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O85297

- FTSI_BUCAP

UniProt

O85297 - FTSI_BUCAP

Protein

Peptidoglycan synthase FtsI

Gene

ftsI

Organism
Buchnera aphidicola subsp. Schizaphis graminum (strain Sg)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 105 (01 Oct 2014)
      Sequence version 1 (01 Nov 1998)
      Previous versions | rss
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    Functioni

    Cell wall formation. Essential for the formation of a septum of the murein sacculus. Synthesis of cross-linked peptidoglycan from the lipid intermediates By similarity.By similarity

    Catalytic activityi

    (GlcNAc-(1->4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala))(n)-diphosphoundecaprenol + GlcNAc-(1->4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)-diphosphoundecaprenol = (GlcNAc-(1->4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala))(n+1)-diphosphoundecaprenol + undecaprenyl diphosphate.

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei302 – 3021Acyl-ester intermediateBy similarity

    GO - Molecular functioni

    1. penicillin binding Source: InterPro
    2. peptidoglycan glycosyltransferase activity Source: UniProtKB-EC

    GO - Biological processi

    1. cell cycle Source: UniProtKB-KW
    2. cell division Source: UniProtKB-KW
    3. peptidoglycan biosynthetic process Source: UniProtKB-UniPathway
    4. regulation of cell shape Source: UniProtKB-KW

    Keywords - Molecular functioni

    Glycosyltransferase, Transferase

    Keywords - Biological processi

    Cell cycle, Cell division, Cell shape, Cell wall biogenesis/degradation, Peptidoglycan synthesis

    Enzyme and pathway databases

    BioCyciBAPH198804:GHMG-226-MONOMER.
    UniPathwayiUPA00219.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Peptidoglycan synthase FtsI (EC:2.4.1.129)
    Alternative name(s):
    Penicillin-binding protein 3
    Short name:
    PBP-3
    Peptidoglycan glycosyltransferase 3
    Gene namesi
    Name:ftsI
    Ordered Locus Names:BUsg_216
    OrganismiBuchnera aphidicola subsp. Schizaphis graminum (strain Sg)
    Taxonomic identifieri198804 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeBuchnera
    ProteomesiUP000000416: Chromosome

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. plasma membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cell membrane, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 568568Peptidoglycan synthase FtsIPRO_0000195459Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi198804.BUsg216.

    Structurei

    3D structure databases

    ProteinModelPortaliO85297.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 1818CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini40 – 568529ExtracellularSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei19 – 3921HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Domaini

    Has an N-terminal penicillin insensitive transglycosylase domain (formation of linear glycan strands) and a C-terminal penicillin-sensitive transpeptidase domain (cross-linking of the peptide subunits).

    Sequence similaritiesi

    Belongs to the transpeptidase family.Curated

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG0768.
    KOiK03587.
    OMAiPDGKYIN.
    OrthoDBiEOG6N0HHV.

    Family and domain databases

    Gene3Di3.40.710.10. 1 hit.
    InterProiIPR012338. Beta-lactam/transpept-like.
    IPR005311. PBP_dimer.
    IPR001460. PCN-bd_Tpept.
    [Graphical view]
    PfamiPF03717. PBP_dimer. 1 hit.
    PF00905. Transpeptidase. 1 hit.
    [Graphical view]
    SUPFAMiSSF56519. SSF56519. 1 hit.
    SSF56601. SSF56601. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    O85297-1 [UniParc]FASTAAdd to Basket

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    MNLFKEKKIK KIIYINWRFV TLCSIVFLFL VILTLRIIFL QIINSKKLAY    50
    EGDRRTLRIQ SVINRRGIIN DRLGYPLAVA VPVNAVFIDP TMITNKNDIK 100
    NNIRWKALSE ILSIPLNKLI FFINSDKNIK FIYLARQINP EIGDYIKALK 150
    LPGVFLIEES KRYYPTGAIA AQLIGINNID GEGIEGIEKS FNSYLTGTPG 200
    KRKIRKDNQG QIIENESLIN KSNSNNLILS IDKKLQTIVY QKLNNAVNEN 250
    QADFGIAILI NIETGEILAM ANSPSYNPNN MQYMINKNLR NKAITDIFEP 300
    GSTVKPIVIM EALKRGIIKK NSIINTKPYF IKKHKITDVA YHEKLNITGI 350
    LKKSSNVGVS KIALSMNTSE LINSYIKFGL GQPTNLGLIG EQKGFLPKKK 400
    KLSDLEKATF SFGYGLMITP LQLARLYTII GSYGIYRPLS IIKIDHPLYE 450
    KRIFPKRYVK NVIHMMETVA HPGEGGSQAA IKGYRVAIKT GTAKKVGIHG 500
    YYIKKYIAYT AGIAPASNPK FSLTIIIDNP KGEKYYGGAV SAPVFSKIMK 550
    LVLKEMKIKP DNLKNKLS 568
    Length:568
    Mass (Da):63,939
    Last modified:November 1, 1998 - v1
    Checksum:i533B30828687CEE1
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF060492 Genomic DNA. Translation: AAC32337.1.
    AE013218 Genomic DNA. Translation: AAM67776.1.
    RefSeqiNP_660565.1. NC_004061.1.
    WP_011053743.1. NC_004061.1.

    Genome annotation databases

    EnsemblBacteriaiAAM67776; AAM67776; BUsg_216.
    GeneIDi1005415.
    KEGGibas:BUsg216.
    PATRICi21247227. VBIBucAph100086_0227.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF060492 Genomic DNA. Translation: AAC32337.1 .
    AE013218 Genomic DNA. Translation: AAM67776.1 .
    RefSeqi NP_660565.1. NC_004061.1.
    WP_011053743.1. NC_004061.1.

    3D structure databases

    ProteinModelPortali O85297.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 198804.BUsg216.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAM67776 ; AAM67776 ; BUsg_216 .
    GeneIDi 1005415.
    KEGGi bas:BUsg216.
    PATRICi 21247227. VBIBucAph100086_0227.

    Phylogenomic databases

    eggNOGi COG0768.
    KOi K03587.
    OMAi PDGKYIN.
    OrthoDBi EOG6N0HHV.

    Enzyme and pathway databases

    UniPathwayi UPA00219 .
    BioCyci BAPH198804:GHMG-226-MONOMER.

    Family and domain databases

    Gene3Di 3.40.710.10. 1 hit.
    InterProi IPR012338. Beta-lactam/transpept-like.
    IPR005311. PBP_dimer.
    IPR001460. PCN-bd_Tpept.
    [Graphical view ]
    Pfami PF03717. PBP_dimer. 1 hit.
    PF00905. Transpeptidase. 1 hit.
    [Graphical view ]
    SUPFAMi SSF56519. SSF56519. 1 hit.
    SSF56601. SSF56601. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Sequence analysis of a DNA fragment from Buchnera aphidicola (Aphid endosymbiont) containing the genes dapD-htrA-ilvI-ilvH-ftsL-ftsI-murE."
      Thao M.L., Baumann P.
      Curr. Microbiol. 37:214-216(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: Sg.

    Entry informationi

    Entry nameiFTSI_BUCAP
    AccessioniPrimary (citable) accession number: O85297
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 30, 2000
    Last sequence update: November 1, 1998
    Last modified: October 1, 2014
    This is version 105 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Multifunctional enzyme

    Documents

    1. Buchnera aphidicola (subsp. Schizaphis graminum)
      Buchnera aphidicola (subsp. Schizaphis graminum): entries and gene names
    2. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3