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Protein

Ornithine carbamoyltransferase, catabolic

Gene

arcB

Organism
Bacillus licheniformis (strain ATCC 14580 / DSM 13 / JCM 2505 / NBRC 12200 / NCIMB 9375 / NRRL NRS-1264 / Gibson 46)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline.By similarity

Catalytic activityi

Carbamoyl phosphate + L-ornithine = phosphate + L-citrulline.

Pathwayi: L-arginine degradation via ADI pathway

This protein is involved in step 2 of the subpathway that synthesizes carbamoyl phosphate from L-arginine.
Proteins known to be involved in the 2 steps of the subpathway in this organism are:
  1. Arginine deiminase (arcA)
  2. Ornithine carbamoyltransferase, catabolic (arcB)
This subpathway is part of the pathway L-arginine degradation via ADI pathway, which is itself part of Amino-acid degradation.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes carbamoyl phosphate from L-arginine, the pathway L-arginine degradation via ADI pathway and in Amino-acid degradation.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei86Carbamoyl phosphateUniRule annotation1
Binding sitei110Carbamoyl phosphateUniRule annotation1
Binding sitei169OrnithineUniRule annotation1
Binding sitei233OrnithineUniRule annotation1
Binding sitei319Carbamoyl phosphateUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionTransferase
Biological processArginine metabolism

Enzyme and pathway databases

UniPathwayiUPA00254; UER00365

Names & Taxonomyi

Protein namesi
Recommended name:
Ornithine carbamoyltransferase, catabolic (EC:2.1.3.3)
Short name:
OTCase
Gene namesi
Name:arcB
Ordered Locus Names:BLi04164, BL01914
OrganismiBacillus licheniformis (strain ATCC 14580 / DSM 13 / JCM 2505 / NBRC 12200 / NCIMB 9375 / NRRL NRS-1264 / Gibson 46)
Taxonomic identifieri279010 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillaceaeBacillus
Proteomesi
  • UP000000606 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001128841 – 335Ornithine carbamoyltransferase, catabolicAdd BLAST335

Interactioni

Protein-protein interaction databases

STRINGi279010.BLi04164

Structurei

3D structure databases

ProteinModelPortaliO86132
SMRiO86132
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni59 – 62Carbamoyl phosphate bindingUniRule annotation4
Regioni137 – 140Carbamoyl phosphate bindingUniRule annotation4
Regioni237 – 238Ornithine bindingUniRule annotation2
Regioni274 – 275Carbamoyl phosphate bindingUniRule annotation2

Sequence similaritiesi

Belongs to the ATCase/OTCase family.Curated

Phylogenomic databases

eggNOGiENOG4105DBV Bacteria
COG0078 LUCA
HOGENOMiHOG000022686
KOiK00611
OMAiKHSKVFD

Family and domain databases

Gene3Di3.40.50.1370, 3 hits
HAMAPiMF_01109 OTCase, 1 hit
InterProiView protein in InterPro
IPR006132 Asp/Orn_carbamoyltranf_P-bd
IPR006130 Asp/Orn_carbamoylTrfase
IPR036901 Asp/Orn_carbamoylTrfase_sf
IPR006131 Asp_carbamoyltransf_Asp/Orn-bd
IPR002292 Orn/put_carbamltrans
IPR024904 OTCase_ArgI
PfamiView protein in Pfam
PF00185 OTCace, 1 hit
PF02729 OTCace_N, 1 hit
PRINTSiPR00100 AOTCASE
PR00102 OTCASE
SUPFAMiSSF53671 SSF53671, 1 hit
TIGRFAMsiTIGR00658 orni_carb_tr, 1 hit
PROSITEiView protein in PROSITE
PS00097 CARBAMOYLTRANSFERASE, 1 hit

Sequencei

Sequence statusi: Complete.

O86132-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNQTINLKGR SYLAEKDFSE EEILYLLDLA QKLKEKKAQG IRHRYLEGKN
60 70 80 90 100
IALLFEKPST RTRCAFTTAC IDLGAHPEYL GKDDIQLGKK ESIEDTAKVL
110 120 130 140 150
GRMFDGIEFR GFEHEKVISL AEHSGVPVWN GLTDLWHPTQ MLADFMTVKE
160 170 180 190 200
HTGRVKGVKL TYIGDGRNNV ANSLLIGGAK VGMDVRICSP QELFPDQDIV
210 220 230 240 250
KMAEAFAEES GGKITVTSDT DKAVSGADVL YTDVWVSMGE EDKFAERIKL
260 270 280 290 300
LKPYQVNMDL VKKTGNDNVI FLHCLPAFHD LHTTYGQNVY EQHGLKEMEV
310 320 330
TDEVFRSKHS KVFDEAENRM HTIKAVMAAT LGDLD
Length:335
Mass (Da):37,659
Last modified:November 1, 1998 - v1
Checksum:iE02ABFE6C227BF16
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y17554 Genomic DNA Translation: CAA76778.1
AE017333 Genomic DNA Translation: AAU42977.1
CP000002 Genomic DNA Translation: AAU25598.1
RefSeqiWP_009329881.1, NC_006322.1

Genome annotation databases

EnsemblBacteriaiAAU25598; AAU25598; BL01914
AAU42977; AAU42977; BLi04164
GeneIDi3029078
KEGGibld:BLi04164
bli:BL01914

Similar proteinsi

Entry informationi

Entry nameiOTCC_BACLD
AccessioniPrimary (citable) accession number: O86132
Secondary accession number(s): Q65D87
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: November 1, 1998
Last modified: March 28, 2018
This is version 120 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health