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O85297

- FTSI_BUCAP

UniProt

O85297 - FTSI_BUCAP

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Protein

Peptidoglycan synthase FtsI

Gene

ftsI

Organism
Buchnera aphidicola subsp. Schizaphis graminum (strain Sg)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Cell wall formation. Essential for the formation of a septum of the murein sacculus. Synthesis of cross-linked peptidoglycan from the lipid intermediates (By similarity).By similarity

Catalytic activityi

(GlcNAc-(1->4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala))(n)-diphosphoundecaprenol + GlcNAc-(1->4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)-diphosphoundecaprenol = (GlcNAc-(1->4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala))(n+1)-diphosphoundecaprenol + undecaprenyl diphosphate.

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei302 – 3021Acyl-ester intermediateBy similarity

GO - Molecular functioni

  1. penicillin binding Source: InterPro
  2. peptidoglycan glycosyltransferase activity Source: UniProtKB-EC

GO - Biological processi

  1. cell cycle Source: UniProtKB-KW
  2. cell division Source: UniProtKB-KW
  3. cell wall organization Source: UniProtKB-KW
  4. peptidoglycan biosynthetic process Source: UniProtKB-UniPathway
  5. regulation of cell shape Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Glycosyltransferase, Transferase

Keywords - Biological processi

Cell cycle, Cell division, Cell shape, Cell wall biogenesis/degradation, Peptidoglycan synthesis

Enzyme and pathway databases

BioCyciBAPH198804:GHMG-226-MONOMER.
UniPathwayiUPA00219.

Names & Taxonomyi

Protein namesi
Recommended name:
Peptidoglycan synthase FtsI (EC:2.4.1.129)
Alternative name(s):
Penicillin-binding protein 3
Short name:
PBP-3
Peptidoglycan glycosyltransferase 3
Gene namesi
Name:ftsI
Ordered Locus Names:BUsg_216
OrganismiBuchnera aphidicola subsp. Schizaphis graminum (strain Sg)
Taxonomic identifieri198804 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeBuchnera
ProteomesiUP000000416: Chromosome

Subcellular locationi

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. plasma membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 568568Peptidoglycan synthase FtsIPRO_0000195459Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi198804.BUsg216.

Structurei

3D structure databases

ProteinModelPortaliO85297.
ModBaseiSearch...
MobiDBiSearch...

Topological domain

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 1818CytoplasmicSequence AnalysisAdd
BLAST
Topological domaini40 – 568529ExtracellularSequence AnalysisAdd
BLAST

Transmembrane

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei19 – 3921HelicalSequence AnalysisAdd
BLAST

Family & Domainsi

Domaini

Has an N-terminal penicillin insensitive transglycosylase domain (formation of linear glycan strands) and a C-terminal penicillin-sensitive transpeptidase domain (cross-linking of the peptide subunits).

Sequence similaritiesi

Belongs to the transpeptidase family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG0768.
KOiK03587.
OMAiPDGKYIN.
OrthoDBiEOG6N0HHV.

Family and domain databases

Gene3Di3.40.710.10. 1 hit.
InterProiIPR012338. Beta-lactam/transpept-like.
IPR005311. PBP_dimer.
IPR001460. PCN-bd_Tpept.
[Graphical view]
PfamiPF03717. PBP_dimer. 1 hit.
PF00905. Transpeptidase. 1 hit.
[Graphical view]
SUPFAMiSSF56519. SSF56519. 1 hit.
SSF56601. SSF56601. 1 hit.

Sequencei

Sequence statusi: Complete.

O85297-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MNLFKEKKIK KIIYINWRFV TLCSIVFLFL VILTLRIIFL QIINSKKLAY
60 70 80 90 100
EGDRRTLRIQ SVINRRGIIN DRLGYPLAVA VPVNAVFIDP TMITNKNDIK
110 120 130 140 150
NNIRWKALSE ILSIPLNKLI FFINSDKNIK FIYLARQINP EIGDYIKALK
160 170 180 190 200
LPGVFLIEES KRYYPTGAIA AQLIGINNID GEGIEGIEKS FNSYLTGTPG
210 220 230 240 250
KRKIRKDNQG QIIENESLIN KSNSNNLILS IDKKLQTIVY QKLNNAVNEN
260 270 280 290 300
QADFGIAILI NIETGEILAM ANSPSYNPNN MQYMINKNLR NKAITDIFEP
310 320 330 340 350
GSTVKPIVIM EALKRGIIKK NSIINTKPYF IKKHKITDVA YHEKLNITGI
360 370 380 390 400
LKKSSNVGVS KIALSMNTSE LINSYIKFGL GQPTNLGLIG EQKGFLPKKK
410 420 430 440 450
KLSDLEKATF SFGYGLMITP LQLARLYTII GSYGIYRPLS IIKIDHPLYE
460 470 480 490 500
KRIFPKRYVK NVIHMMETVA HPGEGGSQAA IKGYRVAIKT GTAKKVGIHG
510 520 530 540 550
YYIKKYIAYT AGIAPASNPK FSLTIIIDNP KGEKYYGGAV SAPVFSKIMK
560
LVLKEMKIKP DNLKNKLS
Length:568
Mass (Da):63,939
Last modified:November 1, 1998 - v1
Checksum:i533B30828687CEE1
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF060492 Genomic DNA. Translation: AAC32337.1.
AE013218 Genomic DNA. Translation: AAM67776.1.
RefSeqiNP_660565.1. NC_004061.1.
WP_011053743.1. NC_004061.1.

Genome annotation databases

EnsemblBacteriaiAAM67776; AAM67776; BUsg_216.
GeneIDi1005415.
KEGGibas:BUsg216.
PATRICi21247227. VBIBucAph100086_0227.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF060492 Genomic DNA. Translation: AAC32337.1 .
AE013218 Genomic DNA. Translation: AAM67776.1 .
RefSeqi NP_660565.1. NC_004061.1.
WP_011053743.1. NC_004061.1.

3D structure databases

ProteinModelPortali O85297.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 198804.BUsg216.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAM67776 ; AAM67776 ; BUsg_216 .
GeneIDi 1005415.
KEGGi bas:BUsg216.
PATRICi 21247227. VBIBucAph100086_0227.

Phylogenomic databases

eggNOGi COG0768.
KOi K03587.
OMAi PDGKYIN.
OrthoDBi EOG6N0HHV.

Enzyme and pathway databases

UniPathwayi UPA00219 .
BioCyci BAPH198804:GHMG-226-MONOMER.

Family and domain databases

Gene3Di 3.40.710.10. 1 hit.
InterProi IPR012338. Beta-lactam/transpept-like.
IPR005311. PBP_dimer.
IPR001460. PCN-bd_Tpept.
[Graphical view ]
Pfami PF03717. PBP_dimer. 1 hit.
PF00905. Transpeptidase. 1 hit.
[Graphical view ]
SUPFAMi SSF56519. SSF56519. 1 hit.
SSF56601. SSF56601. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Sequence analysis of a DNA fragment from Buchnera aphidicola (Aphid endosymbiont) containing the genes dapD-htrA-ilvI-ilvH-ftsL-ftsI-murE."
    Thao M.L., Baumann P.
    Curr. Microbiol. 37:214-216(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Sg.

Entry informationi

Entry nameiFTSI_BUCAP
AccessioniPrimary (citable) accession number: O85297
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: November 1, 1998
Last modified: October 29, 2014
This is version 106 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Multifunctional enzyme

Documents

  1. Buchnera aphidicola (subsp. Schizaphis graminum)
    Buchnera aphidicola (subsp. Schizaphis graminum): entries and gene names
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3