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Protein

Nucleoside diphosphate kinase

Gene

ndk

Organism
Mycobacterium smegmatis (strain ATCC 700084 / mc(2)155)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate.UniRule annotation

Catalytic activityi

ATP + nucleoside diphosphate = ADP + nucleoside triphosphate.UniRule annotation

Cofactori

Mg2+UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei10 – 101ATPUniRule annotation
Binding sitei58 – 581ATPUniRule annotation
Binding sitei86 – 861ATPUniRule annotation
Binding sitei92 – 921ATPUniRule annotation
Binding sitei104 – 1041ATPUniRule annotation
Binding sitei114 – 1141ATPUniRule annotation
Active sitei117 – 1171Pros-phosphohistidine intermediateUniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Kinase, Transferase

Keywords - Biological processi

Nucleotide metabolism

Keywords - Ligandi

ATP-binding, Magnesium, Metal-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciMSME246196:GJ4Y-4626-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Nucleoside diphosphate kinaseUniRule annotation (EC:2.7.4.6UniRule annotation)
Short name:
NDKUniRule annotation
Short name:
NDP kinaseUniRule annotation
Alternative name(s):
Nucleoside-2-P kinaseUniRule annotation
Gene namesi
Name:ndkUniRule annotation
Ordered Locus Names:MSMEG_4627, MSMEI_4510
OrganismiMycobacterium smegmatis (strain ATCC 700084 / mc(2)155)
Taxonomic identifieri246196 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaCorynebacterialesMycobacteriaceaeMycobacterium
Proteomesi
  • UP000006158 Componenti: Chromosome
  • UP000000757 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 139139Nucleoside diphosphate kinasePRO_0000137009Add
BLAST

Keywords - PTMi

Phosphoprotein

Interactioni

Subunit structurei

Homotetramer.UniRule annotation

Protein-protein interaction databases

STRINGi246196.MSMEG_4627.

Structurei

3D structure databases

ProteinModelPortaliO85501.
SMRiO85501. Positions 2-135.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the NDK family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4108UGX. Bacteria.
COG0105. LUCA.
HOGENOMiHOG000224564.
KOiK00940.
OMAiAEHSERP.
OrthoDBiPOG091H040S.

Family and domain databases

HAMAPiMF_00451. NDP_kinase. 1 hit.
InterProiIPR001564. Nucleoside_diP_kinase.
IPR023005. Nucleoside_diP_kinase_AS.
[Graphical view]
PfamiPF00334. NDK. 1 hit.
[Graphical view]
PRINTSiPR01243. NUCDPKINASE.
SMARTiSM00562. NDK. 1 hit.
[Graphical view]
PROSITEiPS00469. NDP_KINASES. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O85501-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTERTLVLIK PDGVKRQLVG EILSRIERKG LTLAALELKN VSDDLARQHY
60 70 80 90 100
AEHADKPFFG SLLEFITSGP LVAAIVEGPR AVAAFRQIAG GTDPVEKAVP
110 120 130
GTIRGDFALI TQDNLVHGSD SPESAAREIA LWFPGEATA
Length:139
Mass (Da):14,916
Last modified:November 1, 1998 - v1
Checksum:i163811D0B2302030
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF069544 Genomic DNA. Translation: AAC23864.1.
CP000480 Genomic DNA. Translation: ABK70634.1.
CP001663 Genomic DNA. Translation: AFP40964.1.
RefSeqiWP_011729972.1. NZ_CP009494.1.
YP_888891.1. NC_008596.1.

Genome annotation databases

EnsemblBacteriaiABK70634; ABK70634; MSMEG_4627.
AFP40964; AFP40964; MSMEI_4510.
GeneIDi4536899.
KEGGimsb:LJ00_22885.
msg:MSMEI_4510.
msm:MSMEG_4627.
PATRICi18081567. VBIMycSme59918_4522.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF069544 Genomic DNA. Translation: AAC23864.1.
CP000480 Genomic DNA. Translation: ABK70634.1.
CP001663 Genomic DNA. Translation: AFP40964.1.
RefSeqiWP_011729972.1. NZ_CP009494.1.
YP_888891.1. NC_008596.1.

3D structure databases

ProteinModelPortaliO85501.
SMRiO85501. Positions 2-135.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi246196.MSMEG_4627.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiABK70634; ABK70634; MSMEG_4627.
AFP40964; AFP40964; MSMEI_4510.
GeneIDi4536899.
KEGGimsb:LJ00_22885.
msg:MSMEI_4510.
msm:MSMEG_4627.
PATRICi18081567. VBIMycSme59918_4522.

Phylogenomic databases

eggNOGiENOG4108UGX. Bacteria.
COG0105. LUCA.
HOGENOMiHOG000224564.
KOiK00940.
OMAiAEHSERP.
OrthoDBiPOG091H040S.

Enzyme and pathway databases

BioCyciMSME246196:GJ4Y-4626-MONOMER.

Family and domain databases

HAMAPiMF_00451. NDP_kinase. 1 hit.
InterProiIPR001564. Nucleoside_diP_kinase.
IPR023005. Nucleoside_diP_kinase_AS.
[Graphical view]
PfamiPF00334. NDK. 1 hit.
[Graphical view]
PRINTSiPR01243. NUCDPKINASE.
SMARTiSM00562. NDK. 1 hit.
[Graphical view]
PROSITEiPS00469. NDP_KINASES. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiNDK_MYCS2
AccessioniPrimary (citable) accession number: O85501
Secondary accession number(s): A0R153, I7GDU8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 5, 2002
Last sequence update: November 1, 1998
Last modified: September 7, 2016
This is version 97 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.