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Protein

2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-succinyltransferase

Gene

dapD

Organism
Buchnera aphidicola subsp. Schizaphis graminum (strain Sg)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic activityi

Succinyl-CoA + (S)-2,3,4,5-tetrahydropyridine-2,6-dicarboxylate + H2O = CoA + N-succinyl-L-2-amino-6-oxoheptanedioate.UniRule annotation

Pathwayi: L-lysine biosynthesis via DAP pathway

This protein is involved in step 1 of the subpathway that synthesizes LL-2,6-diaminopimelate from (S)-tetrahydrodipicolinate (succinylase route).UniRule annotation
Proteins known to be involved in the 3 steps of the subpathway in this organism are:
  1. 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-succinyltransferase (dapD)
  2. Acetylornithine/succinyldiaminopimelate aminotransferase (argD)
  3. Succinyl-diaminopimelate desuccinylase (dapE)
This subpathway is part of the pathway L-lysine biosynthesis via DAP pathway, which is itself part of Amino-acid biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes LL-2,6-diaminopimelate from (S)-tetrahydrodipicolinate (succinylase route), the pathway L-lysine biosynthesis via DAP pathway and in Amino-acid biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei104SubstrateUniRule annotation1
Binding sitei141SubstrateUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionAcyltransferase, Transferase
Biological processAmino-acid biosynthesis, Diaminopimelate biosynthesis, Lysine biosynthesis

Enzyme and pathway databases

BioCyciBAPH198804:G1FZU-237-MONOMER
UniPathwayiUPA00034; UER00019

Names & Taxonomyi

Protein namesi
Recommended name:
2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-succinyltransferaseUniRule annotation (EC:2.3.1.117UniRule annotation)
Alternative name(s):
Tetrahydrodipicolinate N-succinyltransferaseUniRule annotation
Short name:
THDP succinyltransferaseUniRule annotation
Short name:
THP succinyltransferaseUniRule annotation
Short name:
Tetrahydropicolinate succinylaseUniRule annotation
Gene namesi
Name:dapDUniRule annotation
Ordered Locus Names:BUsg_223
OrganismiBuchnera aphidicola subsp. Schizaphis graminum (strain Sg)
Taxonomic identifieri198804 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesErwiniaceaeBuchnera
Proteomesi
  • UP000000416 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001969241 – 2732,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-succinyltransferaseAdd BLAST273

Proteomic databases

PRIDEiO85290

Interactioni

Subunit structurei

Homotrimer.UniRule annotation

Protein-protein interaction databases

STRINGi198804.BUsg223

Structurei

3D structure databases

ProteinModelPortaliO85290
SMRiO85290
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the transferase hexapeptide repeat family.UniRule annotation

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiENOG4105DMJ Bacteria
COG2171 LUCA
KOiK00674
OMAiQVPCALI
OrthoDBiPOG091H0G02

Family and domain databases

Gene3Di1.10.166.10, 1 hit
HAMAPiMF_00811 DapD, 1 hit
InterProiView protein in InterPro
IPR005664 DapD_Trfase_Hexpep_rpt_fam
IPR001451 Hexapep
IPR023180 THP_succinylTrfase_dom1
IPR037133 THP_succinylTrfase_N_sf
IPR011004 Trimer_LpxA-like_sf
PfamiView protein in Pfam
PF14602 Hexapep_2, 1 hit
PF14805 THDPS_N_2, 1 hit
SUPFAMiSSF51161 SSF51161, 1 hit
TIGRFAMsiTIGR00965 dapD, 1 hit

Sequencei

Sequence statusi: Complete.

O85290-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKKYYDIIEN AYLKKNEVNT KNIDIETKQT IHHVIELLNS GKIRVAEKKD
60 70 80 90 100
NIWITNQWIK KSILLYMYLN QNNVFQGSFS NYYDKIPLKY ENYNEKKFKE
110 120 130 140 150
ERIRVVPPAT IRYGSFINSN TIIMPSYVNI GAYVDQGTMI DTWTTVGSCA
160 170 180 190 200
QIGKNVHLSG GVGIGGVLEP LQNNPTIIED NCFIGARSEI VEGVIIEEGS
210 220 230 240 250
VISMGVFIGQ STKIYNRETG EILYGRVPAN SVVVSGSLPS KDRKYNLYAA
260 270
VIVKRVDSKT LNKVEINQLL RDK
Length:273
Mass (Da):30,928
Last modified:August 30, 2002 - v2
Checksum:i58D7AEE35DE356C9
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE013218 Genomic DNA Translation: AAM67782.1
AF060492 Genomic DNA Translation: AAC32330.1
RefSeqiWP_011053749.1, NC_004061.1

Genome annotation databases

EnsemblBacteriaiAAM67782; AAM67782; BUsg_223
KEGGibas:BUsg_223

Similar proteinsi

Entry informationi

Entry nameiDAPD_BUCAP
AccessioniPrimary (citable) accession number: O85290
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: August 30, 2002
Last modified: May 23, 2018
This is version 114 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

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