
KOiK01428.
OMAiDGLNECL.
OrthoDBiEOG6R87B9.
PhylomeDBiO86508.

Enzyme and pathway databases

UniPathwayiUPA00258; UER00370.

Family and domain databases

Gene3Di2.30.40.10. 1 hit.
HAMAPiMF_01953. Urease_alpha.
InterProiIPR006680. Amidohydro-rel.
IPR011059. Metal-dep_hydrolase_composite.
IPR032466. Metal_Hydrolase.
IPR011612. Urease_alpha_N_dom.
IPR005848. Urease_asu.
IPR017951. Urease_asu_c.
IPR029754. Urease_Ni-bd.
[Graphical view]
PfamiPF01979. Amidohydro_1. 1 hit.
PF00449. Urease_alpha. 1 hit.
[Graphical view]
PRINTSiPR01752. UREASE.
SUPFAMiSSF51338. SSF51338. 2 hits.
SSF51556. SSF51556. 2 hits.
PROSITEiPS01120. UREASE_1. 1 hit.
PS51368. UREASE_3. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC BAA-471 / A3(2) / M145.

Entry informationi

Entry nameiURE12_STRCO
AccessioniPrimary (citable) accession number: O86508
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 2, 2006
Last sequence update: November 1, 1998
Last modified: November 11, 2015
This is version 98 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.