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Protein

Chaperone protein DnaK

Gene

dnaK

Organism
Neorickettsia sennetsu (Ehrlichia sennetsu)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Acts as a chaperone.By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Chaperone

Keywords - Biological processi

Stress response

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Chaperone protein DnaK
Alternative name(s):
HSP70
Heat shock 70 kDa protein
Heat shock protein 70
Gene namesi
Name:dnaK
OrganismiNeorickettsia sennetsu (Ehrlichia sennetsu)
Taxonomic identifieri951 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRickettsialesAnaplasmataceaeNeorickettsia

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 636636Chaperone protein DnaKPRO_0000078461Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei197 – 1971Phosphothreonine; by autocatalysisBy similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

PRIDEiO85282.

Expressioni

Inductioni

By stress conditions e.g. heat shock (By similarity).By similarity

Interactioni

Protein-protein interaction databases

STRINGi222891.NSE_0019.

Structurei

3D structure databases

ProteinModelPortaliO85282.
SMRiO85282. Positions 7-596.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the heat shock protein 70 family.Curated

Phylogenomic databases

eggNOGiENOG4105CFG. Bacteria.
COG0443. LUCA.

Family and domain databases

Gene3Di1.20.1270.10. 1 hit.
2.60.34.10. 1 hit.
HAMAPiMF_00332. DnaK. 1 hit.
InterProiIPR012725. Chaperone_DnaK.
IPR018181. Heat_shock_70_CS.
IPR029048. HSP70_C.
IPR029047. HSP70_peptide-bd.
IPR013126. Hsp_70_fam.
[Graphical view]
PfamiPF00012. HSP70. 1 hit.
[Graphical view]
PRINTSiPR00301. HEATSHOCK70.
SUPFAMiSSF100920. SSF100920. 1 hit.
SSF100934. SSF100934. 1 hit.
TIGRFAMsiTIGR02350. prok_dnaK. 1 hit.
PROSITEiPS00297. HSP70_1. 1 hit.
PS00329. HSP70_2. 1 hit.
PS01036. HSP70_3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O85282-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAGEIAIGID LGTTNSCVAI KDKVIENAEG ARTTPSVVAF TSDGQTLVGA
60 70 80 90 100
PAQRQAVTNA KNTIVASKRL IGRRFKDNVI KGIQKDYPYK IVEAKNGDAW
110 120 130 140 150
IEAGGKSYSP SQVGANVLIK LKEAAETYTG KKVTKAVITV PAYFDDAQRT
160 170 180 190 200
ATKDAGRIAG LEVLRIINEP TAAALAYGLD KTATTKNIAV FDLGGGTFDV
210 220 230 240 250
SILELGDGVF EVKATNGDTH LGGEDFDRMI LNFLVEEFKK ENGMDLKNDP
260 270 280 290 300
LALQRLKEAA EKAKKELSST QETDINLPYI TADAAGPKHL NVKFTRAKLE
310 320 330 340 350
SLVSDLIDRT IEPCKKALKD SGLKREEINE VVLVGGMTRM PAVVKKVTEF
360 370 380 390 400
FGKEPHKGVN PDEVVAIGAA IQANILAGGS DAQDIVLLDV TPLSLGIETL
410 420 430 440 450
GGVFTKLIDR NTTIPTKRSQ TFSTAEDNQS AVTIRVFQGE RQMASDNKLL
460 470 480 490 500
GQFSLGGIPP APRGMPQIEV TFDIDANGIV HVSAKDKGTG KEQTVKIQAS
510 520 530 540 550
GGLTEEEIKK MVDEAASKAD EDKKRRELVE AKNSAESLIH STEKSLSEYG
560 570 580 590 600
SKISSSDKQS IDDAISDLKS VLAKDDASLI KEKTDALSKV SMKLGEAMYK
610 620 630
ESQSASNDSS PKNDSTEEGE RVVDPEYEEV KDEDSK
Length:636
Mass (Da):68,358
Last modified:November 1, 1998 - v1
Checksum:i12A9F79C00473676
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF060197 Genomic DNA. Translation: AAC27487.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF060197 Genomic DNA. Translation: AAC27487.1.

3D structure databases

ProteinModelPortaliO85282.
SMRiO85282. Positions 7-596.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi222891.NSE_0019.

Proteomic databases

PRIDEiO85282.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Phylogenomic databases

eggNOGiENOG4105CFG. Bacteria.
COG0443. LUCA.

Family and domain databases

Gene3Di1.20.1270.10. 1 hit.
2.60.34.10. 1 hit.
HAMAPiMF_00332. DnaK. 1 hit.
InterProiIPR012725. Chaperone_DnaK.
IPR018181. Heat_shock_70_CS.
IPR029048. HSP70_C.
IPR029047. HSP70_peptide-bd.
IPR013126. Hsp_70_fam.
[Graphical view]
PfamiPF00012. HSP70. 1 hit.
[Graphical view]
PRINTSiPR00301. HEATSHOCK70.
SUPFAMiSSF100920. SSF100920. 1 hit.
SSF100934. SSF100934. 1 hit.
TIGRFAMsiTIGR02350. prok_dnaK. 1 hit.
PROSITEiPS00297. HSP70_1. 1 hit.
PS00329. HSP70_2. 1 hit.
PS01036. HSP70_3. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiDNAK_NEOSE
AccessioniPrimary (citable) accession number: O85282
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 27, 2001
Last sequence update: November 1, 1998
Last modified: November 11, 2015
This is version 72 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.