O85383 (O85383_STAAU) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Submitted name:
Enterotoxin type I EMBL AAP78522.2

Submitted name:
Extracellular enterotoxin type I EMBL AAC26661.1
Submitted name:
SEI EMBL AAG36953.1

Gene names

Name:	SEI EMBL AAC26661.1
Synonyms:	sei EMBL AAG36953.1

Organism

Staphylococcus aureus EMBL AAC26661.1

Taxonomic identifier

1280 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Firmicutes › Bacilli › Bacillales › Staphylococcaceae › Staphylococcus

Protein attributes

Sequence length	242 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level

Ontologies

Keywords
Domain	Signal EMBL AAC26661.1
Ligand	Metal-binding PDB 2G9H Zinc PDB 2G9H
Technical term	3D-structure PDB 2G9H
Gene Ontology (GO)
Biological_process	pathogenesis Inferred from electronic annotation. Source: InterPro
Cellular_component	extracellular region Inferred from electronic annotation. Source: InterPro
Molecular_function	metal ion binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 24	24	Potential EMBL AAC26661.1
	Chain	25 – 242	218	enterotoxin type I EMBL AAC26661.1		PRO_5000054329
Sites
	Metal binding	193	1	Zinc; via pros nitrogen PDB 2G9H
	Metal binding	231	1	Zinc; via tele nitrogen PDB 2G9H
	Metal binding	233	1	Zinc PDB 2G9H

Sequences

	Sequence		Length	Mass (Da)
	O85383 [UniParc]. Last modified November 1, 1998. Version 1. Checksum: C5C8B4ACEE5414A8	FASTA	242	27,864
	10 20 30 40 50 60 MKKFKYSFIL VFILLFNIKD LTYAQGDIGV GNLRNFYTKH DYIDLKGVTD KNLPIANQLE 70 80 90 100 110 120 FSTGTNDLIS ESNNWDEISK FKGKKLDIFG IDYNGPCKSK YMYGGATLSG QYLNSARKIP 130 140 150 160 170 180 INLWVNGKHK TISTDKIATN KKLVTAQEID VKLRRYLQEE YNIYGHNNTG KGKEYGYKSK 190 200 210 220 230 240 FYSGFNNGKV LFHLNNEKSF SYDLFYTGDG LPVSFLKIYE DNKIIESEKF HLDVEISYVD SN

References

[1]	"Identification and characterization of staphylococcal enterotoxin types G and I from Staphylococcus aureus." Munson S.H., Tremaine M.T., Betley M.J., Welch R.A. Infect. Immun. 66:3337-3348(1998) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE. Strain: FRI445 EMBL AAC26661.1.
[2]	"egc, a highly prevalent operon of enterotoxin gene, forms a putative nursery of superantigens in Staphylococcus aureus." Jarraud S., Peyrat M.A., Lim A., Tristan A., Bes M., Mougel C., Etienne J., Vandenesch F., Bonneville M., Lina G. J. Immunol. 166:669-677(2001) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE. Strain: A900322 EMBL AAG36953.1.
[3]	"PCR detection of staphylococcal enterotoxin genes in Staphylococcus spp. strains isolated from meat and dairy products. Evidence for new variants of seG and seI in S. aureus AB-8802." Blaiotta G., Ercolini D., Pennacchia C., Fusco V., Casaburi A., Pepe O., Villani F. J. Appl. Microbiol. 97:719-730(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE. Strain: R1 EMBL AAP78522.2.
[4]	"Detection and characterization of the Staphylococcus aureus enterotoxin gene cluster (egc) in strains isolated from different source (human, veterinary, food and reference)." Blaiotta G., Fusco V., Villani F., von Eiff C., Becker K. Submitted (FEB-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE. Strain: R1 EMBL AAP78522.2.
[5]	"Biotyping of enterotoxigenic Staphylococcus aureus by enterotoxin gene cluster (egc) polymorphism and spa typing analyses." Blaiotta G., Fusco V., von Eiff C., Villani F., Becker K. Appl. Environ. Microbiol. 72:6117-6123(2006) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE. Strain: 10 EMBL AAX11331.1 and 107 EMBL AAX11332.1.
[6]	"Crystal structure of staphylococcal enterotoxin I (SEI) in complex with a human major histocompatibility complex class II molecule." Fernandez M.M., Guan R., Swaminathan C.P., Malchiodi E.L., Mariuzza R.A. J. Biol. Chem. 281:25356-25364(2006) [PubMed] [Europe PMC] [Abstract] Cited for: X-RAY CRYSTALLOGRAPHY (2.00 ANGSTROMS) OF 25-242 IN COMPLEX WITH ZINC.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ

AF064774 Genomic DNA. Translation: AAC26661.1.
AF285760 Genomic DNA. Translation: AAG36953.1.
AY291443 Genomic DNA. Translation: AAP78522.2.
AY920267 Genomic DNA. Translation: AAX11331.1.
AY920268 Genomic DNA. Translation: AAX11332.1.

PIR

C89969.

3D structure databases

PDBe
RCSB PDB
PDBj

Entry	Method	Resolution (Å)	Chain	Positions	PDBsum
2G9H	X-ray	2.00	D	25-242	[»]

SMR

O85383. Positions 28-240.

ModBase

Search...

Protein family/group databases

Allergome

3908. Sta a SEI.

Protocols and materials databases

StructuralBiologyKnowledgebase

Search...

Family and domain databases

Gene3D

3.10.20.120. 1 hit.

InterPro

IPR008992. Enterotoxin_bac.
IPR006126. Staph/Strept_toxin_CS.
IPR006173. Staph_tox_OB.
IPR016091. SuperAg_toxin_C.
IPR013307. Superantigen_bac.
IPR006123. Toxin_b-grasp_Staph/Strep.
[Graphical view]

Pfam

PF02876. Stap_Strp_tox_C. 1 hit.
PF01123. Stap_Strp_toxin. 1 hit.
[Graphical view]

PRINTS

PR01898. SAGSUPRFAMLY.

SUPFAM

SSF50203. Bact_endotox. 1 hit.
SSF54334. Stap/Strep_toxin. 1 hit.

PROSITE

PS00278. STAPH_STREP_TOXIN_2. 1 hit.
[Graphical view]

ProtoNet

Search...

Other

EvolutionaryTrace

O85383.

Entry information

Entry name

O85383_STAAU

Accession

Primary (citable) accession number: O85383
Secondary accession number(s): Q7X0E9

Entry history

Integrated into UniProtKB/TrEMBL:	November 1, 1998
Last sequence update:	November 1, 1998
Last modified:	May 1, 2013
This is version 75 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)