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O85786 (THID_SYNE7) Reviewed, UniProtKB/Swiss-Prot

Last modified November 13, 2013. Version 74. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Hydroxymethylpyrimidine/phosphomethylpyrimidine kinase

EC=2.7.1.49
EC=2.7.4.7
Alternative name(s):
Hydroxymethylpyrimidine kinase
Short name=HMP kinase
Hydroxymethylpyrimidine phosphate kinase
Short name=HMP-P kinase
Short name=HMP-phosphate kinase
Short name=HMPP kinase
Gene names
Name:thiD
Ordered Locus Names:Synpcc7942_2379
OrganismSynechococcus elongatus (strain PCC 7942) (Anacystis nidulans R2) [Complete proteome] [HAMAP]
Taxonomic identifier1140 [NCBI]
Taxonomic lineageBacteriaCyanobacteriaOscillatoriophycideaeChroococcalesSynechococcus

Protein attributes

Sequence length263 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the phosphorylation of hydroxymethylpyrimidine phosphate (HMP-P) to HMP-PP, and of HMP to HMP-P By similarity.

Catalytic activity

ATP + 4-amino-5-hydroxymethyl-2-methylpyrimidine = ADP + 4-amino-5-phosphonooxymethyl-2-methylpyrimidine.

ATP + 4-amino-2-methyl-5-phosphomethylpyrimidine = ADP + 4-amino-2-methyl-5-diphosphomethylpyrimidine.

Pathway

Cofactor biosynthesis; thiamine diphosphate biosynthesis; 4-amino-2-methyl-5-diphosphomethylpyrimidine from 5-amino-1-(5-phospho-D-ribosyl)imidazole: step 2/3.

Cofactor biosynthesis; thiamine diphosphate biosynthesis; 4-amino-2-methyl-5-diphosphomethylpyrimidine from 5-amino-1-(5-phospho-D-ribosyl)imidazole: step 3/3.

Sequence similarities

Belongs to the ThiD family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 263263Hydroxymethylpyrimidine/phosphomethylpyrimidine kinase
PRO_0000192036

Sites

Binding site441Substrate By similarity

Experimental info

Sequence conflict2431L → F in AAC26228. Ref.1
Sequence conflict2471L → F in AAC26228. Ref.1

Sequences

Sequence LengthMass (Da)Tools
O85786 [UniParc].

Last modified April 18, 2006. Version 2.
Checksum: A530A3F53A2DC46A

FASTA26327,251
        10         20         30         40         50         60 
MAVPIALTIA GSDSGGGAGI QADLRTFAFH QVHGTCAITC VTAQNTLGVT RVDAIAPAGV 

        70         80         90        100        110        120 
AAQLDAVLSD LPPQALKTGM LLNAEIMEVV AGTIAPLFIP RIIDPVMVSR TGAVLIDQAA 

       130        140        150        160        170        180 
IAVLRDHLLP LATVLTPNRY EAQLLAGMDI QDAADLDRAA RIIRDLGPQA VLIKGGAATG 

       190        200        210        220        230        240 
DWHGVDWWWD GQQSHILKTE AIATPHTHGS GCTLAAAIAA NAALGLEILA AAQAAKHYVT 

       250        260 
KALRHSLAIG QGQGPLGHFY PLF 

« Hide

References

« Hide 'large scale' references
[1]"Cloning and sequence of ftsZ and flanking regions from the cyanobacterium Synechococcus sp. PCC7942."
Mori T., Golden S.S., Johnson C.H.
Submitted (JUL-1998) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]"Complete sequence of chromosome 1 of Synechococcus elongatus PCC 7942."
US DOE Joint Genome Institute
Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina T., Hammon N., Israni S., Pitluck S., Schmutz J., Larimer F., Land M., Kyrpides N., Lykidis A., Richardson P.
Submitted (AUG-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: PCC 7942.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF076530 Genomic DNA. Translation: AAC26228.1.
CP000100 Genomic DNA. Translation: ABB58409.1.
PIRT51093.
RefSeqYP_401396.1. NC_007604.1.

3D structure databases

ProteinModelPortalO85786.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING1140.Synpcc7942_2379.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaABB58409; ABB58409; Synpcc7942_2379.
GeneID3774662.
KEGGsyf:Synpcc7942_2379.
PATRIC23790315. VBISynElo51371_2672.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0351.
HOGENOMHOG000225273.
KOK00941.
OrthoDBEOG6XWV53.
ProtClustDBPRK06427.

Enzyme and pathway databases

BioCycSYNEL:SYNPCC7942_2379-MONOMER.
UniPathwayUPA00060; UER00137.
UPA00060; UER00138.

Family and domain databases

InterProIPR013749. HMP-P_kinase-1.
IPR004399. HMP-P_kinase-2.
[Graphical view]
PfamPF08543. Phos_pyr_kin. 1 hit.
[Graphical view]
TIGRFAMsTIGR00097. HMP-P_kinase. 1 hit.
ProtoNetSearch...

Entry information

Entry nameTHID_SYNE7
AccessionPrimary (citable) accession number: O85786
Secondary accession number(s): Q31KL0
Entry history
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: April 18, 2006
Last modified: November 13, 2013
This is version 74 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways