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Protein

Arginine deiminase

Gene

arcA

Organism
Bacillus licheniformis (strain ATCC 14580 / DSM 13 / JCM 2505 / NBRC 12200 / NCIMB 9375 / NRRL NRS-1264 / Gibson 46)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

L-arginine + H2O = L-citrulline + NH3.

Pathwayi: L-arginine degradation via ADI pathway

This protein is involved in step 1 of the subpathway that synthesizes carbamoyl phosphate from L-arginine.
Proteins known to be involved in the 2 steps of the subpathway in this organism are:
  1. Arginine deiminase (arcA)
  2. Ornithine carbamoyltransferase, catabolic (arcB)
This subpathway is part of the pathway L-arginine degradation via ADI pathway, which is itself part of Amino-acid degradation.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes carbamoyl phosphate from L-arginine, the pathway L-arginine degradation via ADI pathway and in Amino-acid degradation.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei402 – 4021Amidino-cysteine intermediateBy similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Biological processi

Arginine metabolism

Enzyme and pathway databases

BioCyciBLIC279010:GJ2P-4115-MONOMER.
UniPathwayiUPA00254; UER00364.

Names & Taxonomyi

Protein namesi
Recommended name:
Arginine deiminase (EC:3.5.3.6)
Short name:
ADI
Alternative name(s):
Arginine dihydrolase
Short name:
AD
Gene namesi
Name:arcA
Ordered Locus Names:BLi04163, BL01912
OrganismiBacillus licheniformis (strain ATCC 14580 / DSM 13 / JCM 2505 / NBRC 12200 / NCIMB 9375 / NRRL NRS-1264 / Gibson 46)
Taxonomic identifieri279010 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillaceaeBacillus
Proteomesi
  • UP000000606 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 413413Arginine deiminasePRO_0000182201Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi279010.BLi04163.

Structurei

3D structure databases

ProteinModelPortaliO86131.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the arginine deiminase family.Curated

Phylogenomic databases

eggNOGiENOG4105CEU. Bacteria.
COG2235. LUCA.
HOGENOMiHOG000284535.
KOiK01478.
OMAiLMHLDTW.
OrthoDBiEOG65J52D.

Family and domain databases

HAMAPiMF_00242. Arg_deiminase.
InterProiIPR003876. Arg_deiminase.
IPR033199. DDAH/AD.
[Graphical view]
PANTHERiPTHR12737. PTHR12737. 3 hits.
PIRSFiPIRSF006356. Arg_deiminase. 1 hit.
PRINTSiPR01466. ARGDEIMINASE.
TIGRFAMsiTIGR01078. arcA. 1 hit.

Sequencei

Sequence statusi: Complete.

O86131-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MIMTTPIHVY SEIGPLKTVM LKRPGRELEN LTPEYLERLL FDDIPFLPAV
60 70 80 90 100
QKEHDQFAET LKQQGAEVLY LEKLTAEALD DALVREQFID ELLTESKADI
110 120 130 140 150
NGAYDRLKEF LLTFDADSMV EQVMSGIRKN ELEREKKSHL HELMEDHYPF
160 170 180 190 200
YLDPMPNLYF TRDPAAAIGS GLTINKMKEP ARRRESLFMR YIINHHPRFK
210 220 230 240 250
GHEIPVWLDR DFKFNIEGGD ELVLNEETVA IGVSERTTAQ AIERLVRNLF
260 270 280 290 300
QRQSRIRRVL AVEIPKSRAF MHLDTVFTMV DRDQFTIHPA IQGPEGDMRI
310 320 330 340 350
FVLERGKTAD EIHTTEEHNL PEVLKRTLGL SDVNLIFCGG GDEIASAREQ
360 370 380 390 400
WNDGSNTLAI APGVVVTYDR NYISNECLRE QGIKVIEIPS GELSRGRGGP
410
RCMSMPLYRE DVK
Length:413
Mass (Da):47,427
Last modified:November 1, 1998 - v1
Checksum:i57BB97714CAA5480
GO

Sequence cautioni

The sequence AAU25597.1 differs from that shown. Reason: Erroneous initiation. Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y17554 Genomic DNA. Translation: CAA76777.1.
AE017333 Genomic DNA. Translation: AAU42976.1.
CP000002 Genomic DNA. Translation: AAU25597.1. Different initiation.

Genome annotation databases

EnsemblBacteriaiAAU25597; AAU25597; BL01912.
AAU42976; AAU42976; BLi04163.
KEGGibld:BLi04163.
bli:BL01912.
PATRICi18954146. VBIBacLic203714_4248.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y17554 Genomic DNA. Translation: CAA76777.1.
AE017333 Genomic DNA. Translation: AAU42976.1.
CP000002 Genomic DNA. Translation: AAU25597.1. Different initiation.

3D structure databases

ProteinModelPortaliO86131.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi279010.BLi04163.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAU25597; AAU25597; BL01912.
AAU42976; AAU42976; BLi04163.
KEGGibld:BLi04163.
bli:BL01912.
PATRICi18954146. VBIBacLic203714_4248.

Phylogenomic databases

eggNOGiENOG4105CEU. Bacteria.
COG2235. LUCA.
HOGENOMiHOG000284535.
KOiK01478.
OMAiLMHLDTW.
OrthoDBiEOG65J52D.

Enzyme and pathway databases

UniPathwayiUPA00254; UER00364.
BioCyciBLIC279010:GJ2P-4115-MONOMER.

Family and domain databases

HAMAPiMF_00242. Arg_deiminase.
InterProiIPR003876. Arg_deiminase.
IPR033199. DDAH/AD.
[Graphical view]
PANTHERiPTHR12737. PTHR12737. 3 hits.
PIRSFiPIRSF006356. Arg_deiminase. 1 hit.
PRINTSiPR01466. ARGDEIMINASE.
TIGRFAMsiTIGR01078. arcA. 1 hit.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "The arcABDC gene cluster, encoding the arginine deiminase pathway of Bacillus licheniformis, and its activation by the arginine repressor argR."
    Maghnouj A., de Sousa Cabral T.F., Stalon V., Vander Wauven C.
    J. Bacteriol. 180:6468-6475(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. "The complete genome sequence of Bacillus licheniformis DSM13, an organism with great industrial potential."
    Veith B., Herzberg C., Steckel S., Feesche J., Maurer K.H., Ehrenreich P., Baeumer S., Henne A., Liesegang H., Merkl R., Ehrenreich A., Gottschalk G.
    J. Mol. Microbiol. Biotechnol. 7:204-211(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 14580 / DSM 13 / JCM 2505 / NBRC 12200 / NCIMB 9375 / NRRL NRS-1264 / Gibson 46.
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 14580 / DSM 13 / JCM 2505 / NBRC 12200 / NCIMB 9375 / NRRL NRS-1264 / Gibson 46.

Entry informationi

Entry nameiARCA_BACLD
AccessioniPrimary (citable) accession number: O86131
Secondary accession number(s): Q62NR4, Q65D88
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: November 1, 1998
Last modified: May 11, 2016
This is version 99 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.