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O85709

- RELA_STRAT

UniProt

O85709 - RELA_STRAT

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Protein
GTP pyrophosphokinase
Gene
relA
Organism
Streptomyces antibioticus
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance. This enzyme catalyzes the formation of pppGpp which is then hydrolyzed to form ppGpp By similarity. Is required for actinomycin production.

Catalytic activityi

ATP + GTP = AMP + guanosine 3'-diphosphate 5'-triphosphate.

Pathwayi

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. GTP binding Source: UniProtKB-KW
  3. GTP diphosphokinase activity Source: UniProtKB-EC
  4. amino acid binding Source: InterPro
  5. kinase activity Source: UniProtKB-KW

GO - Biological processi

  1. antibiotic biosynthetic process Source: UniProtKB-KW
  2. guanosine tetraphosphate biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Transferase

Keywords - Biological processi

Antibiotic biosynthesis

Keywords - Ligandi

ATP-binding, GTP-binding, Nucleotide-binding

Enzyme and pathway databases

UniPathwayiUPA00908; UER00884.

Names & Taxonomyi

Protein namesi
Recommended name:
GTP pyrophosphokinase (EC:2.7.6.5)
Alternative name(s):
(p)ppGpp synthase
ATP:GTP 3'-pyrophosphotransferase
ppGpp synthase I
Gene namesi
Name:relA
OrganismiStreptomyces antibioticus
Taxonomic identifieri1890 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesStreptomycineaeStreptomycetaceaeStreptomyces

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 841841GTP pyrophosphokinase
PRO_0000166563Add
BLAST

Structurei

3D structure databases

ProteinModelPortaliO85709.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini146 – 24398HD
Add
BLAST
Domaini763 – 83775ACT
Add
BLAST

Sequence similaritiesi

Belongs to the RelA/SpoT family.
Contains 1 ACT domain.
Contains 1 HD domain.

Family and domain databases

Gene3Di3.10.20.30. 1 hit.
InterProiIPR002912. ACT_dom.
IPR012675. Beta-grasp_dom.
IPR003607. HD/PDEase_dom.
IPR004811. RelA/Spo_fam.
IPR007685. RelA_SpoT.
IPR004095. TGS.
IPR012676. TGS-like.
[Graphical view]
PfamiPF01842. ACT. 1 hit.
PF04607. RelA_SpoT. 1 hit.
PF02824. TGS. 1 hit.
[Graphical view]
SMARTiSM00471. HDc. 1 hit.
SM00954. RelA_SpoT. 1 hit.
[Graphical view]
SUPFAMiSSF81271. SSF81271. 1 hit.
TIGRFAMsiTIGR00691. spoT_relA. 1 hit.
PROSITEiPS51671. ACT. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O85709-1 [UniParc]FASTAAdd to Basket

« Hide

MPDEAQHLTA AKPDSAAGAA AEPAAHAQDG GGPVEHDRSA PADKPAERTR    50
PKPAPPERPR PPPPRARAAG QPAARSGGSS NRVRARLARL GVQRANLTHP 100
VLEPLLRIVR ANDPKIETST LRQIEKAYQV AERWHRGQKR KSGDPYITHP 150
LAVTTILAEL GMDPATLMAG LLHDSREDTE YGLDDLRRDF GDVVGLLVDG 200
VTKLDKVKFG EAAQAETVRK MVVAMAKDPR VLVIKLADRL HNMRTMRYLK 250
REKQEKKARE TLEIYAPLAH RLGMNTIKWE LEDLAFAILY PKMYDEIVRL 300
VAERAPKRDE YLAIVTDEVQ SDLRARRIKA TVTGRPKHYY SVYQKIIVRG 350
RDFAEIYDLV GIRVLVDTVR DCYAALGTVH ARWNPVPGRF KDYIAMPKFN 400
MYQSLHTTVI GPNGKPVELQ IRTFDMHRRA EYGIAAHWKY KQEAVARASK 450
VRTDVPKPAK GKDDHLNDMA WLRQLLDWQK ETEDPGEFLE SLRFDLSRNE 500
VFVFTPKSDV IALPAGATPV DFAYAVHTEV GHRTIGARVN GRLVPLESTL 550
DNGDLVEVFT SKAAGAGPSR DWLGFVKSPR ARNKIRAWFS KERRDEAIEQ 600
GKDAIARAMR KQNLPIQRIL TGDSLVTLAH EMRYPDISSS DAAIGEGHVG 650
AQNVVQKLVQ ALGGEEAASE EIDEAVPSRS RSRKRRSNQD PGVVVKGVDD 700
VWVKLARCCT PVPGEPIIGF VTRGSAVSVH RSDCVNVESL AREPERILEV 750
EWAPTQSSVF LVAIQVEALD RSRLLSDVTR VLSDQHVNIL SAAVQTSRDR 800
VATSRFTFEM GDPKHLGHVL KAVRGVEGVY DVYRVTPGPQ P 841
Length:841
Mass (Da):93,672
Last modified:November 1, 1998 - v1
Checksum:i632A037BA4EF4C94
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF072829 Genomic DNA. Translation: AAC26021.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF072829 Genomic DNA. Translation: AAC26021.1 .

3D structure databases

ProteinModelPortali O85709.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Enzyme and pathway databases

UniPathwayi UPA00908 ; UER00884 .

Family and domain databases

Gene3Di 3.10.20.30. 1 hit.
InterProi IPR002912. ACT_dom.
IPR012675. Beta-grasp_dom.
IPR003607. HD/PDEase_dom.
IPR004811. RelA/Spo_fam.
IPR007685. RelA_SpoT.
IPR004095. TGS.
IPR012676. TGS-like.
[Graphical view ]
Pfami PF01842. ACT. 1 hit.
PF04607. RelA_SpoT. 1 hit.
PF02824. TGS. 1 hit.
[Graphical view ]
SMARTi SM00471. HDc. 1 hit.
SM00954. RelA_SpoT. 1 hit.
[Graphical view ]
SUPFAMi SSF81271. SSF81271. 1 hit.
TIGRFAMsi TIGR00691. spoT_relA. 1 hit.
PROSITEi PS51671. ACT. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "relA is required for actinomycin production in Streptomyces antibioticus."
    Hoyt S., Jones G.H.
    J. Bacteriol. 181:3824-3829(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: DSM 41481 / IMRU 3720.

Entry informationi

Entry nameiRELA_STRAT
AccessioniPrimary (citable) accession number: O85709
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: November 1, 1998
Last modified: June 11, 2014
This is version 83 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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