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O85978 (ACDH_SPHAR) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 55. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Acetaldehyde dehydrogenase

EC=1.2.1.10
Alternative name(s):
Acetaldehyde dehydrogenase [acetylating]
Gene names
Name:xylQ
Encoded onPlasmid pNL1
OrganismSphingomonas aromaticivorans
Taxonomic identifier48935 [NCBI]
Taxonomic lineageBacteriaProteobacteriaAlphaproteobacteriaSphingomonadalesSphingomonadaceaeNovosphingobium

Protein attributes

Sequence length312 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the conversion of acetaldehyde to acetyl-CoA, using NAD+ and coenzyme A. Is the final enzyme in the meta-cleavage pathway for the degradation of aromatic compounds By similarity. HAMAP-Rule MF_01657

Catalytic activity

Acetaldehyde + CoA + NAD+ = acetyl-CoA + NADH. HAMAP-Rule MF_01657

Sequence similarities

Belongs to the acetaldehyde dehydrogenase family.

Ontologies

Keywords
   Biological processAromatic hydrocarbons catabolism
   LigandNAD
   Molecular functionOxidoreductase
   Technical termPlasmid
Gene Ontology (GO)
   Biological_processaromatic compound catabolic process

Inferred from electronic annotation. Source: UniProtKB-HAMAP

   Molecular_functionNAD binding

Inferred from electronic annotation. Source: UniProtKB-HAMAP

acetaldehyde dehydrogenase (acetylating) activity

Inferred from electronic annotation. Source: UniProtKB-HAMAP

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 312312Acetaldehyde dehydrogenase HAMAP-Rule MF_01657
PRO_0000387742

Regions

Nucleotide binding11 – 144NAD By similarity
Nucleotide binding160 – 1689NAD By similarity

Sites

Active site1291Acyl-thioester intermediate By similarity
Binding site2871NAD By similarity

Sequences

Sequence LengthMass (Da)Tools
O85978 [UniParc].

Last modified November 1, 1998. Version 1.
Checksum: 5E4C8274051EA8CF

FASTA31232,847
        10         20         30         40         50         60 
MAKMKCAIIG SGNIGTDLMI KLLKGSDTLE LAAVVGIDPA SEGLAMASER GVPTTHEGIE 

        70         80         90        100        110        120 
GLCRMPQYAD IGIAFDATSA YAHKAHDEIL ARDGKLMVDL TPAAIGPATI PPVNPAVDAA 

       130        140        150        160        170        180 
VRNINMVTCG GQATIPIVAA VSQVAKVHYA EIVASVSSRS AGPGTRANID EFTRTTARAI 

       190        200        210        220        230        240 
ETVGGAAKGR AVIILNPAEP PMIMRDTIFT LSEMVDEDKV RDSVLAMIAR VQSYVPGYRL 

       250        260        270        280        290        300 
KQEVQFERFG SNRPLKIPGY GEFEGLKTSV FLEVEGAGDY LPNYSGNLDI MTAAAKAAGE 

       310 
SLAKTHMEKT AA 

« Hide

References

[1]"Complete sequence of a 184-kilobase catabolic plasmid from Sphingomonas aromaticivorans F199."
Romine M.F., Stillwell L.C., Wong K.-K., Thurston S.J., Sisk E.C., Sensen C., Gaasterland T., Fredrickson J.K., Saffer J.D.
J. Bacteriol. 181:1585-1602(1999) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: F199.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF079317 Genomic DNA. Translation: AAD03994.1.
PIRT31270.
RefSeqNP_049198.1. NC_002033.1.

3D structure databases

ProteinModelPortalO85978.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID1238506.

Phylogenomic databases

ProtClustDBPRK08300.

Family and domain databases

Gene3D3.40.50.720. 1 hit.
HAMAPMF_01657. Ac_ald_DH_ac.
InterProIPR003361. Acetaldehyde_dehydrogenase.
IPR015426. Acetylaldehyde_DH_C.
IPR016040. NAD(P)-bd_dom.
IPR000534. Semialdehyde_DH_NAD-bd.
[Graphical view]
PfamPF09290. AcetDehyd-dimer. 1 hit.
PF01118. Semialdhyde_dh. 1 hit.
[Graphical view]
PIRSFPIRSF015689. Actaldh_dh_actl. 1 hit.
SMARTSM00859. Semialdhyde_dh. 1 hit.
[Graphical view]
TIGRFAMsTIGR03215. ac_ald_DH_ac. 1 hit.
ProtoNetSearch...

Entry information

Entry nameACDH_SPHAR
AccessionPrimary (citable) accession number: O85978
Entry history
Integrated into UniProtKB/Swiss-Prot: November 3, 2009
Last sequence update: November 1, 1998
Last modified: February 19, 2014
This is version 55 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families