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Protein

Anthranilate 1,2-dioxygenase electron transfer component

Gene

antC

Organism
Acinetobacter baylyi (strain ATCC 33305 / BD413 / ADP1)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Electron transfer component of anthranilate 1,2-dioxygenase system.1 Publication

Catalytic activityi

Reduced ferredoxin + NAD+ = oxidized ferredoxin + NADH.1 Publication

Cofactori

Protein has several cofactor binding sites:

Pathwayi: anthranilate degradation via hydroxylation

This protein is involved in step 1 of the subpathway that synthesizes catechol from anthranilate.1 Publication
Proteins known to be involved in this subpathway in this organism are:
  1. Anthranilate 1,2-dioxygenase electron transfer component (antC), Anthranilate 1,2-dioxygenase large subunit (antA), Anthranilate 1,2-dioxygenase small subunit (antB)
This subpathway is part of the pathway anthranilate degradation via hydroxylation, which is itself part of Aromatic compound metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes catechol from anthranilate, the pathway anthranilate degradation via hydroxylation and in Aromatic compound metabolism.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi40Iron-sulfur (2Fe-2S)PROSITE-ProRule annotation1
Metal bindingi45Iron-sulfur (2Fe-2S)PROSITE-ProRule annotation1
Metal bindingi48Iron-sulfur (2Fe-2S)PROSITE-ProRule annotation1
Metal bindingi80Iron-sulfur (2Fe-2S)PROSITE-ProRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductase
Biological processAromatic hydrocarbons catabolism
Ligand2Fe-2S, FAD, Flavoprotein, Iron, Iron-sulfur, Metal-binding, NAD

Enzyme and pathway databases

BioCyciASP62977:G1GJ8-2446-MONOMER
MetaCyc:MONOMER-7504
UniPathwayiUPA01016; UER01026

Names & Taxonomyi

Protein namesi
Recommended name:
Anthranilate 1,2-dioxygenase electron transfer component1 Publication
Including the following 2 domains:
FerredoxinBy similarity
Ferredoxin--NAD(+) reductaseBy similarity (EC:1.18.1.31 PublicationImported)
Gene namesi
Name:antCImported
Ordered Locus Names:ACIAD2671
OrganismiAcinetobacter baylyi (strain ATCC 33305 / BD413 / ADP1)
Taxonomic identifieri62977 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPseudomonadalesMoraxellaceaeAcinetobacter
Proteomesi
  • UP000000430 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00004151591 – 343Anthranilate 1,2-dioxygenase electron transfer componentAdd BLAST343

Interactioni

Subunit structurei

Monomer. It is part of the anthranilate dioxygenase two component enzyme system. The other component is an oxygenase component consisting of 3 large (AntA) and 3 small (AntB) subunits.1 Publication

Protein-protein interaction databases

STRINGi62977.ACIAD2671

Structurei

3D structure databases

ProteinModelPortaliO85675
SMRiO85675
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini3 – 962Fe-2S ferredoxin-typePROSITE-ProRule annotationAdd BLAST94
Domaini103 – 206FAD-binding FR-typePROSITE-ProRule annotationAdd BLAST104

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni98 – 338Ferredoxin-reductaseAdd BLAST241

Sequence similaritiesi

Phylogenomic databases

eggNOGiENOG4105F57 Bacteria
COG0543 LUCA
HOGENOMiHOG000263663
KOiK11311
OMAiDEIRFEA
OrthoDBiPOG091H05VQ

Family and domain databases

CDDicd00207 fer2, 1 hit
Gene3Di3.10.20.30, 1 hit
InterProiView protein in InterPro
IPR036010 2Fe-2S_ferredoxin-like_sf
IPR001041 2Fe-2S_ferredoxin-type
IPR006058 2Fe2S_fd_BS
IPR012675 Beta-grasp_dom_sf
IPR017927 Fd_Rdtase_FAD-bd
IPR008333 OxRdtase_FAD-bd_dom
IPR001433 OxRdtase_FAD/NAD-bd
IPR001221 Phe_hydroxylase
IPR017938 Riboflavin_synthase-like_b-brl
PfamiView protein in Pfam
PF00970 FAD_binding_6, 1 hit
PF00111 Fer2, 1 hit
PF00175 NAD_binding_1, 1 hit
PRINTSiPR00410 PHEHYDRXLASE
SUPFAMiSSF54292 SSF54292, 1 hit
SSF63380 SSF63380, 1 hit
PROSITEiView protein in PROSITE
PS00197 2FE2S_FER_1, 1 hit
PS51085 2FE2S_FER_2, 1 hit
PS51384 FAD_FR, 1 hit

Sequencei

Sequence statusi: Complete.

O85675-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNHSVALNFA DGKTFFIAVQ EDELLLDAAV RQGINLPLDC REGVCGTCQG
60 70 80 90 100
TCETGIYEQE YVDEDALSER DLAKRKMLAC QTRVKSNAAF YFDHHSSICN
110 120 130 140 150
AGETLKIATV VTGVELVSET TAILHLDASQ HVKQLDFLPG QYARLQIPDT
160 170 180 190 200
DDWRSYSFAN RPNASNQLQF LIRLLPNGVM SNYLRERCQV GQTLIMEAPL
210 220 230 240 250
GSFYLREVER PLVFIAGGTG LSAFLGMLDN IAEQPNQPSV HLYYGVNTEA
260 270 280 290 300
DLCEQKRLTT YAERIKNFSY HPIISKASEQ WQGKSGFIHE HLDKNQLSEQ
310 320 330 340
SFDMYLCGPP PMIEAVKTWL DEQAIADCHI YSEKFLQSNT AKT
Length:343
Mass (Da):38,549
Last modified:November 1, 1998 - v1
Checksum:iA8CEE4658B41234A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF071556 Genomic DNA Translation: AAC34815.1
CR543861 Genomic DNA Translation: CAG69426.1
RefSeqiWP_004928952.1, NC_005966.1

Genome annotation databases

EnsemblBacteriaiCAG69426; CAG69426; ACIAD2671
KEGGiaci:ACIAD2671

Similar proteinsi

Entry informationi

Entry nameiANTDC_ACIAD
AccessioniPrimary (citable) accession number: O85675
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 25, 2012
Last sequence update: November 1, 1998
Last modified: March 28, 2018
This is version 120 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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