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O85709

- RELA_STRAT

UniProt

O85709 - RELA_STRAT

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Protein

GTP pyrophosphokinase

Gene

relA

Organism
Streptomyces antibioticus
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance. This enzyme catalyzes the formation of pppGpp which is then hydrolyzed to form ppGpp (By similarity). Is required for actinomycin production.By similarity

Catalytic activityi

ATP + GTP = AMP + guanosine 3'-diphosphate 5'-triphosphate.

Pathwayi

GO - Molecular functioni

  1. amino acid binding Source: InterPro
  2. ATP binding Source: UniProtKB-KW
  3. GTP binding Source: UniProtKB-KW
  4. GTP diphosphokinase activity Source: UniProtKB-EC
  5. kinase activity Source: UniProtKB-KW

GO - Biological processi

  1. antibiotic biosynthetic process Source: UniProtKB-KW
  2. guanosine tetraphosphate biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Transferase

Keywords - Biological processi

Antibiotic biosynthesis

Keywords - Ligandi

ATP-binding, GTP-binding, Nucleotide-binding

Enzyme and pathway databases

UniPathwayiUPA00908; UER00884.

Names & Taxonomyi

Protein namesi
Recommended name:
GTP pyrophosphokinase (EC:2.7.6.5)
Alternative name(s):
(p)ppGpp synthase
ATP:GTP 3'-pyrophosphotransferase
ppGpp synthase I
Gene namesi
Name:relA
OrganismiStreptomyces antibioticus
Taxonomic identifieri1890 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesStreptomycineaeStreptomycetaceaeStreptomyces

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 841841GTP pyrophosphokinasePRO_0000166563Add
BLAST

Structurei

3D structure databases

ProteinModelPortaliO85709.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini146 – 24398HDAdd
BLAST
Domaini763 – 83775ACTPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the RelA/SpoT family.Curated
Contains 1 ACT domain.PROSITE-ProRule annotation
Contains 1 HD domain.Curated

Family and domain databases

Gene3Di3.10.20.30. 1 hit.
InterProiIPR002912. ACT_dom.
IPR012675. Beta-grasp_dom.
IPR003607. HD/PDEase_dom.
IPR004811. RelA/Spo_fam.
IPR007685. RelA_SpoT.
IPR004095. TGS.
IPR012676. TGS-like.
[Graphical view]
PfamiPF01842. ACT. 1 hit.
PF04607. RelA_SpoT. 1 hit.
PF02824. TGS. 1 hit.
[Graphical view]
SMARTiSM00471. HDc. 1 hit.
SM00954. RelA_SpoT. 1 hit.
[Graphical view]
SUPFAMiSSF81271. SSF81271. 1 hit.
TIGRFAMsiTIGR00691. spoT_relA. 1 hit.
PROSITEiPS51671. ACT. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O85709-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MPDEAQHLTA AKPDSAAGAA AEPAAHAQDG GGPVEHDRSA PADKPAERTR
60 70 80 90 100
PKPAPPERPR PPPPRARAAG QPAARSGGSS NRVRARLARL GVQRANLTHP
110 120 130 140 150
VLEPLLRIVR ANDPKIETST LRQIEKAYQV AERWHRGQKR KSGDPYITHP
160 170 180 190 200
LAVTTILAEL GMDPATLMAG LLHDSREDTE YGLDDLRRDF GDVVGLLVDG
210 220 230 240 250
VTKLDKVKFG EAAQAETVRK MVVAMAKDPR VLVIKLADRL HNMRTMRYLK
260 270 280 290 300
REKQEKKARE TLEIYAPLAH RLGMNTIKWE LEDLAFAILY PKMYDEIVRL
310 320 330 340 350
VAERAPKRDE YLAIVTDEVQ SDLRARRIKA TVTGRPKHYY SVYQKIIVRG
360 370 380 390 400
RDFAEIYDLV GIRVLVDTVR DCYAALGTVH ARWNPVPGRF KDYIAMPKFN
410 420 430 440 450
MYQSLHTTVI GPNGKPVELQ IRTFDMHRRA EYGIAAHWKY KQEAVARASK
460 470 480 490 500
VRTDVPKPAK GKDDHLNDMA WLRQLLDWQK ETEDPGEFLE SLRFDLSRNE
510 520 530 540 550
VFVFTPKSDV IALPAGATPV DFAYAVHTEV GHRTIGARVN GRLVPLESTL
560 570 580 590 600
DNGDLVEVFT SKAAGAGPSR DWLGFVKSPR ARNKIRAWFS KERRDEAIEQ
610 620 630 640 650
GKDAIARAMR KQNLPIQRIL TGDSLVTLAH EMRYPDISSS DAAIGEGHVG
660 670 680 690 700
AQNVVQKLVQ ALGGEEAASE EIDEAVPSRS RSRKRRSNQD PGVVVKGVDD
710 720 730 740 750
VWVKLARCCT PVPGEPIIGF VTRGSAVSVH RSDCVNVESL AREPERILEV
760 770 780 790 800
EWAPTQSSVF LVAIQVEALD RSRLLSDVTR VLSDQHVNIL SAAVQTSRDR
810 820 830 840
VATSRFTFEM GDPKHLGHVL KAVRGVEGVY DVYRVTPGPQ P
Length:841
Mass (Da):93,672
Last modified:November 1, 1998 - v1
Checksum:i632A037BA4EF4C94
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF072829 Genomic DNA. Translation: AAC26021.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF072829 Genomic DNA. Translation: AAC26021.1 .

3D structure databases

ProteinModelPortali O85709.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Enzyme and pathway databases

UniPathwayi UPA00908 ; UER00884 .

Family and domain databases

Gene3Di 3.10.20.30. 1 hit.
InterProi IPR002912. ACT_dom.
IPR012675. Beta-grasp_dom.
IPR003607. HD/PDEase_dom.
IPR004811. RelA/Spo_fam.
IPR007685. RelA_SpoT.
IPR004095. TGS.
IPR012676. TGS-like.
[Graphical view ]
Pfami PF01842. ACT. 1 hit.
PF04607. RelA_SpoT. 1 hit.
PF02824. TGS. 1 hit.
[Graphical view ]
SMARTi SM00471. HDc. 1 hit.
SM00954. RelA_SpoT. 1 hit.
[Graphical view ]
SUPFAMi SSF81271. SSF81271. 1 hit.
TIGRFAMsi TIGR00691. spoT_relA. 1 hit.
PROSITEi PS51671. ACT. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "relA is required for actinomycin production in Streptomyces antibioticus."
    Hoyt S., Jones G.H.
    J. Bacteriol. 181:3824-3829(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: DSM 41481 / IMRU 3720.

Entry informationi

Entry nameiRELA_STRAT
AccessioniPrimary (citable) accession number: O85709
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: November 1, 1998
Last modified: October 1, 2014
This is version 84 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3