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O86422

- UDG_PSEAE

UniProt

O86422 - UDG_PSEAE

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Protein
UDP-glucose 6-dehydrogenase
Gene
udg, ugd, PA2022
Organism
Pseudomonas aeruginosa (strain ATCC 15692 / PAO1 / 1C / PRS 101 / LMG 12228)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

UDP-glucose + 2 NAD+ + H2O = UDP-glucuronate + 2 NADH.

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei266 – 2661 By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi2 – 1918NAD Reviewed prediction
Add
BLAST

GO - Molecular functioni

  1. NAD binding Source: InterPro
  2. UDP-glucose 6-dehydrogenase activity Source: UniProtKB-EC
Complete GO annotation...

GO - Biological processi

  1. UDP-glucuronate biosynthetic process Source: UniProtKB-UniPathway
  2. lipopolysaccharide biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Ligandi

NAD

Enzyme and pathway databases

UniPathwayiUPA00030.
UPA00038; UER00491.

Names & Taxonomyi

Protein namesi
Recommended name:
UDP-glucose 6-dehydrogenase (EC:1.1.1.22)
Short name:
UDP-Glc dehydrogenase
Short name:
UDP-GlcDH
Short name:
UDPGDH
Gene namesi
Name:udg
Synonyms:ugd
Ordered Locus Names:PA2022
OrganismiPseudomonas aeruginosa (strain ATCC 15692 / PAO1 / 1C / PRS 101 / LMG 12228)
Taxonomic identifieri208964 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPseudomonadalesPseudomonadaceaePseudomonas
ProteomesiUP000002438: Chromosome

Organism-specific databases

PseudoCAPiPA2022.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 453453UDP-glucose 6-dehydrogenase
PRO_0000074049Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi208964.PA2022.

Structurei

3D structure databases

ProteinModelPortaliO86422.
SMRiO86422. Positions 1-443.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG1004.
HOGENOMiHOG000153773.
KOiK00012.
OMAiCVERDRE.
OrthoDBiEOG6ZSP7N.
PhylomeDBiO86422.

Family and domain databases

Gene3Di3.40.50.720. 2 hits.
InterProiIPR008927. 6-PGluconate_DH_C-like.
IPR016040. NAD(P)-bd_dom.
IPR017476. UDP-Glc/GDP-Man.
IPR014027. UDP-Glc/GDP-Man_DH_C.
IPR014026. UDP-Glc/GDP-Man_DH_dimer.
IPR001732. UDP-Glc/GDP-Man_DH_N.
IPR028357. UDPglc_DH_bac.
[Graphical view]
PANTHERiPTHR11374. PTHR11374. 1 hit.
PfamiPF00984. UDPG_MGDP_dh. 1 hit.
PF03720. UDPG_MGDP_dh_C. 1 hit.
PF03721. UDPG_MGDP_dh_N. 1 hit.
[Graphical view]
PIRSFiPIRSF500134. UDPglc_DH_bac. 1 hit.
PIRSF000124. UDPglc_GDPman_dh. 1 hit.
SMARTiSM00984. UDPG_MGDP_dh_C. 1 hit.
[Graphical view]
SUPFAMiSSF48179. SSF48179. 1 hit.
SSF52413. SSF52413. 1 hit.
TIGRFAMsiTIGR03026. NDP-sugDHase. 1 hit.

Sequencei

Sequence statusi: Complete.

O86422-1 [UniParc]FASTAAdd to Basket

« Hide

MRLCVIGAGY VGLVTAACFA EMGNQVRCVE RDRERVARLR RGEMPIYEPG    50
LESILRDQLD AARLTFTASL AEGLADAEVV FIAVGTPCGE DGSADLSHVL 100
AVAEQLGAQL RQACIVVNKS TVPVGTAERV EEIIRLGLAR RRKRFRVAVA 150
SNPEFLKEGS AVDDFRRPDR VIIGSAETQA GETLRQLYAP FLRNHERVLL 200
MGRREAEFSK YAANAFLATK ISFMNEMAGL CALTGVDIED VRRGMGSDKR 250
IGTHFIYAGC GYGGSCFPKD VRALIRSAEQ QGYDSQILRA VEARNARQKE 300
LLFETLGELF QGRWQGRTVA LWGLAFKPGT DDLREAPSLV LLEALLRHGV 350
RVRAHDPVAN AGVAARYPEA VACARLTLHD SPYAAVEGAD ALVLVTEWKQ 400
FRQPDFQKIR GSMRTPLLVD GRNLYAPARM AELGFIYQGI GRPRAGHCKA 450
SAA 453
Length:453
Mass (Da):49,690
Last modified:May 4, 2001 - v2
Checksum:iA8E7954D0D11557D
GO

Sequence cautioni

The sequence CAA09327.1 differs from that shown. Reason: Frameshift at positions 336, 372 and 429.

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti81 – 811F → L in CAA09327. 1 Publication
Sequence conflicti453 – 4531A → R in CAA09327. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AJ010734 Genomic DNA. Translation: CAA09327.1. Frameshift.
AE004091 Genomic DNA. Translation: AAG05410.1.
PIRiH83393.
RefSeqiNP_250712.1. NC_002516.2.

Genome annotation databases

EnsemblBacteriaiAAG05410; AAG05410; PA2022.
GeneIDi879866.
KEGGipae:PA2022.
PATRICi19838453. VBIPseAer58763_2107.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AJ010734 Genomic DNA. Translation: CAA09327.1 . Frameshift.
AE004091 Genomic DNA. Translation: AAG05410.1 .
PIRi H83393.
RefSeqi NP_250712.1. NC_002516.2.

3D structure databases

ProteinModelPortali O86422.
SMRi O86422. Positions 1-443.
ModBasei Search...

Protein-protein interaction databases

STRINGi 208964.PA2022.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAG05410 ; AAG05410 ; PA2022 .
GeneIDi 879866.
KEGGi pae:PA2022.
PATRICi 19838453. VBIPseAer58763_2107.

Organism-specific databases

PseudoCAPi PA2022.

Phylogenomic databases

eggNOGi COG1004.
HOGENOMi HOG000153773.
KOi K00012.
OMAi CVERDRE.
OrthoDBi EOG6ZSP7N.
PhylomeDBi O86422.

Enzyme and pathway databases

UniPathwayi UPA00030 .
UPA00038 ; UER00491 .

Family and domain databases

Gene3Di 3.40.50.720. 2 hits.
InterProi IPR008927. 6-PGluconate_DH_C-like.
IPR016040. NAD(P)-bd_dom.
IPR017476. UDP-Glc/GDP-Man.
IPR014027. UDP-Glc/GDP-Man_DH_C.
IPR014026. UDP-Glc/GDP-Man_DH_dimer.
IPR001732. UDP-Glc/GDP-Man_DH_N.
IPR028357. UDPglc_DH_bac.
[Graphical view ]
PANTHERi PTHR11374. PTHR11374. 1 hit.
Pfami PF00984. UDPG_MGDP_dh. 1 hit.
PF03720. UDPG_MGDP_dh_C. 1 hit.
PF03721. UDPG_MGDP_dh_N. 1 hit.
[Graphical view ]
PIRSFi PIRSF500134. UDPglc_DH_bac. 1 hit.
PIRSF000124. UDPglc_GDPman_dh. 1 hit.
SMARTi SM00984. UDPG_MGDP_dh_C. 1 hit.
[Graphical view ]
SUPFAMi SSF48179. SSF48179. 1 hit.
SSF52413. SSF52413. 1 hit.
TIGRFAMsi TIGR03026. NDP-sugDHase. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Organization of UDP glucose dehydrogenase and UDP glucose pyrophosphorylase gene cluster in Pseudomonas aeruginosa PAO1."
    Peng H.L., Chang J.T., Lee J.H., Chang H.Y.
    Submitted (AUG-1998) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: ATCC 15692 / PAO1 / 1C / PRS 101 / LMG 12228.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 15692 / PAO1 / 1C / PRS 101 / LMG 12228.

Entry informationi

Entry nameiUDG_PSEAE
AccessioniPrimary (citable) accession number: O86422
Secondary accession number(s): Q9I292
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 15, 1998
Last sequence update: May 4, 2001
Last modified: July 9, 2014
This is version 101 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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