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O86422 (UDG_PSEAE) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 101. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
UDP-glucose 6-dehydrogenase

Short name=UDP-Glc dehydrogenase
Short name=UDP-GlcDH
Short name=UDPGDH
EC=1.1.1.22
Gene names
Name:udg
Synonyms:ugd
Ordered Locus Names:PA2022
OrganismPseudomonas aeruginosa (strain ATCC 15692 / PAO1 / 1C / PRS 101 / LMG 12228) [Reference proteome] [HAMAP]
Taxonomic identifier208964 [NCBI]
Taxonomic lineageBacteriaProteobacteriaGammaproteobacteriaPseudomonadalesPseudomonadaceaePseudomonas

Protein attributes

Sequence length453 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

UDP-glucose + 2 NAD+ + H2O = UDP-glucuronate + 2 NADH.

Pathway

Nucleotide-sugar biosynthesis; UDP-alpha-D-glucuronate biosynthesis; UDP-alpha-D-glucuronate from UDP-alpha-D-glucose: step 1/1.

Bacterial outer membrane biogenesis; lipopolysaccharide biosynthesis.

Sequence similarities

Belongs to the UDP-glucose/GDP-mannose dehydrogenase family.

Sequence caution

The sequence CAA09327.1 differs from that shown. Reason: Frameshift at positions 336, 372 and 429.

Ontologies

Keywords
   LigandNAD
   Molecular functionOxidoreductase
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processUDP-glucuronate biosynthetic process

Inferred from electronic annotation. Source: UniProtKB-UniPathway

lipopolysaccharide biosynthetic process

Inferred from electronic annotation. Source: UniProtKB-UniPathway

   Molecular_functionNAD binding

Inferred from electronic annotation. Source: InterPro

UDP-glucose 6-dehydrogenase activity

Inferred from electronic annotation. Source: UniProtKB-EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 453453UDP-glucose 6-dehydrogenase
PRO_0000074049

Regions

Nucleotide binding2 – 1918NAD Potential

Sites

Active site2661 By similarity

Experimental info

Sequence conflict811F → L in CAA09327. Ref.1
Sequence conflict4531A → R in CAA09327. Ref.1

Sequences

Sequence LengthMass (Da)Tools
O86422 [UniParc].

Last modified May 4, 2001. Version 2.
Checksum: A8E7954D0D11557D

FASTA45349,690
        10         20         30         40         50         60 
MRLCVIGAGY VGLVTAACFA EMGNQVRCVE RDRERVARLR RGEMPIYEPG LESILRDQLD 

        70         80         90        100        110        120 
AARLTFTASL AEGLADAEVV FIAVGTPCGE DGSADLSHVL AVAEQLGAQL RQACIVVNKS 

       130        140        150        160        170        180 
TVPVGTAERV EEIIRLGLAR RRKRFRVAVA SNPEFLKEGS AVDDFRRPDR VIIGSAETQA 

       190        200        210        220        230        240 
GETLRQLYAP FLRNHERVLL MGRREAEFSK YAANAFLATK ISFMNEMAGL CALTGVDIED 

       250        260        270        280        290        300 
VRRGMGSDKR IGTHFIYAGC GYGGSCFPKD VRALIRSAEQ QGYDSQILRA VEARNARQKE 

       310        320        330        340        350        360 
LLFETLGELF QGRWQGRTVA LWGLAFKPGT DDLREAPSLV LLEALLRHGV RVRAHDPVAN 

       370        380        390        400        410        420 
AGVAARYPEA VACARLTLHD SPYAAVEGAD ALVLVTEWKQ FRQPDFQKIR GSMRTPLLVD 

       430        440        450 
GRNLYAPARM AELGFIYQGI GRPRAGHCKA SAA 

« Hide

References

« Hide 'large scale' references
[1]"Organization of UDP glucose dehydrogenase and UDP glucose pyrophosphorylase gene cluster in Pseudomonas aeruginosa PAO1."
Peng H.L., Chang J.T., Lee J.H., Chang H.Y.
Submitted (AUG-1998) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: ATCC 15692 / PAO1 / 1C / PRS 101 / LMG 12228.
[2]"Complete genome sequence of Pseudomonas aeruginosa PAO1, an opportunistic pathogen."
Stover C.K., Pham X.-Q.T., Erwin A.L., Mizoguchi S.D., Warrener P., Hickey M.J., Brinkman F.S.L., Hufnagle W.O., Kowalik D.J., Lagrou M., Garber R.L., Goltry L., Tolentino E., Westbrock-Wadman S., Yuan Y., Brody L.L., Coulter S.N., Folger K.R. expand/collapse author list , Kas A., Larbig K., Lim R.M., Smith K.A., Spencer D.H., Wong G.K.-S., Wu Z., Paulsen I.T., Reizer J., Saier M.H. Jr., Hancock R.E.W., Lory S., Olson M.V.
Nature 406:959-964(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 15692 / PAO1 / 1C / PRS 101 / LMG 12228.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AJ010734 Genomic DNA. Translation: CAA09327.1. Frameshift.
AE004091 Genomic DNA. Translation: AAG05410.1.
PIRH83393.
RefSeqNP_250712.1. NC_002516.2.

3D structure databases

ProteinModelPortalO86422.
SMRO86422. Positions 1-443.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING208964.PA2022.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAG05410; AAG05410; PA2022.
GeneID879866.
KEGGpae:PA2022.
PATRIC19838453. VBIPseAer58763_2107.

Organism-specific databases

PseudoCAPPA2022.

Phylogenomic databases

eggNOGCOG1004.
HOGENOMHOG000153773.
KOK00012.
OMACVERDRE.
OrthoDBEOG6ZSP7N.
PhylomeDBO86422.

Enzyme and pathway databases

UniPathwayUPA00030.
UPA00038; UER00491.

Family and domain databases

Gene3D3.40.50.720. 2 hits.
InterProIPR008927. 6-PGluconate_DH_C-like.
IPR016040. NAD(P)-bd_dom.
IPR017476. UDP-Glc/GDP-Man.
IPR014027. UDP-Glc/GDP-Man_DH_C.
IPR014026. UDP-Glc/GDP-Man_DH_dimer.
IPR001732. UDP-Glc/GDP-Man_DH_N.
IPR028357. UDPglc_DH_bac.
[Graphical view]
PANTHERPTHR11374. PTHR11374. 1 hit.
PfamPF00984. UDPG_MGDP_dh. 1 hit.
PF03720. UDPG_MGDP_dh_C. 1 hit.
PF03721. UDPG_MGDP_dh_N. 1 hit.
[Graphical view]
PIRSFPIRSF500134. UDPglc_DH_bac. 1 hit.
PIRSF000124. UDPglc_GDPman_dh. 1 hit.
SMARTSM00984. UDPG_MGDP_dh_C. 1 hit.
[Graphical view]
SUPFAMSSF48179. SSF48179. 1 hit.
SSF52413. SSF52413. 1 hit.
TIGRFAMsTIGR03026. NDP-sugDHase. 1 hit.
ProtoNetSearch...

Entry information

Entry nameUDG_PSEAE
AccessionPrimary (citable) accession number: O86422
Secondary accession number(s): Q9I292
Entry history
Integrated into UniProtKB/Swiss-Prot: December 15, 1998
Last sequence update: May 4, 2001
Last modified: July 9, 2014
This is version 101 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways