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Protein

Probable periplasmic serine endoprotease DegP-like

Gene

htrA

Organism
Buchnera aphidicola subsp. Schizaphis graminum (strain Sg)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Might be efficient in the degradation of transiently denatured and unfolded proteins which accumulate in the periplasm following stress conditions.By similarity

Catalytic activityi

Acts on substrates that are at least partially unfolded. The cleavage site P1 residue is normally between a pair of hydrophobic residues, such as Val-|-Val.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei133 – 1331Charge relay systemSequence analysis
Active sitei163 – 1631Charge relay systemSequence analysis
Active sitei238 – 2381Charge relay systemSequence analysis

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protease, Serine protease

Keywords - Biological processi

Stress response

Enzyme and pathway databases

BioCyciBAPH198804:GHMG-232-MONOMER.

Protein family/group databases

MEROPSiS01.273.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable periplasmic serine endoprotease DegP-like (EC:3.4.21.107)
Alternative name(s):
Protease Do
Gene namesi
Name:htrA
Ordered Locus Names:BUsg_222
OrganismiBuchnera aphidicola subsp. Schizaphis graminum (strain Sg)
Taxonomic identifieri198804 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeBuchnera
Proteomesi
  • UP000000416 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Periplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2626Sequence analysisAdd
BLAST
Chaini27 – 478452Probable periplasmic serine endoprotease DegP-likePRO_0000026928Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi87 ↔ 99By similarity

Keywords - PTMi

Disulfide bond

Interactioni

Protein-protein interaction databases

STRINGi198804.BUsg222.

Structurei

3D structure databases

ProteinModelPortaliO85291.
SMRiO85291. Positions 43-478.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini281 – 37292PDZ 1PROSITE-ProRule annotationAdd
BLAST
Domaini387 – 46983PDZ 2PROSITE-ProRule annotationAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni116 – 254139Serine proteaseAdd
BLAST
Regioni236 – 2383Substrate bindingBy similarity
Regioni293 – 2975Substrate bindingBy similarity

Sequence similaritiesi

Belongs to the peptidase S1C family.Curated
Contains 2 PDZ (DHR) domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, Signal

Phylogenomic databases

eggNOGiENOG4105C0H. Bacteria.
COG0265. LUCA.
KOiK04771.
OMAiSVEVHAT.
OrthoDBiPOG091H02EX.

Family and domain databases

Gene3Di2.30.42.10. 2 hits.
InterProiIPR001478. PDZ.
IPR011782. Pept_S1C_Do.
IPR009003. Peptidase_S1_PA.
IPR001940. Peptidase_S1C.
[Graphical view]
PfamiPF00595. PDZ. 1 hit.
[Graphical view]
PRINTSiPR00834. PROTEASES2C.
SMARTiSM00228. PDZ. 2 hits.
[Graphical view]
SUPFAMiSSF50156. SSF50156. 2 hits.
SSF50494. SSF50494. 2 hits.
TIGRFAMsiTIGR02037. degP_htrA_DO. 1 hit.
PROSITEiPS50106. PDZ. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

O85291-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKRINIVLSG IMLFLTLLLS FGMSWGNKNF TSSQNVSSVQ LAPSLAPMLE
60 70 80 90 100
KVMPSVISIN IEGSTVVHTS RLPHQFQPFF GHNSPFCQGN SPFRNSPFCR
110 120 130 140 150
SNPNSNSMHE KFHALGSGVI INADKAYAVT NNHVVENANK IQVQLSDGRR
160 170 180 190 200
YEASIIGKDS RSDIALIQLK NAKNLSAIKI ADSDTLRVGD YTVAIGNPYG
210 220 230 240 250
LGETVTSGII SALGRSGLNI EHYENFIQTD AAINRGNSGG ALVNLKGELI
260 270 280 290 300
GINTAILAPD GGNIGIGFAI PGNMVKNLTE QMVKFGQVKR GELGIIGMEL
310 320 330 340 350
NSDLAHVMKI NAQKGAFVSQ VLPNSSAFHA GIKAGDIIVS LNKKTISSFA
360 370 380 390 400
ALRAEVGSLP VSTKMELGIF RNGITKNVIV ELKPSLKNSV SLGDIYTGIE
410 420 430 440 450
GADLSDCSLN GQKGVKIENI KLNTQASKIG FKKDDIIVEV NQKVINNLND
460 470
LKNILDSKPN ILVFSVKRGN NSIYLVSE
Length:478
Mass (Da):51,303
Last modified:November 1, 1998 - v1
Checksum:iC044824F7EF4E98E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF060492 Genomic DNA. Translation: AAC32331.1.
AE013218 Genomic DNA. Translation: AAM67781.1.
RefSeqiWP_011053748.1. NC_004061.1.

Genome annotation databases

EnsemblBacteriaiAAM67781; AAM67781; BUsg_222.
KEGGibas:BUsg_222.
PATRICi21247239. VBIBucAph100086_0233.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF060492 Genomic DNA. Translation: AAC32331.1.
AE013218 Genomic DNA. Translation: AAM67781.1.
RefSeqiWP_011053748.1. NC_004061.1.

3D structure databases

ProteinModelPortaliO85291.
SMRiO85291. Positions 43-478.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi198804.BUsg222.

Protein family/group databases

MEROPSiS01.273.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAM67781; AAM67781; BUsg_222.
KEGGibas:BUsg_222.
PATRICi21247239. VBIBucAph100086_0233.

Phylogenomic databases

eggNOGiENOG4105C0H. Bacteria.
COG0265. LUCA.
KOiK04771.
OMAiSVEVHAT.
OrthoDBiPOG091H02EX.

Enzyme and pathway databases

BioCyciBAPH198804:GHMG-232-MONOMER.

Family and domain databases

Gene3Di2.30.42.10. 2 hits.
InterProiIPR001478. PDZ.
IPR011782. Pept_S1C_Do.
IPR009003. Peptidase_S1_PA.
IPR001940. Peptidase_S1C.
[Graphical view]
PfamiPF00595. PDZ. 1 hit.
[Graphical view]
PRINTSiPR00834. PROTEASES2C.
SMARTiSM00228. PDZ. 2 hits.
[Graphical view]
SUPFAMiSSF50156. SSF50156. 2 hits.
SSF50494. SSF50494. 2 hits.
TIGRFAMsiTIGR02037. degP_htrA_DO. 1 hit.
PROSITEiPS50106. PDZ. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiDEGPL_BUCAP
AccessioniPrimary (citable) accession number: O85291
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: November 1, 1998
Last modified: September 7, 2016
This is version 109 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. Buchnera aphidicola (subsp. Schizaphis graminum)
    Buchnera aphidicola (subsp. Schizaphis graminum): entries and gene names
  2. Peptidase families
    Classification of peptidase families and list of entries
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.