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O86422

- UDG_PSEAE

UniProt

O86422 - UDG_PSEAE

Protein

UDP-glucose 6-dehydrogenase

Gene

udg

Organism
Pseudomonas aeruginosa (strain ATCC 15692 / PAO1 / 1C / PRS 101 / LMG 12228)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 102 (01 Oct 2014)
      Sequence version 2 (04 May 2001)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    UDP-glucose + 2 NAD+ + H2O = UDP-glucuronate + 2 NADH.

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei266 – 2661By similarity

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi2 – 1918NADSequence AnalysisAdd
    BLAST

    GO - Molecular functioni

    1. NAD binding Source: InterPro
    2. UDP-glucose 6-dehydrogenase activity Source: UniProtKB-EC

    GO - Biological processi

    1. lipopolysaccharide biosynthetic process Source: UniProtKB-UniPathway
    2. UDP-glucuronate biosynthetic process Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Ligandi

    NAD

    Enzyme and pathway databases

    UniPathwayiUPA00030.
    UPA00038; UER00491.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    UDP-glucose 6-dehydrogenase (EC:1.1.1.22)
    Short name:
    UDP-Glc dehydrogenase
    Short name:
    UDP-GlcDH
    Short name:
    UDPGDH
    Gene namesi
    Name:udg
    Synonyms:ugd
    Ordered Locus Names:PA2022
    OrganismiPseudomonas aeruginosa (strain ATCC 15692 / PAO1 / 1C / PRS 101 / LMG 12228)
    Taxonomic identifieri208964 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPseudomonadalesPseudomonadaceaePseudomonas
    ProteomesiUP000002438: Chromosome

    Organism-specific databases

    PseudoCAPiPA2022.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 453453UDP-glucose 6-dehydrogenasePRO_0000074049Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi208964.PA2022.

    Structurei

    3D structure databases

    ProteinModelPortaliO86422.
    SMRiO86422. Positions 1-443.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Phylogenomic databases

    eggNOGiCOG1004.
    HOGENOMiHOG000153773.
    KOiK00012.
    OMAiCVERDRE.
    OrthoDBiEOG6ZSP7N.
    PhylomeDBiO86422.

    Family and domain databases

    Gene3Di3.40.50.720. 2 hits.
    InterProiIPR008927. 6-PGluconate_DH_C-like.
    IPR016040. NAD(P)-bd_dom.
    IPR017476. UDP-Glc/GDP-Man.
    IPR014027. UDP-Glc/GDP-Man_DH_C.
    IPR014026. UDP-Glc/GDP-Man_DH_dimer.
    IPR001732. UDP-Glc/GDP-Man_DH_N.
    IPR028357. UDPglc_DH_bac.
    [Graphical view]
    PANTHERiPTHR11374. PTHR11374. 1 hit.
    PfamiPF00984. UDPG_MGDP_dh. 1 hit.
    PF03720. UDPG_MGDP_dh_C. 1 hit.
    PF03721. UDPG_MGDP_dh_N. 1 hit.
    [Graphical view]
    PIRSFiPIRSF500134. UDPglc_DH_bac. 1 hit.
    PIRSF000124. UDPglc_GDPman_dh. 1 hit.
    SMARTiSM00984. UDPG_MGDP_dh_C. 1 hit.
    [Graphical view]
    SUPFAMiSSF48179. SSF48179. 1 hit.
    SSF52413. SSF52413. 1 hit.
    TIGRFAMsiTIGR03026. NDP-sugDHase. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    O86422-1 [UniParc]FASTAAdd to Basket

    « Hide

    MRLCVIGAGY VGLVTAACFA EMGNQVRCVE RDRERVARLR RGEMPIYEPG    50
    LESILRDQLD AARLTFTASL AEGLADAEVV FIAVGTPCGE DGSADLSHVL 100
    AVAEQLGAQL RQACIVVNKS TVPVGTAERV EEIIRLGLAR RRKRFRVAVA 150
    SNPEFLKEGS AVDDFRRPDR VIIGSAETQA GETLRQLYAP FLRNHERVLL 200
    MGRREAEFSK YAANAFLATK ISFMNEMAGL CALTGVDIED VRRGMGSDKR 250
    IGTHFIYAGC GYGGSCFPKD VRALIRSAEQ QGYDSQILRA VEARNARQKE 300
    LLFETLGELF QGRWQGRTVA LWGLAFKPGT DDLREAPSLV LLEALLRHGV 350
    RVRAHDPVAN AGVAARYPEA VACARLTLHD SPYAAVEGAD ALVLVTEWKQ 400
    FRQPDFQKIR GSMRTPLLVD GRNLYAPARM AELGFIYQGI GRPRAGHCKA 450
    SAA 453
    Length:453
    Mass (Da):49,690
    Last modified:May 4, 2001 - v2
    Checksum:iA8E7954D0D11557D
    GO

    Sequence cautioni

    The sequence CAA09327.1 differs from that shown. Reason: Frameshift at positions 336, 372 and 429.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti81 – 811F → L in CAA09327. 1 PublicationCurated
    Sequence conflicti453 – 4531A → R in CAA09327. 1 PublicationCurated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AJ010734 Genomic DNA. Translation: CAA09327.1. Frameshift.
    AE004091 Genomic DNA. Translation: AAG05410.1.
    PIRiH83393.
    RefSeqiNP_250712.1. NC_002516.2.

    Genome annotation databases

    EnsemblBacteriaiAAG05410; AAG05410; PA2022.
    GeneIDi879866.
    KEGGipae:PA2022.
    PATRICi19838453. VBIPseAer58763_2107.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AJ010734 Genomic DNA. Translation: CAA09327.1 . Frameshift.
    AE004091 Genomic DNA. Translation: AAG05410.1 .
    PIRi H83393.
    RefSeqi NP_250712.1. NC_002516.2.

    3D structure databases

    ProteinModelPortali O86422.
    SMRi O86422. Positions 1-443.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 208964.PA2022.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAG05410 ; AAG05410 ; PA2022 .
    GeneIDi 879866.
    KEGGi pae:PA2022.
    PATRICi 19838453. VBIPseAer58763_2107.

    Organism-specific databases

    PseudoCAPi PA2022.

    Phylogenomic databases

    eggNOGi COG1004.
    HOGENOMi HOG000153773.
    KOi K00012.
    OMAi CVERDRE.
    OrthoDBi EOG6ZSP7N.
    PhylomeDBi O86422.

    Enzyme and pathway databases

    UniPathwayi UPA00030 .
    UPA00038 ; UER00491 .

    Family and domain databases

    Gene3Di 3.40.50.720. 2 hits.
    InterProi IPR008927. 6-PGluconate_DH_C-like.
    IPR016040. NAD(P)-bd_dom.
    IPR017476. UDP-Glc/GDP-Man.
    IPR014027. UDP-Glc/GDP-Man_DH_C.
    IPR014026. UDP-Glc/GDP-Man_DH_dimer.
    IPR001732. UDP-Glc/GDP-Man_DH_N.
    IPR028357. UDPglc_DH_bac.
    [Graphical view ]
    PANTHERi PTHR11374. PTHR11374. 1 hit.
    Pfami PF00984. UDPG_MGDP_dh. 1 hit.
    PF03720. UDPG_MGDP_dh_C. 1 hit.
    PF03721. UDPG_MGDP_dh_N. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF500134. UDPglc_DH_bac. 1 hit.
    PIRSF000124. UDPglc_GDPman_dh. 1 hit.
    SMARTi SM00984. UDPG_MGDP_dh_C. 1 hit.
    [Graphical view ]
    SUPFAMi SSF48179. SSF48179. 1 hit.
    SSF52413. SSF52413. 1 hit.
    TIGRFAMsi TIGR03026. NDP-sugDHase. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Organization of UDP glucose dehydrogenase and UDP glucose pyrophosphorylase gene cluster in Pseudomonas aeruginosa PAO1."
      Peng H.L., Chang J.T., Lee J.H., Chang H.Y.
      Submitted (AUG-1998) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: ATCC 15692 / PAO1 / 1C / PRS 101 / LMG 12228.
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 15692 / PAO1 / 1C / PRS 101 / LMG 12228.

    Entry informationi

    Entry nameiUDG_PSEAE
    AccessioniPrimary (citable) accession number: O86422
    Secondary accession number(s): Q9I292
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: December 15, 1998
    Last sequence update: May 4, 2001
    Last modified: October 1, 2014
    This is version 102 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3