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Protein

Peptidoglycan D,D-transpeptidase FtsI

Gene

ftsI

Organism
Buchnera aphidicola subsp. Schizaphis graminum (strain Sg)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes cross-linking of the peptidoglycan cell wall at the division septum.UniRule annotation

Catalytic activityi

Preferential cleavage: (Ac)2-L-Lys-D-Ala-|-D-Ala. Also transpeptidation of peptidyl-alanyl moieties that are N-acyl substituents of D-alanine.UniRule annotation

Pathwayi: peptidoglycan biosynthesis

This protein is involved in the pathway peptidoglycan biosynthesis, which is part of Cell wall biogenesis.UniRule annotation
View all proteins of this organism that are known to be involved in the pathway peptidoglycan biosynthesis and in Cell wall biogenesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei302Acyl-ester intermediateUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionCarboxypeptidase, Hydrolase, Protease
Biological processCell cycle, Cell division, Cell shape, Cell wall biogenesis/degradation, Peptidoglycan synthesis, Septation

Enzyme and pathway databases

BioCyciBAPH198804:G1FZU-230-MONOMER
UniPathwayiUPA00219

Names & Taxonomyi

Protein namesi
Recommended name:
Peptidoglycan D,D-transpeptidase FtsIUniRule annotation (EC:3.4.16.4UniRule annotation)
Alternative name(s):
Penicillin-binding protein 3UniRule annotation
Short name:
PBP-3UniRule annotation
Gene namesi
Name:ftsIUniRule annotation
Ordered Locus Names:BUsg_216
OrganismiBuchnera aphidicola subsp. Schizaphis graminum (strain Sg)
Taxonomic identifieri198804 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesErwiniaceaeBuchnera
Proteomesi
  • UP000000416 Componenti: Chromosome

Subcellular locationi

  • Cell inner membrane UniRule annotation; Single-pass membrane protein UniRule annotation

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei19 – 39HelicalUniRule annotationAdd BLAST21

GO - Cellular componenti

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001954591 – 568Peptidoglycan D,D-transpeptidase FtsIAdd BLAST568

Proteomic databases

PRIDEiO85297

Interactioni

Protein-protein interaction databases

STRINGi198804.BUsg216

Structurei

3D structure databases

ProteinModelPortaliO85297
SMRiO85297
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the transpeptidase family. FtsI subfamily.UniRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG4105CJN Bacteria
COG0768 LUCA
KOiK03587
OMAiNVGMIKI
OrthoDBiPOG091H01T5

Family and domain databases

HAMAPiMF_02080 FtsI_transpept, 1 hit
InterProiView protein in InterPro
IPR012338 Beta-lactam/transpept-like
IPR037532 FtsI_transpept
IPR005311 PBP_dimer
IPR036138 PBP_dimer_sf
IPR001460 PCN-bd_Tpept
PfamiView protein in Pfam
PF03717 PBP_dimer, 1 hit
PF00905 Transpeptidase, 1 hit
SUPFAMiSSF56519 SSF56519, 1 hit
SSF56601 SSF56601, 1 hit

Sequencei

Sequence statusi: Complete.

O85297-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNLFKEKKIK KIIYINWRFV TLCSIVFLFL VILTLRIIFL QIINSKKLAY
60 70 80 90 100
EGDRRTLRIQ SVINRRGIIN DRLGYPLAVA VPVNAVFIDP TMITNKNDIK
110 120 130 140 150
NNIRWKALSE ILSIPLNKLI FFINSDKNIK FIYLARQINP EIGDYIKALK
160 170 180 190 200
LPGVFLIEES KRYYPTGAIA AQLIGINNID GEGIEGIEKS FNSYLTGTPG
210 220 230 240 250
KRKIRKDNQG QIIENESLIN KSNSNNLILS IDKKLQTIVY QKLNNAVNEN
260 270 280 290 300
QADFGIAILI NIETGEILAM ANSPSYNPNN MQYMINKNLR NKAITDIFEP
310 320 330 340 350
GSTVKPIVIM EALKRGIIKK NSIINTKPYF IKKHKITDVA YHEKLNITGI
360 370 380 390 400
LKKSSNVGVS KIALSMNTSE LINSYIKFGL GQPTNLGLIG EQKGFLPKKK
410 420 430 440 450
KLSDLEKATF SFGYGLMITP LQLARLYTII GSYGIYRPLS IIKIDHPLYE
460 470 480 490 500
KRIFPKRYVK NVIHMMETVA HPGEGGSQAA IKGYRVAIKT GTAKKVGIHG
510 520 530 540 550
YYIKKYIAYT AGIAPASNPK FSLTIIIDNP KGEKYYGGAV SAPVFSKIMK
560
LVLKEMKIKP DNLKNKLS
Length:568
Mass (Da):63,939
Last modified:November 1, 1998 - v1
Checksum:i533B30828687CEE1
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF060492 Genomic DNA Translation: AAC32337.1
AE013218 Genomic DNA Translation: AAM67776.1
RefSeqiWP_011053743.1, NC_004061.1

Genome annotation databases

EnsemblBacteriaiAAM67776; AAM67776; BUsg_216
KEGGibas:BUsg_216

Similar proteinsi

Entry informationi

Entry nameiFTSI_BUCAP
AccessioniPrimary (citable) accession number: O85297
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: November 1, 1998
Last modified: May 23, 2018
This is version 124 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

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