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Protein

Probable periplasmic serine endoprotease DegP-like

Gene

htrA

Organism
Buchnera aphidicola subsp. Schizaphis graminum (strain Sg)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Might be efficient in the degradation of transiently denatured and unfolded proteins which accumulate in the periplasm following stress conditions.By similarity

Catalytic activityi

Acts on substrates that are at least partially unfolded. The cleavage site P1 residue is normally between a pair of hydrophobic residues, such as Val-|-Val.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei133Charge relay systemSequence analysis1
Active sitei163Charge relay systemSequence analysis1
Active sitei238Charge relay systemSequence analysis1

GO - Molecular functioni

Keywordsi

Molecular functionHydrolase, Protease, Serine protease
Biological processStress response

Enzyme and pathway databases

BioCyciBAPH198804:G1FZU-236-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Probable periplasmic serine endoprotease DegP-like (EC:3.4.21.107)
Alternative name(s):
Protease Do
Gene namesi
Name:htrA
Ordered Locus Names:BUsg_222
OrganismiBuchnera aphidicola subsp. Schizaphis graminum (strain Sg)
Taxonomic identifieri198804 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesErwiniaceaeBuchnera
Proteomesi
  • UP000000416 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Periplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 26Sequence analysisAdd BLAST26
ChainiPRO_000002692827 – 478Probable periplasmic serine endoprotease DegP-likeAdd BLAST452

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi87 ↔ 99By similarity

Keywords - PTMi

Disulfide bond

Interactioni

Protein-protein interaction databases

STRINGi198804.BUsg222

Structurei

3D structure databases

ProteinModelPortaliO85291
SMRiO85291
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini281 – 372PDZ 1PROSITE-ProRule annotationAdd BLAST92
Domaini387 – 469PDZ 2PROSITE-ProRule annotationAdd BLAST83

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni116 – 254Serine proteaseAdd BLAST139
Regioni236 – 238Substrate bindingBy similarity3
Regioni293 – 297Substrate bindingBy similarity5

Sequence similaritiesi

Belongs to the peptidase S1C family.Curated

Keywords - Domaini

Repeat, Signal

Phylogenomic databases

eggNOGiENOG4105C0H Bacteria
COG0265 LUCA
KOiK04771
OMAiRVYNDFV
OrthoDBiPOG091H02EX

Family and domain databases

InterProiView protein in InterPro
IPR001478 PDZ
IPR036034 PDZ_sf
IPR011782 Pept_S1C_Do
IPR009003 Peptidase_S1_PA
IPR001940 Peptidase_S1C
PfamiView protein in Pfam
PF00595 PDZ, 1 hit
PRINTSiPR00834 PROTEASES2C
SMARTiView protein in SMART
SM00228 PDZ, 2 hits
SUPFAMiSSF50156 SSF50156, 2 hits
SSF50494 SSF50494, 2 hits
TIGRFAMsiTIGR02037 degP_htrA_DO, 1 hit
PROSITEiView protein in PROSITE
PS50106 PDZ, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

O85291-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKRINIVLSG IMLFLTLLLS FGMSWGNKNF TSSQNVSSVQ LAPSLAPMLE
60 70 80 90 100
KVMPSVISIN IEGSTVVHTS RLPHQFQPFF GHNSPFCQGN SPFRNSPFCR
110 120 130 140 150
SNPNSNSMHE KFHALGSGVI INADKAYAVT NNHVVENANK IQVQLSDGRR
160 170 180 190 200
YEASIIGKDS RSDIALIQLK NAKNLSAIKI ADSDTLRVGD YTVAIGNPYG
210 220 230 240 250
LGETVTSGII SALGRSGLNI EHYENFIQTD AAINRGNSGG ALVNLKGELI
260 270 280 290 300
GINTAILAPD GGNIGIGFAI PGNMVKNLTE QMVKFGQVKR GELGIIGMEL
310 320 330 340 350
NSDLAHVMKI NAQKGAFVSQ VLPNSSAFHA GIKAGDIIVS LNKKTISSFA
360 370 380 390 400
ALRAEVGSLP VSTKMELGIF RNGITKNVIV ELKPSLKNSV SLGDIYTGIE
410 420 430 440 450
GADLSDCSLN GQKGVKIENI KLNTQASKIG FKKDDIIVEV NQKVINNLND
460 470
LKNILDSKPN ILVFSVKRGN NSIYLVSE
Length:478
Mass (Da):51,303
Last modified:November 1, 1998 - v1
Checksum:iC044824F7EF4E98E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF060492 Genomic DNA Translation: AAC32331.1
AE013218 Genomic DNA Translation: AAM67781.1
RefSeqiWP_011053748.1, NC_004061.1

Genome annotation databases

EnsemblBacteriaiAAM67781; AAM67781; BUsg_222
KEGGibas:BUsg_222

Similar proteinsi

Entry informationi

Entry nameiDEGPL_BUCAP
AccessioniPrimary (citable) accession number: O85291
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: November 1, 1998
Last modified: March 28, 2018
This is version 118 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. Buchnera aphidicola (subsp. Schizaphis graminum)
    Buchnera aphidicola (subsp. Schizaphis graminum): entries and gene names
  2. Peptidase families
    Classification of peptidase families and list of entries
  3. SIMILARITY comments
    Index of protein domains and families

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