O86132 (OTCC_BACLD) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Ornithine carbamoyltransferase, catabolic
Short name=OTCase
EC=2.1.3.3

Gene names

Name:	arcB
Ordered Locus Names:	BLi04164, BL01914

Organism

Bacillus licheniformis (strain DSM 13 / ATCC 14580) [Complete proteome] [HAMAP]

Taxonomic identifier

279010 [NCBI]

Taxonomic lineage

Bacteria › Firmicutes › Bacillales › Bacillaceae › Bacillus

Protein attributes

Sequence length	335 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	Carbamoyl phosphate + L-ornithine = phosphate + L-citrulline. HAMAP MF_01109
Pathway	Amino-acid degradation; L-arginine degradation via ADI pathway; carbamoyl phosphate from L-arginine: step 2/2. HAMAP MF_01109
Subcellular location	Cytoplasm Probable HAMAP MF_01109.
Sequence similarities	Belongs to the ATCase/OTCase family.

Ontologies

Keywords
Biological process	Arginine metabolism
Cellular component	Cytoplasm
Molecular function	Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	arginine metabolic process Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	ornithine carbamoyltransferase complex Inferred from electronic annotation. Source: InterPro
Molecular function	amino acid binding Inferred from electronic annotation. Source: InterPro ornithine carbamoyltransferase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 335	335	Ornithine carbamoyltransferase, catabolic HAMAP MF_01109		PRO_0000112884
Regions
	Region	59 – 63	5	Carbamoyl phosphate binding By similarity
	Region	273 – 276	4	Ornithine binding By similarity
Sites
	Binding site	110	1	Carbamoyl phosphate By similarity
	Binding site	137	1	Carbamoyl phosphate By similarity
	Site	34	1	Important for structural integrity By similarity
	Site	150	1	Important for structural integrity By similarity

Sequences

	Sequence		Length	Mass (Da)
	O86132 [UniParc]. Last modified November 1, 1998. Version 1. Checksum: E02ABFE6C227BF16	FASTA	335	37,659
	10 20 30 40 50 60 MNQTINLKGR SYLAEKDFSE EEILYLLDLA QKLKEKKAQG IRHRYLEGKN IALLFEKPST 70 80 90 100 110 120 RTRCAFTTAC IDLGAHPEYL GKDDIQLGKK ESIEDTAKVL GRMFDGIEFR GFEHEKVISL 130 140 150 160 170 180 AEHSGVPVWN GLTDLWHPTQ MLADFMTVKE HTGRVKGVKL TYIGDGRNNV ANSLLIGGAK 190 200 210 220 230 240 VGMDVRICSP QELFPDQDIV KMAEAFAEES GGKITVTSDT DKAVSGADVL YTDVWVSMGE 250 260 270 280 290 300 EDKFAERIKL LKPYQVNMDL VKKTGNDNVI FLHCLPAFHD LHTTYGQNVY EQHGLKEMEV 310 320 330 TDEVFRSKHS KVFDEAENRM HTIKAVMAAT LGDLD

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"The arcABDC gene cluster, encoding the arginine deiminase pathway of Bacillus licheniformis, and its activation by the arginine repressor argR." Maghnouj A., de Sousa Cabral T.F., Stalon V., Vander Wauven C. J. Bacteriol. 180:6468-6475(1998) [PubMed: 9851988] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]	"The complete genome sequence of Bacillus licheniformis DSM13, an organism with great industrial potential." Veith B., Herzberg C., Steckel S., Feesche J., Maurer K.H., Ehrenreich P., Baeumer S., Henne A., Liesegang H., Merkl R., Ehrenreich A., Gottschalk G. J. Mol. Microbiol. Biotechnol. 7:204-211(2004) [PubMed: 15383718] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: DSM 13 / ATCC 14580.
[3]	"Complete genome sequence of the industrial bacterium Bacillus licheniformis and comparisons with closely related Bacillus species." Rey M.W., Ramaiya P., Nelson B.A., Brody-Karpin S.D., Zaretsky E.J., Tang M., Lopez de Leon A., Xiang H., Gusti V., Clausen I.G., Olsen P.B., Rasmussen M.D., Andersen J.T., Joergensen P.L., Larsen T.S., Sorokin A., Bolotin A., Lapidus A. , Galleron N., Ehrlich S.D., Berka R.M. Genome Biol. 5:R77.1-R77.12(2004) [PubMed: 15461803] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: DSM 13 / ATCC 14580.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	Y17554 Genomic DNA. Translation: CAA76778.1. AE017333 Genomic DNA. Translation: AAU42977.1. CP000002 Genomic DNA. Translation: AAU25598.1.
RefSeq	YP_081236.1. NC_006270.3. YP_093670.1. NC_006322.1.
3D structure databases
ProteinModelPortal	O86132.
SMR	O86132. Positions 5-334.
ModBase	Search...
Protein-protein interaction databases
STRING	O86132.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	EBBACT00000054849; EBBACP00000053380; EBBACG00000054840. EBBACT00000062225; EBBACP00000060658; EBBACG00000062216.
GeneID	3029078. 3099318.
GenomeReviews	Gene locus BLi04164 in contig AE017333_GR. Gene locus BL01914 in contig CP000002_GR.
KEGG	bld:BLi04164. bli:BL01914.
NMPDR	fig|279010.5.peg.2954.
PATRIC	18954148. VBIBacLic203714_4249.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0078.
GeneTree	EBGT00050000002562.
HOGENOM	HBG579429.
OMA	VRICTPE.
PhylomeDB	O86132.
ProtClustDB	PRK02102.
Enzyme and pathway databases
BioCyc	BLIC279010-1:BLI04164-MONOMER. BLIC279010:BL01914-MONOMER.
Family and domain databases
HAMAP	MF_01109. OTCase. [Tree]
InterPro	IPR006132. Asp/Orn_carbamoyltranf_P-bd. IPR006130. Asp/Orn_carbamoylTrfase. IPR006131. Asp_carbamoyltransf_Asp/Orn-bd. IPR002292. Orn/put_carbamltrans. IPR024904. Orn_carbamltrans. [Graphical view]
KO	K00611.
Pfam	PF00185. OTCace. 1 hit. PF02729. OTCace_N. 1 hit. [Graphical view]
PRINTS	PR00100. AOTCASE. PR00102. OTCASE.
SUPFAM	SSF53671. Asp/Orn_carbamoyltranf. 1 hit.
TIGRFAMs	TIGR00658. Orni_carb_tr. 1 hit.
PROSITE	PS00097. CARBAMOYLTRANSFERASE. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

OTCC_BACLD

Accession

Primary (citable) accession number: O86132
Secondary accession number(s): Q65D87

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 30, 2000
Last sequence update:	November 1, 1998
Last modified:	January 25, 2012
This is version 82 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program