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Protein

Anthranilate 1,2-dioxygenase electron transfer component

Gene

antC

Organism
Acinetobacter baylyi (strain ATCC 33305 / BD413 / ADP1)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Electron transfer component of anthranilate 1,2-dioxygenase system.1 Publication

Catalytic activityi

Reduced ferredoxin + NAD+ = oxidized ferredoxin + NADH.1 Publication

Cofactori

Protein has several cofactor binding sites:

Pathwayi: anthranilate degradation via hydroxylation

This protein is involved in step 1 of the subpathway that synthesizes catechol from anthranilate.1 Publication
Proteins known to be involved in this subpathway in this organism are:
  1. Anthranilate 1,2-dioxygenase electron transfer component (antC), Anthranilate 1,2-dioxygenase large subunit (antA), Anthranilate 1,2-dioxygenase small subunit (antB)
This subpathway is part of the pathway anthranilate degradation via hydroxylation, which is itself part of Aromatic compound metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes catechol from anthranilate, the pathway anthranilate degradation via hydroxylation and in Aromatic compound metabolism.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi40 – 401Iron-sulfur (2Fe-2S)PROSITE-ProRule annotation
Metal bindingi45 – 451Iron-sulfur (2Fe-2S)PROSITE-ProRule annotation
Metal bindingi48 – 481Iron-sulfur (2Fe-2S)PROSITE-ProRule annotation
Metal bindingi80 – 801Iron-sulfur (2Fe-2S)PROSITE-ProRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Aromatic hydrocarbons catabolism

Keywords - Ligandi

2Fe-2S, FAD, Flavoprotein, Iron, Iron-sulfur, Metal-binding, NAD

Enzyme and pathway databases

BioCyciASP62977:GJVV-2485-MONOMER.
MetaCyc:MONOMER-7504.
UniPathwayiUPA01016; UER01026.

Names & Taxonomyi

Protein namesi
Recommended name:
Anthranilate 1,2-dioxygenase electron transfer component1 Publication
Including the following 2 domains:
FerredoxinBy similarity
Ferredoxin--NAD(+) reductaseBy similarity (EC:1.18.1.31 PublicationImported)
Gene namesi
Name:antCImported
Ordered Locus Names:ACIAD2671
OrganismiAcinetobacter baylyi (strain ATCC 33305 / BD413 / ADP1)
Taxonomic identifieri62977 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPseudomonadalesMoraxellaceaeAcinetobacter
Proteomesi
  • UP000000430 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 343343Anthranilate 1,2-dioxygenase electron transfer componentPRO_0000415159Add
BLAST

Interactioni

Subunit structurei

Monomer. It is part of the anthranilate dioxygenase two component enzyme system. The other component is an oxygenase component consisting of 3 large (AntA) and 3 small (AntB) subunits.1 Publication

Protein-protein interaction databases

STRINGi62977.ACIAD2671.

Structurei

3D structure databases

ProteinModelPortaliO85675.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini3 – 96942Fe-2S ferredoxin-typePROSITE-ProRule annotationAdd
BLAST
Domaini103 – 206104FAD-binding FR-typePROSITE-ProRule annotationAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni98 – 338241Ferredoxin-reductaseAdd
BLAST

Sequence similaritiesi

Contains 1 2Fe-2S ferredoxin-type domain.PROSITE-ProRule annotation
Contains 1 FAD-binding FR-type domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiENOG4105F57. Bacteria.
COG0543. LUCA.
HOGENOMiHOG000263663.
KOiK11311.
OMAiGSCHASV.
OrthoDBiPOG091H05VQ.

Family and domain databases

CDDicd00207. fer2. 1 hit.
Gene3Di3.10.20.30. 1 hit.
InterProiIPR001041. 2Fe-2S_ferredoxin-type.
IPR006058. 2Fe2S_fd_BS.
IPR012675. Beta-grasp_dom.
IPR017927. Fd_Rdtase_FAD-bd.
IPR008333. OxRdtase_FAD-bd_dom.
IPR001433. OxRdtase_FAD/NAD-bd.
IPR001221. Phe_hydroxylase.
IPR017938. Riboflavin_synthase-like_b-brl.
[Graphical view]
PfamiPF00970. FAD_binding_6. 1 hit.
PF00111. Fer2. 1 hit.
PF00175. NAD_binding_1. 1 hit.
[Graphical view]
PRINTSiPR00410. PHEHYDRXLASE.
SUPFAMiSSF54292. SSF54292. 1 hit.
SSF63380. SSF63380. 1 hit.
PROSITEiPS00197. 2FE2S_FER_1. 1 hit.
PS51085. 2FE2S_FER_2. 1 hit.
PS51384. FAD_FR. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O85675-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNHSVALNFA DGKTFFIAVQ EDELLLDAAV RQGINLPLDC REGVCGTCQG
60 70 80 90 100
TCETGIYEQE YVDEDALSER DLAKRKMLAC QTRVKSNAAF YFDHHSSICN
110 120 130 140 150
AGETLKIATV VTGVELVSET TAILHLDASQ HVKQLDFLPG QYARLQIPDT
160 170 180 190 200
DDWRSYSFAN RPNASNQLQF LIRLLPNGVM SNYLRERCQV GQTLIMEAPL
210 220 230 240 250
GSFYLREVER PLVFIAGGTG LSAFLGMLDN IAEQPNQPSV HLYYGVNTEA
260 270 280 290 300
DLCEQKRLTT YAERIKNFSY HPIISKASEQ WQGKSGFIHE HLDKNQLSEQ
310 320 330 340
SFDMYLCGPP PMIEAVKTWL DEQAIADCHI YSEKFLQSNT AKT
Length:343
Mass (Da):38,549
Last modified:November 1, 1998 - v1
Checksum:iA8CEE4658B41234A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF071556 Genomic DNA. Translation: AAC34815.1.
CR543861 Genomic DNA. Translation: CAG69426.1.
RefSeqiWP_004928952.1. NC_005966.1.

Genome annotation databases

EnsemblBacteriaiCAG69426; CAG69426; ACIAD2671.
GeneIDi25685159.
KEGGiaci:ACIAD2671.
PATRICi20742941. VBIAciSp98416_2411.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF071556 Genomic DNA. Translation: AAC34815.1.
CR543861 Genomic DNA. Translation: CAG69426.1.
RefSeqiWP_004928952.1. NC_005966.1.

3D structure databases

ProteinModelPortaliO85675.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi62977.ACIAD2671.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiCAG69426; CAG69426; ACIAD2671.
GeneIDi25685159.
KEGGiaci:ACIAD2671.
PATRICi20742941. VBIAciSp98416_2411.

Phylogenomic databases

eggNOGiENOG4105F57. Bacteria.
COG0543. LUCA.
HOGENOMiHOG000263663.
KOiK11311.
OMAiGSCHASV.
OrthoDBiPOG091H05VQ.

Enzyme and pathway databases

UniPathwayiUPA01016; UER01026.
BioCyciASP62977:GJVV-2485-MONOMER.
MetaCyc:MONOMER-7504.

Family and domain databases

CDDicd00207. fer2. 1 hit.
Gene3Di3.10.20.30. 1 hit.
InterProiIPR001041. 2Fe-2S_ferredoxin-type.
IPR006058. 2Fe2S_fd_BS.
IPR012675. Beta-grasp_dom.
IPR017927. Fd_Rdtase_FAD-bd.
IPR008333. OxRdtase_FAD-bd_dom.
IPR001433. OxRdtase_FAD/NAD-bd.
IPR001221. Phe_hydroxylase.
IPR017938. Riboflavin_synthase-like_b-brl.
[Graphical view]
PfamiPF00970. FAD_binding_6. 1 hit.
PF00111. Fer2. 1 hit.
PF00175. NAD_binding_1. 1 hit.
[Graphical view]
PRINTSiPR00410. PHEHYDRXLASE.
SUPFAMiSSF54292. SSF54292. 1 hit.
SSF63380. SSF63380. 1 hit.
PROSITEiPS00197. 2FE2S_FER_1. 1 hit.
PS51085. 2FE2S_FER_2. 1 hit.
PS51384. FAD_FR. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiANTDC_ACIAD
AccessioniPrimary (citable) accession number: O85675
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 25, 2012
Last sequence update: November 1, 1998
Last modified: September 7, 2016
This is version 111 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.