O85709RELA_STRATGTP pyrophosphokinase2.7.6.5(p)ppGpp synthaseATP:GTP 3'-pyrophosphotransferaseppGpp synthase IrelAStreptomyces antibioticusBacteriaActinomycetotaActinomycetesKitasatosporalesStreptomycetaceaeStreptomycesrelA is required for actinomycin production in Streptomyces antibioticus.NUCLEOTIDE SEQUENCE [GENOMIC DNA]In eubacteria ppGpp (guanosine 3'-diphosphate 5'-diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance. This enzyme catalyzes the formation of pppGpp which is then hydrolyzed to form ppGpp (By similarity). Is required for actinomycin production.ATP + GTP = AMP + guanosine 3'-diphosphate 5'-triphosphatePurine metabolism; ppGpp biosynthesis; ppGpp from GTP: step 1/2.Belongs to the RelA/SpoT family.Antibiotic biosynthesisATP-bindingGTP-bindingKinaseNucleotide-bindingTransferaseMPDEAQHLTAAKPDSAAGAAAEPAAHAQDGGGPVEHDRSAPADKPAERTRPKPAPPERPRPPPPRARAAGQPAARSGGSSNRVRARLARLGVQRANLTHPVLEPLLRIVRANDPKIETSTLRQIEKAYQVAERWHRGQKRKSGDPYITHPLAVTTILAELGMDPATLMAGLLHDSREDTEYGLDDLRRDFGDVVGLLVDGVTKLDKVKFGEAAQAETVRKMVVAMAKDPRVLVIKLADRLHNMRTMRYLKREKQEKKARETLEIYAPLAHRLGMNTIKWELEDLAFAILYPKMYDEIVRLVAERAPKRDEYLAIVTDEVQSDLRARRIKATVTGRPKHYYSVYQKIIVRGRDFAEIYDLVGIRVLVDTVRDCYAALGTVHARWNPVPGRFKDYIAMPKFNMYQSLHTTVIGPNGKPVELQIRTFDMHRRAEYGIAAHWKYKQEAVARASKVRTDVPKPAKGKDDHLNDMAWLRQLLDWQKETEDPGEFLESLRFDLSRNEVFVFTPKSDVIALPAGATPVDFAYAVHTEVGHRTIGARVNGRLVPLESTLDNGDLVEVFTSKAAGAGPSRDWLGFVKSPRARNKIRAWFSKERRDEAIEQGKDAIARAMRKQNLPIQRILTGDSLVTLAHEMRYPDISSSDAAIGEGHVGAQNVVQKLVQALGGEEAASEEIDEAVPSRSRSRKRRSNQDPGVVVKGVDDVWVKLARCCTPVPGEPIIGFVTRGSAVSVHRSDCVNVESLAREPERILEVEWAPTQSSVFLVAIQVEALDRSRLLSDVTRVLSDQHVNILSAAVQTSRDRVATSRFTFEMGDPKHLGHVLKAVRGVEGVYDVYRVTPGPQP
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