Reviewed, UniProtKB/Swiss-Prot O85387 (RL22_COXBU)

Names and origin

Protein names

Recommended name:
    50S ribosomal protein L22

Gene names

Name:	rplV
Ordered Locus Names:	CBU_0243

Organism

Coxiella burnetii [Complete proteome] [HAMAP]

Taxonomic identifier

777 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Legionellales › Coxiellaceae › Coxiella

Protein attributes

Sequence length	115 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	This protein binds specifically to 23S rRNA; its binding is stimulated by other ribosomal proteins, e.g., L4, L17, and L20. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome By similarity. The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome By similarity.
Subunit structure	Part of the 50S ribosomal subunit. HAMAP MF_01331
Sequence similarities	Belongs to the ribosomal protein L22P family.

Ontologies

Keywords
Ligand	RNA-binding rRNA-binding
Molecular function	Ribonucleoprotein Ribosomal protein
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	translation Inferred from electronic annotation. Source: HAMAP
Cellular component	large ribosomal subunit Inferred from electronic annotation. Source: InterPro
Molecular function	rRNA binding Inferred from electronic annotation. Source: HAMAP structural constituent of ribosome Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 115	115	50S ribosomal protein L22 HAMAP MF_01331		PRO_0000125150

Sequences

	Sequence		Length	Mass (Da)
	O85387-1 [UniParc]. Last modified November 1, 1998. Version 1. Checksum: 7062A01A0CFED921	FASTA	115	12,582
	10 20 30 40 50 60 MEVAAKLKYA RISAQKARLV ADQVRGLGAE QAVNLLRFSN KKAAALMKKV LDSAIANAEH 70 80 90 100 110 NEGADIDELK VSTVMVDEGP SARRFHARAR GRANQILKRT CHITVKVSDS QVEND

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Physical and genetic map of the obligate intracellular bacterium Coxiella burnetii." Willems H., Jaeger C., Baljer G. J. Bacteriol. 180:3816-3822(1998) [PubMed: 9683477] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: Nine Mile phase I / RSA 493.
[2]	"Complete genome sequence of the Q-fever pathogen, Coxiella burnetii." Seshadri R., Paulsen I.T., Eisen J.A., Read T.D., Nelson K.E., Nelson W.C., Ward N.L., Tettelin H., Davidsen T.M., Beanan M.J., DeBoy R.T., Daugherty S.C., Brinkac L.M., Madupu R., Dodson R.J., Khouri H.M., Lee K.H., Carty H.A. , Scanlan D., Heinzen R.A., Thompson H.A., Samuel J.E., Fraser C.M., Heidelberg J.F. Proc. Natl. Acad. Sci. U.S.A. 100:5455-5460(2003) [PubMed: 12704232] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Nine Mile phase I / RSA 493.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AF064946 Genomic DNA. Translation: AAD09928.1. AE016828 Genomic DNA. Translation: AAO89801.1.
RefSeq	NP_819287.1.
3D structure databases
ModBase	Search...
Genome annotation databases
GeneID	1208124.
GenomeReviews	Gene locus CBU_0243 in contig AE016828_GR.
KEGG	cbu:CBU_0243.
NMPDR	fig|227377.1.peg.231.
TIGR	CBU_0243.
Phylogenomic databases
HOGENOM	O85387.
OMA	AILKFAP
Enzyme and pathway databases
BioCyc	CBUR227377:CBU_0243-MON.
Family and domain databases
HAMAP	MF_01331. [Tree]
InterPro	IPR001063. Ribosomal_L22. IPR018260. Ribosomal_L22/L17_CS. IPR005727. Ribosomal_L22_bac-type. [Graphical view]
Gene3D	G3DSA:3.90.470.10. Ribosomal_L22. 1 hit.
PANTHER	PTHR13501. Ribosom_L22_bac. 1 hit.
Pfam	PF00237. Ribosomal_L22. 1 hit. [Graphical view]
TIGRFAMs	TIGR01044. rplV_bact. 1 hit.
PROSITE	PS00464. RIBOSOMAL_L22. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

RL22_COXBU

Accession

Primary (citable) accession number: O85387

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 30, 2000
Last sequence update:	November 1, 1998
Last modified:	November 24, 2009
This is version 55 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)