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Protein

D-beta-hydroxybutyrate dehydrogenase

Gene

bdhA

Organism
Rhizobium meliloti (strain 1021) (Ensifer meliloti) (Sinorhizobium meliloti)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Catalytic activityi

(R)-3-hydroxybutanoate + NAD+ = acetoacetate + NADH.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei140SubstrateBy similarity1
Active sitei153Proton acceptorPROSITE-ProRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi6 – 30NADBy similarityAdd BLAST25

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Ligandi

NAD

Names & Taxonomyi

Protein namesi
Recommended name:
D-beta-hydroxybutyrate dehydrogenase (EC:1.1.1.30)
Short name:
BDH
Alternative name(s):
3-hydroxybutyrate dehydrogenase
Short name:
3-HBDH
Gene namesi
Name:bdhA
Ordered Locus Names:RB1136
ORF Names:SMb21010
Encoded oniPlasmid pSymB (megaplasmid 2)0 Publication
OrganismiRhizobium meliloti (strain 1021) (Ensifer meliloti) (Sinorhizobium meliloti)
Taxonomic identifieri266834 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesRhizobiaceaeSinorhizobium/Ensifer groupSinorhizobium
Proteomesi
  • UP000001976 Componenti: Plasmid pSymB

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000545281 – 258D-beta-hydroxybutyrate dehydrogenaseAdd BLAST258

Structurei

Secondary structure

1258
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi4 – 8Combined sources5
Helixi13 – 24Combined sources12
Beta strandi28 – 32Combined sources5
Helixi37 – 48Combined sources12
Beta strandi55 – 58Combined sources4
Helixi65 – 78Combined sources14
Beta strandi79 – 81Combined sources3
Beta strandi83 – 87Combined sources5
Helixi97 – 99Combined sources3
Helixi102 – 112Combined sources11
Helixi114 – 130Combined sources17
Beta strandi133 – 138Combined sources6
Helixi141 – 143Combined sources3
Helixi151 – 171Combined sources21
Helixi172 – 174Combined sources3
Beta strandi176 – 183Combined sources8
Helixi226 – 237Combined sources12
Helixi240 – 243Combined sources4
Beta strandi248 – 252Combined sources5
Helixi255 – 257Combined sources3

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3V2HX-ray3.00A/B1-258[»]
ProteinModelPortaliO86034.
SMRiO86034.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

KOiK00019.
OMAiESMSKGR.

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
InterProiIPR011294. 3-OHbutyrate_DH.
IPR016040. NAD(P)-bd_dom.
IPR020904. Sc_DH/Rdtase_CS.
IPR002347. SDR_fam.
[Graphical view]
PANTHERiPTHR24322. PTHR24322. 2 hits.
PRINTSiPR00081. GDHRDH.
PR00080. SDRFAMILY.
SUPFAMiSSF51735. SSF51735. 1 hit.
TIGRFAMsiTIGR01963. PHB_DH. 1 hit.
PROSITEiPS00061. ADH_SHORT. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O86034-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTKTAVITGS TSGIGLAIAR TLAKAGANIV LNGFGAPDEI RTVTDEVAGL
60 70 80 90 100
SSGTVLHHPA DMTKPSEIAD MMAMVADRFG GADILVNNAG VQFVEKIEDF
110 120 130 140 150
PVEQWDRIIA VNLSSSFHTI RGAIPPMKKK GWGRIINIAS AHGLVASPFK
160 170 180 190 200
SAYVAAKHGI MGLTKTVALE VAESGVTVNS ICPGYVLTPL VEKQIPDQAR
210 220 230 240 250
TRGITEEQVI NEVMLKGQPT KKFITVEQVA SLALYLAGDD AAQITGTHVS

MDGGWTAQ
Length:258
Mass (Da):27,179
Last modified:November 1, 1998 - v1
Checksum:iACE9D388A4F0D0BA
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF080548 Genomic DNA. Translation: AAD12733.1.
AL591985 Genomic DNA. Translation: CAC49536.1.
PIRiH95983.
RefSeqiNP_437676.1. NC_003078.1.
WP_010975968.1. NC_003078.1.

Genome annotation databases

EnsemblBacteriaiCAC49536; CAC49536; SM_b21010.
GeneIDi1237467.
KEGGisme:SM_b21010.
PATRICi23638688. VBISinMel96828_6065.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF080548 Genomic DNA. Translation: AAD12733.1.
AL591985 Genomic DNA. Translation: CAC49536.1.
PIRiH95983.
RefSeqiNP_437676.1. NC_003078.1.
WP_010975968.1. NC_003078.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3V2HX-ray3.00A/B1-258[»]
ProteinModelPortaliO86034.
SMRiO86034.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiCAC49536; CAC49536; SM_b21010.
GeneIDi1237467.
KEGGisme:SM_b21010.
PATRICi23638688. VBISinMel96828_6065.

Phylogenomic databases

KOiK00019.
OMAiESMSKGR.

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
InterProiIPR011294. 3-OHbutyrate_DH.
IPR016040. NAD(P)-bd_dom.
IPR020904. Sc_DH/Rdtase_CS.
IPR002347. SDR_fam.
[Graphical view]
PANTHERiPTHR24322. PTHR24322. 2 hits.
PRINTSiPR00081. GDHRDH.
PR00080. SDRFAMILY.
SUPFAMiSSF51735. SSF51735. 1 hit.
TIGRFAMsiTIGR01963. PHB_DH. 1 hit.
PROSITEiPS00061. ADH_SHORT. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiBDHA_RHIME
AccessioniPrimary (citable) accession number: O86034
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: November 1, 1998
Last modified: November 2, 2016
This is version 105 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Plasmid, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.