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O85786

- THID_SYNE7

UniProt

O85786 - THID_SYNE7

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Protein

Hydroxymethylpyrimidine/phosphomethylpyrimidine kinase

Gene

thiD

Organism
Synechococcus elongatus (strain PCC 7942) (Anacystis nidulans R2)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Catalyzes the phosphorylation of hydroxymethylpyrimidine phosphate (HMP-P) to HMP-PP, and of HMP to HMP-P.By similarity

Catalytic activityi

ATP + 4-amino-5-hydroxymethyl-2-methylpyrimidine = ADP + 4-amino-5-phosphonooxymethyl-2-methylpyrimidine.
ATP + 4-amino-2-methyl-5-phosphomethylpyrimidine = ADP + 4-amino-2-methyl-5-diphosphomethylpyrimidine.

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei44 – 441SubstrateBy similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. hydroxymethylpyrimidine kinase activity Source: UniProtKB-EC
  3. phosphomethylpyrimidine kinase activity Source: UniProtKB-EC

GO - Biological processi

  1. thiamine biosynthetic process Source: UniProtKB-KW
  2. thiamine diphosphate biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Transferase

Keywords - Biological processi

Thiamine biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciSYNEL:SYNPCC7942_2379-MONOMER.
UniPathwayiUPA00060; UER00137.
UPA00060; UER00138.

Names & Taxonomyi

Protein namesi
Recommended name:
Hydroxymethylpyrimidine/phosphomethylpyrimidine kinase (EC:2.7.1.49, EC:2.7.4.7)
Alternative name(s):
Hydroxymethylpyrimidine kinase
Short name:
HMP kinase
Hydroxymethylpyrimidine phosphate kinase
Short name:
HMP-P kinase
Short name:
HMP-phosphate kinase
Short name:
HMPP kinase
Gene namesi
Name:thiD
Ordered Locus Names:Synpcc7942_2379
OrganismiSynechococcus elongatus (strain PCC 7942) (Anacystis nidulans R2)
Taxonomic identifieri1140 [NCBI]
Taxonomic lineageiBacteriaCyanobacteriaOscillatoriophycideaeChroococcalesSynechococcus
ProteomesiUP000002717: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 263263Hydroxymethylpyrimidine/phosphomethylpyrimidine kinasePRO_0000192036Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi1140.Synpcc7942_2379.

Structurei

3D structure databases

ProteinModelPortaliO85786.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the ThiD family.Curated

Phylogenomic databases

eggNOGiCOG0351.
HOGENOMiHOG000225273.
KOiK00941.
OrthoDBiEOG6XWV53.

Family and domain databases

Gene3Di3.40.1190.20. 1 hit.
InterProiIPR004399. HMP/HMP-P_kinase.
IPR013749. PM/HMP-P_kinase-1.
IPR029056. Ribokinase-like.
[Graphical view]
PfamiPF08543. Phos_pyr_kin. 1 hit.
[Graphical view]
SUPFAMiSSF53613. SSF53613. 1 hit.
TIGRFAMsiTIGR00097. HMP-P_kinase. 1 hit.

Sequencei

Sequence statusi: Complete.

O85786-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MAVPIALTIA GSDSGGGAGI QADLRTFAFH QVHGTCAITC VTAQNTLGVT
60 70 80 90 100
RVDAIAPAGV AAQLDAVLSD LPPQALKTGM LLNAEIMEVV AGTIAPLFIP
110 120 130 140 150
RIIDPVMVSR TGAVLIDQAA IAVLRDHLLP LATVLTPNRY EAQLLAGMDI
160 170 180 190 200
QDAADLDRAA RIIRDLGPQA VLIKGGAATG DWHGVDWWWD GQQSHILKTE
210 220 230 240 250
AIATPHTHGS GCTLAAAIAA NAALGLEILA AAQAAKHYVT KALRHSLAIG
260
QGQGPLGHFY PLF
Length:263
Mass (Da):27,251
Last modified:April 18, 2006 - v2
Checksum:iA530A3F53A2DC46A
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti243 – 2431L → F in AAC26228. 1 PublicationCurated
Sequence conflicti247 – 2471L → F in AAC26228. 1 PublicationCurated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF076530 Genomic DNA. Translation: AAC26228.1.
CP000100 Genomic DNA. Translation: ABB58409.1.
PIRiT51093.
RefSeqiYP_401396.1. NC_007604.1.

Genome annotation databases

EnsemblBacteriaiABB58409; ABB58409; Synpcc7942_2379.
GeneIDi3774662.
KEGGisyf:Synpcc7942_2379.
PATRICi23790315. VBISynElo51371_2672.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF076530 Genomic DNA. Translation: AAC26228.1 .
CP000100 Genomic DNA. Translation: ABB58409.1 .
PIRi T51093.
RefSeqi YP_401396.1. NC_007604.1.

3D structure databases

ProteinModelPortali O85786.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 1140.Synpcc7942_2379.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABB58409 ; ABB58409 ; Synpcc7942_2379 .
GeneIDi 3774662.
KEGGi syf:Synpcc7942_2379.
PATRICi 23790315. VBISynElo51371_2672.

Phylogenomic databases

eggNOGi COG0351.
HOGENOMi HOG000225273.
KOi K00941.
OrthoDBi EOG6XWV53.

Enzyme and pathway databases

UniPathwayi UPA00060 ; UER00137 .
UPA00060 ; UER00138 .
BioCyci SYNEL:SYNPCC7942_2379-MONOMER.

Family and domain databases

Gene3Di 3.40.1190.20. 1 hit.
InterProi IPR004399. HMP/HMP-P_kinase.
IPR013749. PM/HMP-P_kinase-1.
IPR029056. Ribokinase-like.
[Graphical view ]
Pfami PF08543. Phos_pyr_kin. 1 hit.
[Graphical view ]
SUPFAMi SSF53613. SSF53613. 1 hit.
TIGRFAMsi TIGR00097. HMP-P_kinase. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Cloning and sequence of ftsZ and flanking regions from the cyanobacterium Synechococcus sp. PCC7942."
    Mori T., Golden S.S., Johnson C.H.
    Submitted (JUL-1998) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. "Complete sequence of chromosome 1 of Synechococcus elongatus PCC 7942."
    US DOE Joint Genome Institute
    Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina T., Hammon N., Israni S., Pitluck S., Schmutz J., Larimer F., Land M., Kyrpides N., Lykidis A., Richardson P.
    Submitted (AUG-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: PCC 7942.

Entry informationi

Entry nameiTHID_SYNE7
AccessioniPrimary (citable) accession number: O85786
Secondary accession number(s): Q31KL0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: April 18, 2006
Last modified: October 1, 2014
This is version 78 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3