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O85290 (DAPD_BUCAP) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 92. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-succinyltransferase

EC=2.3.1.117
Alternative name(s):
Tetrahydrodipicolinate N-succinyltransferase
Short name=THDP succinyltransferase
Short name=THP succinyltransferase
Short name=Tetrahydropicolinate succinylase
Gene names
Name:dapD
Ordered Locus Names:BUsg_223
OrganismBuchnera aphidicola subsp. Schizaphis graminum (strain Sg) [Complete proteome] [HAMAP]
Taxonomic identifier198804 [NCBI]
Taxonomic lineageBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeBuchnera

Protein attributes

Sequence length273 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

Succinyl-CoA + (S)-2,3,4,5-tetrahydropyridine-2,6-dicarboxylate + H2O = CoA + N-succinyl-L-2-amino-6-oxoheptanedioate. HAMAP-Rule MF_00811

Pathway

Amino-acid biosynthesis; L-lysine biosynthesis via DAP pathway; LL-2,6-diaminopimelate from (S)-tetrahydrodipicolinate (succinylase route): step 1/3. HAMAP-Rule MF_00811

Subunit structure

Homotrimer By similarity. HAMAP-Rule MF_00811

Subcellular location

Cytoplasm By similarity HAMAP-Rule MF_00811.

Sequence similarities

Belongs to the transferase hexapeptide repeat family.

Ontologies

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 2732732,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-succinyltransferase HAMAP-Rule MF_00811
PRO_0000196924

Sites

Binding site1041Substrate By similarity
Binding site1411Substrate By similarity

Sequences

Sequence LengthMass (Da)Tools
O85290 [UniParc].

Last modified August 30, 2002. Version 2.
Checksum: 58D7AEE35DE356C9

FASTA27330,928
        10         20         30         40         50         60 
MKKYYDIIEN AYLKKNEVNT KNIDIETKQT IHHVIELLNS GKIRVAEKKD NIWITNQWIK 

        70         80         90        100        110        120 
KSILLYMYLN QNNVFQGSFS NYYDKIPLKY ENYNEKKFKE ERIRVVPPAT IRYGSFINSN 

       130        140        150        160        170        180 
TIIMPSYVNI GAYVDQGTMI DTWTTVGSCA QIGKNVHLSG GVGIGGVLEP LQNNPTIIED 

       190        200        210        220        230        240 
NCFIGARSEI VEGVIIEEGS VISMGVFIGQ STKIYNRETG EILYGRVPAN SVVVSGSLPS 

       250        260        270 
KDRKYNLYAA VIVKRVDSKT LNKVEINQLL RDK 

« Hide

References

« Hide 'large scale' references
[1]"50 million years of genomic stasis in endosymbiotic bacteria."
Tamas I., Klasson L., Canbaeck B., Naeslund A.K., Eriksson A.-S., Wernegreen J.J., Sandstroem J.P., Moran N.A., Andersson S.G.E.
Science 296:2376-2379(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: Sg.
[2]"Sequence analysis of a DNA fragment from Buchnera aphidicola (Aphid endosymbiont) containing the genes dapD-htrA-ilvI-ilvH-ftsL-ftsI-murE."
Thao M.L., Baumann P.
Curr. Microbiol. 37:214-216(1998) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 103-273.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AE013218 Genomic DNA. Translation: AAM67782.1.
AF060492 Genomic DNA. Translation: AAC32330.1.
RefSeqNP_660571.1. NC_004061.1.

3D structure databases

ProteinModelPortalO85290.
SMRO85290. Positions 1-271.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING198804.BUsg223.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAM67782; AAM67782; BUsg_223.
GeneID1005422.
KEGGbas:BUsg223.
PATRIC21247241. VBIBucAph100086_0234.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG2171.
KOK00674.
OMAWVTVGSC.
OrthoDBEOG68H8BV.
ProtClustDBPRK11830.

Enzyme and pathway databases

BioCycBAPH198804:GHMG-233-MONOMER.
UniPathwayUPA00034; UER00019.

Family and domain databases

Gene3D1.10.166.10. 1 hit.
HAMAPMF_00811. DapD.
InterProIPR005664. DapD_Trfase_Hexpep_rpt_fam.
IPR001451. Hexapep_transf.
IPR023180. THP_succinylTrfase_dom1.
IPR011004. Trimer_LpxA-like.
[Graphical view]
PANTHERPTHR19136:SF52. PTHR19136:SF52. 1 hit.
PfamPF00132. Hexapep. 1 hit.
[Graphical view]
SUPFAMSSF51161. SSF51161. 1 hit.
TIGRFAMsTIGR00965. dapD. 1 hit.
ProtoNetSearch...

Entry information

Entry nameDAPD_BUCAP
AccessionPrimary (citable) accession number: O85290
Entry history
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: August 30, 2002
Last modified: February 19, 2014
This is version 92 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways

Buchnera aphidicola (subsp. Schizaphis graminum)

Buchnera aphidicola (subsp. Schizaphis graminum): entries and gene names