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Protein

Ornithine carbamoyltransferase, catabolic

Gene

arcB

Organism
Bacillus licheniformis (strain ATCC 14580 / DSM 13 / JCM 2505 / NBRC 12200 / NCIMB 9375 / NRRL NRS-1264 / Gibson 46)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline.By similarity

Catalytic activityi

Carbamoyl phosphate + L-ornithine = phosphate + L-citrulline.

Pathwayi: L-arginine degradation via ADI pathway

This protein is involved in step 2 of the subpathway that synthesizes carbamoyl phosphate from L-arginine.
Proteins known to be involved in the 2 steps of the subpathway in this organism are:
  1. Arginine deiminase (arcA)
  2. Ornithine carbamoyltransferase, catabolic (arcB)
This subpathway is part of the pathway L-arginine degradation via ADI pathway, which is itself part of Amino-acid degradation.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes carbamoyl phosphate from L-arginine, the pathway L-arginine degradation via ADI pathway and in Amino-acid degradation.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei13 – 131Carbamoyl phosphateBy similarity
Binding sitei75 – 751Carbamoyl phosphateBy similarity
Binding sitei86 – 861Carbamoyl phosphateBy similarity
Binding sitei110 – 1101Carbamoyl phosphateBy similarity
Binding sitei169 – 1691OrnithineBy similarity
Binding sitei233 – 2331OrnithineBy similarity
Binding sitei301 – 3011Carbamoyl phosphateBy similarity
Binding sitei319 – 3191Carbamoyl phosphateBy similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Transferase

Keywords - Biological processi

Arginine metabolism

Enzyme and pathway databases

BioCyciBLIC279010:GJ2P-4116-MONOMER.
UniPathwayiUPA00254; UER00365.

Names & Taxonomyi

Protein namesi
Recommended name:
Ornithine carbamoyltransferase, catabolic (EC:2.1.3.3)
Short name:
OTCase
Gene namesi
Name:arcB
Ordered Locus Names:BLi04164, BL01914
OrganismiBacillus licheniformis (strain ATCC 14580 / DSM 13 / JCM 2505 / NBRC 12200 / NCIMB 9375 / NRRL NRS-1264 / Gibson 46)
Taxonomic identifieri279010 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillaceaeBacillus
Proteomesi
  • UP000000606 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 335335Ornithine carbamoyltransferase, catabolicPRO_0000112884Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi279010.BLi04164.

Structurei

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sitei34 – 341Important for structural integrityBy similarity
Sitei150 – 1501Important for structural integrityBy similarity

3D structure databases

ProteinModelPortaliO86132.
SMRiO86132. Positions 5-334.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni59 – 635Carbamoyl phosphate bindingBy similarity
Regioni137 – 1404Carbamoyl phosphate bindingBy similarity
Regioni237 – 2382Ornithine bindingBy similarity
Regioni273 – 2764Carbamoyl phosphate bindingBy similarity

Sequence similaritiesi

Belongs to the ATCase/OTCase family.Curated

Phylogenomic databases

eggNOGiENOG4105DBV. Bacteria.
COG0078. LUCA.
HOGENOMiHOG000022686.
KOiK00611.
OMAiMGMEIRL.

Family and domain databases

Gene3Di3.40.50.1370. 2 hits.
HAMAPiMF_01109. OTCase. 1 hit.
InterProiIPR006132. Asp/Orn_carbamoyltranf_P-bd.
IPR006130. Asp/Orn_carbamoylTrfase.
IPR006131. Asp_carbamoyltransf_Asp/Orn-bd.
IPR002292. Orn/put_carbamltrans.
IPR024904. OTCase_ArgI.
[Graphical view]
PfamiPF00185. OTCace. 1 hit.
PF02729. OTCace_N. 1 hit.
[Graphical view]
PRINTSiPR00100. AOTCASE.
PR00102. OTCASE.
SUPFAMiSSF53671. SSF53671. 1 hit.
TIGRFAMsiTIGR00658. orni_carb_tr. 1 hit.
PROSITEiPS00097. CARBAMOYLTRANSFERASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O86132-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNQTINLKGR SYLAEKDFSE EEILYLLDLA QKLKEKKAQG IRHRYLEGKN
60 70 80 90 100
IALLFEKPST RTRCAFTTAC IDLGAHPEYL GKDDIQLGKK ESIEDTAKVL
110 120 130 140 150
GRMFDGIEFR GFEHEKVISL AEHSGVPVWN GLTDLWHPTQ MLADFMTVKE
160 170 180 190 200
HTGRVKGVKL TYIGDGRNNV ANSLLIGGAK VGMDVRICSP QELFPDQDIV
210 220 230 240 250
KMAEAFAEES GGKITVTSDT DKAVSGADVL YTDVWVSMGE EDKFAERIKL
260 270 280 290 300
LKPYQVNMDL VKKTGNDNVI FLHCLPAFHD LHTTYGQNVY EQHGLKEMEV
310 320 330
TDEVFRSKHS KVFDEAENRM HTIKAVMAAT LGDLD
Length:335
Mass (Da):37,659
Last modified:November 1, 1998 - v1
Checksum:iE02ABFE6C227BF16
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y17554 Genomic DNA. Translation: CAA76778.1.
AE017333 Genomic DNA. Translation: AAU42977.1.
CP000002 Genomic DNA. Translation: AAU25598.1.
RefSeqiWP_009329881.1. NC_006322.1.

Genome annotation databases

EnsemblBacteriaiAAU25598; AAU25598; BL01914.
AAU42977; AAU42977; BLi04164.
GeneIDi3029078.
KEGGibld:BLi04164.
bli:BL01914.
PATRICi18954148. VBIBacLic203714_4249.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y17554 Genomic DNA. Translation: CAA76778.1.
AE017333 Genomic DNA. Translation: AAU42977.1.
CP000002 Genomic DNA. Translation: AAU25598.1.
RefSeqiWP_009329881.1. NC_006322.1.

3D structure databases

ProteinModelPortaliO86132.
SMRiO86132. Positions 5-334.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi279010.BLi04164.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAU25598; AAU25598; BL01914.
AAU42977; AAU42977; BLi04164.
GeneIDi3029078.
KEGGibld:BLi04164.
bli:BL01914.
PATRICi18954148. VBIBacLic203714_4249.

Phylogenomic databases

eggNOGiENOG4105DBV. Bacteria.
COG0078. LUCA.
HOGENOMiHOG000022686.
KOiK00611.
OMAiMGMEIRL.

Enzyme and pathway databases

UniPathwayiUPA00254; UER00365.
BioCyciBLIC279010:GJ2P-4116-MONOMER.

Family and domain databases

Gene3Di3.40.50.1370. 2 hits.
HAMAPiMF_01109. OTCase. 1 hit.
InterProiIPR006132. Asp/Orn_carbamoyltranf_P-bd.
IPR006130. Asp/Orn_carbamoylTrfase.
IPR006131. Asp_carbamoyltransf_Asp/Orn-bd.
IPR002292. Orn/put_carbamltrans.
IPR024904. OTCase_ArgI.
[Graphical view]
PfamiPF00185. OTCace. 1 hit.
PF02729. OTCace_N. 1 hit.
[Graphical view]
PRINTSiPR00100. AOTCASE.
PR00102. OTCASE.
SUPFAMiSSF53671. SSF53671. 1 hit.
TIGRFAMsiTIGR00658. orni_carb_tr. 1 hit.
PROSITEiPS00097. CARBAMOYLTRANSFERASE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiOTCC_BACLD
AccessioniPrimary (citable) accession number: O86132
Secondary accession number(s): Q65D87
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: November 1, 1998
Last modified: September 7, 2016
This is version 112 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.