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O85726 (O85726_STRCL) Unreviewed, UniProtKB/TrEMBL

Last modified April 16, 2014. Version 51. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein names
Gene names
Name:cmcI EMBL AAC32491.1
OrganismStreptomyces clavuligerus EMBL AAC32491.1
Taxonomic identifier1901 [NCBI]
Taxonomic lineageBacteriaActinobacteriaActinobacteridaeActinomycetalesStreptomycineaeStreptomycetaceaeStreptomyces

Protein attributes

Sequence length236 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

Ontologies

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Regions

Region64 – 652S-adenosyl-L-homocysteine binding
Region64 – 652S-adenosyl-L-methionine binding PDB 2BM9 PDB 2BR4
Region87 – 915S-adenosyl-L-homocysteine binding
Region87 – 915S-adenosyl-L-methionine binding PDB 2BM9 PDB 2BR4
Region116 – 1172S-adenosyl-L-homocysteine binding
Region116 – 1172S-adenosyl-L-methionine binding PDB 2BM9 PDB 2BR4
Region138 – 1392S-adenosyl-L-homocysteine binding
Region138 – 1392S-adenosyl-L-methionine binding PDB 2BM9 PDB 2BR4
Region160 – 1612S-adenosyl-L-methionine binding PDB 2BM9 PDB 2BR4

Sites

Binding site171S-adenosyl-L-methionine; via carbonyl oxygen PDB 2BM9
Binding site951S-adenosyl-L-homocysteine
Binding site951S-adenosyl-L-methionine PDB 2BM9 PDB 2BR4
Binding site1211S-adenosyl-L-homocysteine
Binding site1211S-adenosyl-L-methionine PDB 2BM9 PDB 2BR4
Binding site1611S-adenosyl-L-homocysteine
Binding site1871S-adenosyl-L-homocysteine
Binding site1871S-adenosyl-L-methionine PDB 2BM9

Sequences

Sequence LengthMass (Da)Tools
O85726 [UniParc].

Last modified November 1, 1998. Version 1.
Checksum: FD1EF1B650AF8070

FASTA23627,584
        10         20         30         40         50         60 
MNDYSRQNFL DLNLFRGLGE DPAYHPPVLT DRPRDWPLDR WAEAPRDLGY SDFSPYQWRG 

        70         80         90        100        110        120 
LRMLKDPDTQ AVYHDMLWEL RPRTIVELGV YNGGSLAWFR DLTKIMGIDC QVIGIDRDLS 

       130        140        150        160        170        180 
RCQIPASDME NITLHQGDCS DLTTFEHLRE MAHPLIFIDD AHANTFNIMK WAVDHLLEEG 

       190        200        210        220        230 
DYFIIEDMIP YWYRYAPQLL SEYLGAFRDV LSMDMLYANA SSQLDRGVLR RVAAKQ 

« Hide

References

[1]"Investigation of the Streptomyces clavuligerus cephamycin C gene cluster and its regulation by the CcaR protein."
Alexander D.C., Jensen S.E.
J. Bacteriol. 180:4068-4079(1998) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE.
Strain: NRRL 3585 EMBL AAC32491.1.
[2]"Insights into cephamycin biosynthesis: the crystal structure of CmcI from Streptomyces clavuligerus."
Oster L.M., Lester D.R., Terwisscha van Scheltinga A., Svenda M., van Lun M., Genereux C., Andersson I.
J. Mol. Biol. 358:546-558(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: X-RAY CRYSTALLOGRAPHY (2.50 ANGSTROMS) IN COMPLEX WITH S-ADENOSYL-L-HOMOCYSTEINE AND S-ADENOSYL-L-METHIONINE.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF073896 Genomic DNA. Translation: AAC32491.1.

3D structure databases

PDBe
RCSB PDB
PDBj
EntryMethodResolution (Å)ChainPositionsPDBsum
2BM8X-ray2.50A/B/C/D/E/F/G/H/I/J/K/L1-236[»]
2BM9X-ray2.94A/B/C/D/E/F1-236[»]
2BR3X-ray2.79A/B/C/D/E/F1-236[»]
2BR4X-ray2.59A/B/C/D/E/F1-236[»]
2BR5X-ray2.83A/B/C/D/E/F1-236[»]
ProteinModelPortalO85726.
SMRO85726. Positions 2-234.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

PATRIC29741601. VBIStrCla15562_0183.

Enzyme and pathway databases

BioCycMetaCyc:MONOMER-13421.

Family and domain databases

InterProIPR007072. Rhamnosyl_O-MeTrfase_CmcI.
[Graphical view]
PfamPF04989. CmcI. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

EvolutionaryTraceO85726.

Entry information

Entry nameO85726_STRCL
AccessionPrimary (citable) accession number: O85726
Entry history
Integrated into UniProtKB/TrEMBL: November 1, 1998
Last sequence update: November 1, 1998
Last modified: April 16, 2014
This is version 51 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)